JP2012504660A5 - - Google Patents
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- JP2012504660A5 JP2012504660A5 JP2011530297A JP2011530297A JP2012504660A5 JP 2012504660 A5 JP2012504660 A5 JP 2012504660A5 JP 2011530297 A JP2011530297 A JP 2011530297A JP 2011530297 A JP2011530297 A JP 2011530297A JP 2012504660 A5 JP2012504660 A5 JP 2012504660A5
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- Prior art keywords
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- 239000000203 mixture Substances 0.000 claims description 148
- 239000000427 antigen Substances 0.000 claims description 125
- 102000036639 antigens Human genes 0.000 claims description 125
- 108091007433 antigens Proteins 0.000 claims description 125
- 238000000034 method Methods 0.000 claims description 125
- 239000012634 fragment Substances 0.000 claims description 58
- 230000002163 immunogen Effects 0.000 claims description 46
- 108700035708 EsaB Proteins 0.000 claims description 28
- 150000001720 carbohydrates Chemical class 0.000 claims description 28
- 206010041925 Staphylococcal infections Diseases 0.000 claims description 22
- 239000002671 adjuvant Substances 0.000 claims description 18
- 230000028993 immune response Effects 0.000 claims description 15
- 150000004676 glycans Chemical class 0.000 claims description 14
- 230000003834 intracellular effect Effects 0.000 claims description 14
- 229920001282 polysaccharide Polymers 0.000 claims description 14
- 239000005017 polysaccharide Substances 0.000 claims description 14
- 102000004169 proteins and genes Human genes 0.000 claims description 14
- 108090000623 proteins and genes Proteins 0.000 claims description 14
- 241000295644 Staphylococcaceae Species 0.000 claims description 13
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 12
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 12
- 230000002265 prevention Effects 0.000 claims description 12
- 150000001413 amino acids Chemical class 0.000 claims description 8
- 101710092462 Alpha-hemolysin Proteins 0.000 claims description 7
- 101710197219 Alpha-toxin Proteins 0.000 claims description 7
- 108010071134 CRM197 (non-toxic variant of diphtheria toxin) Proteins 0.000 claims description 7
- 102100037840 Dehydrogenase/reductase SDR family member 2, mitochondrial Human genes 0.000 claims description 7
- 241000606768 Haemophilus influenzae Species 0.000 claims description 7
- 108010006464 Hemolysin Proteins Proteins 0.000 claims description 7
- 101710124951 Phospholipase C Proteins 0.000 claims description 7
- 101710188053 Protein D Proteins 0.000 claims description 7
- 101710132893 Resolvase Proteins 0.000 claims description 7
- 239000002776 alpha toxin Substances 0.000 claims description 7
- 229960003983 diphtheria toxoid Drugs 0.000 claims description 7
- 229940047650 haemophilus influenzae Drugs 0.000 claims description 7
- 239000003228 hemolysin Substances 0.000 claims description 7
- 229960000814 tetanus toxoid Drugs 0.000 claims description 7
- 229960005486 vaccine Drugs 0.000 claims description 7
- 239000003814 drug Substances 0.000 claims description 5
- 230000001939 inductive effect Effects 0.000 claims description 5
- 238000011109 contamination Methods 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 230000004936 stimulating effect Effects 0.000 claims description 4
- 230000001225 therapeutic effect Effects 0.000 claims description 3
- 108010037896 heparin-binding hemagglutinin Proteins 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 38
- 108060003951 Immunoglobulin Proteins 0.000 description 10
- 102000018358 immunoglobulin Human genes 0.000 description 10
- 241000191940 Staphylococcus Species 0.000 description 9
- 102000039446 nucleic acids Human genes 0.000 description 9
- 108020004707 nucleic acids Proteins 0.000 description 9
- 150000007523 nucleic acids Chemical class 0.000 description 9
- 230000001580 bacterial effect Effects 0.000 description 7
- 230000000694 effects Effects 0.000 description 7
- 102000004196 processed proteins & peptides Human genes 0.000 description 7
- 125000003275 alpha amino acid group Chemical group 0.000 description 6
- 230000003053 immunization Effects 0.000 description 6
- 239000003112 inhibitor Substances 0.000 description 6
- 239000013598 vector Substances 0.000 description 6
- 241000894006 Bacteria Species 0.000 description 5
- 208000035143 Bacterial infection Diseases 0.000 description 5
- 208000022362 bacterial infectious disease Diseases 0.000 description 5
- 229940079593 drug Drugs 0.000 description 4
- 239000008194 pharmaceutical composition Substances 0.000 description 4
- 241000124008 Mammalia Species 0.000 description 3
- RJQXTJLFIWVMTO-TYNCELHUSA-N Methicillin Chemical compound COC1=CC=CC(OC)=C1C(=O)N[C@@H]1C(=O)N2[C@@H](C(O)=O)C(C)(C)S[C@@H]21 RJQXTJLFIWVMTO-TYNCELHUSA-N 0.000 description 3
- 241000607142 Salmonella Species 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 229960003085 meticillin Drugs 0.000 description 3
- 239000013612 plasmid Substances 0.000 description 3
- 230000001681 protective effect Effects 0.000 description 3
- 239000013603 viral vector Substances 0.000 description 3
- 102000006395 Globulins Human genes 0.000 description 2
- 108010044091 Globulins Proteins 0.000 description 2
- 206010041917 Staphylococcal abscess Diseases 0.000 description 2
- 241000191967 Staphylococcus aureus Species 0.000 description 2
- 241000191963 Staphylococcus epidermidis Species 0.000 description 2
- 210000000628 antibody-producing cell Anatomy 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 229920001184 polypeptide Polymers 0.000 description 2
- 150000003384 small molecules Chemical group 0.000 description 2
- 230000004083 survival effect Effects 0.000 description 2
- 241000193738 Bacillus anthracis Species 0.000 description 1
- 208000031729 Bacteremia Diseases 0.000 description 1
- 101000728671 Comamonas testosteroni Bifunctional aspartate aminotransferase and L-aspartate beta-decarboxylase Proteins 0.000 description 1
- -1 EsaC Proteins 0.000 description 1
- 206010057249 Phagocytosis Diseases 0.000 description 1
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine group Chemical group [C@@H]1([C@H](O)[C@H](O)[C@@H](CO)O1)N1C=NC=2C(N)=NC=NC12 OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 description 1
- 150000003838 adenosines Chemical class 0.000 description 1
- 208000022338 anthrax infection Diseases 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000003197 catalytic effect Effects 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 108020001507 fusion proteins Proteins 0.000 description 1
- 102000037865 fusion proteins Human genes 0.000 description 1
- 229940072221 immunoglobulins Drugs 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 125000005647 linker group Chemical group 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000003607 modifier Substances 0.000 description 1
- 230000008782 phagocytosis Effects 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10319008P | 2008-10-06 | 2008-10-06 | |
| US10319608P | 2008-10-06 | 2008-10-06 | |
| US61/103,196 | 2008-10-06 | ||
| US61/103,190 | 2008-10-06 | ||
| US17077909P | 2009-04-20 | 2009-04-20 | |
| US61/170,779 | 2009-04-20 | ||
| PCT/US2009/059648 WO2010042481A1 (en) | 2008-10-06 | 2009-10-06 | Compositions and methods related to bacterial eap, emp, and/or adsa proteins |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012504660A JP2012504660A (ja) | 2012-02-23 |
| JP2012504660A5 true JP2012504660A5 (enExample) | 2012-06-07 |
Family
ID=41382468
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011530297A Pending JP2012504660A (ja) | 2008-10-06 | 2009-10-06 | 細菌ｅａｐ、ｅｍｐおよび／またはａｄｓａタンパク質に関連する組成物および方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20110262477A1 (enExample) |
| EP (1) | EP2341929B1 (enExample) |
| JP (1) | JP2012504660A (enExample) |
| CN (1) | CN102333540B (enExample) |
| AU (1) | AU2009302582A1 (enExample) |
| BR (1) | BRPI0920041A2 (enExample) |
| CA (1) | CA2739581A1 (enExample) |
| WO (1) | WO2010042481A1 (enExample) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20180221466A9 (en) * | 2006-06-12 | 2018-08-09 | Glaxosmithkline Biologicals S.A. | Use of alpha-toxin for treating and preventing staphylococcus infections |
| CA2697538C (en) * | 2007-08-31 | 2019-02-12 | University Of Chicago | Methods and compositions related to immunizing against staphylococcal lung diseases and conditions |
| US9181329B2 (en) | 2007-08-31 | 2015-11-10 | The University Of Chicago | Methods and compositions related to immunizing against Staphylococcal lung diseases and conditions |
| SMT201700275T1 (it) | 2009-10-30 | 2017-07-18 | Glaxosmithkline Biologicals Sa | Purificazione di saccaridi capsulari di staphylococcus aureus tipo 5 e tipo 8 |
| CN101914144B (zh) * | 2010-04-30 | 2013-01-09 | 浙江大学 | 金黄色葡萄球菌荚膜多糖和蛋白质偶联物及制备方法和用途 |
| BR112013000097B1 (pt) | 2010-07-02 | 2022-02-01 | The University Of Chicago | Polipeptídeo imunogênico isolado, composição imunogênica e seu uso |
| EP2614074A1 (en) * | 2010-09-09 | 2013-07-17 | The University of Chicago | Methods and compositions involving protective staphylococcal antigens |
| US9556281B2 (en) | 2011-08-15 | 2017-01-31 | The University Of Chicago | Compositions and methods related to antibodies to staphylococcal protein A |
| AU2013252888B2 (en) | 2012-04-26 | 2018-06-14 | University Of Chicago | Compositions and methods related to antibodies that neutralize coagulase activity during Staphylococcus aureus disease |
| EP2844275B1 (en) * | 2012-04-26 | 2020-05-13 | University of Chicago | Staphylococcal coagulase antigens and methods of their use |
| CN102993308B (zh) * | 2012-09-29 | 2014-11-05 | 重庆原伦生物科技有限公司 | 耐甲氧西林金黄色葡萄球菌（mrsa）疫苗重组蛋白抗原hi2及制备方法和应用 |
| CA2890427C (en) | 2012-11-06 | 2022-05-31 | Medimmune, Llc | Antibodies to s. aureus surface determinants |
| US9803002B2 (en) | 2013-05-31 | 2017-10-31 | Genentench, Inc. | Anti-wall teichoic antibodies and conjugates |
| MX369022B (es) | 2013-05-31 | 2019-10-25 | Genentech Inc | Anticuerpos anti-ácido teicoico de la pared celular y conjugados. |
| US9884126B2 (en) | 2013-05-31 | 2018-02-06 | Genentech, Inc. | Anti-wall teichoic antibodies and conjugates |
| CN106661125B (zh) | 2014-05-02 | 2021-10-01 | 动量制药公司 | 涉及工程化Fc构建体的组合物和方法 |
| MX2017007231A (es) | 2014-12-03 | 2017-11-08 | Genentech Inc | Conjugados de rifamicina y anticuerpos contra el staphylococcuss aureus y usos de estos. |
| WO2016090038A1 (en) | 2014-12-03 | 2016-06-09 | Genentech, Inc. | Anti-staphylococcus aureus antibody rifamycin conjugates and uses thereof |
| WO2016095832A1 (en) * | 2014-12-18 | 2016-06-23 | The University Of Hong Kong | Immunotherapeutic targets against staphylococcus aureus |
| CN105424930A (zh) * | 2015-11-23 | 2016-03-23 | 天津科技大学 | 一种快速检测金黄色葡萄球菌的方法 |
| US12391759B2 (en) | 2016-03-02 | 2025-08-19 | Momenta Pharmaceuticals, Inc. | Methods related to engineered Fc constructs |
| KR102635635B1 (ko) | 2016-05-23 | 2024-02-14 | 모멘타 파머슈티컬스 인코포레이티드 | 유전자 조작 Fc 작제물에 관한 조성물 및 방법 |
| US10738338B2 (en) | 2016-10-18 | 2020-08-11 | The Research Foundation for the State University | Method and composition for biocatalytic protein-oligonucleotide conjugation and protein-oligonucleotide conjugate |
| WO2018083476A1 (en) * | 2016-11-03 | 2018-05-11 | Oxford University Innovation Limited | Fusion polypeptides derived from staphylococcus aureus antigens |
| CN110650748B (zh) | 2017-01-06 | 2024-01-02 | 动量制药公司 | 与经工程改造的Fc构建体相关的组合物和方法 |
| CN110418649A (zh) * | 2017-03-15 | 2019-11-05 | 伦敦卫生及热带医学学院 | 全细胞疫苗 |
| CN111788299A (zh) | 2018-01-05 | 2020-10-16 | 阿兹特拉公司 | 葡萄球菌属细菌的营养缺陷型菌株 |
| WO2021233420A1 (en) * | 2020-05-22 | 2021-11-25 | Versitech Limited | A live strain of staphylococcus aureus and uses thereof |
| CN116472342A (zh) * | 2020-05-22 | 2023-07-21 | 港大科桥有限公司 | 一种金黄色葡萄球菌的活菌株及其用途 |
| CN118598380B (zh) * | 2024-08-08 | 2024-10-22 | 生态环境部南京环境科学研究所 | 一种长效修复石油化工企业地下水石油烃污染的方法 |
Family Cites Families (100)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL154600B (nl) | 1971-02-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen. |
| US3949064A (en) | 1973-10-26 | 1976-04-06 | Baxter Laboratories, Inc. | Method of detecting antigens or antibodies |
| US4174384A (en) | 1975-06-30 | 1979-11-13 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
| JPS5452794A (en) | 1977-09-30 | 1979-04-25 | Kousaku Yoshida | Extracting of polysacchride from capusle containing epidermis staphylococus |
| US4367110A (en) | 1979-07-02 | 1983-01-04 | Toppan Printing Co. | Decorative laminate and a manufacturing method therefor |
| US4372945A (en) | 1979-11-13 | 1983-02-08 | Likhite Vilas V | Antigen compounds |
| US4452901A (en) | 1980-03-20 | 1984-06-05 | Ciba-Geigy Corporation | Electrophoretically transferring electropherograms to nitrocellulose sheets for immuno-assays |
| US4338298A (en) | 1980-04-04 | 1982-07-06 | Endowment And Research Foundation At Montana State University | Vaccine for passive immunization against enteric colibacillosis and method of use |
| US4554101A (en) | 1981-01-09 | 1985-11-19 | New York Blood Center, Inc. | Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity |
| IL61904A (en) | 1981-01-13 | 1985-07-31 | Yeda Res & Dev | Synthetic vaccine against influenza virus infections comprising a synthetic peptide and process for producing same |
| US4356170A (en) | 1981-05-27 | 1982-10-26 | Canadian Patents & Development Ltd. | Immunogenic polysaccharide-protein conjugates |
| US4596792A (en) | 1981-09-04 | 1986-06-24 | The Regents Of The University Of California | Safe vaccine for hepatitis containing polymerized serum albumin |
| US4748018A (en) | 1984-02-07 | 1988-05-31 | Stolle Research & Development Corp. | Method of passive immunization of mammals using avian antibody |
| JPS5938877A (ja) | 1982-08-30 | 1984-03-02 | Musashi Eng Kk | 紙葉判別方法 |
| US4599231A (en) | 1984-03-09 | 1986-07-08 | Scripps Clinic And Research Foundation | Synthetic hepatitis B virus vaccine including both T cell and B cell determinants |
| US4599230A (en) | 1984-03-09 | 1986-07-08 | Scripps Clinic And Research Foundation | Synthetic hepatitis B virus vaccine including both T cell and B cell determinants |
| US4879236A (en) | 1984-05-16 | 1989-11-07 | The Texas A&M University System | Method for producing a recombinant baculovirus expression vector |
| US5221605A (en) | 1984-10-31 | 1993-06-22 | Igen, Inc. | Luminescent metal chelate labels and means for detection |
| US5310687A (en) | 1984-10-31 | 1994-05-10 | Igen, Inc. | Luminescent metal chelate labels and means for detection |
| US5238808A (en) | 1984-10-31 | 1993-08-24 | Igen, Inc. | Luminescent metal chelate labels and means for detection |
| US4608251A (en) | 1984-11-09 | 1986-08-26 | Pitman-Moore, Inc. | LHRH analogues useful in stimulating anti-LHRH antibodies and vaccines containing such analogues |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4601903A (en) | 1985-05-01 | 1986-07-22 | The United States Of America As Represented By The Department Of Health And Human Services | Vaccine against Neisseria meningitidis Group B serotype 2 invasive disease |
| US4690915A (en) | 1985-08-08 | 1987-09-01 | The United States Of America As Represented By The Department Of Health And Human Services | Adoptive immunotherapy as a treatment modality in humans |
| US4800159A (en) | 1986-02-07 | 1989-01-24 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences |
| US5084269A (en) | 1986-11-06 | 1992-01-28 | Kullenberg Fred W | Adjuvant for dose treatment with antigens |
| AU622104B2 (en) | 1987-03-11 | 1992-04-02 | Sangtec Molecular Diagnostics Ab | Method of assaying of nucleic acids, a reagent combination and kit therefore |
| US5858652A (en) | 1988-08-30 | 1999-01-12 | Abbott Laboratories | Detection and amplification of target nucleic acid sequences |
| US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| SE8901687D0 (sv) | 1989-05-11 | 1989-05-11 | Alfa Laval Agri Int | Fibronectin binding protein as well as its preparation |
| US5550318A (en) | 1990-04-17 | 1996-08-27 | Dekalb Genetics Corporation | Methods and compositions for the production of stably transformed, fertile monocot plants and cells thereof |
| US7705215B1 (en) | 1990-04-17 | 2010-04-27 | Dekalb Genetics Corporation | Methods and compositions for the production of stably transformed, fertile monocot plants and cells thereof |
| US5322783A (en) | 1989-10-17 | 1994-06-21 | Pioneer Hi-Bred International, Inc. | Soybean transformation by microparticle bombardment |
| US5484956A (en) | 1990-01-22 | 1996-01-16 | Dekalb Genetics Corporation | Fertile transgenic Zea mays plant comprising heterologous DNA encoding Bacillus thuringiensis endotoxin |
| SE466259B (sv) | 1990-05-31 | 1992-01-20 | Arne Forsgren | Protein d - ett igd-bindande protein fraan haemophilus influenzae, samt anvaendning av detta foer analys, vacciner och uppreningsaendamaal |
| US5384253A (en) | 1990-12-28 | 1995-01-24 | Dekalb Genetics Corporation | Genetic transformation of maize cells by electroporation of cells pretreated with pectin degrading enzymes |
| CA2059692C (en) | 1991-01-28 | 2004-11-16 | Peter J. Kniskern | Pneumoccoccal polysaccharide conjugate vaccine |
| CA2059693C (en) | 1991-01-28 | 2003-08-19 | Peter J. Kniskern | Polysaccharide antigens from streptococcus pneumoniae |
| US5199942A (en) | 1991-06-07 | 1993-04-06 | Immunex Corporation | Method for improving autologous transplantation |
| WO1993004169A1 (en) | 1991-08-20 | 1993-03-04 | Genpharm International, Inc. | Gene targeting in animal cells using isogenic dna constructs |
| US5610042A (en) | 1991-10-07 | 1997-03-11 | Ciba-Geigy Corporation | Methods for stable transformation of wheat |
| US5620896A (en) | 1992-03-23 | 1997-04-15 | University Of Massachusetts Medical Center | DNA vaccines against rotavirus infections |
| NZ251621A (en) | 1992-03-26 | 1996-04-26 | Microcarb Inc | Polyclonal antibodies to shiga-like toxins |
| US5702932A (en) | 1992-07-20 | 1997-12-30 | University Of Florida | Microinjection methods to transform arthropods with exogenous DNA |
| EP0652965A1 (en) | 1992-07-27 | 1995-05-17 | Pioneer Hi-Bred International, Inc. | An improved method of agrobacterium-mediated transformation of cultured soybean cells |
| DE4228457A1 (de) | 1992-08-27 | 1994-04-28 | Beiersdorf Ag | Herstellung von heterodimerem PDGF-AB mit Hilfe eines bicistronischen Vektorsystems in Säugerzellen |
| GB9222888D0 (en) | 1992-10-30 | 1992-12-16 | British Tech Group | Tomography |
| US5846709A (en) | 1993-06-15 | 1998-12-08 | Imclone Systems Incorporated | Chemical process for amplifying and detecting nucleic acid sequences |
| FR2708288B1 (fr) | 1993-07-26 | 1995-09-01 | Bio Merieux | Procédé d'amplification d'acides nucléiques par transcription utilisant le déplacement, réactifs et nécessaire pour la mise en Óoeuvre de ce procédé. |
| ATE254475T1 (de) | 1993-09-22 | 2003-12-15 | Jackson H M Found Military Med | Verfahren zur aktivierung von löslichem kohlenhydraten durch verwendung von neuen cyanylierungsreagenzien, zur herstellung von immunogenischen konstrukten |
| US5928905A (en) | 1995-04-18 | 1999-07-27 | Glaxo Group Limited | End-complementary polymerase reaction |
| US5648240A (en) | 1994-05-24 | 1997-07-15 | Texas A&M University | MHC II analog from Staphylococcus aureus |
| WO1995033073A1 (en) | 1994-05-28 | 1995-12-07 | Tepnel Medical Limited | Producing copies of nucleic acids |
| US5656610A (en) | 1994-06-21 | 1997-08-12 | University Of Southern California | Producing a protein in a mammal by injection of a DNA-sequence into the tongue |
| US5942391A (en) | 1994-06-22 | 1999-08-24 | Mount Sinai School Of Medicine | Nucleic acid amplification method: ramification-extension amplification method (RAM) |
| FR2722208B1 (fr) | 1994-07-05 | 1996-10-04 | Inst Nat Sante Rech Med | Nouveau site interne d'entree des ribosomes, vecteur le contenant et utilisation therapeutique |
| US6008341A (en) | 1994-08-22 | 1999-12-28 | The Provost, Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth Near Dublin | S. aureus fibrinogen binding protein gene |
| US5871986A (en) | 1994-09-23 | 1999-02-16 | The General Hospital Corporation | Use of a baculovirus to express and exogenous gene in a mammalian cell |
| US5736524A (en) | 1994-11-14 | 1998-04-07 | Merck & Co.,. Inc. | Polynucleotide tuberculosis vaccine |
| US5935825A (en) | 1994-11-18 | 1999-08-10 | Shimadzu Corporation | Process and reagent for amplifying nucleic acid sequences |
| US5548066A (en) | 1994-12-02 | 1996-08-20 | Central Biomedia, Inc. | Failure of passive transfer immune serum and method of making same |
| US6770278B1 (en) | 1994-12-02 | 2004-08-03 | Central Biomedia, Inc. | Methods of making and using immunoglobulin (Ig) compositions |
| US5843650A (en) | 1995-05-01 | 1998-12-01 | Segev; David | Nucleic acid detection and amplification by chemical linkage of oligonucleotides |
| JPH11514870A (ja) | 1995-10-16 | 1999-12-21 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | 新規な唾液結合タンパク質 |
| US5780448A (en) | 1995-11-07 | 1998-07-14 | Ottawa Civic Hospital Loeb Research | DNA-based vaccination of fish |
| US5612473A (en) | 1996-01-16 | 1997-03-18 | Gull Laboratories | Methods, kits and solutions for preparing sample material for nucleic acid amplification |
| US5928906A (en) | 1996-05-09 | 1999-07-27 | Sequenom, Inc. | Process for direct sequencing during template amplification |
| WO1997043314A2 (en) | 1996-05-16 | 1997-11-20 | The Texas A & M University System | Collagen binding protein compositions and methods of use |
| US5939291A (en) | 1996-06-14 | 1999-08-17 | Sarnoff Corporation | Microfluidic method for nucleic acid amplification |
| US5945100A (en) | 1996-07-31 | 1999-08-31 | Fbp Corporation | Tumor delivery vehicles |
| US6294177B1 (en) | 1996-09-11 | 2001-09-25 | Nabi | Staphylococcus aureus antigen-containing whole cell vaccine |
| US5849546A (en) | 1996-09-13 | 1998-12-15 | Epicentre Technologies Corporation | Methods for using mutant RNA polymerases with reduced discrimination between non-canonical and canonical nucleoside triphosphates |
| US5981274A (en) | 1996-09-18 | 1999-11-09 | Tyrrell; D. Lorne J. | Recombinant hepatitis virus vectors |
| JP2002514056A (ja) | 1996-10-23 | 2002-05-14 | アメリカン・ホーム・プロダクツ・コーポレーション | ワクチン |
| US5849497A (en) | 1997-04-03 | 1998-12-15 | The Research Foundation Of State University Of New York | Specific inhibition of the polymerase chain reaction using a non-extendable oligonucleotide blocker |
| US5866366A (en) | 1997-07-01 | 1999-02-02 | Smithkline Beecham Corporation | gidB |
| US5916776A (en) | 1997-08-27 | 1999-06-29 | Sarnoff Corporation | Amplification method for a polynucleotide |
| US6756361B1 (en) | 1997-10-14 | 2004-06-29 | Nabi | Enterococcus antigens and vaccines |
| US5994624A (en) | 1997-10-20 | 1999-11-30 | Cotton Incorporated | In planta method for the production of transgenic plants |
| US5932451A (en) | 1997-11-19 | 1999-08-03 | Incyte Pharmaceuticals, Inc. | Method for unbiased mRNA amplification |
| AU758019B2 (en) | 1998-07-10 | 2003-03-13 | U.S. Medical Research Institute Of Infectious Diseases | Anthrax vaccine |
| US6635473B1 (en) | 1998-08-31 | 2003-10-21 | The Provost Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth Near Dublin | Polypeptides and polynucleotides from coagulase-negative staphylococci |
| AU769539B2 (en) | 1999-01-29 | 2004-01-29 | Zoetis Services Llc | Adjuvants for use in vaccines |
| US6936258B1 (en) | 1999-03-19 | 2005-08-30 | Nabi Biopharmaceuticals | Staphylococcus antigen and vaccine |
| EP1196193B1 (en) | 1999-12-03 | 2008-11-05 | Celltech Chiroscience Limited | Interleukin-1 mutein useful as vaccine adjuvant |
| US6482240B1 (en) | 1999-12-07 | 2002-11-19 | Ed. Geistlich Soehne Ag Fur Chemische Industrie | Method of making a collagen membrane from porcine skin |
| US6651655B1 (en) | 2000-01-18 | 2003-11-25 | Quadrant Technologies Limited | Inhaled vaccines |
| SE0000514D0 (sv) | 2000-02-17 | 2000-02-17 | Biostapro Ab | A 52 kDa protein from coagulase negative staphylococci and fragments |
| AU1486102A (en) | 2000-11-07 | 2002-05-21 | Immunovaccine Technologies Inc | Vaccines with enhanced immune response and methods for their preparation |
| AT410798B (de) * | 2001-01-26 | 2003-07-25 | Cistem Biotechnologies Gmbh | Verfahren zur identifizierung, isolierung und herstellung von antigenen gegen ein spezifisches pathogen |
| WO2002074324A1 (en) | 2001-03-15 | 2002-09-26 | The Texas A & M University System | Collagen-binding adhesin from staphylococcus epidermidis and method of use |
| GB0107661D0 (en) * | 2001-03-27 | 2001-05-16 | Chiron Spa | Staphylococcus aureus |
| US7115264B2 (en) | 2001-11-05 | 2006-10-03 | Inhibitex | Monoclonal antibodies to the fibronectin binding protein and method of use in treating or preventing infections |
| WO2003053462A2 (en) | 2001-12-11 | 2003-07-03 | Merck & Co., Inc. | Staphylococcus aureus exopolysaccharide and process |
| US7723087B2 (en) | 2002-11-12 | 2010-05-25 | The Brigham And Women's Hospital, Inc. | Nucleic acid molecules for enhanced production of a bacterial polysaccharide and methods of use thereof |
| US10919956B2 (en) | 2002-11-12 | 2021-02-16 | The Brigham And Women's Hospital, Inc. | Polysaccharide vaccine for staphylococcal infections |
| EP1791560A4 (en) * | 2004-09-17 | 2009-01-14 | Merck & Co Inc | POLYPEPTIDES FOR INDUCING A PROTECTIVE IMMUNE RESPONSE AGAINST STAPHYLOCOCCUS AUREUS |
| US8758765B2 (en) * | 2008-07-29 | 2014-06-24 | The University Of Chicago | Compositions and methods related to Staphylococcal bacterium proteins |
| FR2957821B1 (fr) | 2010-03-24 | 2014-08-29 | Inst Francais Du Petrole | Nouvelle zone de regeneration du catalyseur divisee en secteurs pour unites catalytiques regeneratives |
-
2009
- 2009-10-06 WO PCT/US2009/059648 patent/WO2010042481A1/en not_active Ceased
- 2009-10-06 CA CA2739581A patent/CA2739581A1/en not_active Abandoned
- 2009-10-06 US US13/122,793 patent/US20110262477A1/en not_active Abandoned
- 2009-10-06 BR BRPI0920041A patent/BRPI0920041A2/pt not_active IP Right Cessation
- 2009-10-06 AU AU2009302582A patent/AU2009302582A1/en not_active Abandoned
- 2009-10-06 JP JP2011530297A patent/JP2012504660A/ja active Pending
- 2009-10-06 EP EP09793315.4A patent/EP2341929B1/en not_active Not-in-force
- 2009-10-06 CN CN200980146554.XA patent/CN102333540B/zh not_active Expired - Fee Related
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