AU5893286A - 2-arylimidazoles - Google Patents

2-arylimidazoles

Info

Publication number
AU5893286A
AU5893286A AU58932/86A AU5893286A AU5893286A AU 5893286 A AU5893286 A AU 5893286A AU 58932/86 A AU58932/86 A AU 58932/86A AU 5893286 A AU5893286 A AU 5893286A AU 5893286 A AU5893286 A AU 5893286A
Authority
AU
Australia
Prior art keywords
arylimidazoles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU58932/86A
Inventor
Andreas Bomhard
Willi Diederen
Norbert Hauel
Joachim Heider
Jacques Van Meel
Erich Muller
Berthold Narr
Klaus Noll
Manfred Psiorz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Publication of AU5893286A publication Critical patent/AU5893286A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
AU58932/86A 1985-06-21 1986-06-20 2-arylimidazoles Abandoned AU5893286A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3522230 1985-06-21
DE19853522230 DE3522230A1 (en) 1985-06-21 1985-06-21 NEW 2-ARYLIMIDAZOLES, MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS, AND METHOD FOR THE PRODUCTION THEREOF

Publications (1)

Publication Number Publication Date
AU5893286A true AU5893286A (en) 1986-12-24

Family

ID=6273829

Family Applications (1)

Application Number Title Priority Date Filing Date
AU58932/86A Abandoned AU5893286A (en) 1985-06-21 1986-06-20 2-arylimidazoles

Country Status (12)

Country Link
EP (1) EP0209707A3 (en)
JP (1) JPS62471A (en)
AU (1) AU5893286A (en)
DE (1) DE3522230A1 (en)
DK (1) DK290986A (en)
ES (3) ES8800907A1 (en)
FI (1) FI862623A (en)
GR (1) GR861583B (en)
HU (1) HUT42452A (en)
NO (1) NO862477L (en)
PT (1) PT82789B (en)
ZA (1) ZA864602B (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU578310B2 (en) * 1984-09-19 1988-10-20 Centre International De Recherches Dermatologiques C.I.R.D. Therapeutic and cosmetic heteroaromatic compounds
AU581507B2 (en) * 1985-04-27 1989-02-23 Wellcome Foundation Limited, The 8-Substituted phenyl-xanthine derivatives and their pharmaceutical use
US4997840A (en) * 1988-02-22 1991-03-05 The Boots Company, Plc Quinolone sulphonates having antihypertensive activity
AU610314B2 (en) * 1987-12-22 1991-05-16 Merck Patent Gmbh 2-{2-methoxy-4-(methylsulfinyl)-phenyl}-1(3)H- imidazo{4,5-c}pyridine hydrochloride hydrates
AU643599B2 (en) * 1991-03-12 1993-11-18 Merrell Pharmaceuticals Inc. Novel 8-substituted purines as selective adenosine receptor agents

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3634066A1 (en) * 1986-10-07 1988-04-21 Boehringer Mannheim Gmbh NEW 5-ALKYLBENZIMIDAZOLES, PROCESS FOR THEIR PRODUCTION AND MEDICINAL PRODUCTS
IL94390A (en) * 1989-05-30 1996-03-31 Merck & Co Inc Di-substituted imidazo fused 6-membered nitrogen-containing heterocycles and pharmaceutical compositions containing them
US5064825A (en) * 1989-06-01 1991-11-12 Merck & Co., Inc. Angiotensin ii antagonists
JPH06759B2 (en) * 1989-09-22 1994-01-05 ファイザー製薬株式会社 Novel benzimidazole compound
US5506361A (en) * 1991-05-08 1996-04-09 Theupjohn Company Imidazobenzoquinones and composition for preventing or treating hypertension or congestive heart failure containing the same
JPH05112533A (en) * 1991-05-08 1993-05-07 Upjohn Co:The Imidazobenzoquinoline and agent for preventing and treating hypertension and conjestive heart failure containing same as effective component
US5821258A (en) * 1994-12-27 1998-10-13 Mitsui Chemicals, Inc. Phenylbenzimidazole derivatives
JPH11510154A (en) 1995-08-02 1999-09-07 ニューキャッスル ユニバーシティ ベンチャーズ リミテッド Benzimidazole compounds
WO2000026192A1 (en) * 1998-11-03 2000-05-11 Basf Aktiengesellschaft Substituted 2-phenylbenzimidazoles, the production thereof and their use
SK6742001A3 (en) * 1998-11-17 2001-12-03 Basf Ag 2-phenylbenzimidazoles and 2-phenylindoles, and production and use thereof
DE19918211A1 (en) 1999-04-22 2000-10-26 Basf Ag New 2-carbocyclyl-benzimidazole-carboxamide derivatives, are PARP inhibitors useful e.g. for treating neurodegenerative disease, epilepsy, ischemia, tumors, inflammation or diabetes
US6448281B1 (en) 2000-07-06 2002-09-10 Boehringer Ingelheim (Canada) Ltd. Viral polymerase inhibitors
EP2335700A1 (en) 2001-07-25 2011-06-22 Boehringer Ingelheim (Canada) Ltd. Hepatitis C virus polymerase inhibitors with a heterobicylic structure
WO2003032984A1 (en) 2001-10-19 2003-04-24 Ortho-Mcneil Pharmaceutical,Inc. 2-phenyl benzimidazoles and imidazo-[4,5]-pyridines as cdsi/chk2-inhibitors and adjuvants to chemotherapy or radiation therapy in the treatment of cancer
MXPA04009463A (en) * 2002-04-05 2005-01-25 Cadila Healthcare Ltd New heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in medicine.
JP4334476B2 (en) * 2002-07-29 2009-09-30 株式会社静岡カフェイン工業所 1,3-azole derivative and pharmaceutical composition for treating thrombosis comprising the derivative
US7098231B2 (en) 2003-01-22 2006-08-29 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
US7223785B2 (en) 2003-01-22 2007-05-29 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
WO2004093873A1 (en) 2003-04-17 2004-11-04 Janssen Pharmaceutica, N.V. 2-phenyl-benzimidazol and 2-phenyl-imidazo-`4,5!-pyridine derivatives as checkpoint kinase cds1 (chk2) inhibitors for the treatment of cancer
ES2431314T3 (en) 2004-02-20 2013-11-26 Boehringer Ingelheim International Gmbh Viral Polymerase Inhibitors
ATE507206T1 (en) 2004-06-30 2011-05-15 Janssen Pharmaceutica Nv ARYL-SUBSTITUTED BENZIMIDAZOLE AND IMIDAZOPYRIDINE ETHER AS ACTIVE INGREDIENTS AGAINST CANCER
US7728026B2 (en) 2005-04-11 2010-06-01 Abbott Laboratories, Inc. 2-substituted-1 h-benzimidazile-4-carboxamides are PARP inhibitors
TWI375673B (en) 2005-04-11 2012-11-01 Abbott Lab 1h-benzimidazole-4-carboxamides substituted with a quaternary carbon at the 2-position are potent parp inhibitors
JP5015154B2 (en) 2005-08-12 2012-08-29 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Viral polymerase inhibitor
CN101309908A (en) 2005-11-15 2008-11-19 艾博特公司 Substituted 1h-benzimidazole-4-carboxamides are potent parp inhibitors
ATE553104T1 (en) 2006-05-02 2012-04-15 Abbott Lab SUBSTITUTED 1H-BENZIMIDAZOLE-4-CARBOXAMIDE AS POTENT PARP INHIBITORS
US8067613B2 (en) 2007-07-16 2011-11-29 Abbott Laboratories Benzimidazole poly(ADP ribose)polymerase inhibitors
WO2010083199A1 (en) 2009-01-19 2010-07-22 Abbott Laboratories Benzthiazole inhibitors of poly(adp-ribose)polymerase
MX2013006847A (en) * 2010-12-24 2013-07-29 Sumitomo Chemical Co Fused heterocyclic compound and use for pest control thereof.
WO2014132971A1 (en) * 2013-02-28 2014-09-04 住友化学株式会社 Fused heterocyclic compound and pest control applications thereof

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1089853A (en) * 1965-02-25 1967-11-08 Merck & Co Inc Substituted benzimidazoles and compositions containing them
US3669979A (en) * 1967-12-14 1972-06-13 Gaf Corp Novel process for the production of 2-benzothiazolyl-phenol and derivatives thereof employing phosphorus trichloride as a catalyst
DE2305339C3 (en) * 1973-02-03 1980-05-08 Dr. Karl Thomae Gmbh, 7950 Biberach Imidazo [4,5-b] pyridines, their preparation and their use as cardiotonica
DE2927988A1 (en) * 1979-07-11 1981-02-05 Thomae Gmbh Dr K NEW 8-PHENYL PURINS, THEIR PRODUCTION AND THEIR USE AS MEDICINAL PRODUCTS
DE2927987A1 (en) * 1979-07-11 1981-02-05 Thomae Gmbh Dr K NEW 2-ALKOXYPHENYL-IMIDAZO ANGLE CLAMP ON 4.5-B ANGLE CLAMP ON PYRIDINE, THEIR PRODUCTION AND THE USE THEREOF AS MEDICINAL PRODUCTS
DD147317A1 (en) * 1979-11-23 1981-04-01 Gerald Igel DEVICE FOR ELECTRIC STIMULATION OF THE HEART
DE3037464A1 (en) * 1980-10-03 1982-05-19 Dr. Karl Thomae Gmbh, 7950 Biberach 6-HYDROXY-2-PHENYL-IMIDAZO 4,5-B TO PYRIDINE, THEIR PRODUCTION AND THIS MEDICINAL PRODUCT CONTAINING IT
DE3044497A1 (en) * 1980-11-26 1982-06-24 Dr. Karl Thomae Gmbh, 7950 Biberach NEW METHOD FOR PRODUCING IMIDAZO (4,5-B) PYRIDINES AND PYRIMIDINES
ES517193A0 (en) * 1981-11-10 1983-12-01 Wellcome Found A PROCEDURE FOR THE PREPARATION OF NEW IMIDAZO DERIVATIVES (4,5-C) PIRIDINA.
ZA832938B (en) * 1982-05-03 1984-12-24 Lilly Co Eli 2-phenylimidazo(4,5-c)pyridines
DE3224512A1 (en) * 1982-07-01 1984-01-05 Dr. Karl Thomae Gmbh, 7950 Biberach NEW IMIDAZOLE DERIVATIVES, THEIR PRODUCTION AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
DE3324115A1 (en) * 1983-07-05 1985-01-17 Dr. Karl Thomae Gmbh, 7950 Biberach NEW IMIDAZOLES, THEIR PRODUCTION AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
US4515796A (en) * 1983-09-08 1985-05-07 Eli Lilly And Company Certain naphthalenyl imidazo compounds and their pharmaceutical use
DE3340076A1 (en) * 1983-11-05 1985-05-15 Dr. Karl Thomae Gmbh, 7950 Biberach NEW PURINE DERIVATIVES, THEIR PRODUCTION AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
DE3346575A1 (en) * 1983-12-23 1985-07-04 Dr. Karl Thomae Gmbh, 7950 Biberach NEW BENZIMIDAZOLES, THEIR PRODUCTION AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
ZA851236B (en) * 1984-02-24 1986-09-24 Lilly Co Eli 2-arylimidazo 4,5-cpyridines

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU578310B2 (en) * 1984-09-19 1988-10-20 Centre International De Recherches Dermatologiques C.I.R.D. Therapeutic and cosmetic heteroaromatic compounds
AU581507B2 (en) * 1985-04-27 1989-02-23 Wellcome Foundation Limited, The 8-Substituted phenyl-xanthine derivatives and their pharmaceutical use
AU610314B2 (en) * 1987-12-22 1991-05-16 Merck Patent Gmbh 2-{2-methoxy-4-(methylsulfinyl)-phenyl}-1(3)H- imidazo{4,5-c}pyridine hydrochloride hydrates
US4997840A (en) * 1988-02-22 1991-03-05 The Boots Company, Plc Quinolone sulphonates having antihypertensive activity
AU643599B2 (en) * 1991-03-12 1993-11-18 Merrell Pharmaceuticals Inc. Novel 8-substituted purines as selective adenosine receptor agents

Also Published As

Publication number Publication date
PT82789B (en) 1988-05-17
ES8705864A1 (en) 1987-05-16
ES8705863A1 (en) 1987-05-16
EP0209707A3 (en) 1989-02-01
EP0209707A2 (en) 1987-01-28
ES557240A0 (en) 1987-05-16
PT82789A (en) 1986-07-01
ES8800907A1 (en) 1987-12-01
DK290986D0 (en) 1986-06-20
JPS62471A (en) 1987-01-06
ES556338A0 (en) 1987-12-01
FI862623A (en) 1986-12-22
DK290986A (en) 1986-12-22
HUT42452A (en) 1987-07-28
ES557241A0 (en) 1987-05-16
NO862477L (en) 1986-12-22
FI862623A0 (en) 1986-06-19
GR861583B (en) 1986-10-21
DE3522230A1 (en) 1987-01-02
ZA864602B (en) 1988-02-24
NO862477D0 (en) 1986-06-20

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