IL72085A - 13alpha-alkylgonanes,processes for their preparation and pharmaceutical compositions containing them - Google Patents

13alpha-alkylgonanes,processes for their preparation and pharmaceutical compositions containing them

Info

Publication number
IL72085A
IL72085A IL72085A IL7208584A IL72085A IL 72085 A IL72085 A IL 72085A IL 72085 A IL72085 A IL 72085A IL 7208584 A IL7208584 A IL 7208584A IL 72085 A IL72085 A IL 72085A
Authority
IL
Israel
Prior art keywords
alkylgonanes
13alpha
processes
preparation
pharmaceutical compositions
Prior art date
Application number
IL72085A
Other versions
IL72085A0 (en
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE3321826A external-priority patent/DE3321826A1/en
Priority claimed from DE19843413036 external-priority patent/DE3413036A1/en
Application filed by Schering Ag filed Critical Schering Ag
Priority to IL8181884A priority Critical patent/IL81818A/en
Publication of IL72085A0 publication Critical patent/IL72085A0/en
Priority to IL7720485A priority patent/IL77204A/en
Priority to IL81818A priority patent/IL81818A0/en
Publication of IL72085A publication Critical patent/IL72085A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
    • C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
IL72085A 1983-06-15 1984-06-13 13alpha-alkylgonanes,processes for their preparation and pharmaceutical compositions containing them IL72085A (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
IL8181884A IL81818A (en) 1983-06-15 1984-06-13 13-epi-steroids and process for the preparation thereof
IL7720485A IL77204A (en) 1984-06-13 1985-12-03 11beta-(4-dimethylamino-phenyl)-13alpha-alkylogonane derivatives,process for the preparation thereof and pharmaceutical compositions containing the same
IL81818A IL81818A0 (en) 1983-06-15 1987-03-08 13-epi-steroids and process for the preparation thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3321826A DE3321826A1 (en) 1983-06-15 1983-06-15 13 alpha -Alkylgonanes, the preparation thereof and pharmaceutical products containing these
DE19843413036 DE3413036A1 (en) 1984-04-04 1984-04-04 13a-Alkylgonanes, the preparation thereof and pharmaceutical products containing these

Publications (2)

Publication Number Publication Date
IL72085A0 IL72085A0 (en) 1984-10-31
IL72085A true IL72085A (en) 1987-09-16

Family

ID=25811539

Family Applications (1)

Application Number Title Priority Date Filing Date
IL72085A IL72085A (en) 1983-06-15 1984-06-13 13alpha-alkylgonanes,processes for their preparation and pharmaceutical compositions containing them

Country Status (16)

Country Link
EP (1) EP0129499B1 (en)
JP (1) JPH02167296A (en)
AU (1) AU572849B2 (en)
CA (1) CA1307784C (en)
DD (1) DD218624A5 (en)
DE (1) DE3468030D1 (en)
DK (1) DK166729B1 (en)
ES (1) ES8502612A1 (en)
FI (1) FI78709C (en)
GR (1) GR82210B (en)
HU (1) HU191131B (en)
IE (1) IE57620B1 (en)
IL (1) IL72085A (en)
NO (1) NO160521C (en)
NZ (1) NZ208441A (en)
PT (1) PT78732B (en)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3446661A1 (en) * 1984-12-18 1986-06-19 Schering AG, 1000 Berlin und 4709 Bergkamen NEW 13 (ALPHA) -ALKYL-17 (BETA) - (3-ACYLOXYPROPYL) GONANA
DE3506785A1 (en) * 1985-02-22 1986-08-28 Schering AG, Berlin und Bergkamen, 1000 Berlin 11SS-N, N-DIMETHYLAMINOPHENYL ESTRADIENE, THE PRODUCTION THEREOF AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM
DE3630030A1 (en) * 1986-09-01 1988-03-03 Schering Ag 13 (ALPHA) -ALKYLGONAN- (DELTA) (UP ARROW) 9 (UP ARROW) (UP ARROW) ((UP ARROW) (UP ARROW) 1 (UP ARROW) 1 (UP ARROW)) (UP ARROW) -5, 10-EPOXIDE
US4774236A (en) * 1986-09-17 1988-09-27 Research Triangle Institute 17α-(substituted-methyl)-17β-hydroxy/esterified hydroxy steroids and pharmaceutical compositions containing them
IE60780B1 (en) * 1987-01-23 1994-08-10 Akzo Nv New 11-aryl steroid derivatives
EP0310542B1 (en) * 1987-10-01 1994-06-08 Schering Aktiengesellschaft Antigestagenic and antioestrogenic compounds for the treatment of hormone-dependent tumours
JP2785023B2 (en) * 1987-12-30 1998-08-13 ルセル―ユクラフ Novel derivative of 17β-OH-19-norsteroid substituted at 17α position, process for its preparation, its use as drug and pharmaceutical composition containing it
US4954490A (en) * 1988-06-23 1990-09-04 Research Triangle Institute 11 β-substituted progesterone analogs
DE3822770A1 (en) * 1988-07-01 1990-01-04 Schering Ag 13-ALKYL-11SS-PHENYLGONANE
DE3832303A1 (en) * 1988-09-20 1990-04-12 Schering Ag 11SS-PHENYL-14SSH STEROIDS
US5372996A (en) * 1989-03-10 1994-12-13 Endorecherche, Inc. Method of treatment of androgen-related diseases
US5364847A (en) * 1989-03-10 1994-11-15 Endorecherche Inhibitors of sex steroid biosynthesis and methods for their production and use
KR0181264B1 (en) * 1989-07-07 1999-03-20 라브리 페르낭 Androgen derivatives for use in the inhibition of sex steroid activity
DK0595796T3 (en) * 1989-07-07 2003-05-05 Endorech Inc Method of treating androgen-related diseases
EP0411733B1 (en) * 1989-08-04 1998-10-21 Schering Aktiengesellschaft 11-Beta-aryle-gona-4,9-dien-3-ones
FR2654337B1 (en) * 1989-11-15 1994-08-05 Roussel Uclaf NOVEL BIODEGRADABLE INJECTABLE MICROSPHERES PREPARATION METHOD AND INJECTABLE SUSPENSIONS CONTAINING THEM.
DE4008584A1 (en) * 1990-03-15 1991-09-26 Schering Ag METHOD FOR PRODUCING INTERMEDIATE PRODUCTS FOR THE ANTIGESTAGE SYNTHESIS (ONAPRISTONE SYNTHESIS)
US5407928A (en) * 1990-08-15 1995-04-18 Schering Aktiengesellschaft 11β-aryl-gona-4,9-dien-3-ones
US5472854A (en) * 1990-08-18 1995-12-05 Schering Aktiengesellschaft Process for the production of 17-oxosteroids via the fermentative oxidation of 17β-hydroxysteroids by Mycobacterium
RU2082762C1 (en) * 1990-08-18 1997-06-27 Шеринг АГ Берлин унд Бергкамен Process for preparing 17-oxosteroids
US7704983B1 (en) 1992-03-02 2010-04-27 Eastern Virginia Medical School Antiprogestin method for reducing side effects associated with low dosage HRT and oral contraception
MX9301121A (en) 1992-03-02 1993-09-01 Schering Ag METHOD AND EQUIPMENT FOR ORAL CONTRACEPTION AND REGULATION OF MENSTRUATION WITH ESTROGEN / PROGESTIN / ANIPROGESTIN.
US5439913A (en) 1992-05-12 1995-08-08 Schering Aktiengesellschaft Contraception method using competitive progesterone antagonists and novel compounds useful therein
UA35589C2 (en) * 1992-05-21 2001-04-16 Андорешерш Інк. INHIBITORS OF TESTOSTERONE 5-<font face="Symbol">a</font>-REDUCTASE activity, pharmaceutical composition and a method for inhibiting activity of testosterone 5-<font face="Symbol">a</font>-REDUCTASE
DE4413185A1 (en) * 1994-04-12 1995-10-19 Schering Ag 11beta, 19-bridged 13alpha alkyl steroids
DE4415590A1 (en) * 1994-04-28 1995-11-02 Schering Ag Process for the stereoselective introduction of an alkynyl side chain to 11β-aryl-substituted 13alpha-alkylgonan-17-ones
DE4434488A1 (en) * 1994-09-14 1996-03-21 Schering Ag Steroid esters and amides, processes for their preparation and their pharmaceutical use
ZA9510926B (en) 1994-12-23 1996-07-03 Schering Ag Compounds with progesterone-antagonistic and antiestrogenic action to be used together for female contraception
US6900193B1 (en) 1996-05-01 2005-05-31 The United States Of America As Represented By The Department Of Health And Human Services Structural modification of 19-norprogesterone I: 17-α-substituted-11-β-substituted-4-aryl and 21-substituted 19-norpregnadienedione as new antiprogestational agents
ES2152671T3 (en) 1996-05-01 2001-02-01 Us Gov Health & Human Serv PROGESTERONE DERIVATIVES REPLACED IN POSITION 21 AS NEW ANTIPROGESTATIONAL AGENTS.
CA2966753A1 (en) 2014-11-17 2016-05-26 Arno Therapeutics, Inc. Onapristone extended-release compositions and methods
CA2998924A1 (en) 2015-09-25 2017-03-30 Context Biopharma Inc. Methods of making onapristone intermediates
US10548905B2 (en) 2015-12-15 2020-02-04 Context Biopharma Inc. Amorphous onapristone compositions and methods of making the same
US20180148471A1 (en) 2016-11-30 2018-05-31 Arno Therapeutics, Inc. Methods for onapristone synthesis dehydration and deprotection

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2377418A1 (en) * 1977-01-13 1978-08-11 Roussel Uclaf NEW 4,9-DIENIC 11B-SUBSTITUTE STEROID DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICINAL PRODUCTS
ZA8231B (en) * 1981-01-09 1982-11-24 Roussel Uclaf New 11 -substituted steroid derivatives, their preparation, their use as medicaments, the compositions containing them and the new intermediates thus obtained
DE3347126A1 (en) * 1983-12-22 1985-07-11 Schering AG, 1000 Berlin und 4709 Bergkamen 11SS-ARYL-ESTRADIENE, THEIR PRODUCTION AND THE PHARMACEUTICAL PREPARATIONS CONTAINING THEM
CA1304916C (en) * 1984-10-18 1992-07-14 Wilhelm Bannwarth Apparatus for the parallel performance of a plurality of chemical reaction sequences

Also Published As

Publication number Publication date
JPH0369919B2 (en) 1991-11-05
IE841484L (en) 1984-12-15
ES533260A0 (en) 1985-02-01
DK166729B1 (en) 1993-07-05
DD218624A5 (en) 1985-02-13
HU191131B (en) 1987-01-28
NO842394L (en) 1984-12-17
DK288184D0 (en) 1984-06-12
FI78709C (en) 1989-09-11
EP0129499A2 (en) 1984-12-27
PT78732A (en) 1985-01-01
DE3468030D1 (en) 1988-01-21
PT78732B (en) 1986-06-03
NO160521C (en) 1989-04-26
EP0129499A3 (en) 1985-10-09
GR82210B (en) 1984-12-13
DK288184A (en) 1984-12-16
NZ208441A (en) 1988-01-08
EP0129499B1 (en) 1987-12-09
HUT36139A (en) 1985-08-28
AU572849B2 (en) 1988-05-19
IE57620B1 (en) 1993-02-10
FI842395A (en) 1984-12-16
FI78709B (en) 1989-05-31
ES8502612A1 (en) 1985-02-01
JPH02167296A (en) 1990-06-27
AU2936184A (en) 1984-12-20
IL72085A0 (en) 1984-10-31
FI842395A0 (en) 1984-06-13
NO160521B (en) 1989-01-16
CA1307784C (en) 1992-09-22

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