DK568487D0 - NORSTATIN AND NORCYCLOSTAT CONTAINING POLYPEPTIDES AND PHARMACEUTICAL PREPARATIONS CONTAINING THESE. - Google Patents

NORSTATIN AND NORCYCLOSTAT CONTAINING POLYPEPTIDES AND PHARMACEUTICAL PREPARATIONS CONTAINING THESE.

Info

Publication number
DK568487D0
DK568487D0 DK568487A DK568487A DK568487D0 DK 568487 D0 DK568487 D0 DK 568487D0 DK 568487 A DK568487 A DK 568487A DK 568487 A DK568487 A DK 568487A DK 568487 D0 DK568487 D0 DK 568487D0
Authority
DK
Denmark
Prior art keywords
norcyclostat
norstatin
pharmaceutical preparations
polypeptides
preparations containing
Prior art date
Application number
DK568487A
Other languages
Danish (da)
Other versions
DK568487A (en
Inventor
Dennis Jay Hoover
Robert Louis Rosati
Ronald Thure Wester
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of DK568487D0 publication Critical patent/DK568487D0/en
Publication of DK568487A publication Critical patent/DK568487A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/14—Angiotensins: Related peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/205—Radicals derived from carbonic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C07D265/32—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings with oxygen atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0227—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
DK568487A 1986-10-31 1987-10-30 NORSTATIN AND NORCYCLOSTAT CONTAINING POLYPEPTIDES AND PHARMACEUTICAL PREPARATIONS CONTAINING THESE. DK568487A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US92544986A 1986-10-31 1986-10-31
US6898287A 1987-07-01 1987-07-01

Publications (2)

Publication Number Publication Date
DK568487D0 true DK568487D0 (en) 1987-10-30
DK568487A DK568487A (en) 1988-05-01

Family

ID=26749566

Family Applications (1)

Application Number Title Priority Date Filing Date
DK568487A DK568487A (en) 1986-10-31 1987-10-30 NORSTATIN AND NORCYCLOSTAT CONTAINING POLYPEPTIDES AND PHARMACEUTICAL PREPARATIONS CONTAINING THESE.

Country Status (22)

Country Link
EP (1) EP0266950B1 (en)
JP (1) JPH07108901B2 (en)
KR (1) KR910002544B1 (en)
CN (1) CN1027271C (en)
AR (1) AR245732A1 (en)
AU (1) AU585180B2 (en)
CA (1) CA1310793C (en)
DE (1) DE3788626T2 (en)
DK (1) DK568487A (en)
EG (1) EG18378A (en)
ES (1) ES2061512T3 (en)
FI (1) FI90346C (en)
HU (1) HU207869B (en)
IE (1) IE61087B1 (en)
IL (1) IL84270A0 (en)
MY (1) MY103189A (en)
NO (1) NO173017C (en)
NZ (1) NZ222373A (en)
PH (1) PH25231A (en)
PL (1) PL151679B1 (en)
PT (1) PT86024B (en)
YU (1) YU46819B (en)

Families Citing this family (51)

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US5214129A (en) * 1985-01-23 1993-05-25 Abbott Laboratories Peptidylaminodiols
IL81234A (en) * 1986-01-16 1992-09-06 Abbott Lab Peptidylaminodiols,process for their preparation and pharmaceutical compositions comprising them
WO1988003022A1 (en) * 1986-10-31 1988-05-05 Pfizer Inc. Relatively low molecular weight polypeptides as renin inhibitors
US4977141A (en) * 1987-10-01 1990-12-11 G. D. Searle & Co. Peptidyl α-aminoacyl aminodiol carbamates as anti-hypertensive agents
US4927807A (en) * 1987-10-06 1990-05-22 Abbott Laboratories Glaucoma treatment
US5217958A (en) * 1988-03-03 1993-06-08 E. R. Squibb & Sons, Inc. 1,2-hydroxy phosphonates and derivatives thereof
WO1989007940A1 (en) * 1988-03-03 1989-09-08 E.R. Squibb & Sons, Inc. 1,2-hydroxy phosphonates and derivatives thereof
ZA897514B (en) * 1988-10-07 1990-06-27 Merrell Dow Pharma Novel peptidase inhibitors
US5736520A (en) * 1988-10-07 1998-04-07 Merrell Pharmaceuticals Inc. Peptidase inhibitors
EP0376040A3 (en) * 1988-12-27 1990-09-12 American Cyanamid Company N-phosphinyl di-and tripeptides as renin inhibitors
US4965372A (en) * 1989-01-19 1990-10-23 Pfizer Inc. Process and intermediates for isopropyl 3S-amino-2R-hydroxy-alkanoates
WO1990009172A1 (en) * 1989-02-16 1990-08-23 Pfizer Inc. Phosphorus containing renin inhibitors
US5468732A (en) * 1989-02-16 1995-11-21 Pfizer Inc. Phosphorus containing renin inhibitors
US5223514A (en) * 1989-12-04 1993-06-29 G. D. Searle & Co. Quinolinyl/quinolinylalkyl-N-terminal cycloalkoxy-C-terminal amino hydroxy β-amino acid derivatives
ATE118207T1 (en) * 1989-12-04 1995-02-15 Searle & Co HETEROCYCLIC ACYLAMINODIOL BETA-AMINO ACID DERIVATIVES.
US5231111A (en) * 1989-12-04 1993-07-27 G. D. Searle & Co. Imidazolyl/imidazolylalkyl-N-terminal cycloalkoxy-C-terminal amino hydroxy β-amino acid derivatives
US5223534A (en) * 1989-12-04 1993-06-29 G. D. Searle & Co. Benzofuuranyl/benofuranylaklyl-N-terminal cycloalkoxy-C-terminal amino hydroxy β-amino acid derivatives
US5171751A (en) * 1989-12-04 1992-12-15 G. D. Searle & Co. Benzofuran/benzofuranalkyl-N-terminal amino hydroxy
US5179102A (en) * 1989-12-04 1993-01-12 G. D. Searle & Co. Naphthyridinyl/naphthyridinylalkyl-n-terminal anino hydroxy β-amino acid derivatives
US5175170A (en) * 1989-12-04 1992-12-29 G. D. Searle & Co. β-amino acid derivatives
US5216013A (en) * 1989-12-04 1993-06-01 G. D. Searle & Co. Aralkyl-N-terminal cycloalkoxy-C terminal amino hydroxy β-amino acid derivatives
US5180725A (en) * 1989-12-04 1993-01-19 G. D. Searle & Co. Quinoxalinyl/quinoxaliy; alkyl-N-terminal amino hydroxy
US5212175A (en) * 1989-12-04 1993-05-18 G. D. Searle & Co. Benzothiophenyl benzothiophenylalkyl-N-terminal amino hydroxy β-amino acid derivatives
US5210095A (en) * 1989-12-04 1993-05-11 G. D. Searle & Co. Chromonyl/chromonylalkyl-N-terminal amino hydroxy
US5217989A (en) * 1989-12-04 1993-06-08 G. D. Searle & Co. Benothiophenyl/benzothiophenylalkyl-N-terminal cycloalkoxy-C-terminal amino hydroxy β-amino acid derivatives
US5180744A (en) * 1989-12-04 1993-01-19 G. D. Searle & Co. Aralkyl-N-terminal amino hydroxy
US5215996A (en) * 1989-12-04 1993-06-01 G. D. Searle & Co. Naphthyridinyl/naphthyridinylalkyl-N-terminal cycloalkoxy-C-terminal amino hydroxy β-amino acid derivatives
US5147888A (en) * 1989-12-04 1992-09-15 G. D. Searle & Co. N-terminal indolyy indolylalkylaminodiol β-amino acid derivatives
US5223532A (en) * 1989-12-04 1993-06-29 G. D. Searle & Co. Chromonyl/chromonylalkyl-N-terminal cycloalkoxy-C-terminal amino hydroxy β-amino derivatives
US5217991A (en) * 1989-12-04 1993-06-08 G. D. Searle & Co. Cycloalkyl/cycloalkylalkyl-N-terminal cycloalkoxy-C-terminal amino hydroxy β-amino acid derivatives
US5217988A (en) * 1989-12-04 1993-06-08 G. D. Searle & Co. Indolyl indolylakyl-N-terminal cycloalkoxy-C-terminal amino hydroxyβ-amino acid derivatives
US5223512A (en) * 1989-12-04 1993-06-29 G. D. Searle & Co. Quinolonyl/quinolonylalkyl-N-terminal cycloalkoxy-C-terminal amino hydroxy β-amino acid derivatives
US5175181A (en) * 1989-12-04 1992-12-29 G. D. Searle & Co. Imidazolyl/imidazolylalkyl-N-terminal amino hydroxy
TW209870B (en) * 1990-01-18 1993-07-21 Pfizer
US5064965A (en) * 1990-03-08 1991-11-12 American Home Products Corporation Renin inhibitors
US5023338A (en) * 1990-03-08 1991-06-11 American Home Products Corporation Renin inhibitors
US5075451A (en) * 1990-03-08 1991-12-24 American Home Products Corporation Pyrrolimidazolones useful as renin inhibitors
US5095119A (en) * 1990-03-08 1992-03-10 American Home Products Corporation Renin inhibitors
US5278161A (en) * 1990-06-28 1994-01-11 Hoffmann-La Roche Inc. Amino acid derivatives useful as renin inhibitors
JPH04243835A (en) * 1990-08-29 1992-08-31 Pfizer Inc Drug composition for therapy of disease on high intraocular tension or glaucoma and method for therapy thereof
JP2847584B2 (en) * 1991-06-21 1999-01-20 高砂香料工業株式会社 Cyclohexylbutyric acid derivative and method for producing the same
US5442105A (en) * 1991-06-21 1995-08-15 Takasago International Corporation Process for producing cyclohexylbutyric acid derivative
JPH06510796A (en) * 1991-12-18 1994-12-01 ファイザー　インク． Soy protein or hydrolyzate in pharmaceutical compositions for protecting bioactive peptides from enzymatic inactivation
US6153592A (en) * 1992-11-09 2000-11-28 Port Systems, Llc Enhancing the bioavailability of proteolytically labile therapeutic agents
US6017887A (en) * 1995-01-06 2000-01-25 Sibia Neurosciences, Inc. Peptide, peptide analog and amino acid analog protease inhibitors
US5804560A (en) * 1995-01-06 1998-09-08 Sibia Neurosciences, Inc. Peptide and peptide analog protease inhibitors
DK0832065T3 (en) * 1995-06-06 2001-11-19 Pfizer Substituted N- (indole-2-carbonyl) glycinamides and derivatives as glycogen phosphorylase inhibitors
EP1134214A4 (en) * 1998-11-04 2004-12-15 Meiji Seika Kaisha Picolinamide derivatives and pest controllers containing the same as the active ingredient
US6117870A (en) * 1998-11-12 2000-09-12 Fujirebio Kabushiki Kaisha Cyclic amide derivatives
US20020002152A1 (en) 2000-04-14 2002-01-03 Craig Richard A. Hydrazide and alkoxyamide angiogenesis inhibitors
UA108742C2 (en) 2009-09-23 2015-06-10 PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF MCP-1 MEDIATED DISEASES

Family Cites Families (5)

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Publication number Priority date Publication date Assignee Title
FI850948L (en) * 1984-03-12 1985-09-13 Pfizer RENIN INHIBITORER SOM INNEHAOLLER STATIN ELLER DESS DERIVAT.
DE3418491A1 (en) * 1984-05-18 1985-11-21 Merck Patent Gmbh, 6100 Darmstadt DIAMINO ACID DERIVATIVES
EP0190891A3 (en) * 1985-01-31 1988-04-20 Kissei Pharmaceutical Co. Ltd. Novel amino acid derivatives
US4743585A (en) * 1986-11-21 1988-05-10 Warner-Lambert Company Renin inhibitors
NZ222755A (en) * 1986-12-23 1989-11-28 Warner Lambert Co Renin inhibiting acyl peptide derivatives containing two to four amino acid residues, and pharmaceutical compositions

Also Published As

Publication number Publication date
AU8054187A (en) 1988-05-05
IE872929L (en) 1988-04-30
PT86024B (en) 1990-07-31
FI874787A0 (en) 1987-10-30
NO173017B (en) 1993-07-05
NO874530L (en) 1988-05-02
NZ222373A (en) 1989-09-27
NO173017C (en) 1993-10-13
FI874787A (en) 1988-05-01
ES2061512T3 (en) 1994-12-16
KR880005152A (en) 1988-06-28
DE3788626T2 (en) 1994-04-28
CN87101499A (en) 1988-05-11
AU585180B2 (en) 1989-06-08
NO874530D0 (en) 1987-10-30
JPH07173134A (en) 1995-07-11
HUT45270A (en) 1988-06-28
IE61087B1 (en) 1994-09-21
KR910002544B1 (en) 1991-04-23
AR245732A1 (en) 1994-02-28
PL268521A1 (en) 1988-09-01
HU207869B (en) 1993-06-28
JPH07108901B2 (en) 1995-11-22
EG18378A (en) 1993-04-30
EP0266950A2 (en) 1988-05-11
PT86024A (en) 1987-11-01
FI90346B (en) 1993-10-15
DE3788626D1 (en) 1994-02-10
YU46819B (en) 1994-06-10
FI90346C (en) 1994-01-25
CA1310793C (en) 1992-11-24
MY103189A (en) 1993-05-29
EP0266950A3 (en) 1990-04-11
PL151679B1 (en) 1990-09-28
DK568487A (en) 1988-05-01
YU198087A (en) 1989-02-28
IL84270A0 (en) 1988-03-31
CN1027271C (en) 1995-01-04
EP0266950B1 (en) 1993-12-29
PH25231A (en) 1991-03-27

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