DK290986A - 2-ARYLIMIDAZOLE COMPOUNDS, PHARMACEUTICALS CONTAINING THESE COMPOUNDS AND THEIR PREPARATION - Google Patents

2-ARYLIMIDAZOLE COMPOUNDS, PHARMACEUTICALS CONTAINING THESE COMPOUNDS AND THEIR PREPARATION Download PDF

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Publication number
DK290986A
DK290986A DK290986A DK290986A DK290986A DK 290986 A DK290986 A DK 290986A DK 290986 A DK290986 A DK 290986A DK 290986 A DK290986 A DK 290986A DK 290986 A DK290986 A DK 290986A
Authority
DK
Denmark
Prior art keywords
compounds
preparation
arylimidazole
pharmaceuticals containing
pharmaceuticals
Prior art date
Application number
DK290986A
Other languages
Danish (da)
Other versions
DK290986D0 (en
Inventor
Erich Mueller
Norbert Hauel
Klaus Noll
Berthold Narr
Joachim Heider
Manfred Psiorz
Andreas Bomhard
Jacques Van Meel
Willi Diederen
Original Assignee
Thomae Gmbh Dr K
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K
Publication of DK290986D0 publication Critical patent/DK290986D0/en
Publication of DK290986A publication Critical patent/DK290986A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK290986A 1985-06-21 1986-06-20 2-ARYLIMIDAZOLE COMPOUNDS, PHARMACEUTICALS CONTAINING THESE COMPOUNDS AND THEIR PREPARATION DK290986A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19853522230 DE3522230A1 (en) 1985-06-21 1985-06-21 NEW 2-ARYLIMIDAZOLES, MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS, AND METHOD FOR THE PRODUCTION THEREOF

Publications (2)

Publication Number Publication Date
DK290986D0 DK290986D0 (en) 1986-06-20
DK290986A true DK290986A (en) 1986-12-22

Family

ID=6273829

Family Applications (1)

Application Number Title Priority Date Filing Date
DK290986A DK290986A (en) 1985-06-21 1986-06-20 2-ARYLIMIDAZOLE COMPOUNDS, PHARMACEUTICALS CONTAINING THESE COMPOUNDS AND THEIR PREPARATION

Country Status (12)

Country Link
EP (1) EP0209707A3 (en)
JP (1) JPS62471A (en)
AU (1) AU5893286A (en)
DE (1) DE3522230A1 (en)
DK (1) DK290986A (en)
ES (3) ES8800907A1 (en)
FI (1) FI862623A (en)
GR (1) GR861583B (en)
HU (1) HUT42452A (en)
NO (1) NO862477L (en)
PT (1) PT82789B (en)
ZA (1) ZA864602B (en)

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WO1997004771A1 (en) * 1995-08-02 1997-02-13 Newcastle University Ventures Limited Benzimidazole compounds
LU85544A1 (en) * 1984-09-19 1986-04-03 Cird AROMATIC HETEROCYCLIC DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR APPLICATION IN THE THERAPEUTIC AND COSMETIC FIELDS
GB8510758D0 (en) * 1985-04-27 1985-06-05 Wellcome Found Compounds
DE3634066A1 (en) * 1986-10-07 1988-04-21 Boehringer Mannheim Gmbh NEW 5-ALKYLBENZIMIDAZOLES, PROCESS FOR THEIR PRODUCTION AND MEDICINAL PRODUCTS
EP0322149A2 (en) * 1987-12-22 1989-06-28 Eli Lilly And Company Hydrates of an inotropic agent
GB8804016D0 (en) * 1988-02-22 1988-03-23 Boots Co Plc Therapeutic agents
IL94390A (en) * 1989-05-30 1996-03-31 Merck & Co Inc Di-substituted imidazo fused 6-membered nitrogen-containing heterocycles and pharmaceutical compositions containing them
US5064825A (en) * 1989-06-01 1991-11-12 Merck & Co., Inc. Angiotensin ii antagonists
JPH06759B2 (en) * 1989-09-22 1994-01-05 ファイザー製薬株式会社 Novel benzimidazole compound
US5208240A (en) * 1991-03-12 1993-05-04 Merrell Dow Pharmaceuticals Inc. 8-substituted purines as selective adenosine receptor agents
JPH05112533A (en) * 1991-05-08 1993-05-07 Upjohn Co:The Imidazobenzoquinoline and agent for preventing and treating hypertension and conjestive heart failure containing same as effective component
US5506361A (en) * 1991-05-08 1996-04-09 Theupjohn Company Imidazobenzoquinones and composition for preventing or treating hypertension or congestive heart failure containing the same
US5821258A (en) * 1994-12-27 1998-10-13 Mitsui Chemicals, Inc. Phenylbenzimidazole derivatives
CZ20011546A3 (en) 1998-11-03 2001-08-15 Basf Aktiengesellschaft Substituted 2-phenyl benzimidazole, process of its preparation and use thereof
PL347684A1 (en) * 1998-11-17 2002-04-22 Basf Ag 2-phenylbenzimidazoles and 2-phenylindoles, and production and use thereof
DE19918211A1 (en) 1999-04-22 2000-10-26 Basf Ag New 2-carbocyclyl-benzimidazole-carboxamide derivatives, are PARP inhibitors useful e.g. for treating neurodegenerative disease, epilepsy, ischemia, tumors, inflammation or diabetes
US6448281B1 (en) 2000-07-06 2002-09-10 Boehringer Ingelheim (Canada) Ltd. Viral polymerase inhibitors
EP2335700A1 (en) 2001-07-25 2011-06-22 Boehringer Ingelheim (Canada) Ltd. Hepatitis C virus polymerase inhibitors with a heterobicylic structure
CA2464000C (en) 2001-10-19 2011-04-19 Ortho-Mcneil Pharmaceutical, Inc. 2-phenyl benzimidazoles and imidazo-[4,5]-pyridines as cdsi/chk2-inhibitors and adjuvants to chemotherapy or radiation therapy in the treatment of cancer
ATE422201T1 (en) * 2002-04-05 2009-02-15 Cadila Healthcare Ltd 4-(HETEROCYCLYL)-BENZENESULFOXIMINE COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISEASES
JP4334476B2 (en) * 2002-07-29 2009-09-30 株式会社静岡カフェイン工業所 1,3-azole derivative and pharmaceutical composition for treating thrombosis comprising the derivative
US7223785B2 (en) 2003-01-22 2007-05-29 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
US7098231B2 (en) 2003-01-22 2006-08-29 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
JP4726235B2 (en) 2003-04-17 2011-07-20 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 2-Phenyl-benzimidazole and 2-phenyl-imidazo-'4,5 as checkpoint kinase CDS1 (CHK2) inhibitors for the treatment of cancer! -Pyridine derivatives
DK1718608T3 (en) 2004-02-20 2013-10-14 Boehringer Ingelheim Int Viral polymerase inhibitors
DE602005027739D1 (en) 2004-06-30 2011-06-09 Janssen Pharmaceutica Nv ARYLSUBSTITUTED BENZIMIDAZOLE AND IMIDAZOPYRIDINETHERS AS ACTIVE AGENTS AGAINST CANCER
TWI375673B (en) 2005-04-11 2012-11-01 Abbott Lab 1h-benzimidazole-4-carboxamides substituted with a quaternary carbon at the 2-position are potent parp inhibitors
WO2006110683A1 (en) 2005-04-11 2006-10-19 Abbott Laboratories 2-substituted-1h-benzimidazole-4-carboxamides are parp inhibitors
US8076365B2 (en) 2005-08-12 2011-12-13 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
WO2007059230A2 (en) 2005-11-15 2007-05-24 Abbott Laboratories Substituted 1h-benzimidazole-4-carboxamides are potent parp inhibitors
ATE553104T1 (en) 2006-05-02 2012-04-15 Abbott Lab SUBSTITUTED 1H-BENZIMIDAZOLE-4-CARBOXAMIDE AS POTENT PARP INHIBITORS
US8067613B2 (en) 2007-07-16 2011-11-29 Abbott Laboratories Benzimidazole poly(ADP ribose)polymerase inhibitors
WO2010083199A1 (en) 2009-01-19 2010-07-22 Abbott Laboratories Benzthiazole inhibitors of poly(adp-ribose)polymerase
BR112013016022B1 (en) * 2010-12-24 2019-05-07 Sumitomo Chemical Company, Limited Fused heterocyclic compound and use for same control.
EP2985278B1 (en) * 2013-02-28 2020-01-22 Sumitomo Chemical Company, Limited Fused heterocyclic compound and pest control applications thereof

Family Cites Families (16)

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Publication number Priority date Publication date Assignee Title
GB1089853A (en) * 1965-02-25 1967-11-08 Merck & Co Inc Substituted benzimidazoles and compositions containing them
US3669979A (en) * 1967-12-14 1972-06-13 Gaf Corp Novel process for the production of 2-benzothiazolyl-phenol and derivatives thereof employing phosphorus trichloride as a catalyst
DE2305339C3 (en) * 1973-02-03 1980-05-08 Dr. Karl Thomae Gmbh, 7950 Biberach Imidazo [4,5-b] pyridines, their preparation and their use as cardiotonica
DE2927988A1 (en) * 1979-07-11 1981-02-05 Thomae Gmbh Dr K NEW 8-PHENYL PURINS, THEIR PRODUCTION AND THEIR USE AS MEDICINAL PRODUCTS
DE2927987A1 (en) * 1979-07-11 1981-02-05 Thomae Gmbh Dr K NEW 2-ALKOXYPHENYL-IMIDAZO ANGLE CLAMP ON 4.5-B ANGLE CLAMP ON PYRIDINE, THEIR PRODUCTION AND THE USE THEREOF AS MEDICINAL PRODUCTS
DD147317A1 (en) * 1979-11-23 1981-04-01 Gerald Igel DEVICE FOR ELECTRIC STIMULATION OF THE HEART
DE3037464A1 (en) * 1980-10-03 1982-05-19 Dr. Karl Thomae Gmbh, 7950 Biberach 6-HYDROXY-2-PHENYL-IMIDAZO 4,5-B TO PYRIDINE, THEIR PRODUCTION AND THIS MEDICINAL PRODUCT CONTAINING IT
DE3044497A1 (en) * 1980-11-26 1982-06-24 Dr. Karl Thomae Gmbh, 7950 Biberach NEW METHOD FOR PRODUCING IMIDAZO (4,5-B) PYRIDINES AND PYRIMIDINES
ES517193A0 (en) * 1981-11-10 1983-12-01 Wellcome Found A PROCEDURE FOR THE PREPARATION OF NEW IMIDAZO DERIVATIVES (4,5-C) PIRIDINA.
RO86850B (en) * 1982-05-03 1985-05-31 Eli Lilly And Company Process for the preparation of 2-phenylimdazo [4,5 c] pyridines
DE3224512A1 (en) * 1982-07-01 1984-01-05 Dr. Karl Thomae Gmbh, 7950 Biberach NEW IMIDAZOLE DERIVATIVES, THEIR PRODUCTION AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
DE3324115A1 (en) * 1983-07-05 1985-01-17 Dr. Karl Thomae Gmbh, 7950 Biberach NEW IMIDAZOLES, THEIR PRODUCTION AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
US4515796A (en) * 1983-09-08 1985-05-07 Eli Lilly And Company Certain naphthalenyl imidazo compounds and their pharmaceutical use
DE3340076A1 (en) * 1983-11-05 1985-05-15 Dr. Karl Thomae Gmbh, 7950 Biberach NEW PURINE DERIVATIVES, THEIR PRODUCTION AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
DE3346575A1 (en) * 1983-12-23 1985-07-04 Dr. Karl Thomae Gmbh, 7950 Biberach NEW BENZIMIDAZOLES, THEIR PRODUCTION AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
GR850426B (en) * 1984-02-24 1985-06-18 Lilly Co Eli

Also Published As

Publication number Publication date
ES557241A0 (en) 1987-05-16
PT82789A (en) 1986-07-01
FI862623A0 (en) 1986-06-19
DK290986D0 (en) 1986-06-20
GR861583B (en) 1986-10-21
JPS62471A (en) 1987-01-06
EP0209707A3 (en) 1989-02-01
NO862477D0 (en) 1986-06-20
AU5893286A (en) 1986-12-24
FI862623A (en) 1986-12-22
ES556338A0 (en) 1987-12-01
EP0209707A2 (en) 1987-01-28
DE3522230A1 (en) 1987-01-02
ZA864602B (en) 1988-02-24
ES557240A0 (en) 1987-05-16
ES8800907A1 (en) 1987-12-01
NO862477L (en) 1986-12-22
PT82789B (en) 1988-05-17
ES8705863A1 (en) 1987-05-16
HUT42452A (en) 1987-07-28
ES8705864A1 (en) 1987-05-16

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