RU2402347C2 - Иммуногенная композиция - Google Patents
Иммуногенная композиция Download PDFInfo
- Publication number
- RU2402347C2 RU2402347C2 RU2007110029/10A RU2007110029A RU2402347C2 RU 2402347 C2 RU2402347 C2 RU 2402347C2 RU 2007110029/10 A RU2007110029/10 A RU 2007110029/10A RU 2007110029 A RU2007110029 A RU 2007110029A RU 2402347 C2 RU2402347 C2 RU 2402347C2
- Authority
- RU
- Russia
- Prior art keywords
- staphylococcal
- protein
- immunogenic composition
- fragment
- composition according
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract 22
- 230000002163 immunogen Effects 0.000 title claims abstract 20
- 102000004169 proteins and genes Human genes 0.000 claims abstract 12
- 108090000623 proteins and genes Proteins 0.000 claims abstract 12
- 102000014914 Carrier Proteins Human genes 0.000 claims abstract 11
- 239000012634 fragment Substances 0.000 claims abstract 9
- 150000004676 glycans Chemical class 0.000 claims abstract 8
- 229920001282 polysaccharide Polymers 0.000 claims abstract 8
- 239000005017 polysaccharide Substances 0.000 claims abstract 8
- 229960005486 vaccine Drugs 0.000 claims abstract 8
- 101710092462 Alpha-hemolysin Proteins 0.000 claims abstract 7
- 101710197219 Alpha-toxin Proteins 0.000 claims abstract 7
- 108010078791 Carrier Proteins Proteins 0.000 claims abstract 7
- 101710124951 Phospholipase C Proteins 0.000 claims abstract 7
- 239000002776 alpha toxin Substances 0.000 claims abstract 7
- 206010041925 Staphylococcal infections Diseases 0.000 claims abstract 6
- 229920001542 oligosaccharide Polymers 0.000 claims abstract 6
- 150000002482 oligosaccharides Chemical class 0.000 claims abstract 6
- 241000191967 Staphylococcus aureus Species 0.000 claims abstract 4
- 238000000034 method Methods 0.000 claims abstract 4
- 241000191963 Staphylococcus epidermidis Species 0.000 claims abstract 3
- 230000002265 prevention Effects 0.000 claims abstract 3
- 108010071134 CRM197 (non-toxic variant of diphtheria toxin) Proteins 0.000 claims abstract 2
- 102100037840 Dehydrogenase/reductase SDR family member 2, mitochondrial Human genes 0.000 claims abstract 2
- 101710183389 Pneumolysin Proteins 0.000 claims abstract 2
- 101710188053 Protein D Proteins 0.000 claims abstract 2
- 101710132893 Resolvase Proteins 0.000 claims abstract 2
- 238000006640 acetylation reaction Methods 0.000 claims abstract 2
- 229960003983 diphtheria toxoid Drugs 0.000 claims abstract 2
- 230000028993 immune response Effects 0.000 claims abstract 2
- 229960000814 tetanus toxoid Drugs 0.000 claims abstract 2
- 108091008324 binding proteins Proteins 0.000 claims 4
- 102000005416 ATP-Binding Cassette Transporters Human genes 0.000 claims 3
- 108010006533 ATP-Binding Cassette Transporters Proteins 0.000 claims 3
- 102100026189 Beta-galactosidase Human genes 0.000 claims 3
- 101000822695 Clostridium perfringens (strain 13 / Type A) Small, acid-soluble spore protein C1 Proteins 0.000 claims 3
- 108010065152 Coagulase Proteins 0.000 claims 3
- 102000002297 Laminin Receptors Human genes 0.000 claims 3
- 108010000851 Laminin Receptors Proteins 0.000 claims 3
- 102000004882 Lipase Human genes 0.000 claims 3
- 108090001060 Lipase Proteins 0.000 claims 3
- 239000004367 Lipase Substances 0.000 claims 3
- 101710087657 Manganese ABC transporter substrate-binding lipoprotein Proteins 0.000 claims 3
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 claims 3
- 241000404883 Pisa Species 0.000 claims 3
- 101000576807 Protobothrops flavoviridis Small serum protein 2 Proteins 0.000 claims 3
- 240000005499 Sasa Species 0.000 claims 3
- 108010031318 Vitronectin Proteins 0.000 claims 3
- 102100035140 Vitronectin Human genes 0.000 claims 3
- 108010064033 elastin-binding proteins Proteins 0.000 claims 3
- 235000019421 lipase Nutrition 0.000 claims 3
- 102220117512 rs886041928 Human genes 0.000 claims 3
- 101710154607 Azurocidin Proteins 0.000 claims 2
- 101000822677 Clostridium perfringens (strain 13 / Type A) Small, acid-soluble spore protein 1 Proteins 0.000 claims 2
- 101710141457 Histidine-binding periplasmic protein Proteins 0.000 claims 2
- CPLXHLVBOLITMK-UHFFFAOYSA-N Magnesium oxide Chemical compound [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 claims 2
- 101710092628 Probable histidine-binding protein Proteins 0.000 claims 2
- 101000576806 Protobothrops flavoviridis Small serum protein 1 Proteins 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 239000003053 toxin Substances 0.000 claims 2
- 231100000765 toxin Toxicity 0.000 claims 2
- 230000001018 virulence Effects 0.000 claims 2
- 241000894006 Bacteria Species 0.000 claims 1
- 241000606768 Haemophilus influenzae Species 0.000 claims 1
- 102000004160 Phosphoric Monoester Hydrolases Human genes 0.000 claims 1
- 108090000608 Phosphoric Monoester Hydrolases Proteins 0.000 claims 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 229940047650 haemophilus influenzae Drugs 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000007935 neutral effect Effects 0.000 claims 1
- 241000295644 Staphylococcaceae Species 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/085—Staphylococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
- C07K16/1271—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Micrococcaceae (F), e.g. Staphylococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/116—Polyvalent bacterial antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0421081A GB0421081D0 (en) | 2004-09-22 | 2004-09-22 | Immunogenic composition |
| GB0421082.9 | 2004-09-22 | ||
| GB0421082A GB0421082D0 (en) | 2004-09-22 | 2004-09-22 | Immunogenic composition |
| GB0421079A GB0421079D0 (en) | 2004-09-22 | 2004-09-22 | Immunogenic composition |
| GB0421079.5 | 2004-09-22 | ||
| GB0421078.7 | 2004-09-22 | ||
| GB0421081.1 | 2004-09-22 | ||
| GB0421078A GB0421078D0 (en) | 2004-09-22 | 2004-09-22 | Immunogenic composition |
| GB0503143A GB0503143D0 (en) | 2005-02-15 | 2005-02-15 | Immunogenic composition |
| GB0503143.0 | 2005-02-15 | ||
| PCT/EP2005/010260 WO2006032500A2 (en) | 2004-09-22 | 2005-09-20 | Immunogenic composition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2007110029A RU2007110029A (ru) | 2008-10-27 |
| RU2402347C2 true RU2402347C2 (ru) | 2010-10-27 |
Family
ID=36000843
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2007110029/10A RU2402347C2 (ru) | 2004-09-22 | 2005-09-20 | Иммуногенная композиция |
Country Status (17)
| Country | Link |
|---|---|
| US (6) | US20080095777A1 (enExample) |
| EP (9) | EP2298340B1 (enExample) |
| JP (5) | JP2008513409A (enExample) |
| KR (4) | KR101359930B1 (enExample) |
| CN (2) | CN102657855B (enExample) |
| AU (3) | AU2005287532B2 (enExample) |
| BR (3) | BRPI0515520A (enExample) |
| CA (4) | CA2580103C (enExample) |
| ES (4) | ES2730275T3 (enExample) |
| IL (4) | IL181825A0 (enExample) |
| MA (2) | MA28994B1 (enExample) |
| MX (2) | MX2007003402A (enExample) |
| NO (2) | NO20071609L (enExample) |
| NZ (4) | NZ582441A (enExample) |
| RU (1) | RU2402347C2 (enExample) |
| WO (3) | WO2006032472A2 (enExample) |
| ZA (1) | ZA200702224B (enExample) |
Families Citing this family (94)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100351260C (zh) | 2002-11-12 | 2007-11-28 | 布赖汉姆妇女医院 | 葡萄球菌感染的多糖疫苗 |
| MX2007003402A (es) | 2004-09-22 | 2007-05-10 | Glaxosmithkline Biolog Sa | Composicion inmunogena para su uso en vacunacion contra estafilococos. |
| EP2213298A3 (en) | 2004-10-21 | 2011-07-20 | Wyeth LLC | Immunogenic compositions of staphylococcus epidermidis polypeptide and polynucleotide antigens |
| AU2005310981A1 (en) * | 2004-10-25 | 2006-06-08 | The University Of Western Ontario | Vaccines, compositions and methods based on Staphylococcus aureus iron-regulated surface determinants IsdA, IsdB, and IsdC |
| US20060228368A1 (en) * | 2005-04-07 | 2006-10-12 | Nabi Biopharmaceuticals | Method of protecting against staphylococcal infection |
| PE20070163A1 (es) * | 2005-06-27 | 2007-03-01 | Glaxosmithkline Biolog Sa | Composicion inmunogenica de conjugados de sacaridos de n. meningitidis |
| GB0526038D0 (en) * | 2005-12-21 | 2006-02-01 | Glaxosmithkline Biolog Sa | Immunogenic composition |
| AU2007281934B2 (en) * | 2006-01-18 | 2012-11-15 | University Of Chicago | Compositions and methods related to Staphylococcal bacterium proteins |
| EA015833B1 (ru) * | 2006-03-30 | 2011-12-30 | Глаксосмитклайн Байолоджикалс С.А. | Иммуногенная композиция |
| BRPI0710889A2 (pt) * | 2006-04-24 | 2011-08-16 | Sigma Alimentos Sa De Cv | método para a detecção e quantificação múltipla e simultánea de patogênicos mediante a reação em cadeia da polimerasa em tempo real |
| GB0610776D0 (en) * | 2006-05-31 | 2006-07-12 | Univ Bath | Novel applications for staphylococcus aureus Sbi protein |
| US20180221466A9 (en) * | 2006-06-12 | 2018-08-09 | Glaxosmithkline Biologicals S.A. | Use of alpha-toxin for treating and preventing staphylococcus infections |
| NZ597046A (en) * | 2006-06-12 | 2014-01-31 | Glaxosmithkline Biolog Sa | Use of alpha-toxin for treating and preventing staphylococcus infections |
| GB0700136D0 (en) * | 2007-01-04 | 2007-02-14 | Glaxosmithkline Biolog Sa | Process for manufacturing vaccines |
| EP2374467B1 (en) * | 2007-05-04 | 2013-08-28 | Martin Krönke | Protective staphylococcus aureus vaccine based on cell wall-associated proteins |
| US8146781B2 (en) * | 2007-08-09 | 2012-04-03 | Huhtamaki, Inc. | Dispenser for viscous condiments |
| WO2009023164A2 (en) * | 2007-08-10 | 2009-02-19 | President And Fellows Of Harvard College | Induction of mucosal immunity |
| US9181329B2 (en) | 2007-08-31 | 2015-11-10 | The University Of Chicago | Methods and compositions related to immunizing against Staphylococcal lung diseases and conditions |
| CA2697538C (en) * | 2007-08-31 | 2019-02-12 | University Of Chicago | Methods and compositions related to immunizing against staphylococcal lung diseases and conditions |
| ES2546213T3 (es) | 2008-03-03 | 2015-09-21 | Novartis Ag | Compuestos y composiciones como moduladores de la actividad de TLR |
| JP5509067B2 (ja) * | 2008-03-31 | 2014-06-04 | 大塚製薬株式会社 | 肺炎球菌検出方法 |
| KR20110009158A (ko) * | 2008-04-16 | 2011-01-27 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | 백신 |
| TWI551295B (zh) * | 2008-04-18 | 2016-10-01 | 英特威特國際股份有限公司 | 防備胞內勞森菌(Lawsonia intracellularis)用疫苗 |
| KR20110031393A (ko) | 2008-07-21 | 2011-03-25 | 더 브리검 앤드 우먼즈 하스피털, 인크. | 합성 베타-1,6 글루코사민 올리고당에 관한 방법 및 조성물 |
| WO2010014304A1 (en) | 2008-07-29 | 2010-02-04 | University Of Chicago | Compositions and methods related to staphylococcal bacterium proteins |
| CA2738793A1 (en) * | 2008-09-30 | 2010-04-08 | University Of Maryland, Baltimore | Protective vaccine against staphylococcus aureus biofilms comprising cell wall-associated immunogens |
| EP2208787A1 (en) * | 2009-01-19 | 2010-07-21 | Université de Liège | A recombinant alpha-hemolysin polypeptide of Staphylococcus aureus, having a deletion in the stem domain and heterologous sequences inserted |
| US8101190B2 (en) * | 2009-03-03 | 2012-01-24 | Ingen Biosciences | Method for diagnosing staphylococcal infections |
| SG174968A1 (en) | 2009-04-03 | 2011-11-28 | Univ Chicago | Compositions and methods related to protein a (spa) variants |
| CN102762226A (zh) | 2009-06-10 | 2012-10-31 | 诺华有限公司 | 含苯并萘啶的疫苗 |
| CN107096020A (zh) * | 2009-06-22 | 2017-08-29 | 惠氏有限责任公司 | 金黄色葡萄球菌抗原的免疫原性组合物 |
| BRPI1011753B8 (pt) | 2009-06-22 | 2021-05-25 | Wyeth Llc | conjugados imunogênicos de polissacarídeo capsular de staphylococcus aureus de sorotipos 5 e 8, seu uso e composições que os compreendem |
| WO2012122533A2 (en) * | 2011-03-10 | 2012-09-13 | The University Of Chicago | Compositions and methods related to antibodies to staphylococcal proteins isda or isdb |
| US8647621B2 (en) | 2009-07-27 | 2014-02-11 | Fina Biosolutions, Llc | Method of producing protein-carbohydrate vaccines reduced in free carbohydrate |
| GB0913681D0 (en) * | 2009-08-05 | 2009-09-16 | Glaxosmithkline Biolog Sa | Immunogenic composition |
| GB0913680D0 (en) | 2009-08-05 | 2009-09-16 | Glaxosmithkline Biolog Sa | Immunogenic composition |
| CN102844047B (zh) | 2009-09-02 | 2017-04-05 | 诺华股份有限公司 | 含tlr活性调节剂的免疫原性组合物 |
| TWI445708B (zh) | 2009-09-02 | 2014-07-21 | Irm Llc | 作為tlr活性調節劑之化合物及組合物 |
| RU2603267C2 (ru) | 2009-09-30 | 2016-11-27 | Новартис Аг | Конъюгация капсульных полисахаридов staphylococcus aureus типа 5 и типа 8 |
| EP3199177A1 (en) | 2009-10-30 | 2017-08-02 | GlaxoSmithKline Biologicals S.A. | Purification of staphylococcus aureus type 5 and type 8 capsular saccharides |
| WO2011057148A1 (en) | 2009-11-05 | 2011-05-12 | Irm Llc | Compounds and compositions as tlr-7 activity modulators |
| WO2011060379A2 (en) * | 2009-11-16 | 2011-05-19 | Snapper Clifford M | (poly)-glycerolphosphate-based anti-gram positive bacterial vaccine |
| WO2011084549A1 (en) | 2009-12-15 | 2011-07-14 | Novartis Ag | Homogeneous suspension of immunopotentiating compounds and uses thereof |
| SG10201506165TA (en) | 2009-12-17 | 2015-09-29 | Fina Biosolutions Llc | Chemical reagents for the activation of polysaccharides in the preparation of conjugate vaccines |
| EP2549990A1 (en) | 2010-03-23 | 2013-01-30 | Irm Llc | Compounds (cystein based lipopeptides) and compositions as tlr2 agonists used for treating infections, inflammations, respiratory diseases etc. |
| EP2555794A4 (en) | 2010-04-05 | 2014-01-15 | Univ Chicago | COMPOSITIONS AND METHODS RELATING TO PROTEIN A (SPA) ANTIBODIES AS IMMUNE REACTION AMPLIFIERS |
| NZ602971A (en) | 2010-04-23 | 2014-11-28 | Serum Inst India Ltd | Simple method for simultaneous removal of multiple impurities from culture supernatants to ultralow levels |
| CN102268444B (zh) * | 2010-06-03 | 2015-05-13 | 中国人民解放军军事医学科学院生物工程研究所 | 金黄色葡萄球菌截短SasA蛋白在大肠杆菌中的表达及应用 |
| BR112013000097B1 (pt) | 2010-07-02 | 2022-02-01 | The University Of Chicago | Polipeptídeo imunogênico isolado, composição imunogênica e seu uso |
| US9192661B2 (en) | 2010-07-06 | 2015-11-24 | Novartis Ag | Delivery of self-replicating RNA using biodegradable polymer particles |
| WO2012009247A1 (en) * | 2010-07-15 | 2012-01-19 | Merck Sharp & Dohme Corp. | Protective vaccine based on staphylococcus aureus protein sa2412 |
| JP5793194B2 (ja) | 2010-09-09 | 2015-10-14 | ザ・ユニバーシティ・オブ・シカゴThe University Of Chicago | 感染防御ブドウ球菌抗原が関与する方法および組成物 |
| WO2012065034A1 (en) * | 2010-11-12 | 2012-05-18 | Merck Sharp & Dohme Corp. | Enolase peptide conjugate vaccines against staphylococcus aureus |
| SI2654784T1 (sl) * | 2010-12-22 | 2017-01-31 | Wyeth Llc | Stabilni imunogeni sestavki antigenov staphylococcus aureus |
| US9109036B2 (en) * | 2011-02-08 | 2015-08-18 | Integrated Biotherapeutics, Inc. | Immunogenic composition comprising alpha-hemolysin oligopeptides |
| HUE040734T2 (hu) * | 2011-02-08 | 2019-03-28 | Medimmune Llc | Antitestek, amelyek specifikusan kötik staphylococcus aureus alfatoxinját és alkalmazási eljárások |
| US8945588B2 (en) | 2011-05-06 | 2015-02-03 | The University Of Chicago | Methods and compositions involving protective staphylococcal antigens, such as EBH polypeptides |
| US8846609B2 (en) | 2011-06-19 | 2014-09-30 | New York University | Leukotoxin E/D as a new anti-inflammatory agent and microbicide |
| CN104474531A (zh) | 2011-06-19 | 2015-04-01 | 纽约大学 | 治疗和预防金黄色葡萄球菌感染及相关病状的方法 |
| EP2744517B1 (en) | 2011-08-15 | 2019-03-13 | The University of Chicago | Compositions and methods related to antibodies to staphylococcal protein a |
| EP2773370A4 (en) | 2011-10-31 | 2016-09-28 | Merck Sharp & Dohme | PROTECTIVE VACCINE BASED ON THE STAPHYLOCOCCUS AUREUS PROTEIN SA2451 |
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