AU572849B2 - 13alpha-gonanes - Google Patents

13alpha-gonanes

Info

Publication number
AU572849B2
AU572849B2 AU29361/84A AU2936184A AU572849B2 AU 572849 B2 AU572849 B2 AU 572849B2 AU 29361/84 A AU29361/84 A AU 29361/84A AU 2936184 A AU2936184 A AU 2936184A AU 572849 B2 AU572849 B2 AU 572849B2
Authority
AU
Australia
Prior art keywords
gonanes
13alpha
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU29361/84A
Other versions
AU2936184A (en
Inventor
Sybille Dr. Beier
Gunter Neef
Gerhard Sauer
Rudolf Weichert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to DE3321826A priority Critical patent/DE3321826A1/en
Priority to DE3321826 priority
Priority to DE3413036 priority
Priority to DE19843413036 priority patent/DE3413036A1/en
Application filed by Bayer Pharma AG filed Critical Bayer Pharma AG
Publication of AU2936184A publication Critical patent/AU2936184A/en
Application granted granted Critical
Publication of AU572849B2 publication Critical patent/AU572849B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J41/00Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0077Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
    • C07J41/0083Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J71/00Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005Oxygen-containing hetero ring
    • C07J71/001Oxiranes
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
AU29361/84A 1983-06-15 1984-06-14 13alpha-gonanes Ceased AU572849B2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
DE3321826A DE3321826A1 (en) 1983-06-15 1983-06-15 13 alpha -Alkylgonanes, the preparation thereof and pharmaceutical products containing these
DE3321826 1983-06-15
DE3413036 1984-04-04
DE19843413036 DE3413036A1 (en) 1984-04-04 1984-04-04 13a-Alkylgonanes, the preparation thereof and pharmaceutical products containing these

Publications (2)

Publication Number Publication Date
AU2936184A AU2936184A (en) 1984-12-20
AU572849B2 true AU572849B2 (en) 1988-05-19

Family

ID=25811539

Family Applications (1)

Application Number Title Priority Date Filing Date
AU29361/84A Ceased AU572849B2 (en) 1983-06-15 1984-06-14 13alpha-gonanes

Country Status (15)

Country Link
EP (1) EP0129499B1 (en)
JP (1) JPH0369919B2 (en)
AU (1) AU572849B2 (en)
CA (1) CA1307784C (en)
DD (1) DD218624A5 (en)
DK (1) DK166729B1 (en)
ES (1) ES533260A0 (en)
FI (1) FI78709C (en)
GR (1) GR82210B (en)
HU (1) HU191131B (en)
IE (1) IE57620B1 (en)
IL (1) IL72085A (en)
NO (1) NO160521C (en)
NZ (1) NZ208441A (en)
PT (1) PT78732B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU580646B2 (en) * 1984-12-18 1989-01-19 Schering Aktiengesellschaft 13``-alkyl-17``-(3-aceloxy-propyl)-gonane

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2785023B2 (en) * 1987-12-30 1998-08-13 ルセル―ユクラフ Novel derivative of 17β-OH-19-norsteroid substituted at 17α position, process for its preparation, its use as drug and pharmaceutical composition containing it
DE3506785A1 (en) * 1985-02-22 1986-08-28 Schering Ag 11ss-n, n-dimethylaminophenyl estradiene, the production thereof and pharmaceutical preparations containing them
DE3630030A1 (en) * 1986-09-01 1988-03-03 Schering Ag 13 (alpha) -alkylgonan- (delta) (up arrow) 9 (up arrow) (up arrow) ((up arrow) (up arrow) 1 (up arrow) 1 (up arrow)) (up arrow) -5, 10-epoxide
US4774236A (en) * 1986-09-17 1988-09-27 Research Triangle Institute 17α-(substituted-methyl)-17β-hydroxy/esterified hydroxy steroids and pharmaceutical compositions containing them
IE60780B1 (en) * 1987-01-23 1994-08-10 Akzo Nv New 11-aryl steroid derivatives
EP0310542B1 (en) * 1987-10-01 1994-06-08 Schering Aktiengesellschaft Antigestagenic and antioestrogenic compounds for the treatment of hormone-dependent tumours
US4954490A (en) * 1988-06-23 1990-09-04 Research Triangle Institute 11 β-substituted progesterone analogs
DE3822770A1 (en) * 1988-07-01 1990-01-04 Schering Ag 13-alkyl-11ss-phenylgonane
DE3832303A1 (en) * 1988-09-20 1990-04-12 Schering Ag 11ss-phenyl-14ssh steroids
US5364847A (en) * 1989-03-10 1994-11-15 Endorecherche Inhibitors of sex steroid biosynthesis and methods for their production and use
US5372996A (en) * 1989-03-10 1994-12-13 Endorecherche, Inc. Method of treatment of androgen-related diseases
EP0485392B1 (en) * 1989-07-07 1998-09-09 Endorecherche Inc. Androgen derivatives for use in the inhibition of sex steroid activity
KR920703065A (en) * 1989-07-07 1992-12-17 원본미기재 Treatment of Androgen-Related Diseases
JP3202224B2 (en) * 1989-08-04 2001-08-27 シエーリング アクチエンゲゼルシヤフト 11β-aryl-gon-4,9-dien-3-ones, process for their preparation and pharmaceutical preparations containing them
FR2654337B1 (en) * 1989-11-15 1994-08-05 Roussel Uclaf Novel biodegradable injectable microspheres preparation method and injectable suspensions containing them.
DE4008584A1 (en) * 1990-03-15 1991-09-26 Schering Ag Method for producing intermediate products for the antigestage synthesis (onapristone synthesis)
US5407928A (en) * 1990-08-15 1995-04-18 Schering Aktiengesellschaft 11β-aryl-gona-4,9-dien-3-ones
US5472854A (en) * 1990-08-18 1995-12-05 Schering Aktiengesellschaft Process for the production of 17-oxosteroids via the fermentative oxidation of 17β-hydroxysteroids by Mycobacterium
DE59108700D1 (en) * 1990-08-18 1997-06-12 Schering Ag Method for producing 17-oxosteroids
MX9301121A (en) 1992-03-02 1993-09-01 Schering Ag Method and equipment for oral and menstrual regulation with estrogen / progestin / aniprogestina contraception.
US7704983B1 (en) 1992-03-02 2010-04-27 Eastern Virginia Medical School Antiprogestin method for reducing side effects associated with low dosage HRT and oral contraception
US5439913A (en) 1992-05-12 1995-08-08 Schering Aktiengesellschaft Contraception method using competitive progesterone antagonists and novel compounds useful therein
KR950701527A (en) * 1992-05-21 1995-04-28 라브리 페르낭 INHIBITORS OF TESTOSTERONE 5α-REDUCTASE ACTIVITY
DE4413185A1 (en) * 1994-04-12 1995-10-19 Schering Ag 11beta, 19-bridged 13alpha alkyl steroids
DE4415590A1 (en) * 1994-04-28 1995-11-02 Schering Ag Process for the stereoselective introduction of an alkynyl side chain to 11β-aryl-substituted 13alpha-alkylgonan-17-ones
DE4434488A1 (en) 1994-09-14 1996-03-21 Schering Ag Steroid esters and amides, processes for their preparation and their pharmaceutical use
ZA9510926B (en) 1994-12-23 1996-07-03 Schering Ag Compounds with progesterone-antagonistic and antiestrogenic action to be used together for female contraception
AU710139B2 (en) 1996-05-01 1999-09-16 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The 21-substituted progesterone derivatives as new antiprogestational agents
US6900193B1 (en) 1996-05-01 2005-05-31 The United States Of America As Represented By The Department Of Health And Human Services Structural modification of 19-norprogesterone I: 17-α-substituted-11-β-substituted-4-aryl and 21-substituted 19-norpregnadienedione as new antiprogestational agents
WO2016081383A1 (en) 2014-11-17 2016-05-26 Arno Therapeutics, Inc. Onapristone extended-release compositions and methods
CA2998924A1 (en) 2015-09-25 2017-03-30 Context Biopharma Inc. Methods of making onapristone intermediates
EP3389632A4 (en) * 2015-12-15 2019-11-06 Context Biopharma Inc. Amorphous onapristone compositions and methods of making the same
US20180148471A1 (en) 2016-11-30 2018-05-31 Arno Therapeutics, Inc. Methods for onapristone synthesis dehydration and deprotection

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3701384A (en) * 1983-12-22 1985-07-04 Schering Aktiengesellschaft 11-beta-arylestradienes
EP0181491A1 (en) * 1984-10-18 1986-05-21 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Device for simultaneously carrying out a plurality of chemical reaction steps

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2377418B1 (en) * 1977-01-13 1979-04-20 Roussel Uclaf
ZA8200031B (en) * 1981-01-09 1982-11-24 Roussel Uclaf New 11 -substituted steroid derivatives, their preparation, their use as medicaments, the compositions containing them and the new intermediates thus obtained

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3701384A (en) * 1983-12-22 1985-07-04 Schering Aktiengesellschaft 11-beta-arylestradienes
EP0181491A1 (en) * 1984-10-18 1986-05-21 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Device for simultaneously carrying out a plurality of chemical reaction steps

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU580646B2 (en) * 1984-12-18 1989-01-19 Schering Aktiengesellschaft 13``-alkyl-17``-(3-aceloxy-propyl)-gonane

Also Published As

Publication number Publication date
ES533260A0 (en) 1985-02-01
FI842395A (en) 1984-12-16
FI78709B (en) 1989-05-31
DK288184A (en) 1984-12-16
DK166729B1 (en) 1993-07-05
IE841484L (en) 1984-12-15
EP0129499A2 (en) 1984-12-27
EP0129499B1 (en) 1987-12-09
IL72085A (en) 1987-09-16
DK288184D0 (en) 1984-06-12
FI842395D0 (en)
FI78709C (en) 1989-09-11
NO160521B (en) 1989-01-16
HU191131B (en) 1987-01-28
CA1307784C (en) 1992-09-22
PT78732B (en) 1986-06-03
DD218624A5 (en) 1985-02-13
FI842395A0 (en) 1984-06-13
GR82210B (en) 1984-12-13
NO160521C (en) 1989-04-26
NZ208441A (en) 1988-01-08
NO842394L (en) 1984-12-17
PT78732A (en) 1985-01-01
JPH02167296A (en) 1990-06-27
AU2936184A (en) 1984-12-20
ES8502612A1 (en) 1985-02-01
IE57620B1 (en) 1993-02-10
ES533260D0 (en)
EP0129499A3 (en) 1985-10-09
HUT36139A (en) 1985-08-28
IL72085D0 (en) 1984-10-31
JPH0369919B2 (en) 1991-11-05

Similar Documents

Publication Publication Date Title
AU555460B2 (en) Photoradiator
AU551549B2 (en) Quadricycle
AU551215B2 (en) Curler-styler
AU567593B2 (en) Polysaccharide - haemoglobin compound
AU569086B2 (en) 2-pyrimidinyl-1-piperazine derivatives
AU1146383A (en) Amidoximeguinolines
AU1383083A (en) Ligator-clip
AU2415184A (en) Zahnreinigungsgerat
AU566119B2 (en) Accumulator-dehydrator assembly
AU2290283A (en) Diorgandpolysiloxane
AU2290088A (en) Halogen-aniline derivatives
AU548268B2 (en) 2-ammo-5-hydroxy-4-methylpyrimidinme derivatives
AU1659483A (en) 14-fluoromorphinans
AU1112583A (en) Pyrazolo-quinolines, -thiazines and -oxazines
AU561591B2 (en) line
AU564879B2 (en) Composition
AU567140B2 (en) Sulphonamido-benzamide derivatives
AU565491B2 (en) 2-hydroxy-5-acryloxyalkylphenyl -2h- benzotriazoles
AU560628B2 (en) Fluoro-terpolymers
AU573294B2 (en) 11-beta-arylestradienes
AU566192B2 (en) Alkynamide compounds
AU2496184A (en) **
AU563978B2 (en) Azolyl-propanol derivatives
AU3435584A (en) Separationsstabil extremlatt betonggjutmassa
AU572849B2 (en) 13alpha-gonanes