JP2010514817A5 - - Google Patents
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- Publication number
- JP2010514817A5 JP2010514817A5 JP2009544404A JP2009544404A JP2010514817A5 JP 2010514817 A5 JP2010514817 A5 JP 2010514817A5 JP 2009544404 A JP2009544404 A JP 2009544404A JP 2009544404 A JP2009544404 A JP 2009544404A JP 2010514817 A5 JP2010514817 A5 JP 2010514817A5
- Authority
- JP
- Japan
- Prior art keywords
- saccharide
- protein carrier
- protein
- aliquot
- carbodiimide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000004169 proteins and genes Human genes 0.000 claims 22
- 108090000623 proteins and genes Proteins 0.000 claims 22
- 150000001720 carbohydrates Chemical class 0.000 claims 19
- 238000000034 method Methods 0.000 claims 18
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 17
- 150000001718 carbodiimides Chemical class 0.000 claims 12
- 125000003277 amino group Chemical group 0.000 claims 9
- 230000021615 conjugation Effects 0.000 claims 8
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 8
- LMDZBCPBFSXMTL-UHFFFAOYSA-N 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide Chemical group CCN=C=NCCCN(C)C LMDZBCPBFSXMTL-UHFFFAOYSA-N 0.000 claims 6
- 230000002163 immunogen Effects 0.000 claims 5
- 230000000694 effects Effects 0.000 claims 4
- 229960005486 vaccine Drugs 0.000 claims 3
- 102000005416 ATP-Binding Cassette Transporters Human genes 0.000 claims 2
- 108010006533 ATP-Binding Cassette Transporters Proteins 0.000 claims 2
- 101710092462 Alpha-hemolysin Proteins 0.000 claims 2
- 101710197219 Alpha-toxin Proteins 0.000 claims 2
- -1 MRPII Proteins 0.000 claims 2
- 101710124951 Phospholipase C Proteins 0.000 claims 2
- 240000005499 Sasa Species 0.000 claims 2
- 239000002776 alpha toxin Substances 0.000 claims 2
- 238000009833 condensation Methods 0.000 claims 2
- 230000005494 condensation Effects 0.000 claims 2
- 230000001268 conjugating effect Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 101710154607 Azurocidin Proteins 0.000 claims 1
- 102100026189 Beta-galactosidase Human genes 0.000 claims 1
- 102000014914 Carrier Proteins Human genes 0.000 claims 1
- 108010078791 Carrier Proteins Proteins 0.000 claims 1
- 101000822677 Clostridium perfringens (strain 13 / Type A) Small, acid-soluble spore protein 1 Proteins 0.000 claims 1
- 101000822695 Clostridium perfringens (strain 13 / Type A) Small, acid-soluble spore protein C1 Proteins 0.000 claims 1
- 101710105699 D-alanyl-D-alanine carboxypeptidase DacB Proteins 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 101710128530 Fibrinogen-binding protein Proteins 0.000 claims 1
- 101710141457 Histidine-binding periplasmic protein Proteins 0.000 claims 1
- 102000002297 Laminin Receptors Human genes 0.000 claims 1
- 108010000851 Laminin Receptors Proteins 0.000 claims 1
- 102000004882 Lipase Human genes 0.000 claims 1
- 108090001060 Lipase Proteins 0.000 claims 1
- 239000004367 Lipase Substances 0.000 claims 1
- CPLXHLVBOLITMK-UHFFFAOYSA-N Magnesium oxide Chemical compound [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 claims 1
- 101710087657 Manganese ABC transporter substrate-binding lipoprotein Proteins 0.000 claims 1
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 claims 1
- 101710167890 Penicillin-binding protein 4 Proteins 0.000 claims 1
- 241000404883 Pisa Species 0.000 claims 1
- 101710092628 Probable histidine-binding protein Proteins 0.000 claims 1
- 101000576806 Protobothrops flavoviridis Small serum protein 1 Proteins 0.000 claims 1
- 101000576807 Protobothrops flavoviridis Small serum protein 2 Proteins 0.000 claims 1
- 101710202103 Putative beta-lactamase HcpD Proteins 0.000 claims 1
- 108091030066 RNAIII Proteins 0.000 claims 1
- 108010031318 Vitronectin Proteins 0.000 claims 1
- 102100035140 Vitronectin Human genes 0.000 claims 1
- 230000003213 activating effect Effects 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 108091008324 binding proteins Proteins 0.000 claims 1
- 230000015271 coagulation Effects 0.000 claims 1
- 238000005345 coagulation Methods 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 108010064033 elastin-binding proteins Proteins 0.000 claims 1
- 102000025748 fibrinogen binding proteins Human genes 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 102000037865 fusion proteins Human genes 0.000 claims 1
- 108020001507 fusion proteins Proteins 0.000 claims 1
- 235000019421 lipase Nutrition 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 102220117512 rs886041928 Human genes 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0700136.5A GB0700136D0 (en) | 2007-01-04 | 2007-01-04 | Process for manufacturing vaccines |
| GB0700136.5 | 2007-01-04 | ||
| PCT/EP2008/050011 WO2008081014A2 (en) | 2007-01-04 | 2008-01-02 | Process for manufacturing vaccines |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010514817A JP2010514817A (ja) | 2010-05-06 |
| JP2010514817A5 true JP2010514817A5 (enExample) | 2011-02-10 |
| JP5683815B2 JP5683815B2 (ja) | 2015-03-11 |
Family
ID=37801736
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009544404A Expired - Fee Related JP5683815B2 (ja) | 2007-01-04 | 2008-01-02 | ワクチンの製造方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8858955B2 (enExample) |
| EP (1) | EP2099487B1 (enExample) |
| JP (1) | JP5683815B2 (enExample) |
| CA (1) | CA2674007A1 (enExample) |
| ES (1) | ES2546186T3 (enExample) |
| GB (1) | GB0700136D0 (enExample) |
| WO (1) | WO2008081014A2 (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1946769B1 (en) * | 2000-06-29 | 2012-05-30 | SmithKline Beecham Biologicals S.A. | Multivalent vaccine composition with reduced dose of Haemophilus influenzae type B |
| AU2000278267A1 (en) | 2000-09-01 | 2002-03-22 | The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | Vibrio cholerae o139 conjugate vaccines |
| HUE045482T2 (hu) | 2005-06-27 | 2019-12-30 | Glaxosmithkline Biologicals Sa | Immunogén készítmény |
| US20180221466A9 (en) * | 2006-06-12 | 2018-08-09 | Glaxosmithkline Biologicals S.A. | Use of alpha-toxin for treating and preventing staphylococcus infections |
| KR20100072228A (ko) | 2007-08-31 | 2010-06-30 | 유니버시티 오브 시카고 | 스타필로코커스 폐 질환 및 상태에 대한 면역화와 관련된 방법 및 조성물 |
| US9181329B2 (en) | 2007-08-31 | 2015-11-10 | The University Of Chicago | Methods and compositions related to immunizing against Staphylococcal lung diseases and conditions |
| US8758765B2 (en) | 2008-07-29 | 2014-06-24 | The University Of Chicago | Compositions and methods related to Staphylococcal bacterium proteins |
| CN106008679A (zh) | 2008-12-24 | 2016-10-12 | 荷兰王国卫生福利和运动部国家公共卫生和环境研究所 | 修饰的肺炎链球菌溶血素(ply)多肽 |
| HRP20160274T1 (hr) | 2009-04-03 | 2016-04-08 | University Of Chicago | Pripravci i metode vezane za varijante proteina a (spa) |
| EP2419129A2 (en) * | 2009-04-14 | 2012-02-22 | Novartis AG | Compositions for immunising against staphylococcus aerus |
| JP5931724B2 (ja) * | 2009-06-29 | 2016-06-08 | ジェノセア バイオサイエンシーズ， インコーポレイテッド | ＳｔｒｅｐｔｏｃｏｃｃｕｓＰｎｅｕｍｏｎｉａｅに対するワクチンおよび組成物 |
| PT2493498T (pt) | 2009-10-30 | 2017-05-24 | Glaxosmithkline Biologicals Sa | Purificação de sacáridos capsulares de staphylococcus aureus tipo 5 e tipo 8 |
| WO2011075822A1 (en) | 2009-12-22 | 2011-06-30 | Sanofi Pasteur Limited | Immunogenic compositions and related methods |
| AU2011274367B2 (en) | 2010-07-02 | 2015-04-23 | The University Of Chicago | Compositions and methods related to protein A (SpA) variants |
| SG10201600435UA (en) | 2011-01-20 | 2016-02-26 | Genocea Biosciences Inc | Vaccines And Compositions Against Streptococcus Pneumoniae |
| US8945588B2 (en) | 2011-05-06 | 2015-02-03 | The University Of Chicago | Methods and compositions involving protective staphylococcal antigens, such as EBH polypeptides |
| WO2013162746A1 (en) * | 2012-04-26 | 2013-10-31 | University Of Chicago | Staphylococcal coagulase antigens and methods of their use |
| WO2016010081A1 (ja) * | 2014-07-18 | 2016-01-21 | 一般財団法人化学及血清療法研究所 | ウイルス様粒子を含むワクチン |
| US9107906B1 (en) | 2014-10-28 | 2015-08-18 | Adma Biologics, Inc. | Compositions and methods for the treatment of immunodeficiency |
| AU2017207076B2 (en) * | 2016-01-15 | 2021-04-29 | Km Biologics Co., Ltd. | Vaccine containing immobilized virus particles |
| JP7117244B2 (ja) * | 2016-02-12 | 2022-08-12 | ザ・ユニバーシティ・オブ・シカゴ | 黄色ブドウ球菌疾患の間にコアグラーゼ活性を中和する抗体に関連した組成物および方法 |
| CN109890413B (zh) | 2016-09-02 | 2024-04-16 | 赛诺菲巴斯德股份有限公司 | 脑膜炎奈瑟氏菌疫苗 |
| IL267709B2 (en) | 2016-12-30 | 2025-04-01 | Vaxcyte Inc | Polypeptide-antigen conjugates with unnatural amino acids |
| US11951165B2 (en) | 2016-12-30 | 2024-04-09 | Vaxcyte, Inc. | Conjugated vaccine carrier proteins |
| US10259865B2 (en) | 2017-03-15 | 2019-04-16 | Adma Biologics, Inc. | Anti-pneumococcal hyperimmune globulin for the treatment and prevention of pneumococcal infection |
| CA3139981A1 (en) | 2019-05-14 | 2020-11-19 | The University Of Chicago | Methods and compositions comprising staphylococcus protein a (spa) variants |
| US12528882B2 (en) | 2019-09-13 | 2026-01-20 | The University Of Chicago | Methods and compositions for treating staphylococcal infections |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0027888B1 (en) * | 1979-09-21 | 1986-04-16 | Hitachi, Ltd. | Semiconductor switch |
| DE3040825A1 (de) * | 1980-10-30 | 1982-09-09 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neues tridekapeptid, verfahren zu seiner herstellung und verwendung |
| US4673574A (en) * | 1981-08-31 | 1987-06-16 | Anderson Porter W | Immunogenic conjugates |
| US4695624A (en) | 1984-05-10 | 1987-09-22 | Merck & Co., Inc. | Covalently-modified polyanionic bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins with bigeneric spacers, and methods of preparing such polysaccharides and conjugates and of confirming covalency |
| IT1187753B (it) | 1985-07-05 | 1987-12-23 | Sclavo Spa | Coniugati glicoproteici ad attivita' immunogenica trivalente |
| US5180815A (en) * | 1988-04-13 | 1993-01-19 | Fuji Photo Film Co., Ltd. | Modified protein for carrying hapten |
| JPH0776236B2 (ja) * | 1988-04-13 | 1995-08-16 | 富士写真フイルム株式会社 | 蛋白質修飾物 |
| CA2006700A1 (en) | 1989-01-17 | 1990-07-17 | Antonello Pessi | Synthetic peptides and their use as universal carriers for the preparation of immunogenic conjugates suitable for the development of synthetic vaccines |
| AU651949B2 (en) | 1989-07-14 | 1994-08-11 | American Cyanamid Company | Cytokine and hormone carriers for conjugate vaccines |
| IT1237764B (it) | 1989-11-10 | 1993-06-17 | Eniricerche Spa | Peptidi sintetici utili come carriers universali per la preparazione di coniugati immunogenici e loro impiego per lo sviluppo di vaccini sintetici. |
| ATE128628T1 (de) | 1990-08-13 | 1995-10-15 | American Cyanamid Co | Faser-hemagglutinin von bordetella pertussis als träger für konjugierten impfstoff. |
| US5153312A (en) | 1990-09-28 | 1992-10-06 | American Cyanamid Company | Oligosaccharide conjugate vaccines |
| CA2059692C (en) | 1991-01-28 | 2004-11-16 | Peter J. Kniskern | Pneumoccoccal polysaccharide conjugate vaccine |
| EP0625910B1 (en) | 1992-02-11 | 2003-07-23 | Henry M. Jackson Foundation For The Advancement Of Military Medicine | Dual carrier immunogenic construct |
| IT1262896B (it) | 1992-03-06 | 1996-07-22 | Composti coniugati formati da proteine heat shock (hsp) e oligo-poli- saccaridi, loro uso per la produzione di vaccini. | |
| IL102687A (en) | 1992-07-30 | 1997-06-10 | Yeda Res & Dev | Conjugates of poorly immunogenic antigens and synthetic pepide carriers and vaccines comprising them |
| EP0720485B1 (en) | 1993-09-22 | 2003-11-19 | Henry M. Jackson Foundation For The Advancement Of Military Medicine | Method of activating soluble carbohydrate using novel cyanylating reagents for the production of immunogenic constructs |
| DE69628418T2 (de) | 1995-03-22 | 2004-04-01 | Henry M. Jackson Foundation For The Advancement Of Military Medicine | Herstellung von immunogenen konstrukten unter verwendung von löslichen kohlehydraten, die durch organische cyanylierungs-reagenzien aktiviert wurden |
| NZ311000A (en) | 1995-06-07 | 1999-04-29 | Smithkline Beecham Biolog | Vaccine comprising a polysaccharide antigen-carrier protein conjugate and a free carrier protein |
| WO1998026799A1 (en) | 1996-12-18 | 1998-06-25 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Conjugate vaccine for salmonella paratyphi a |
| GB9713156D0 (en) | 1997-06-20 | 1997-08-27 | Microbiological Res Authority | Vaccines |
| US5965714A (en) * | 1997-10-02 | 1999-10-12 | Connaught Laboratories, Inc. | Method for the covalent attachment of polysaccharides to protein molecules |
| US6573245B1 (en) * | 1998-04-28 | 2003-06-03 | Galenica Pharmaceuticals, Inc. | Modified polysaccharide adjuvant-protein antigen conjugates, the preparation thereof and the use thereof |
| CA2366152A1 (en) | 1999-03-19 | 2000-09-28 | Smithkline Beecham Biologicals S.A. | Streptococcus pneumoniae vaccine |
| WO2000061761A2 (en) | 1999-04-09 | 2000-10-19 | Techlab, Inc. | Recombinant clostridium toxin a protein carrier for polysaccharide conjugate vaccines |
| GB0007432D0 (en) | 2000-03-27 | 2000-05-17 | Microbiological Res Authority | Proteins for use as carriers in conjugate vaccines |
| AU2002309706A1 (en) | 2001-05-11 | 2002-11-25 | Aventis Pasteur, Inc. | Novel meningitis conjugate vaccine |
| GB0115176D0 (en) | 2001-06-20 | 2001-08-15 | Chiron Spa | Capular polysaccharide solubilisation and combination vaccines |
| US20030113350A1 (en) * | 2001-09-19 | 2003-06-19 | Fattom Ali I. | Glycoconjugate vaccines for use in immune-compromised populations |
| CN1674933B (zh) | 2002-08-02 | 2012-09-26 | 葛兰素史密丝克莱恩生物有限公司 | 疫苗组合物 |
| NZ561879A (en) * | 2003-03-07 | 2009-05-31 | Wyeth Corp | Polysaccharide - staphylococcal surface adhesin carrier protein conjugates for immunization against nosocomial infections |
| ES2730275T3 (es) * | 2004-09-22 | 2019-11-11 | Glaxosmithkline Biologicals Sa | Composición inmunógena para uso en vacunación contra estafilococos |
| GB0428394D0 (en) * | 2004-12-24 | 2005-02-02 | Chiron Srl | Saccharide conjugate vaccines |
| HUE045482T2 (hu) * | 2005-06-27 | 2019-12-30 | Glaxosmithkline Biologicals Sa | Immunogén készítmény |
| US7491517B2 (en) | 2006-07-19 | 2009-02-17 | Jeeri R Reddy | Method of producing meningococcal meningitis vaccine for Neisseria meningitidis serotypes A,C,Y, and W-135 |
| US7935407B2 (en) * | 2009-02-23 | 2011-05-03 | Tsung-Wei Chen | Decorations |
-
2007
- 2007-01-04 GB GBGB0700136.5A patent/GB0700136D0/en not_active Ceased
-
2008
- 2008-01-02 US US12/521,797 patent/US8858955B2/en not_active Expired - Fee Related
- 2008-01-02 CA CA002674007A patent/CA2674007A1/en not_active Abandoned
- 2008-01-02 WO PCT/EP2008/050011 patent/WO2008081014A2/en not_active Ceased
- 2008-01-02 EP EP08707820.0A patent/EP2099487B1/en not_active Not-in-force
- 2008-01-02 JP JP2009544404A patent/JP5683815B2/ja not_active Expired - Fee Related
- 2008-01-02 ES ES08707820.0T patent/ES2546186T3/es active Active
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