DK288184A - 13ALFA ALKYLGONANES, THEIR PREPARATION AND PHARMACEUTICAL PREPARATIONS CONTAINING THESE - Google Patents

13ALFA ALKYLGONANES, THEIR PREPARATION AND PHARMACEUTICAL PREPARATIONS CONTAINING THESE Download PDF

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Publication number
DK288184A
DK288184A DK288184A DK288184A DK288184A DK 288184 A DK288184 A DK 288184A DK 288184 A DK288184 A DK 288184A DK 288184 A DK288184 A DK 288184A DK 288184 A DK288184 A DK 288184A
Authority
DK
Denmark
Prior art keywords
13alfa
alkylgonanes
preparation
pharmaceutical preparations
preparations containing
Prior art date
Application number
DK288184A
Other languages
Danish (da)
Other versions
DK288184D0 (en
DK166729B1 (en
Inventor
Guenter Neef
Gerhard Sauer
Rudolf Wiechert
Sybille Beier
Walter Elger
David Henderson
Ralph Rohde
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE3321826A external-priority patent/DE3321826A1/en
Priority claimed from DE19843413036 external-priority patent/DE3413036A1/en
Application filed by Schering Ag filed Critical Schering Ag
Publication of DK288184D0 publication Critical patent/DK288184D0/en
Publication of DK288184A publication Critical patent/DK288184A/en
Application granted granted Critical
Publication of DK166729B1 publication Critical patent/DK166729B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
    • C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK288184A 1983-06-15 1984-06-12 13ALFA METHYL AND 13ALFA ETHYLGONANES AND PROCEDURES FOR PREPARING THEREOF AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM DK166729B1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE3321826 1983-06-15
DE3321826A DE3321826A1 (en) 1983-06-15 1983-06-15 13 alpha -Alkylgonanes, the preparation thereof and pharmaceutical products containing these
DE19843413036 DE3413036A1 (en) 1984-04-04 1984-04-04 13a-Alkylgonanes, the preparation thereof and pharmaceutical products containing these
DE3413036 1984-04-04

Publications (3)

Publication Number Publication Date
DK288184D0 DK288184D0 (en) 1984-06-12
DK288184A true DK288184A (en) 1984-12-16
DK166729B1 DK166729B1 (en) 1993-07-05

Family

ID=25811539

Family Applications (1)

Application Number Title Priority Date Filing Date
DK288184A DK166729B1 (en) 1983-06-15 1984-06-12 13ALFA METHYL AND 13ALFA ETHYLGONANES AND PROCEDURES FOR PREPARING THEREOF AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM

Country Status (16)

Country Link
EP (1) EP0129499B1 (en)
JP (1) JPH02167296A (en)
AU (1) AU572849B2 (en)
CA (1) CA1307784C (en)
DD (1) DD218624A5 (en)
DE (1) DE3468030D1 (en)
DK (1) DK166729B1 (en)
ES (1) ES533260A0 (en)
FI (1) FI78709C (en)
GR (1) GR82210B (en)
HU (1) HU191131B (en)
IE (1) IE57620B1 (en)
IL (1) IL72085A (en)
NO (1) NO160521C (en)
NZ (1) NZ208441A (en)
PT (1) PT78732B (en)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3446661A1 (en) * 1984-12-18 1986-06-19 Schering AG, 1000 Berlin und 4709 Bergkamen NEW 13 (ALPHA) -ALKYL-17 (BETA) - (3-ACYLOXYPROPYL) GONANA
DE3506785A1 (en) * 1985-02-22 1986-08-28 Schering AG, Berlin und Bergkamen, 1000 Berlin 11SS-N, N-DIMETHYLAMINOPHENYL ESTRADIENE, THE PRODUCTION THEREOF AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM
DE3630030A1 (en) * 1986-09-01 1988-03-03 Schering Ag 13 (ALPHA) -ALKYLGONAN- (DELTA) (UP ARROW) 9 (UP ARROW) (UP ARROW) ((UP ARROW) (UP ARROW) 1 (UP ARROW) 1 (UP ARROW)) (UP ARROW) -5, 10-EPOXIDE
US4774236A (en) * 1986-09-17 1988-09-27 Research Triangle Institute 17α-(substituted-methyl)-17β-hydroxy/esterified hydroxy steroids and pharmaceutical compositions containing them
IE60780B1 (en) * 1987-01-23 1994-08-10 Akzo Nv New 11-aryl steroid derivatives
EP0310542B1 (en) * 1987-10-01 1994-06-08 Schering Aktiengesellschaft Antigestagenic and antioestrogenic compounds for the treatment of hormone-dependent tumours
JP2785023B2 (en) * 1987-12-30 1998-08-13 ルセル―ユクラフ Novel derivative of 17β-OH-19-norsteroid substituted at 17α position, process for its preparation, its use as drug and pharmaceutical composition containing it
US4954490A (en) * 1988-06-23 1990-09-04 Research Triangle Institute 11 β-substituted progesterone analogs
DE3822770A1 (en) * 1988-07-01 1990-01-04 Schering Ag 13-ALKYL-11SS-PHENYLGONANE
DE3832303A1 (en) * 1988-09-20 1990-04-12 Schering Ag 11SS-PHENYL-14SSH STEROIDS
US5364847A (en) * 1989-03-10 1994-11-15 Endorecherche Inhibitors of sex steroid biosynthesis and methods for their production and use
US5372996A (en) * 1989-03-10 1994-12-13 Endorecherche, Inc. Method of treatment of androgen-related diseases
WO1991000733A1 (en) * 1989-07-07 1991-01-24 Endorecherche Inc. Method of treatment of androgen-related diseases
CA2063378A1 (en) * 1989-07-07 1991-01-08 Fernand Labrie Androgen derivatives for use in the inhibition of sex steroid activity
DK0411733T3 (en) * 1989-08-04 1999-06-28 Schering Ag 11-beta-aryl-gona-4,9-dien-3-ones
FR2654337B1 (en) * 1989-11-15 1994-08-05 Roussel Uclaf NOVEL BIODEGRADABLE INJECTABLE MICROSPHERES PREPARATION METHOD AND INJECTABLE SUSPENSIONS CONTAINING THEM.
DE4008584A1 (en) * 1990-03-15 1991-09-26 Schering Ag METHOD FOR PRODUCING INTERMEDIATE PRODUCTS FOR THE ANTIGESTAGE SYNTHESIS (ONAPRISTONE SYNTHESIS)
US5407928A (en) * 1990-08-15 1995-04-18 Schering Aktiengesellschaft 11β-aryl-gona-4,9-dien-3-ones
CA2069956C (en) * 1990-08-18 2001-05-08 Alfred Weber Process for the production of 17-oxosteroids
US5472854A (en) * 1990-08-18 1995-12-05 Schering Aktiengesellschaft Process for the production of 17-oxosteroids via the fermentative oxidation of 17β-hydroxysteroids by Mycobacterium
US7704983B1 (en) 1992-03-02 2010-04-27 Eastern Virginia Medical School Antiprogestin method for reducing side effects associated with low dosage HRT and oral contraception
MX9301121A (en) 1992-03-02 1993-09-01 Schering Ag METHOD AND EQUIPMENT FOR ORAL CONTRACEPTION AND REGULATION OF MENSTRUATION WITH ESTROGEN / PROGESTIN / ANIPROGESTIN.
US5439913A (en) 1992-05-12 1995-08-08 Schering Aktiengesellschaft Contraception method using competitive progesterone antagonists and novel compounds useful therein
SK140494A3 (en) * 1992-05-21 1995-07-11 Endorecherche Inc Inhibitors of testosterone 5-alpha-reductase activity
DE4413185A1 (en) * 1994-04-12 1995-10-19 Schering Ag 11beta, 19-bridged 13alpha alkyl steroids
DE4415590A1 (en) * 1994-04-28 1995-11-02 Schering Ag Process for the stereoselective introduction of an alkynyl side chain to 11β-aryl-substituted 13alpha-alkylgonan-17-ones
DE4434488A1 (en) * 1994-09-14 1996-03-21 Schering Ag Steroid esters and amides, processes for their preparation and their pharmaceutical use
ZA9510926B (en) 1994-12-23 1996-07-03 Schering Ag Compounds with progesterone-antagonistic and antiestrogenic action to be used together for female contraception
HU230492B1 (en) 1996-05-01 2016-08-29 The Government Of The United States Of America Novel 21-substituted progesterone derivatives as antiprogestational agents medicoments containing the same, use thereof
US6900193B1 (en) 1996-05-01 2005-05-31 The United States Of America As Represented By The Department Of Health And Human Services Structural modification of 19-norprogesterone I: 17-α-substituted-11-β-substituted-4-aryl and 21-substituted 19-norpregnadienedione as new antiprogestational agents
CN113559075A (en) 2014-11-17 2021-10-29 康泰科思特生物制药公司 Onapristone extended release compositions and methods
CA2998924A1 (en) * 2015-09-25 2017-03-30 Context Biopharma Inc. Methods of making onapristone intermediates
CA3008422A1 (en) * 2015-12-15 2017-06-22 Context Biopharma Inc. Amorphous onapristone compositions and methods of making the same
WO2018102369A1 (en) 2016-11-30 2018-06-07 Arno Therapeutics, Inc. Methods for onapristone synthesis dehydration and deprotection

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2377418A1 (en) * 1977-01-13 1978-08-11 Roussel Uclaf NEW 4,9-DIENIC 11B-SUBSTITUTE STEROID DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICINAL PRODUCTS
ZA8231B (en) * 1981-01-09 1982-11-24 Roussel Uclaf New 11 -substituted steroid derivatives, their preparation, their use as medicaments, the compositions containing them and the new intermediates thus obtained
DE3347126A1 (en) * 1983-12-22 1985-07-11 Schering AG, 1000 Berlin und 4709 Bergkamen 11SS-ARYL-ESTRADIENE, THEIR PRODUCTION AND THE PHARMACEUTICAL PREPARATIONS CONTAINING THEM
CA1304916C (en) * 1984-10-18 1992-07-14 Wilhelm Bannwarth Apparatus for the parallel performance of a plurality of chemical reaction sequences

Also Published As

Publication number Publication date
DD218624A5 (en) 1985-02-13
FI842395A (en) 1984-12-16
DK288184D0 (en) 1984-06-12
PT78732A (en) 1985-01-01
AU2936184A (en) 1984-12-20
IE57620B1 (en) 1993-02-10
EP0129499B1 (en) 1987-12-09
NO842394L (en) 1984-12-17
DE3468030D1 (en) 1988-01-21
NO160521C (en) 1989-04-26
AU572849B2 (en) 1988-05-19
FI78709B (en) 1989-05-31
JPH0369919B2 (en) 1991-11-05
FI78709C (en) 1989-09-11
HUT36139A (en) 1985-08-28
GR82210B (en) 1984-12-13
CA1307784C (en) 1992-09-22
ES8502612A1 (en) 1985-02-01
HU191131B (en) 1987-01-28
NZ208441A (en) 1988-01-08
FI842395A0 (en) 1984-06-13
IL72085A0 (en) 1984-10-31
JPH02167296A (en) 1990-06-27
ES533260A0 (en) 1985-02-01
NO160521B (en) 1989-01-16
EP0129499A2 (en) 1984-12-27
PT78732B (en) 1986-06-03
IL72085A (en) 1987-09-16
IE841484L (en) 1984-12-15
DK166729B1 (en) 1993-07-05
EP0129499A3 (en) 1985-10-09

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Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PBP Patent lapsed