RU2559620C2 - Новые производные оксазолидинона, способ их получения и применение - Google Patents

Новые производные оксазолидинона, способ их получения и применение Download PDF

Info

Publication number
RU2559620C2
RU2559620C2 RU2010149618/04A RU2010149618A RU2559620C2 RU 2559620 C2 RU2559620 C2 RU 2559620C2 RU 2010149618/04 A RU2010149618/04 A RU 2010149618/04A RU 2010149618 A RU2010149618 A RU 2010149618A RU 2559620 C2 RU2559620 C2 RU 2559620C2
Authority
RU
Russia
Prior art keywords
fluorophenyl
pyridin
compound
acid
derivative
Prior art date
Application number
RU2010149618/04A
Other languages
English (en)
Russian (ru)
Other versions
RU2010149618A (ru
Inventor
Джае Кеол РХИ
Веон Бин ИМ
Чонг Хван ЧО
Сунг Хак ЧОЙ
Тае Хо ЛИ
Original Assignee
Донг-А Ст Ко., Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36660051&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=RU2559620(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Донг-А Ст Ко., Лтд. filed Critical Донг-А Ст Ко., Лтд.
Publication of RU2010149618A publication Critical patent/RU2010149618A/ru
Application granted granted Critical
Publication of RU2559620C2 publication Critical patent/RU2559620C2/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07F9/653—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
RU2010149618/04A 2003-12-18 2004-12-17 Новые производные оксазолидинона, способ их получения и применение RU2559620C2 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR10-2003-0093342 2003-12-18
KR20030093342 2003-12-18
KR1020040058809A KR100854211B1 (ko) 2003-12-18 2004-07-27 신규한 옥사졸리디논 유도체, 그의 제조방법 및 이를유효성분으로 하는 항생제용 약학 조성물
KR10-2004-0058809 2004-07-27

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
RU2006125761A Division RU2414469C3 (ru) 2003-12-18 2004-12-17 Новые производные оксазолидинона

Publications (2)

Publication Number Publication Date
RU2010149618A RU2010149618A (ru) 2012-06-27
RU2559620C2 true RU2559620C2 (ru) 2015-08-10

Family

ID=36660051

Family Applications (2)

Application Number Title Priority Date Filing Date
RU2010149618/04A RU2559620C2 (ru) 2003-12-18 2004-12-17 Новые производные оксазолидинона, способ их получения и применение
RU2006125761A RU2414469C3 (ru) 2003-12-18 2004-12-17 Новые производные оксазолидинона

Family Applications After (1)

Application Number Title Priority Date Filing Date
RU2006125761A RU2414469C3 (ru) 2003-12-18 2004-12-17 Новые производные оксазолидинона

Country Status (25)

Country Link
US (9) US7816379B2 (enExample)
EP (2) EP1699784B1 (enExample)
JP (1) JP4739229B2 (enExample)
KR (1) KR100854211B1 (enExample)
CN (4) CN102702184B (enExample)
AT (1) ATE514686T1 (enExample)
AU (2) AU2004299413C1 (enExample)
BE (1) BE2015C050I2 (enExample)
BR (1) BRPI0417800B8 (enExample)
CA (1) CA2549062C (enExample)
CY (2) CY1112445T1 (enExample)
DK (1) DK1699784T3 (enExample)
ES (1) ES2391820T3 (enExample)
FR (1) FR15C0062I2 (enExample)
HU (1) HUS1500046I1 (enExample)
LT (1) LTC1699784I2 (enExample)
LU (1) LU92834I2 (enExample)
MX (2) MXPA06006955A (enExample)
NL (1) NL300759I1 (enExample)
NZ (2) NZ575842A (enExample)
PL (1) PL1699784T3 (enExample)
PT (1) PT1699784E (enExample)
RU (2) RU2559620C2 (enExample)
SI (1) SI1699784T1 (enExample)
WO (1) WO2005058886A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2792687C1 (ru) * 2019-08-20 2023-03-23 Хангжоу Дике Технологиес Ко., Лтд. Способ синтеза n-замещенного фенил-5-гидроксиметил-2-оксазолидинона

Families Citing this family (87)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8324398B2 (en) 2003-06-03 2012-12-04 Rib-X Pharmaceuticals, Inc. Process for the synthesis of biaryl oxazolidinones
MXPA05013132A (es) 2003-06-03 2006-05-25 Rib X Pharmaceuticals Inc Compuestos heterociclicos de biarilo y metodos de produccion y su uso.
US7129259B2 (en) 2003-12-17 2006-10-31 Rib-X Pharmaceuticals, Inc. Halogenated biaryl heterocyclic compounds and methods of making and using the same
KR100854211B1 (ko) 2003-12-18 2008-08-26 동아제약주식회사 신규한 옥사졸리디논 유도체, 그의 제조방법 및 이를유효성분으로 하는 항생제용 약학 조성물
JP2008500319A (ja) * 2004-05-25 2008-01-10 アストラゼネカ アクチボラグ 細菌感染症の治療のためのｍａｏ阻害剤としての３−（４−（２−ジヒドロイソオキサゾール−３−イルピリジン−５−イル）フェニル−５−トリアゾール−１−イルメチルオキサゾリジン−２−オン誘導体
WO2006038100A1 (en) * 2004-10-08 2006-04-13 Ranbaxy Laboratories Limited Oxazolidinone derivatives as antimicrobials
US8399660B2 (en) 2005-06-08 2013-03-19 Rib-X Pharmaceuticals, Inc. Process for the synthesis of triazoles
CN100406455C (zh) * 2006-02-20 2008-07-30 中国科学院上海药物研究所 含三氮唑基的噁唑烷酮类化合物及其制备方法和用途
EP2086968B1 (en) * 2006-11-10 2012-02-08 Actelion Pharmaceuticals Ltd. 5-hydroxymethyl-oxazolidin-2-one derivatives
US8124623B2 (en) 2006-11-10 2012-02-28 Actelion Pharmaceuticals Ltd. 5-hydroxymethyl-oxazolidin-2-one-derivatives and their uses as antibacterials
JP4819980B2 (ja) 2008-05-09 2011-11-24 アクテリオン ファーマシューティカルズ リミテッド 細菌性腸管疾患の治療のための５−ヒドロキシメチル−オキサゾリジン−２−オン誘導体
WO2010047737A2 (en) 2008-09-02 2010-04-29 Micurx Pharmaceuticals, Inc. Antimicrobial indoline compounds for treatment of bacterial infections
EP2346858B1 (en) * 2008-10-10 2019-08-07 Merck Sharp & Dohme Corp. Methods for preparing oxazolidinones and compositions containing them
MY161597A (en) 2008-11-15 2017-04-28 Rib-X Pharmaceuticals Inc Antimicrobial compositions
RU2522582C2 (ru) 2008-11-20 2014-07-20 Панацеа Биотек Лтд. Новые противомикробные средства
WO2010061908A1 (ja) 2008-11-28 2010-06-03 中外製薬株式会社 １－（２ｈ）－イソキノロン誘導体
UA114068C2 (xx) 2009-02-03 2017-04-25 Кристалічні частинки (r)-3-(4-(2-(2-метилтетразол-5-іл)піридин-5-іл)-3-фторфеніл)-5-гідроксиметилоксазолідин-2-ондиводеньфосфату
CN101798302B (zh) 2009-02-06 2014-11-05 上海盟科药业有限公司 抗生素类药物1-(邻-氟苯基)二氢吡啶酮的合成及生产的方法和工艺
JP5731413B2 (ja) * 2009-03-13 2015-06-10 サン ケミカル ベスローテン フェンノートシャップ エネルギー硬化性組成物に有用な環式カルバメート化合物
US8580767B2 (en) * 2009-05-28 2013-11-12 Trius Therapeutics, Inc. Oxazolidinone containing dimer compounds, compositions and methods to make and use
US8906913B2 (en) 2009-06-26 2014-12-09 Panacea Biotec Limited Azabicyclohexanes
NZ599151A (en) * 2009-10-13 2014-07-25 Melinta Therapeutics Inc Pharmaceutical composition comprising radezolid or salt thereof and uses thereof
IT1397023B1 (it) 2009-11-27 2012-12-20 Professional Dietetics Srl Composizioni comprendenti amminoacidi, per il trattamento della broncopneumopatia cronica ostruttiva
ES2368236B1 (es) * 2009-12-23 2012-09-26 Merck Sharp & Dohme Corp. Agentes antibacterianos.
CN102276595A (zh) * 2010-04-16 2011-12-14 山东轩竹医药科技有限公司 含有五元杂环的噁唑烷酮抗菌素
KR101180174B1 (ko) 2010-04-23 2012-09-05 동아제약주식회사 신규한 벤즈아미드 유도체
WO2012033952A1 (en) 2010-09-10 2012-03-15 Micurx Pharmaceuticals, Inc. 3 - phenyl- 2 -oxo- 1, 3 -oxazolidines for treatment of bacterial infections
HUE051133T2 (hu) 2010-11-01 2021-03-01 Melinta Subsidiary Corp Gyógyászati készítmények
KR101944124B1 (ko) 2010-11-24 2019-01-30 멜린타 서브시디어리 코프. 약학 조성물
WO2012105574A1 (ja) * 2011-01-31 2012-08-09 国立大学法人長崎大学 光学活性化合物又はその塩の製造方法
KR101653570B1 (ko) * 2011-03-30 2016-09-02 주식회사 레고켐 바이오사이언스 신규한 옥사졸리디논 유도체 및 이를 함유하는 의약 조성물
EP2762479A4 (en) 2011-09-29 2015-04-22 Xuanzhu Pharma Co Ltd OXAZOLIDINONE ANTIBACTERIAL MEDICINE BASED ON BIARYLIC HETEROCYCLE SUBSTITUTED
US8461188B2 (en) 2011-10-20 2013-06-11 Trius Therapeutics, Inc. Therapeutic combination of daptomycin and protein synthesis inhibitor antibiotic, and methods of use
CN103896963B (zh) * 2012-12-26 2017-06-09 中国科学院上海药物研究所 苯并噁嗪噁唑烷酮类化合物及其制备方法和用途
KR102237887B1 (ko) 2013-03-15 2021-04-07 멜린타 서브시디어리 코프. 항생제를 사용하여 과체중 및 비만 환자에서 감염을 치료하는 방법
KR101480982B1 (ko) * 2013-03-20 2015-02-03 (주)셀인바이오 골형성 유도 화합물 및 이의 응용
CN104650142B (zh) * 2013-11-25 2018-06-22 山东新时代药业有限公司 一种福沙匹坦二甲葡胺的制备方法
WO2015127316A1 (en) 2014-02-21 2015-08-27 Micurx Pharmaceuticals, Inc. Water-soluble o-carbonyl phosphoramidate prodrugs for therapeutic administration
WO2015158202A1 (zh) * 2014-04-18 2015-10-22 杭州普晒医药科技有限公司 一种噁唑烷酮类抗生素的晶型及制备方法、组合物和用途
KR101597327B1 (ko) * 2014-04-24 2016-02-24 동아에스티 주식회사 옥사졸리딘계 화합물 및 이를 포함하는 선택적 안드로겐 수용체 효능제
WO2016009401A2 (en) * 2014-07-18 2016-01-21 Dr. Reddy's Laboratories Limited Preparation of tedizolid phosphate
CN105837633B (zh) * 2015-01-12 2018-11-20 正大天晴药业集团股份有限公司 一种抗菌化合物的制备方法
WO2016041505A1 (zh) * 2014-09-17 2016-03-24 正大天晴药业集团股份有限公司 一种磷酸特地唑胺、其中间体以及它们的制备方法
CN104496979A (zh) * 2014-09-17 2015-04-08 博瑞生物医药技术(苏州)有限公司 一种噁唑烷酮类化合物及其中间体的制备方法
CN105418678B (zh) * 2014-09-17 2018-11-20 正大天晴药业集团股份有限公司 一种磷酸特地唑胺的制备方法
CN105566392B (zh) * 2014-10-15 2018-12-21 正大天晴药业集团股份有限公司 一种细菌蛋白质合成抑制剂的制备方法
CN105503955B (zh) * 2014-10-15 2018-11-20 正大天晴药业集团股份有限公司 一种抗革兰氏阳性菌的化合物的制备方法
CN104327119A (zh) * 2014-10-17 2015-02-04 苏州明锐医药科技有限公司 磷酸泰地唑胺的制备方法
WO2016061772A1 (en) 2014-10-22 2016-04-28 Merck Sharp & Dohme Corp. Nargenicin compounds and uses thereof as antibacterial agents
WO2016088100A1 (en) * 2014-12-05 2016-06-09 Sun Pharmaceutical Industries Limited Processes for the preparation of tedizolid phosphate and its intermediates
WO2016088101A1 (en) * 2014-12-05 2016-06-09 Sun Pharmaceutical Industries Limited Processes for the preparation of tedizolid phosphate and its intermediates
WO2016088103A1 (en) * 2014-12-05 2016-06-09 Sun Pharmaceutical Industries Limited A process for the preparation of tedizolid phosphate
CN104530128B (zh) * 2014-12-30 2016-08-24 石药集团中诺药业（石家庄）有限公司 一种磷酸特地唑胺二钠盐及其制备方法
CN104558034A (zh) * 2015-01-21 2015-04-29 齐鲁制药有限公司 磷酸特地唑胺二钠盐的新晶型及其制备方法
CN105859780A (zh) * 2015-01-21 2016-08-17 山东康美乐医药科技有限公司 磷酸特地唑胺的制备方法
CN104610359B (zh) * 2015-01-26 2017-07-14 成都新恒创药业有限公司 一种制备磷酸特地唑胺的关键中间体及其制备方法
CN105837634B (zh) * 2015-01-30 2020-09-04 上海创诺制药有限公司 一种泰地唑胺磷酸酯结晶体及其制备方法
CN104592218B (zh) * 2015-02-13 2015-11-04 江苏欧信医药化工有限公司 一种泰地唑胺的合成方法
CN106146558A (zh) * 2015-04-10 2016-11-23 博瑞生物医药（苏州）股份有限公司 新的噁唑烷酮类化合物及其制备方法
CN106146559B (zh) * 2015-04-10 2019-08-09 博瑞生物医药（苏州）股份有限公司 一种噁唑烷酮类化合物的制备方法
CN106279281B (zh) * 2015-05-15 2018-08-03 重庆圣华曦药业股份有限公司 噁唑烷酮类抗菌素泰地唑胺磷酸酯的精制方法
CN106317114B (zh) * 2015-07-02 2018-11-20 南京优科制药有限公司 一种磷酸特地唑胺的制备方法
CN106632298B (zh) * 2015-11-03 2021-06-01 上海科胜药物研发有限公司 一种泰地唑胺的制备方法及其中间体
KR101855334B1 (ko) 2015-12-11 2018-06-08 에스티팜 주식회사 옥사졸리디논 유도체의 중간체 제조방법
CN105496976A (zh) * 2015-12-18 2016-04-20 北京万全德众医药生物技术有限公司 一种磷酸特地唑胺片及其制备方法
CN105949278B (zh) * 2016-03-30 2019-12-06 南京曼杰生物科技有限公司 一种取代的四氢呋喃水溶性衍生物及其应用
CN106083994B (zh) * 2016-04-18 2019-12-06 南京曼杰生物科技有限公司 取代的噁唑烷酮水溶性衍生物及其应用
WO2017181948A1 (zh) * 2016-04-22 2017-10-26 深圳市塔吉瑞生物医药有限公司 取代的恶唑烷酮化合物及其应用
CN107400126A (zh) * 2016-05-19 2017-11-28 陕西合成药业股份有限公司 新型噁唑烷酮类化合物及其制备方法和在医学上的应用
CN106432182B (zh) * 2016-09-06 2019-04-30 铜仁学院 特地唑胺中间体的合成方法
CN106632240A (zh) * 2016-11-25 2017-05-10 山东轩德医药科技有限公司 一种2‑甲基‑5‑(5‑溴吡啶‑2‑基)四氮唑的制备方法
US10087171B2 (en) 2016-12-19 2018-10-02 Actelion Pharmaceuticals Ltd Crystalline forms of cadazolid
CN107226825B (zh) * 2017-06-14 2019-08-02 浙江海正药业股份有限公司 磷酸泰地唑胺铵盐及其晶型、制备方法和医药用途
EP3723758A4 (en) 2017-12-13 2021-06-23 Merck Sharp & Dohme Corp. PHARMACEUTICAL COMPOSITIONS OF TEDICOLIDE PHOSPHATE
CN110804038B (zh) * 2018-08-06 2021-03-05 上海博志研新药物技术有限公司 磷酸特地唑胺及其中间体的制备方法
US12365656B2 (en) 2019-01-18 2025-07-22 Merck Sharp & Dohme Llc Oxazolidinone compounds and methods of use thereof as antibacterial agents
WO2021000297A1 (en) 2019-07-03 2021-01-07 Merck Sharp & Dohme Corp. Compounds and methods of use thereof as antibacterial agents
CN112940038A (zh) * 2019-12-11 2021-06-11 华创合成制药股份有限公司 新型噁唑烷酮类化合物及其制备方法
CN111116551B (zh) * 2020-01-03 2022-05-20 中国医科大学 1-氮杂螺[5.5]十一烷-3-酮类及1-氮杂螺[5.5]十一烷-3-醇类化合物
CN115968290A (zh) * 2020-06-18 2023-04-14 阿卡格拉医药公司 噁唑烷酮类化合物、包含噁唑烷酮类化合物的脂质体组合物、及其使用方法
US11555033B2 (en) 2020-06-18 2023-01-17 Akagera Medicines, Inc. Oxazolidinone compounds, liposome compositions comprising oxazolidinone compounds and method of use thereof
CN114315897B (zh) * 2020-09-30 2024-05-17 北京澳合药物研究院有限公司 一种磷酸特地唑胺新晶体及其制备方法
US11591544B2 (en) 2020-11-25 2023-02-28 Akagera Medicines, Inc. Ionizable cationic lipids
CN112500433A (zh) * 2020-12-23 2021-03-16 桂林南药股份有限公司 一种磷酸特地唑胺的制备方法
CN113197874B (zh) * 2021-04-28 2023-05-26 北京福元医药股份有限公司 一种磷酸特地唑胺口服固体制剂
KR20240152302A (ko) * 2021-12-22 2024-10-21 아카제라 메디신즈, 인크. 옥사졸리디논 리포좀 조성물
AU2023275780A1 (en) 2022-05-25 2024-12-05 Akagera Medicines, Inc. Lipid nanoparticles for delivery of nucleic acids and methods of use thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2175324C2 (ru) * 1995-09-01 2001-10-27 Фармация Энд Апджон Компани Фенилоксазолидиноны, имеющие с-с-связь с 4-8-членными гетероциклическими кольцами
WO2001094342A1 (en) * 2000-06-05 2001-12-13 Dong A Pharm. Co., Ltd. Novel oxazolidinone derivatives and a process for the preparation thereof
WO2003022824A1 (en) * 2001-09-11 2003-03-20 Astrazeneca Ab Oxazolidinone and/or isoxazoline as antibacterial agents
RU2215740C2 (ru) * 1997-11-12 2003-11-10 Фармация Энд Апджон Компани Оксазолидиноновые производные и фармацевтические композиции на их основе

Family Cites Families (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU80081A1 (fr) 1977-08-26 1979-05-15 Delalande Sa Nouvelles hydroxymethyl-5 oxazolidinones-2,leur procede de preparation et leur application therapeutique
US4128654A (en) 1978-02-10 1978-12-05 E. I. Du Pont De Nemours And Company 5-Halomethyl-3-phenyl-2-oxazolidinones
US4340606A (en) * 1980-10-23 1982-07-20 E. I. Du Pont De Nemours And Company 3-(p-Alkylsulfonylphenyl)oxazolidinone derivatives as antibacterial agents
FR2500450A1 (fr) 1981-02-25 1982-08-27 Delalande Sa Nouveaux derives aminomethyl-5 oxazolidiniques, leur procede de preparation et leur application en therapeutique
US4461773A (en) 1982-09-15 1984-07-24 E. I. Dupont De Nemours And Company P-Oxooxazolidinylbenzene compounds as antibacterial agents
CA1320730C (en) 1987-10-16 1993-07-27 The Du Pont Merck Pharmaceutical Company Aminomethyl oxooxazolidinyl aroylbenzene derivatives useful as antibacterial agents
US5254577A (en) 1988-07-29 1993-10-19 The Du Pont Merck Pharmaceutical Company Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents
US4948801A (en) 1988-07-29 1990-08-14 E. I. Du Pont De Nemours And Company Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents
CA2119556C (en) * 1991-11-01 2004-07-06 Michael Robert Barbachyn Substituted aryl- and heteroaryl-phenyloxazolidinones
SK283420B6 (sk) 1992-05-08 2003-07-01 Pharmacia & Upjohn Company Antimikrobiálne oxazolidinóny obsahujúce substituované diazínové skupiny
NZ257031A (en) * 1992-12-08 1996-07-26 Upjohn Co Tropone substituted phenyloxazolidinone derivatives and anti-bacterial medicaments thereof
MY115155A (en) 1993-09-09 2003-04-30 Upjohn Co Substituted oxazine and thiazine oxazolidinone antimicrobials.
US5688792A (en) 1994-08-16 1997-11-18 Pharmacia & Upjohn Company Substituted oxazine and thiazine oxazolidinone antimicrobials
CA2174107C (en) 1993-11-22 2005-04-12 Steven J. Brickner Esters of substituted-hydroxyacetyl piperazine phenyl oxazolidinones
GB9702213D0 (en) 1996-02-24 1997-03-26 Zeneca Ltd Chemical compounds
CA2294293A1 (en) 1997-07-11 1999-01-21 Pharmacia & Upjohn Company Thiadiazolyl and oxadiazolyl phenyl oxazolidinone antibacterial agents
EP1077718B1 (en) * 1998-05-18 2002-08-14 PHARMACIA & UPJOHN COMPANY Enhancement of oxazolidinone antibacterial agents activity by arginine derivatives
US6413981B1 (en) 1999-08-12 2002-07-02 Ortho-Mcneil Pharamceutical, Inc. Bicyclic heterocyclic substituted phenyl oxazolidinone antibacterials, and related compositions and methods
GB0009803D0 (en) 2000-04-25 2000-06-07 Astrazeneca Ab Chemical compounds
KR100731469B1 (ko) * 2000-06-05 2007-06-21 동아제약주식회사 피리딘 고리를 포함하는 옥사졸리디논 유도체 및 그의제조방법
KR100713170B1 (ko) * 2001-03-07 2007-05-02 동아제약주식회사 헤테로고리 또는 헤테로아로마틱 고리가 치환된 피리딘고리를 포함하는 옥사졸리디논 유도체 및 그의 제조방법
US20020115669A1 (en) 2000-08-31 2002-08-22 Wiedeman Paul E. Oxazolidinone chemotherapeutic agents
YU52403A (sh) 2000-12-26 2006-03-03 Dr.Reddy's Research Foundation Heterociklična jedinjenja koja imaju antibakterijsko dejstvo, postupak za njihovo dobijanje i farmaceutske smeše koje ih sadrže
WO2002081470A1 (en) 2001-04-07 2002-10-17 Astrazeneca Ab Oxazolidinones containing a sulfonimid group as antibiotics
US6627646B2 (en) 2001-07-17 2003-09-30 Sepracor Inc. Norastemizole polymorphs
JP2005519870A (ja) 2001-10-25 2005-07-07 アストラゼネカ アクチボラグ 抗菌活性をもつアリール置換オキサゾリジノン類
NZ515881A (en) 2001-12-03 2004-09-24 New Zealand Dairy Board Cheese flavour ingredient and method of its production
AR038536A1 (es) * 2002-02-25 2005-01-19 Upjohn Co N-aril-2-oxazolidinona-5- carboxamidas y sus derivados
US7473699B2 (en) * 2002-02-28 2009-01-06 Astrazeneca Ab 3-cyclyl-5-(nitrogen-containing 5-membered ring)methyl-oxazolidinone derivatives and their use as antibacterial agents
RU2004129278A (ru) 2002-02-28 2005-06-10 Астразенека Аб (Se) Химические соединения
JP2006515601A (ja) * 2002-11-28 2006-06-01 アストラゼネカ アクチボラグ 抗細菌性薬剤としてのオキサゾリジノン
CA2507468A1 (en) 2002-11-28 2004-06-10 Astrazeneca Ab Oxazolidinone and / or isoxazoline derivatives as antibacterial agents
GB0229518D0 (en) 2002-12-19 2003-01-22 Astrazeneca Ab Chemical compounds
US7144911B2 (en) 2002-12-31 2006-12-05 Deciphera Pharmaceuticals Llc Anti-inflammatory medicaments
US7202257B2 (en) 2003-12-24 2007-04-10 Deciphera Pharmaceuticals, Llc Anti-inflammatory medicaments
TW200500360A (en) 2003-03-01 2005-01-01 Astrazeneca Ab Hydroxymethyl compounds
GB0306358D0 (en) 2003-03-20 2003-04-23 Astrazeneca Ab Chemical compounds
AU2004256083B2 (en) * 2003-07-02 2007-10-11 Kyorin Pharmaceutical Co., Ltd. Cyclopropyl group substituted oxazolidinone antibiotics and derivatives thereof
WO2005005420A1 (en) * 2003-07-02 2005-01-20 Merck & Co., Inc. Cyclopropyl group substituted oyazolidinone antibiotics and derivatives thereof
WO2005051933A1 (en) 2003-11-28 2005-06-09 Ranbaxy Laboratories Limited An improved process for the synthesis of 4-(4-benzyloxy-carbonylamino-2-fluorophenyl)-piperazine-1-carboxylic acid tert-butyl ester, a key intermediate for oxazolidinone antimicrobials and compounds prepared thereby
NZ529860A (en) 2003-11-28 2006-10-27 Ovita Ltd Muscle growth regulator mighty and use in promoting muscle mass and treating muscle wasting diseases
US7129259B2 (en) * 2003-12-17 2006-10-31 Rib-X Pharmaceuticals, Inc. Halogenated biaryl heterocyclic compounds and methods of making and using the same
KR100854211B1 (ko) 2003-12-18 2008-08-26 동아제약주식회사 신규한 옥사졸리디논 유도체, 그의 제조방법 및 이를유효성분으로 하는 항생제용 약학 조성물
US20070191336A1 (en) 2003-12-24 2007-08-16 Flynn Daniel L Anti-inflammatory medicaments
GB0411596D0 (en) 2004-05-25 2004-06-30 Astrazeneca Ab Chemical process
WO2005116023A1 (en) 2004-05-25 2005-12-08 Astrazeneca Ab 3- {4- (pyridin-3-yl) phenyl} -5- (1h-1, 2, 3-triazol-1-ylmethyl) -1, 3-oxazolidin-2-ones as antibacterial agents
BRPI0511526A (pt) 2004-05-25 2007-12-26 Astrazeneca Ab composto, pró-droga, método para a produção de um efeito antibacteriano em um animal de sangue quente, uso de um composto, composição farmacêutica, e, processo para a preparação de um composto
JP2008500319A (ja) 2004-05-25 2008-01-10 アストラゼネカ アクチボラグ 細菌感染症の治療のためのｍａｏ阻害剤としての３−（４−（２−ジヒドロイソオキサゾール−３−イルピリジン−５−イル）フェニル−５−トリアゾール−１−イルメチルオキサゾリジン−２−オン誘導体
US20080064689A1 (en) 2004-05-25 2008-03-13 Astrazeneca Ab 3-[4-(6-Pyridin-3-Yl)-3-Phenyl] -5-(1H-1,2,3-Triazol-1-Ylmethyl)-1,3-Oxazolidin-2-Ones as Antibacterial Agents
WO2006038100A1 (en) 2004-10-08 2006-04-13 Ranbaxy Laboratories Limited Oxazolidinone derivatives as antimicrobials
WO2007023507A2 (en) 2005-06-20 2007-03-01 Wockhardt Limited Oxazolidinones bearing antimicrobial activity composition and methods of preparation
WO2007138381A2 (en) 2005-10-14 2007-12-06 Targanta Therapeutics Inc. Phosphonated oxazolidinones and uses thereof for the prevention and treatment of bone and joint infections
JP5455906B2 (ja) 2007-08-06 2014-03-26 ミクウルク ファーマシューティカルズ，インコーポレイテッド 細菌感染症治療のための抗微生物性オルト−フルオロフェニルオキサゾリジノン
EP2346858B1 (en) * 2008-10-10 2019-08-07 Merck Sharp & Dohme Corp. Methods for preparing oxazolidinones and compositions containing them
UA114068C2 (xx) 2009-02-03 2017-04-25 Кристалічні частинки (r)-3-(4-(2-(2-метилтетразол-5-іл)піридин-5-іл)-3-фторфеніл)-5-гідроксиметилоксазолідин-2-ондиводеньфосфату
US8580767B2 (en) 2009-05-28 2013-11-12 Trius Therapeutics, Inc. Oxazolidinone containing dimer compounds, compositions and methods to make and use

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2175324C2 (ru) * 1995-09-01 2001-10-27 Фармация Энд Апджон Компани Фенилоксазолидиноны, имеющие с-с-связь с 4-8-членными гетероциклическими кольцами
RU2215740C2 (ru) * 1997-11-12 2003-11-10 Фармация Энд Апджон Компани Оксазолидиноновые производные и фармацевтические композиции на их основе
WO2001094342A1 (en) * 2000-06-05 2001-12-13 Dong A Pharm. Co., Ltd. Novel oxazolidinone derivatives and a process for the preparation thereof
WO2003022824A1 (en) * 2001-09-11 2003-03-20 Astrazeneca Ab Oxazolidinone and/or isoxazoline as antibacterial agents

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BAE et al., High-performance liquid chromatographic analysis of DA-7868, a new oxazolidinone, in human plasma and urine and in rat tissue homogenates, JOURNAL OF CHROMATOGRAPHY B, 2003, 794, p.397-403. *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2792687C1 (ru) * 2019-08-20 2023-03-23 Хангжоу Дике Технологиес Ко., Лтд. Способ синтеза n-замещенного фенил-5-гидроксиметил-2-оксазолидинона

Also Published As

Publication number Publication date
NL300759I2 (enExample) 2015-12-22
SI1699784T1 (sl) 2011-11-30
NL300759I1 (enExample) 2015-12-22
US7816379B2 (en) 2010-10-19
US20170333414A1 (en) 2017-11-23
JP2007514737A (ja) 2007-06-07
RU2006125761A (ru) 2008-01-27
ES2391820T3 (es) 2012-11-30
CN102702184A (zh) 2012-10-03
CA2549062A1 (en) 2005-06-30
LU92834I2 (fr) 2015-11-17
AU2009200606B2 (en) 2011-01-06
CN102702184B (zh) 2016-06-08
EP1699784A4 (en) 2008-09-03
EP2305657A2 (en) 2011-04-06
HK1155747A1 (en) 2012-05-25
CA2549062C (en) 2011-07-05
MX339597B (es) 2016-06-01
JP4739229B2 (ja) 2011-08-03
US9163043B2 (en) 2015-10-20
CN102516238A (zh) 2012-06-27
CN101982468A (zh) 2011-03-02
CY2015036I2 (el) 2016-06-22
EP2305657A3 (en) 2011-04-27
US20170049763A1 (en) 2017-02-23
US20130281492A1 (en) 2013-10-24
US20140350059A1 (en) 2014-11-27
US20070155798A1 (en) 2007-07-05
FR15C0062I2 (fr) 2016-08-26
NZ547928A (en) 2009-05-31
PT1699784E (pt) 2011-10-06
BRPI0417800B8 (pt) 2021-05-25
EP1699784B1 (en) 2011-06-29
US20200078345A1 (en) 2020-03-12
CN102516238B (zh) 2016-08-03
US20180344716A1 (en) 2018-12-06
HUS1500046I1 (hu) 2017-05-29
EP2305657B1 (en) 2012-08-22
LTC1699784I2 (lt) 2017-09-11
AU2004299413C1 (en) 2009-07-02
BRPI0417800B1 (pt) 2019-10-08
RU2010149618A (ru) 2012-06-27
ATE514686T1 (de) 2011-07-15
BRPI0417800A (pt) 2007-04-10
US20210121449A1 (en) 2021-04-29
CN101982468B (zh) 2012-02-08
CN1894242B (zh) 2012-07-04
DK1699784T3 (da) 2011-10-10
CY1112445T1 (el) 2015-12-09
US20090192197A1 (en) 2009-07-30
AU2004299413A1 (en) 2005-06-30
AU2009200606A1 (en) 2009-03-05
HK1153738A1 (en) 2012-04-05
EP1699784A1 (en) 2006-09-13
BE2015C050I2 (enExample) 2024-08-08
MXPA06006955A (es) 2006-12-19
US8420676B2 (en) 2013-04-16
CY2015036I1 (el) 2016-06-22
KR100854211B1 (ko) 2008-08-26
FR15C0062I1 (fr) 2015-10-30
KR20050061271A (ko) 2005-06-22
WO2005058886A1 (en) 2005-06-30
RU2414469C3 (ru) 2017-06-14
CN1894242A (zh) 2007-01-10
PL1699784T3 (pl) 2011-11-30
RU2414469C2 (ru) 2011-03-20
AU2004299413B2 (en) 2008-11-20
NZ575842A (en) 2010-10-29

Similar Documents

Publication Publication Date Title
RU2559620C2 (ru) Новые производные оксазолидинона, способ их получения и применение
US6689779B2 (en) Oxazolidinone derivatives and a process for the preparation thereof
JP5662940B2 (ja) 新規な抗微生物薬
KR20110088737A (ko) 사이클릭 아미드라존 기를 가지는 신규한 옥사졸리디논 유도체 및 이를 함유하는 의약 조성물
KR100948345B1 (ko) 신규한 옥사졸리디논 유도체, 이의 제조방법 및 이를함유하는 의약 조성물
KR100713170B1 (ko) 헤테로고리 또는 헤테로아로마틱 고리가 치환된 피리딘고리를 포함하는 옥사졸리디논 유도체 및 그의 제조방법
ES2368918T3 (es) Nuevos derivados de oxazolidinona.
HK1155747B (en) Oxazolidinone derivatives
HK1153738B (en) Oxazolidinone derivatives and pharmaceutical composition comprising the same
KR20120081579A (ko) 사이클릭 아미드라존 기를 가지는 신규한 옥사졸리디논 유도체 및 이를 함유하는 의약 조성물

Legal Events

Date Code Title Description
HZ9A Changing address for correspondence with an applicant