NO160521C - ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE 13ALFA ALKYLGONANES. - Google Patents

ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE 13ALFA ALKYLGONANES.

Info

Publication number
NO160521C
NO160521C NO842394A NO842394A NO160521C NO 160521 C NO160521 C NO 160521C NO 842394 A NO842394 A NO 842394A NO 842394 A NO842394 A NO 842394A NO 160521 C NO160521 C NO 160521C
Authority
NO
Norway
Prior art keywords
13alfa
alkylgonanes
preparation
therapeutic active
analogy procedure
Prior art date
Application number
NO842394A
Other languages
Norwegian (no)
Other versions
NO842394L (en
NO160521B (en
Inventor
Guenter Neef
Gerhard Sauer
Rudolf Wiechert
Sybille Beier
Walter Elger
David Henderson
Ralph Rohde
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE3321826A external-priority patent/DE3321826A1/en
Priority claimed from DE19843413036 external-priority patent/DE3413036A1/en
Application filed by Schering Ag filed Critical Schering Ag
Publication of NO842394L publication Critical patent/NO842394L/en
Priority to NO863963A priority Critical patent/NO161895C/en
Priority to NO863964A priority patent/NO160522C/en
Publication of NO160521B publication Critical patent/NO160521B/en
Publication of NO160521C publication Critical patent/NO160521C/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
    • C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
NO842394A 1983-06-15 1984-06-14 ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE 13ALFA ALKYLGONANES. NO160521C (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
NO863963A NO161895C (en) 1983-06-15 1986-10-03 ANTI-CONCEPTING AGENT CONTAINING 13ALFA ALKYLGONANES AS A SUBSTANTIAL COMPONENT.
NO863964A NO160522C (en) 1983-06-15 1986-10-03 13-EPISTEROIDER.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3321826A DE3321826A1 (en) 1983-06-15 1983-06-15 13 alpha -Alkylgonanes, the preparation thereof and pharmaceutical products containing these
DE19843413036 DE3413036A1 (en) 1984-04-04 1984-04-04 13a-Alkylgonanes, the preparation thereof and pharmaceutical products containing these

Publications (3)

Publication Number Publication Date
NO842394L NO842394L (en) 1984-12-17
NO160521B NO160521B (en) 1989-01-16
NO160521C true NO160521C (en) 1989-04-26

Family

ID=25811539

Family Applications (1)

Application Number Title Priority Date Filing Date
NO842394A NO160521C (en) 1983-06-15 1984-06-14 ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE 13ALFA ALKYLGONANES.

Country Status (16)

Country Link
EP (1) EP0129499B1 (en)
JP (1) JPH02167296A (en)
AU (1) AU572849B2 (en)
CA (1) CA1307784C (en)
DD (1) DD218624A5 (en)
DE (1) DE3468030D1 (en)
DK (1) DK166729B1 (en)
ES (1) ES533260A0 (en)
FI (1) FI78709C (en)
GR (1) GR82210B (en)
HU (1) HU191131B (en)
IE (1) IE57620B1 (en)
IL (1) IL72085A (en)
NO (1) NO160521C (en)
NZ (1) NZ208441A (en)
PT (1) PT78732B (en)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3446661A1 (en) * 1984-12-18 1986-06-19 Schering AG, 1000 Berlin und 4709 Bergkamen NEW 13 (ALPHA) -ALKYL-17 (BETA) - (3-ACYLOXYPROPYL) GONANA
DE3506785A1 (en) * 1985-02-22 1986-08-28 Schering AG, Berlin und Bergkamen, 1000 Berlin 11SS-N, N-DIMETHYLAMINOPHENYL ESTRADIENE, THE PRODUCTION THEREOF AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM
DE3630030A1 (en) * 1986-09-01 1988-03-03 Schering Ag 13 (ALPHA) -ALKYLGONAN- (DELTA) (UP ARROW) 9 (UP ARROW) (UP ARROW) ((UP ARROW) (UP ARROW) 1 (UP ARROW) 1 (UP ARROW)) (UP ARROW) -5, 10-EPOXIDE
US4774236A (en) * 1986-09-17 1988-09-27 Research Triangle Institute 17α-(substituted-methyl)-17β-hydroxy/esterified hydroxy steroids and pharmaceutical compositions containing them
IE60780B1 (en) * 1987-01-23 1994-08-10 Akzo Nv New 11-aryl steroid derivatives
EP0310542B1 (en) * 1987-10-01 1994-06-08 Schering Aktiengesellschaft Antigestagenic and antioestrogenic compounds for the treatment of hormone-dependent tumours
JP2785023B2 (en) * 1987-12-30 1998-08-13 ルセル―ユクラフ Novel derivative of 17β-OH-19-norsteroid substituted at 17α position, process for its preparation, its use as drug and pharmaceutical composition containing it
US4954490A (en) * 1988-06-23 1990-09-04 Research Triangle Institute 11 β-substituted progesterone analogs
DE3822770A1 (en) * 1988-07-01 1990-01-04 Schering Ag 13-ALKYL-11SS-PHENYLGONANE
DE3832303A1 (en) * 1988-09-20 1990-04-12 Schering Ag 11SS-PHENYL-14SSH STEROIDS
US5372996A (en) * 1989-03-10 1994-12-13 Endorecherche, Inc. Method of treatment of androgen-related diseases
US5364847A (en) * 1989-03-10 1994-11-15 Endorecherche Inhibitors of sex steroid biosynthesis and methods for their production and use
CA2062792C (en) * 1989-07-07 2006-03-21 Fernard Labrie Treatment of androgen-related diseases
AU5856090A (en) * 1989-07-07 1991-02-06 Endorecherche Inc. Androgen derivatives for use in the inhibition of sex steroid activity
ATE172469T1 (en) * 1989-08-04 1998-11-15 Schering Ag 11 BETA-ARYL-GONA-4,9-DIENE-3-ONE
FR2654337B1 (en) * 1989-11-15 1994-08-05 Roussel Uclaf NOVEL BIODEGRADABLE INJECTABLE MICROSPHERES PREPARATION METHOD AND INJECTABLE SUSPENSIONS CONTAINING THEM.
DE4008584A1 (en) * 1990-03-15 1991-09-26 Schering Ag METHOD FOR PRODUCING INTERMEDIATE PRODUCTS FOR THE ANTIGESTAGE SYNTHESIS (ONAPRISTONE SYNTHESIS)
US5407928A (en) * 1990-08-15 1995-04-18 Schering Aktiengesellschaft 11β-aryl-gona-4,9-dien-3-ones
DK0496846T3 (en) * 1990-08-18 1997-12-01 Schering Ag Process for Preparation of 17-Oxosteroids
US5472854A (en) * 1990-08-18 1995-12-05 Schering Aktiengesellschaft Process for the production of 17-oxosteroids via the fermentative oxidation of 17β-hydroxysteroids by Mycobacterium
MX9301121A (en) * 1992-03-02 1993-09-01 Schering Ag METHOD AND EQUIPMENT FOR ORAL CONTRACEPTION AND REGULATION OF MENSTRUATION WITH ESTROGEN / PROGESTIN / ANIPROGESTIN.
US7704983B1 (en) 1992-03-02 2010-04-27 Eastern Virginia Medical School Antiprogestin method for reducing side effects associated with low dosage HRT and oral contraception
US5439913A (en) 1992-05-12 1995-08-08 Schering Aktiengesellschaft Contraception method using competitive progesterone antagonists and novel compounds useful therein
EP0641211A1 (en) * 1992-05-21 1995-03-08 Endorecherche Inc. INHIBITORS OF TESTOSTERONE 5$g(a)-REDUCTASE ACTIVITY
DE4413185A1 (en) * 1994-04-12 1995-10-19 Schering Ag 11beta, 19-bridged 13alpha alkyl steroids
DE4415590A1 (en) * 1994-04-28 1995-11-02 Schering Ag Process for the stereoselective introduction of an alkynyl side chain to 11β-aryl-substituted 13alpha-alkylgonan-17-ones
DE4434488A1 (en) 1994-09-14 1996-03-21 Schering Ag Steroid esters and amides, processes for their preparation and their pharmaceutical use
ZA9510926B (en) 1994-12-23 1996-07-03 Schering Ag Compounds with progesterone-antagonistic and antiestrogenic action to be used together for female contraception
CA2668824A1 (en) 1996-05-01 1997-11-06 The Government Of The United States Of America, Represented By The Secre Tary Of The Department Of Health And Human Services 21-substituted progesterone derivatives as new antiprogestational agents
US6900193B1 (en) * 1996-05-01 2005-05-31 The United States Of America As Represented By The Department Of Health And Human Services Structural modification of 19-norprogesterone I: 17-α-substituted-11-β-substituted-4-aryl and 21-substituted 19-norpregnadienedione as new antiprogestational agents
CN113559075A (en) 2014-11-17 2021-10-29 康泰科思特生物制药公司 Onapristone extended release compositions and methods
BR112018005999A2 (en) * 2015-09-25 2019-01-08 Context Biopharma Inc methods for the production of onapristone intermediates
AU2016370499B2 (en) * 2015-12-15 2022-06-30 Context Biopharma Inc. Amorphous onapristone compositions and methods of making the same
US20180148471A1 (en) 2016-11-30 2018-05-31 Arno Therapeutics, Inc. Methods for onapristone synthesis dehydration and deprotection

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2377418A1 (en) * 1977-01-13 1978-08-11 Roussel Uclaf NEW 4,9-DIENIC 11B-SUBSTITUTE STEROID DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICINAL PRODUCTS
ZA8231B (en) * 1981-01-09 1982-11-24 Roussel Uclaf New 11 -substituted steroid derivatives, their preparation, their use as medicaments, the compositions containing them and the new intermediates thus obtained
DE3347126A1 (en) * 1983-12-22 1985-07-11 Schering AG, 1000 Berlin und 4709 Bergkamen 11SS-ARYL-ESTRADIENE, THEIR PRODUCTION AND THE PHARMACEUTICAL PREPARATIONS CONTAINING THEM
CA1304916C (en) * 1984-10-18 1992-07-14 Wilhelm Bannwarth Apparatus for the parallel performance of a plurality of chemical reaction sequences

Also Published As

Publication number Publication date
FI78709C (en) 1989-09-11
CA1307784C (en) 1992-09-22
IE841484L (en) 1984-12-15
DE3468030D1 (en) 1988-01-21
ES8502612A1 (en) 1985-02-01
DD218624A5 (en) 1985-02-13
NO842394L (en) 1984-12-17
IL72085A (en) 1987-09-16
PT78732B (en) 1986-06-03
DK288184D0 (en) 1984-06-12
FI842395A (en) 1984-12-16
JPH0369919B2 (en) 1991-11-05
JPH02167296A (en) 1990-06-27
ES533260A0 (en) 1985-02-01
AU2936184A (en) 1984-12-20
IE57620B1 (en) 1993-02-10
GR82210B (en) 1984-12-13
EP0129499A2 (en) 1984-12-27
FI78709B (en) 1989-05-31
FI842395A0 (en) 1984-06-13
IL72085A0 (en) 1984-10-31
NZ208441A (en) 1988-01-08
HUT36139A (en) 1985-08-28
AU572849B2 (en) 1988-05-19
EP0129499B1 (en) 1987-12-09
EP0129499A3 (en) 1985-10-09
NO160521B (en) 1989-01-16
DK288184A (en) 1984-12-16
DK166729B1 (en) 1993-07-05
PT78732A (en) 1985-01-01
HU191131B (en) 1987-01-28

Similar Documents

Publication Publication Date Title
NO160521C (en) ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE 13ALFA ALKYLGONANES.
NO158021C (en) ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE D-PHENYLALANYL-L-PROLYL-L-ARGINALDEHYDE SULFATE.
NO158099C (en) ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE CARBOSTYRIC DERIVATIVES.
NO156864C (en) ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE PIPERIN DERIVATIVES.
NO165239C (en) ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE 1-BENZYL-AMINOALKYL-PYRROLIDINON DERIVATIVES.
NO165192C (en) ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE GLYCLE DERIVATIVES.
NO166320C (en) ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE TETRAZOLD DERIVATIVES.
NO162858C (en) ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTICALLY ACTIVE THIAZOLIDE INGREDIATES.
NO156693C (en) ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE 10-PROPYNYL STEROIDS.
NO161679C (en) ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE STEROIDS.
NO158183C (en) ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE IMIDAZOLYLPHENYLAMIDINES.
NO161562C (en) ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE ERGOLIN DERIVATIVES.
NO161676C (en) ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE MITOSANDER DERIVATIVES.
NO159528C (en) ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE AMINOGUANIDE INGREDIENTS.
NO165400C (en) ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE CEFEM COMPOUNDS.
NO161559C (en) ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE TRIAZOLD DERIVATIVES.
NO158941C (en) ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE 4-PIPERIDINO-CHINAZOLINE DERIVATIVES.
NO161313C (en) ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE FLUORALLYLAMINE DERIVATIVES.
NO160511C (en) ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE PHENYL-CYCLO-BUTAND DERIVATIVES.
NO160000C (en) ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE COMPOUNDS.
NO164415C (en) ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE 5-ACYL-2- (1H) -PYRIDINONES.
NO158673C (en) ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTICALLY ACTIVE AZUREND DERIVATIVES.
NO168478C (en) ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE VINYLTHIOACETAMIDO-OXACEPHALOSPORINE DERIVATIVES.
NO161800C (en) ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE 1- (2-ARYL-2-HALO-1-ETHENYL) -1H-AZOLES.
NO160512C (en) ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE CARBOSTYRIC DERIVATIVES.