RU2018123825A - Соединения и способы для модуляции киназ, и показания для этого - Google Patents
Соединения и способы для модуляции киназ, и показания для этого Download PDFInfo
- Publication number
- RU2018123825A RU2018123825A RU2018123825A RU2018123825A RU2018123825A RU 2018123825 A RU2018123825 A RU 2018123825A RU 2018123825 A RU2018123825 A RU 2018123825A RU 2018123825 A RU2018123825 A RU 2018123825A RU 2018123825 A RU2018123825 A RU 2018123825A
- Authority
- RU
- Russia
- Prior art keywords
- pyridin
- pyrrolo
- phenyl
- methyl
- cyano
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title claims 33
- 238000000034 method Methods 0.000 title claims 10
- 102000001253 Protein Kinase Human genes 0.000 title 1
- 108060006633 protein kinase Proteins 0.000 title 1
- -1 hydroxyalkylene Chemical group 0.000 claims 109
- 125000000217 alkyl group Chemical group 0.000 claims 61
- 229910052739 hydrogen Inorganic materials 0.000 claims 21
- 239000001257 hydrogen Substances 0.000 claims 21
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 20
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 20
- 201000010099 disease Diseases 0.000 claims 16
- 125000004938 5-pyridyl group Chemical group N1=CC=CC(=C1)* 0.000 claims 15
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 12
- 125000004093 cyano group Chemical group *C#N 0.000 claims 12
- 125000000753 cycloalkyl group Chemical group 0.000 claims 12
- 229910052736 halogen Inorganic materials 0.000 claims 12
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 11
- 125000001072 heteroaryl group Chemical group 0.000 claims 11
- 150000003839 salts Chemical class 0.000 claims 11
- 150000002367 halogens Chemical class 0.000 claims 10
- 150000002431 hydrogen Chemical class 0.000 claims 10
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 10
- 239000012634 fragment Substances 0.000 claims 8
- 101000932478 Homo sapiens Receptor-type tyrosine-protein kinase FLT3 Proteins 0.000 claims 7
- 102100020718 Receptor-type tyrosine-protein kinase FLT3 Human genes 0.000 claims 7
- 125000003545 alkoxy group Chemical group 0.000 claims 7
- 230000035772 mutation Effects 0.000 claims 7
- 125000004043 oxo group Chemical group O=* 0.000 claims 7
- 230000001575 pathological effect Effects 0.000 claims 7
- 239000008194 pharmaceutical composition Substances 0.000 claims 7
- 239000012453 solvate Substances 0.000 claims 7
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 6
- 208000008955 Mucolipidoses Diseases 0.000 claims 6
- 206010028980 Neoplasm Diseases 0.000 claims 6
- 125000003118 aryl group Chemical group 0.000 claims 6
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 6
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 5
- 125000001731 2-cyanoethyl group Chemical group [H]C([H])(*)C([H])([H])C#N 0.000 claims 4
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- 208000035475 disorder Diseases 0.000 claims 4
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 claims 3
- 206010003445 Ascites Diseases 0.000 claims 3
- 206010027406 Mesothelioma Diseases 0.000 claims 3
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 3
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims 3
- 125000002947 alkylene group Chemical group 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 125000006310 cycloalkyl amino group Chemical group 0.000 claims 3
- 125000005843 halogen group Chemical group 0.000 claims 3
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 3
- 230000001404 mediated effect Effects 0.000 claims 3
- WSFSSNUMVMOOMR-BJUDXGSMSA-N methanone Chemical compound O=[11CH2] WSFSSNUMVMOOMR-BJUDXGSMSA-N 0.000 claims 3
- 125000002757 morpholinyl group Chemical group 0.000 claims 3
- IBBMAWULFFBRKK-UHFFFAOYSA-N picolinamide Chemical compound NC(=O)C1=CC=CC=N1 IBBMAWULFFBRKK-UHFFFAOYSA-N 0.000 claims 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 3
- 201000002510 thyroid cancer Diseases 0.000 claims 3
- WRLSNQXIGKWPGJ-UHFFFAOYSA-N 2-methylpropanamide Chemical group C[C](C)C(N)=O WRLSNQXIGKWPGJ-UHFFFAOYSA-N 0.000 claims 2
- FJHBVJOVLFPMQE-QFIPXVFZSA-N 7-Ethyl-10-Hydroxy-Camptothecin Chemical compound C1=C(O)C=C2C(CC)=C(CN3C(C4=C([C@@](C(=O)OC4)(O)CC)C=C33)=O)C3=NC2=C1 FJHBVJOVLFPMQE-QFIPXVFZSA-N 0.000 claims 2
- 208000031277 Amaurotic familial idiocy Diseases 0.000 claims 2
- BFYIZQONLCFLEV-DAELLWKTSA-N Aromasine Chemical compound O=C1C=C[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CC(=C)C2=C1 BFYIZQONLCFLEV-DAELLWKTSA-N 0.000 claims 2
- 206010068220 Aspartylglucosaminuria Diseases 0.000 claims 2
- 201000009030 Carcinoma Diseases 0.000 claims 2
- 206010009944 Colon cancer Diseases 0.000 claims 2
- 206010011777 Cystinosis Diseases 0.000 claims 2
- 206010012289 Dementia Diseases 0.000 claims 2
- 206010012335 Dependence Diseases 0.000 claims 2
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 2
- 206010063045 Effusion Diseases 0.000 claims 2
- 208000024720 Fabry Disease Diseases 0.000 claims 2
- 208000001948 Farber Lipogranulomatosis Diseases 0.000 claims 2
- 208000017462 Galactosialidosis Diseases 0.000 claims 2
- 208000009796 Gangliosidoses Diseases 0.000 claims 2
- 206010051066 Gastrointestinal stromal tumour Diseases 0.000 claims 2
- 208000015872 Gaucher disease Diseases 0.000 claims 2
- 208000007569 Giant Cell Tumors Diseases 0.000 claims 2
- 201000011442 Metachromatic leukodystrophy Diseases 0.000 claims 2
- 206010072927 Mucolipidosis type I Diseases 0.000 claims 2
- 208000002678 Mucopolysaccharidoses Diseases 0.000 claims 2
- 208000036110 Neuroinflammatory disease Diseases 0.000 claims 2
- NKANXQFJJICGDU-QPLCGJKRSA-N Tamoxifen Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=CC(OCCN(C)C)=CC=1)/C1=CC=CC=C1 NKANXQFJJICGDU-QPLCGJKRSA-N 0.000 claims 2
- 201000004810 Vascular dementia Diseases 0.000 claims 2
- RJURFGZVJUQBHK-UHFFFAOYSA-N actinomycin D Natural products CC1OC(=O)C(C(C)C)N(C)C(=O)CN(C)C(=O)C2CCCN2C(=O)C(C(C)C)NC(=O)C1NC(=O)C1=C(N)C(=O)C(C)=C2OC(C(C)=CC=C3C(=O)NC4C(=O)NC(C(N5CCCC5C(=O)N(C)CC(=O)N(C)C(C(C)C)C(=O)OC4C)=O)C(C)C)=C3N=C21 RJURFGZVJUQBHK-UHFFFAOYSA-N 0.000 claims 2
- 125000000304 alkynyl group Chemical group 0.000 claims 2
- 229960002932 anastrozole Drugs 0.000 claims 2
- YBBLVLTVTVSKRW-UHFFFAOYSA-N anastrozole Chemical compound N#CC(C)(C)C1=CC(C(C)(C#N)C)=CC(CN2N=CN=C2)=C1 YBBLVLTVTVSKRW-UHFFFAOYSA-N 0.000 claims 2
- 201000006486 beta-mannosidosis Diseases 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 2
- 230000008021 deposition Effects 0.000 claims 2
- 229960000255 exemestane Drugs 0.000 claims 2
- 201000008049 fucosidosis Diseases 0.000 claims 2
- 201000006440 gangliosidosis Diseases 0.000 claims 2
- 201000011243 gastrointestinal stromal tumor Diseases 0.000 claims 2
- 201000008977 glycoproteinosis Diseases 0.000 claims 2
- 125000001188 haloalkyl group Chemical group 0.000 claims 2
- 125000004366 heterocycloalkenyl group Chemical group 0.000 claims 2
- 125000005885 heterocycloalkylalkyl group Chemical group 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 229960003881 letrozole Drugs 0.000 claims 2
- HPJKCIUCZWXJDR-UHFFFAOYSA-N letrozole Chemical compound C1=CC(C#N)=CC=C1C(N1N=CN=C1)C1=CC=C(C#N)C=C1 HPJKCIUCZWXJDR-UHFFFAOYSA-N 0.000 claims 2
- 208000032839 leukemia Diseases 0.000 claims 2
- 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 claims 2
- 206010028093 mucopolysaccharidosis Diseases 0.000 claims 2
- 230000003959 neuroinflammation Effects 0.000 claims 2
- 210000000578 peripheral nerve Anatomy 0.000 claims 2
- 239000008177 pharmaceutical agent Substances 0.000 claims 2
- 125000004076 pyridyl group Chemical group 0.000 claims 2
- DATJETPTDKFEEF-UHFFFAOYSA-N pyrrolidine-3-carbonitrile Chemical compound N#CC1CCNC1 DATJETPTDKFEEF-UHFFFAOYSA-N 0.000 claims 2
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 2
- RIWLPSIAFBLILR-WVNGMBSFSA-N (2s)-1-[(2s)-2-[[(2s,3s)-2-[[(2s)-2-[[(2s,3r)-2-[[(2r,3s)-2-[[(2s)-2-[[2-[[2-[acetyl(methyl)amino]acetyl]amino]acetyl]amino]-3-methylbutanoyl]amino]-3-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]pentanoyl]amino]-3-methylpentanoyl]amino]-5-(diaminomethy Chemical compound CC(=O)N(C)CC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)NCC RIWLPSIAFBLILR-WVNGMBSFSA-N 0.000 claims 1
- KPTFRXIEDVLJGF-UHFFFAOYSA-N (3,3-difluoroazetidin-1-yl)-[6-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyridin-2-yl]methanone Chemical compound FC1(CN(C1)C(=O)C1=NC(=CC=C1)C=1C=C2C(=NC=1)NC(=C2)C1=CC=CC=C1)F KPTFRXIEDVLJGF-UHFFFAOYSA-N 0.000 claims 1
- ZBFPSKYOKYKQJW-UHFFFAOYSA-N (3,3-difluoropyrrolidin-1-yl)-[6-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyridin-2-yl]methanone Chemical compound FC1(CN(CC1)C(=O)C1=NC(=CC=C1)C=1C=C2C(=NC=1)NC(=C2)C1=CC=CC=C1)F ZBFPSKYOKYKQJW-UHFFFAOYSA-N 0.000 claims 1
- ZUTOECYBJUNDSO-UHFFFAOYSA-N (3,3-difluoropyrrolidin-1-yl)-[6-[2-[1-(2,2,2-trifluoroethyl)pyrazol-4-yl]-1H-pyrrolo[2,3-b]pyridin-5-yl]pyridin-2-yl]methanone Chemical compound FC1(CN(CC1)C(=O)C1=NC(=CC=C1)C=1C=C2C(=NC=1)NC(=C2)C=1C=NN(C=1)CC(F)(F)F)F ZUTOECYBJUNDSO-UHFFFAOYSA-N 0.000 claims 1
- DSAIGQOKYZLYOL-UHFFFAOYSA-N (3-amino-3-methylpiperidin-1-yl)-[6-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyridin-2-yl]methanone Chemical compound NC1(CN(CCC1)C(=O)C1=NC(=CC=C1)C=1C=C2C(=NC=1)NC(=C2)C1=CC=CC=C1)C DSAIGQOKYZLYOL-UHFFFAOYSA-N 0.000 claims 1
- FSNTTXBPUGSTFU-UHFFFAOYSA-N (3-amino-3-methylpyrrolidin-1-yl)-[6-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyridin-2-yl]methanone Chemical compound NC1(CN(CC1)C(=O)C1=NC(=CC=C1)C=1C=C2C(=NC=1)NC(=C2)C1=CC=CC=C1)C FSNTTXBPUGSTFU-UHFFFAOYSA-N 0.000 claims 1
- HRLQKTUNZYDTDG-UHFFFAOYSA-N (3-aminoazetidin-1-yl)-[5-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-indazol-3-yl]methanone Chemical compound NC1CN(C1)C(=O)C1=NNC2=CC=C(C=C12)C=1C=C2C(=NC=1)NC(=C2)C1=CC=CC=C1 HRLQKTUNZYDTDG-UHFFFAOYSA-N 0.000 claims 1
- OFRZCUGGICNRRK-UHFFFAOYSA-N (3-aminopiperidin-1-yl)-[6-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyridin-2-yl]methanone Chemical compound NC1CN(CCC1)C(=O)C1=NC(=CC=C1)C=1C=C2C(=NC=1)NC(=C2)C1=CC=CC=C1 OFRZCUGGICNRRK-UHFFFAOYSA-N 0.000 claims 1
- UGNVFWOOMUSDEE-UHFFFAOYSA-N (3-hydroxypiperidin-1-yl)-[6-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyridin-2-yl]methanone Chemical compound OC1CN(CCC1)C(=O)C1=NC(=CC=C1)C=1C=C2C(=NC=1)NC(=C2)C1=CC=CC=C1 UGNVFWOOMUSDEE-UHFFFAOYSA-N 0.000 claims 1
- DQVRUNGCAQYYBW-UHFFFAOYSA-N (3-hydroxypyrrolidin-1-yl)-[6-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyridin-2-yl]methanone Chemical compound OC1CN(CC1)C(=O)C1=NC(=CC=C1)C=1C=C2C(=NC=1)NC(=C2)C1=CC=CC=C1 DQVRUNGCAQYYBW-UHFFFAOYSA-N 0.000 claims 1
- GXOJEKBQKITKCM-UHFFFAOYSA-N (3-imidazol-1-ylpyrrolidin-1-yl)-[6-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyridin-2-yl]methanone Chemical compound N1(C=NC=C1)C1CN(CC1)C(=O)C1=NC(=CC=C1)C=1C=C2C(=NC=1)NC(=C2)C1=CC=CC=C1 GXOJEKBQKITKCM-UHFFFAOYSA-N 0.000 claims 1
- PNCRRVPEIHXIQH-UHFFFAOYSA-N (3-methoxyazetidin-1-yl)-[6-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyridin-2-yl]methanone Chemical compound COC1CN(C1)C(=O)C1=NC(=CC=C1)C=1C=C2C(=NC=1)NC(=C2)C1=CC=CC=C1 PNCRRVPEIHXIQH-UHFFFAOYSA-N 0.000 claims 1
- WYPJKXOREPLEFJ-UHFFFAOYSA-N (3-methoxypyrrolidin-1-yl)-[6-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyridin-2-yl]methanone Chemical compound COC1CN(CC1)C(=O)C1=NC(=CC=C1)C=1C=C2C(=NC=1)NC(=C2)C1=CC=CC=C1 WYPJKXOREPLEFJ-UHFFFAOYSA-N 0.000 claims 1
- SIPRAPUBXCFVON-UHFFFAOYSA-N (3-morpholin-4-ylpyrrolidin-1-yl)-[6-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyridin-2-yl]methanone Chemical compound O1CCN(CC1)C1CN(CC1)C(=O)C1=NC(=CC=C1)C=1C=C2C(=NC=1)NC(=C2)C1=CC=CC=C1 SIPRAPUBXCFVON-UHFFFAOYSA-N 0.000 claims 1
- NNYPVESQVUCLML-INIZCTEOSA-N (3R)-1-[6-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyridine-2-carbonyl]pyrrolidine-3-carbonitrile Chemical compound C1(=CC=CC=C1)C1=CC=2C(=NC=C(C=2)C2=CC=CC(=N2)C(=O)N2C[C@@H](CC2)C#N)N1 NNYPVESQVUCLML-INIZCTEOSA-N 0.000 claims 1
- NNYPVESQVUCLML-MRXNPFEDSA-N (3S)-1-[6-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyridine-2-carbonyl]pyrrolidine-3-carbonitrile Chemical compound C1(=CC=CC=C1)C1=CC=2C(=NC=C(C=2)C2=CC=CC(=N2)C(=O)N2C[C@H](CC2)C#N)N1 NNYPVESQVUCLML-MRXNPFEDSA-N 0.000 claims 1
- QAEITCNJMUJHEG-UHFFFAOYSA-N (4,4-difluoropiperidin-1-yl)-[6-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyridin-2-yl]methanone Chemical compound FC1(CCN(CC1)C(=O)C1=NC(=CC=C1)C=1C=C2C(=NC=1)NC(=C2)C1=CC=CC=C1)F QAEITCNJMUJHEG-UHFFFAOYSA-N 0.000 claims 1
- UMWGYALDDHNKQR-UHFFFAOYSA-N (4-amino-4-methylpiperidin-1-yl)-[6-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyridin-2-yl]methanone Chemical compound NC1(CCN(CC1)C(=O)C1=NC(=CC=C1)C=1C=C2C(=NC=1)NC(=C2)C1=CC=CC=C1)C UMWGYALDDHNKQR-UHFFFAOYSA-N 0.000 claims 1
- PQEDBJYVWKQTBL-UHFFFAOYSA-N (4-aminopiperidin-1-yl)-[2-methyl-5-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl]methanone Chemical compound NC1CCN(CC1)C(=O)C1=C(C=CC(=C1)C=1C=C2C(=NC=1)NC(=C2)C1=CC=CC=C1)C PQEDBJYVWKQTBL-UHFFFAOYSA-N 0.000 claims 1
- CJHMHMPCKXVDEB-UHFFFAOYSA-N (4-aminopiperidin-1-yl)-[3-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl]methanone Chemical compound NC1CCN(CC1)C(=O)C1=CC(=CC=C1)C=1C=C2C(=NC=1)NC(=C2)C1=CC=CC=C1 CJHMHMPCKXVDEB-UHFFFAOYSA-N 0.000 claims 1
- BWHLZXGXQVQBFA-UHFFFAOYSA-N (4-aminopiperidin-1-yl)-[3-methyl-6-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyridin-2-yl]methanone Chemical compound NC1CCN(CC1)C(=O)C1=NC(=CC=C1C)C=1C=C2C(=NC=1)NC(=C2)C1=CC=CC=C1 BWHLZXGXQVQBFA-UHFFFAOYSA-N 0.000 claims 1
- XNJDFENMBXYFDJ-UHFFFAOYSA-N (4-aminopiperidin-1-yl)-[4-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyridin-2-yl]methanone Chemical compound NC1CCN(CC1)C(=O)C1=NC=CC(=C1)C=1C=C2C(=NC=1)NC(=C2)C1=CC=CC=C1 XNJDFENMBXYFDJ-UHFFFAOYSA-N 0.000 claims 1
- RUWZHFGKUSCQAY-UHFFFAOYSA-N (4-aminopiperidin-1-yl)-[5-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-indazol-3-yl]methanone Chemical compound NC1CCN(CC1)C(=O)C1=NNC2=CC=C(C=C12)C=1C=C2C(=NC=1)NC(=C2)C1=CC=CC=C1 RUWZHFGKUSCQAY-UHFFFAOYSA-N 0.000 claims 1
- ZOVDQZCXUBIYNJ-UHFFFAOYSA-N (4-aminopiperidin-1-yl)-[5-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-indol-3-yl]methanone Chemical compound NC1CCN(CC1)C(=O)C1=CNC2=CC=C(C=C12)C=1C=C2C(=NC=1)NC(=C2)C1=CC=CC=C1 ZOVDQZCXUBIYNJ-UHFFFAOYSA-N 0.000 claims 1
- FLODFAJPIHJHRE-UHFFFAOYSA-N (4-aminopiperidin-1-yl)-[6-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyridin-2-yl]methanone Chemical compound NC1CCN(CC1)C(=O)C1=NC(=CC=C1)C=1C=C2C(=NC=1)NC(=C2)C1=CC=CC=C1 FLODFAJPIHJHRE-UHFFFAOYSA-N 0.000 claims 1
- DDMMWVCSVOIJGX-UHFFFAOYSA-N (4-methoxypiperidin-1-yl)-[6-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyridin-2-yl]methanone Chemical compound COC1CCN(CC1)C(=O)C1=NC(=CC=C1)C=1C=C2C(=NC=1)NC(=C2)C1=CC=CC=C1 DDMMWVCSVOIJGX-UHFFFAOYSA-N 0.000 claims 1
- NFVYBJGUADNXNT-UHFFFAOYSA-N (4-methylpiperidin-1-yl)-[5-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-indazol-3-yl]methanone Chemical compound CC1CCN(CC1)C(=O)C1=NNC2=CC=C(C=C12)C=1C=C2C(=NC=1)NC(=C2)C1=CC=CC=C1 NFVYBJGUADNXNT-UHFFFAOYSA-N 0.000 claims 1
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 1
- FDKXTQMXEQVLRF-ZHACJKMWSA-N (E)-dacarbazine Chemical compound CN(C)\N=N\c1[nH]cnc1C(N)=O FDKXTQMXEQVLRF-ZHACJKMWSA-N 0.000 claims 1
- URSUZYQDYXQOLH-UHFFFAOYSA-N 1-[6-(2-phenyl-1H-imidazo[4,5-b]pyridin-6-yl)pyridine-2-carbonyl]pyrrolidine-3-carbonitrile Chemical compound C1(=CC=CC=C1)C1=NC=2C(=NC=C(C=2)C2=CC=CC(=N2)C(=O)N2CC(CC2)C#N)N1 URSUZYQDYXQOLH-UHFFFAOYSA-N 0.000 claims 1
- UAXNBCWFFSKQKW-UHFFFAOYSA-N 1-[6-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyridin-2-yl]sulfonylpiperidin-4-amine Chemical compound C1(=CC=CC=C1)C1=CC=2C(=NC=C(C=2)C2=CC=CC(=N2)S(=O)(=O)N2CCC(CC2)N)N1 UAXNBCWFFSKQKW-UHFFFAOYSA-N 0.000 claims 1
- WKYLSNBVWDKFDE-UHFFFAOYSA-N 1-[6-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyridin-2-yl]sulfonylpyrrolidine-3-carbonitrile Chemical compound C1(=CC=CC=C1)C1=CC=2C(=NC=C(C=2)C2=CC=CC(=N2)S(=O)(=O)N2CC(CC2)C#N)N1 WKYLSNBVWDKFDE-UHFFFAOYSA-N 0.000 claims 1
- GXKZBLKXSNGPBB-UHFFFAOYSA-N 1-[6-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyridine-2-carbonyl]piperidine-4-carboxylic acid Chemical compound C1(=CC=CC=C1)C1=CC=2C(=NC=C(C=2)C2=CC=CC(=N2)C(=O)N2CCC(CC2)C(=O)O)N1 GXKZBLKXSNGPBB-UHFFFAOYSA-N 0.000 claims 1
- NNYPVESQVUCLML-UHFFFAOYSA-N 1-[6-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyridine-2-carbonyl]pyrrolidine-3-carbonitrile Chemical compound C1(=CC=CC=C1)C1=CC=2C(=NC=C(C=2)C2=CC=CC(=N2)C(=O)N2CC(CC2)C#N)N1 NNYPVESQVUCLML-UHFFFAOYSA-N 0.000 claims 1
- XMYXGZZQEKTYER-UHFFFAOYSA-N 1-[6-[2-(3,6-dihydro-2H-pyran-4-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl]pyridine-2-carbonyl]pyrrolidine-3-carbonitrile Chemical compound O1CCC(=CC1)C1=CC=2C(=NC=C(C=2)C2=CC=CC(=N2)C(=O)N2CC(CC2)C#N)N1 XMYXGZZQEKTYER-UHFFFAOYSA-N 0.000 claims 1
- MUMXVSYHOGBHTJ-UHFFFAOYSA-N 1-[6-[2-(3-cyanophenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]pyridine-2-carbonyl]pyrrolidine-3-carbonitrile Chemical compound C(#N)C=1C=C(C=CC=1)C1=CC=2C(=NC=C(C=2)C2=CC=CC(=N2)C(=O)N2CC(CC2)C#N)N1 MUMXVSYHOGBHTJ-UHFFFAOYSA-N 0.000 claims 1
- MTURUCCUDYMBPA-UHFFFAOYSA-N 1-[6-[2-(4,4-dimethylcyclohexen-1-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl]pyridine-2-carbonyl]pyrrolidine-3-carbonitrile Chemical compound CC1(CC=C(CC1)C1=CC=2C(=NC=C(C=2)C2=CC=CC(=N2)C(=O)N2CC(CC2)C#N)N1)C MTURUCCUDYMBPA-UHFFFAOYSA-N 0.000 claims 1
- RSUHNMRCVJJCTK-UHFFFAOYSA-N 1-[6-[2-(4-cyano-2-methylphenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]pyridine-2-carbonyl]pyrrolidine-3-carbonitrile Chemical compound C(#N)C1=CC(=C(C=C1)C1=CC=2C(=NC=C(C=2)C2=CC=CC(=N2)C(=O)N2CC(CC2)C#N)N1)C RSUHNMRCVJJCTK-UHFFFAOYSA-N 0.000 claims 1
- VEYIHUSZLBBWIC-UHFFFAOYSA-N 1-[6-[2-(4-fluorophenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]pyridine-2-carbonyl]pyrrolidine-3-carbonitrile Chemical compound FC1=CC=C(C=C1)C1=CC=2C(=NC=C(C=2)C2=CC=CC(=N2)C(=O)N2CC(CC2)C#N)N1 VEYIHUSZLBBWIC-UHFFFAOYSA-N 0.000 claims 1
- NAGIVODFTNZRBC-UHFFFAOYSA-N 1-[6-[2-[1-(difluoromethyl)pyrazol-4-yl]-1H-pyrrolo[2,3-b]pyridin-5-yl]pyridine-2-carbonyl]pyrrolidine-3-carbonitrile Chemical compound FC(N1N=CC(=C1)C1=CC=2C(=NC=C(C=2)C2=CC=CC(=N2)C(=O)N2CC(CC2)C#N)N1)F NAGIVODFTNZRBC-UHFFFAOYSA-N 0.000 claims 1
- KWPBNNHDWMHVIO-UHFFFAOYSA-N 1-[6-[3-chloro-2-(3,6-dihydro-2H-pyran-4-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl]pyridine-2-carbonyl]pyrrolidine-3-carbonitrile Chemical compound ClC1=C(NC2=NC=C(C=C21)C1=CC=CC(=N1)C(=O)N1CC(CC1)C#N)C=1CCOCC=1 KWPBNNHDWMHVIO-UHFFFAOYSA-N 0.000 claims 1
- MPXHTIKQVNGFPJ-UHFFFAOYSA-N 1-ethyl-3-[1-[6-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyridine-2-carbonyl]piperidin-4-yl]urea Chemical compound C(C)NC(=O)NC1CCN(CC1)C(=O)C1=NC(=CC=C1)C=1C=C2C(=NC=1)NC(=C2)C1=CC=CC=C1 MPXHTIKQVNGFPJ-UHFFFAOYSA-N 0.000 claims 1
- MDPIFEZQBMGTIJ-UHFFFAOYSA-N 1-methyl-3-[4-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl]urea Chemical compound CNC(=O)NC1=CC=C(C=C1)C=1C=C2C(=NC=1)NC(=C2)C1=CC=CC=C1 MDPIFEZQBMGTIJ-UHFFFAOYSA-N 0.000 claims 1
- VSNHCAURESNICA-NJFSPNSNSA-N 1-oxidanylurea Chemical compound N[14C](=O)NO VSNHCAURESNICA-NJFSPNSNSA-N 0.000 claims 1
- 125000005955 1H-indazolyl group Chemical group 0.000 claims 1
- QMVPQBFHUJZJCS-NTKFZFFISA-N 1v8x590xdp Chemical compound O=C1N(NC(CO)CO)C(=O)C(C2=C3[CH]C=C(O)C=C3NC2=C23)=C1C2=C1C=CC(O)=C[C]1N3[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O QMVPQBFHUJZJCS-NTKFZFFISA-N 0.000 claims 1
- UEJJHQNACJXSKW-UHFFFAOYSA-N 2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione Chemical compound O=C1C2=CC=CC=C2C(=O)N1C1CCC(=O)NC1=O UEJJHQNACJXSKW-UHFFFAOYSA-N 0.000 claims 1
- MQJWNJHORZMLBS-UHFFFAOYSA-N 2-(3-aminocyclopentanecarbonyl)-4-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-3H-isoindol-1-one Chemical compound NC1CC(CC1)C(=O)N1C(C2=CC=CC(=C2C1)C=1C=C2C(=NC=1)NC(=C2)C1=CC=CC=C1)=O MQJWNJHORZMLBS-UHFFFAOYSA-N 0.000 claims 1
- MXWHMTNPTTVWDM-UHFFFAOYSA-N 2-[1-(diaminomethylidenehydrazinylidene)propan-2-ylideneamino]guanidine Chemical compound NC(N)=NN=C(C)C=NN=C(N)N MXWHMTNPTTVWDM-UHFFFAOYSA-N 0.000 claims 1
- CQOQDQWUFQDJMK-SSTWWWIQSA-N 2-methoxy-17beta-estradiol Chemical compound C([C@@H]12)C[C@]3(C)[C@@H](O)CC[C@H]3[C@@H]1CCC1=C2C=C(OC)C(O)=C1 CQOQDQWUFQDJMK-SSTWWWIQSA-N 0.000 claims 1
- 125000004200 2-methoxyethyl group Chemical group [H]C([H])([H])OC([H])([H])C([H])([H])* 0.000 claims 1
- VMBOMDCGLICXIO-UHFFFAOYSA-N 2-phenyl-5-(6-piperidin-4-yloxypyridin-2-yl)-1H-pyrrolo[2,3-b]pyridine Chemical compound C1(=CC=CC=C1)C1=CC=2C(=NC=C(C=2)C2=NC(=CC=C2)OC2CCNCC2)N1 VMBOMDCGLICXIO-UHFFFAOYSA-N 0.000 claims 1
- NDMPLJNOPCLANR-UHFFFAOYSA-N 3,4-dihydroxy-15-(4-hydroxy-18-methoxycarbonyl-5,18-seco-ibogamin-18-yl)-16-methoxy-1-methyl-6,7-didehydro-aspidospermidine-3-carboxylic acid methyl ester Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 NDMPLJNOPCLANR-UHFFFAOYSA-N 0.000 claims 1
- DCXBEUDQEVVHHY-UHFFFAOYSA-N 3-[2-(2-cyclohexylethynyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-N-cyclopropylbenzenesulfonamide Chemical compound C1(CCCCC1)C#CC1=CC=2C(=NC=C(C=2)C=2C=C(C=CC=2)S(=O)(=O)NC2CC2)N1 DCXBEUDQEVVHHY-UHFFFAOYSA-N 0.000 claims 1
- RCSUERKNALONNE-UHFFFAOYSA-N 3-[5-[6-[3-(methylamino)pyrrolidine-1-carbonyl]pyridin-2-yl]-1H-pyrrolo[2,3-b]pyridin-2-yl]benzonitrile Chemical compound CNC1CN(CC1)C(=O)C1=CC=CC(=N1)C=1C=C2C(=NC=1)NC(=C2)C=1C=C(C#N)C=CC=1 RCSUERKNALONNE-UHFFFAOYSA-N 0.000 claims 1
- RTOLIHSYEXWHAF-UHFFFAOYSA-N 3-fluoro-1-[6-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyridine-2-carbonyl]pyrrolidine-3-carbonitrile Chemical compound FC1(CN(CC1)C(=O)C1=NC(=CC=C1)C=1C=C2C(=NC=1)NC(=C2)C1=CC=CC=C1)C#N RTOLIHSYEXWHAF-UHFFFAOYSA-N 0.000 claims 1
- AOJJSUZBOXZQNB-VTZDEGQISA-N 4'-epidoxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-VTZDEGQISA-N 0.000 claims 1
- FVQVPAWONWILLC-UHFFFAOYSA-N 4-[6-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyridine-2-carbonyl]piperazine-1-carboximidamide Chemical compound C1(=CC=CC=C1)C1=CC=2C(=NC=C(C=2)C2=CC=CC(=N2)C(=O)N2CCN(CC2)C(=N)N)N1 FVQVPAWONWILLC-UHFFFAOYSA-N 0.000 claims 1
- LLEZYPYKJBKYSZ-UHFFFAOYSA-N 4-methyl-1-[6-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyridine-2-carbonyl]piperidine-4-carbonitrile Chemical compound CC1(CCN(CC1)C(=O)C1=NC(=CC=C1)C=1C=C2C(=NC=1)NC(=C2)C1=CC=CC=C1)C#N LLEZYPYKJBKYSZ-UHFFFAOYSA-N 0.000 claims 1
- XECSKKIRBIMFKU-UHFFFAOYSA-N 5-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-N-piperidin-4-yl-1H-indazol-3-amine Chemical compound C1(=CC=CC=C1)C1=CC=2C(=NC=C(C=2)C=2C=C3C(=NNC3=CC=2)NC2CCNCC2)N1 XECSKKIRBIMFKU-UHFFFAOYSA-N 0.000 claims 1
- XYCRBMVSCANTAR-UHFFFAOYSA-N 5-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-N-pyrrolidin-3-yl-1H-indazol-3-amine Chemical compound C1(=CC=CC=C1)C1=CC=2C(=NC=C(C=2)C=2C=C3C(=NNC3=CC=2)NC2CNCC2)N1 XYCRBMVSCANTAR-UHFFFAOYSA-N 0.000 claims 1
- RBVFDWUOAGZRNF-UHFFFAOYSA-N 5-[3-(dimethylsulfamoylamino)phenyl]-2-phenyl-1H-pyrrolo[2,3-b]pyridine Chemical compound CN(S(=O)(=O)NC=1C=C(C=CC=1)C=1C=C2C(=NC=1)NC(=C2)C1=CC=CC=C1)C RBVFDWUOAGZRNF-UHFFFAOYSA-N 0.000 claims 1
- XAUDJQYHKZQPEU-KVQBGUIXSA-N 5-aza-2'-deoxycytidine Chemical compound O=C1N=C(N)N=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 XAUDJQYHKZQPEU-KVQBGUIXSA-N 0.000 claims 1
- NMUSYJAQQFHJEW-KVTDHHQDSA-N 5-azacytidine Chemical compound O=C1N=C(N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 NMUSYJAQQFHJEW-KVTDHHQDSA-N 0.000 claims 1
- SCSQTPXKVAPXEV-UHFFFAOYSA-N 6-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-N-pyrrolidin-3-ylpyridine-2-sulfonamide Chemical compound C1(=CC=CC=C1)C1=CC=2C(=NC=C(C=2)C2=CC=CC(=N2)S(=O)(=O)NC2CNCC2)N1 SCSQTPXKVAPXEV-UHFFFAOYSA-N 0.000 claims 1
- WYWHKKSPHMUBEB-UHFFFAOYSA-N 6-Mercaptoguanine Natural products N1C(N)=NC(=S)C2=C1N=CN2 WYWHKKSPHMUBEB-UHFFFAOYSA-N 0.000 claims 1
- STQGQHZAVUOBTE-UHFFFAOYSA-N 7-Cyan-hept-2t-en-4,6-diinsaeure Natural products C1=2C(O)=C3C(=O)C=4C(OC)=CC=CC=4C(=O)C3=C(O)C=2CC(O)(C(C)=O)CC1OC1CC(N)C(O)C(C)O1 STQGQHZAVUOBTE-UHFFFAOYSA-N 0.000 claims 1
- GOJJWDOZNKBUSR-UHFFFAOYSA-N 7-sulfamoyloxyheptyl sulfamate Chemical compound NS(=O)(=O)OCCCCCCCOS(N)(=O)=O GOJJWDOZNKBUSR-UHFFFAOYSA-N 0.000 claims 1
- FUXVKZWTXQUGMW-FQEVSTJZSA-N 9-Aminocamptothecin Chemical compound C1=CC(N)=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 FUXVKZWTXQUGMW-FQEVSTJZSA-N 0.000 claims 1
- SHGAZHPCJJPHSC-ZVCIMWCZSA-N 9-cis-retinoic acid Chemical compound OC(=O)/C=C(\C)/C=C/C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-ZVCIMWCZSA-N 0.000 claims 1
- OONFNUWBHFSNBT-HXUWFJFHSA-N AEE788 Chemical compound C1CN(CC)CCN1CC1=CC=C(C=2NC3=NC=NC(N[C@H](C)C=4C=CC=CC=4)=C3C=2)C=C1 OONFNUWBHFSNBT-HXUWFJFHSA-N 0.000 claims 1
- 229940126638 Akt inhibitor Drugs 0.000 claims 1
- 208000007848 Alcoholism Diseases 0.000 claims 1
- 208000029602 Alpha-N-acetylgalactosaminidase deficiency Diseases 0.000 claims 1
- 208000001446 Anaplastic Thyroid Carcinoma Diseases 0.000 claims 1
- 206010002240 Anaplastic thyroid cancer Diseases 0.000 claims 1
- 229940122815 Aromatase inhibitor Drugs 0.000 claims 1
- 102000015790 Asparaginase Human genes 0.000 claims 1
- 108010024976 Asparaginase Proteins 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- MLDQJTXFUGDVEO-UHFFFAOYSA-N BAY-43-9006 Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=CC(NC(=O)NC=3C=C(C(Cl)=CC=3)C(F)(F)F)=CC=2)=C1 MLDQJTXFUGDVEO-UHFFFAOYSA-N 0.000 claims 1
- 206010004146 Basal cell carcinoma Diseases 0.000 claims 1
- 102100022548 Beta-hexosaminidase subunit alpha Human genes 0.000 claims 1
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 108010006654 Bleomycin Proteins 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 108010037003 Buserelin Proteins 0.000 claims 1
- COVZYZSDYWQREU-UHFFFAOYSA-N Busulfan Chemical compound CS(=O)(=O)OCCCCOS(C)(=O)=O COVZYZSDYWQREU-UHFFFAOYSA-N 0.000 claims 1
- FVLVBPDQNARYJU-XAHDHGMMSA-N C[C@H]1CCC(CC1)NC(=O)N(CCCl)N=O Chemical compound C[C@H]1CCC(CC1)NC(=O)N(CCCl)N=O FVLVBPDQNARYJU-XAHDHGMMSA-N 0.000 claims 1
- GAGWJHPBXLXJQN-UORFTKCHSA-N Capecitabine Chemical compound C1=C(F)C(NC(=O)OCCCCC)=NC(=O)N1[C@H]1[C@H](O)[C@H](O)[C@@H](C)O1 GAGWJHPBXLXJQN-UORFTKCHSA-N 0.000 claims 1
- GAGWJHPBXLXJQN-UHFFFAOYSA-N Capecitabine Natural products C1=C(F)C(NC(=O)OCCCCC)=NC(=O)N1C1C(O)C(O)C(C)O1 GAGWJHPBXLXJQN-UHFFFAOYSA-N 0.000 claims 1
- 208000024172 Cardiovascular disease Diseases 0.000 claims 1
- DLGOEMSEDOSKAD-UHFFFAOYSA-N Carmustine Chemical compound ClCCNC(=O)N(N=O)CCCl DLGOEMSEDOSKAD-UHFFFAOYSA-N 0.000 claims 1
- PTOAARAWEBMLNO-KVQBGUIXSA-N Cladribine Chemical compound C1=NC=2C(N)=NC(Cl)=NC=2N1[C@H]1C[C@H](O)[C@@H](CO)O1 PTOAARAWEBMLNO-KVQBGUIXSA-N 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 208000023890 Complex Regional Pain Syndromes Diseases 0.000 claims 1
- 208000013586 Complex regional pain syndrome type 1 Diseases 0.000 claims 1
- 229940083347 Cyclin-dependent kinase 4 inhibitor Drugs 0.000 claims 1
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 claims 1
- UHDGCWIWMRVCDJ-CCXZUQQUSA-N Cytarabine Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O1 UHDGCWIWMRVCDJ-CCXZUQQUSA-N 0.000 claims 1
- 229960005500 DHA-paclitaxel Drugs 0.000 claims 1
- 108010092160 Dactinomycin Proteins 0.000 claims 1
- ZBNZXTGUTAYRHI-UHFFFAOYSA-N Dasatinib Chemical compound C=1C(N2CCN(CCO)CC2)=NC(C)=NC=1NC(S1)=NC=C1C(=O)NC1=C(C)C=CC=C1Cl ZBNZXTGUTAYRHI-UHFFFAOYSA-N 0.000 claims 1
- 206010013801 Duchenne Muscular Dystrophy Diseases 0.000 claims 1
- 206010014733 Endometrial cancer Diseases 0.000 claims 1
- 206010014759 Endometrial neoplasm Diseases 0.000 claims 1
- HTIJFSOGRVMCQR-UHFFFAOYSA-N Epirubicin Natural products COc1cccc2C(=O)c3c(O)c4CC(O)(CC(OC5CC(N)C(=O)C(C)O5)c4c(O)c3C(=O)c12)C(=O)CO HTIJFSOGRVMCQR-UHFFFAOYSA-N 0.000 claims 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 claims 1
- 239000005977 Ethylene Substances 0.000 claims 1
- 208000006168 Ewing Sarcoma Diseases 0.000 claims 1
- 208000026097 Factitious disease Diseases 0.000 claims 1
- 229940124226 Farnesyltransferase inhibitor Drugs 0.000 claims 1
- 206010016654 Fibrosis Diseases 0.000 claims 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 1
- GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 claims 1
- 206010016935 Follicular thyroid cancer Diseases 0.000 claims 1
- 201000011240 Frontotemporal dementia Diseases 0.000 claims 1
- VWUXBMIQPBEWFH-WCCTWKNTSA-N Fulvestrant Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3[C@H](CCCCCCCCCS(=O)CCCC(F)(F)C(F)(F)F)CC2=C1 VWUXBMIQPBEWFH-WCCTWKNTSA-N 0.000 claims 1
- JRZJKWGQFNTSRN-UHFFFAOYSA-N Geldanamycin Natural products C1C(C)CC(OC)C(O)C(C)C=C(C)C(OC(N)=O)C(OC)CCC=C(C)C(=O)NC2=CC(=O)C(OC)=C1C2=O JRZJKWGQFNTSRN-UHFFFAOYSA-N 0.000 claims 1
- 208000010412 Glaucoma Diseases 0.000 claims 1
- 208000032612 Glial tumor Diseases 0.000 claims 1
- 206010018338 Glioma Diseases 0.000 claims 1
- 229920002527 Glycogen Polymers 0.000 claims 1
- 208000032007 Glycogen storage disease due to acid maltase deficiency Diseases 0.000 claims 1
- 206010053185 Glycogen storage disease type II Diseases 0.000 claims 1
- BLCLNMBMMGCOAS-URPVMXJPSA-N Goserelin Chemical compound C([C@@H](C(=O)N[C@H](COC(C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1[C@@H](CCC1)C(=O)NNC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 BLCLNMBMMGCOAS-URPVMXJPSA-N 0.000 claims 1
- 108010069236 Goserelin Proteins 0.000 claims 1
- 208000002972 Hepatolenticular Degeneration Diseases 0.000 claims 1
- 208000017604 Hodgkin disease Diseases 0.000 claims 1
- 208000021519 Hodgkin lymphoma Diseases 0.000 claims 1
- 208000010747 Hodgkins lymphoma Diseases 0.000 claims 1
- XDXDZDZNSLXDNA-TZNDIEGXSA-N Idarubicin Chemical compound C1[C@H](N)[C@H](O)[C@H](C)O[C@H]1O[C@@H]1C2=C(O)C(C(=O)C3=CC=CC=C3C3=O)=C3C(O)=C2C[C@@](O)(C(C)=O)C1 XDXDZDZNSLXDNA-TZNDIEGXSA-N 0.000 claims 1
- XDXDZDZNSLXDNA-UHFFFAOYSA-N Idarubicin Natural products C1C(N)C(O)C(C)OC1OC1C2=C(O)C(C(=O)C3=CC=CC=C3C3=O)=C3C(O)=C2CC(O)(C(C)=O)C1 XDXDZDZNSLXDNA-UHFFFAOYSA-N 0.000 claims 1
- JJKOTMDDZAJTGQ-DQSJHHFOSA-N Idoxifene Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=CC(OCCN2CCCC2)=CC=1)/C1=CC=C(I)C=C1 JJKOTMDDZAJTGQ-DQSJHHFOSA-N 0.000 claims 1
- 102100040061 Indoleamine 2,3-dioxygenase 1 Human genes 0.000 claims 1
- 102000006992 Interferon-alpha Human genes 0.000 claims 1
- 108010047761 Interferon-alpha Proteins 0.000 claims 1
- 102000000588 Interleukin-2 Human genes 0.000 claims 1
- 108010002350 Interleukin-2 Proteins 0.000 claims 1
- SHGAZHPCJJPHSC-NUEINMDLSA-N Isotretinoin Chemical compound OC(=O)C=C(C)/C=C/C=C(C)C=CC1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-NUEINMDLSA-N 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 claims 1
- 239000005411 L01XE02 - Gefitinib Substances 0.000 claims 1
- 239000005551 L01XE03 - Erlotinib Substances 0.000 claims 1
- 239000005511 L01XE05 - Sorafenib Substances 0.000 claims 1
- 239000002136 L01XE07 - Lapatinib Substances 0.000 claims 1
- 208000018142 Leiomyosarcoma Diseases 0.000 claims 1
- 206010024305 Leukaemia monocytic Diseases 0.000 claims 1
- 108010000817 Leuprolide Proteins 0.000 claims 1
- GQYIWUVLTXOXAJ-UHFFFAOYSA-N Lomustine Chemical compound ClCCN(N=O)C(=O)NC1CCCCC1 GQYIWUVLTXOXAJ-UHFFFAOYSA-N 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 102100033448 Lysosomal alpha-glucosidase Human genes 0.000 claims 1
- 208000015439 Lysosomal storage disease Diseases 0.000 claims 1
- 229940124647 MEK inhibitor Drugs 0.000 claims 1
- 206010025538 Malignant ascites Diseases 0.000 claims 1
- 208000009018 Medullary thyroid cancer Diseases 0.000 claims 1
- 229930192392 Mitomycin Natural products 0.000 claims 1
- 206010072928 Mucolipidosis type II Diseases 0.000 claims 1
- 206010072929 Mucolipidosis type III Diseases 0.000 claims 1
- 206010072930 Mucolipidosis type IV Diseases 0.000 claims 1
- 102100026502 Mucolipin-1 Human genes 0.000 claims 1
- 208000005314 Multi-Infarct Dementia Diseases 0.000 claims 1
- 208000000149 Multiple Sulfatase Deficiency Disease Diseases 0.000 claims 1
- 208000035032 Multiple sulfatase deficiency Diseases 0.000 claims 1
- NWIBSHFKIJFRCO-WUDYKRTCSA-N Mytomycin Chemical compound C1N2C(C(C(C)=C(N)C3=O)=O)=C3[C@@H](COC(N)=O)[C@@]2(OC)[C@@H]2[C@H]1N2 NWIBSHFKIJFRCO-WUDYKRTCSA-N 0.000 claims 1
- OPHLUNCRXQRPIS-UHFFFAOYSA-N N-(2-cyano-2-methylpropyl)-6-[2-(3,6-dihydro-2H-thiopyran-4-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl]pyridine-2-carboxamide Chemical compound C(#N)C(CNC(=O)C1=NC(=CC=C1)C=1C=C2C(=NC=1)NC(=C2)C=1CCSCC=1)(C)C OPHLUNCRXQRPIS-UHFFFAOYSA-N 0.000 claims 1
- FITFIDGZBIOCLW-UHFFFAOYSA-N N-(2-cyano-2-methylpropyl)-6-[2-[1-(cyclopropanecarbonyl)-2,5-dihydropyrrol-3-yl]-1H-pyrrolo[2,3-b]pyridin-5-yl]pyridine-2-carboxamide Chemical compound C(#N)C(CNC(=O)C1=NC(=CC=C1)C=1C=C2C(=NC=1)NC(=C2)C=1CN(CC=1)C(=O)C1CC1)(C)C FITFIDGZBIOCLW-UHFFFAOYSA-N 0.000 claims 1
- YJUOSKXHPDJRJF-UHFFFAOYSA-N N-[1-[3-[2-(4-fluorophenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]benzoyl]piperidin-4-yl]acetamide Chemical compound FC1=CC=C(C=C1)C1=CC=2C(=NC=C(C=2)C=2C=C(C(=O)N3CCC(CC3)NC(C)=O)C=CC=2)N1 YJUOSKXHPDJRJF-UHFFFAOYSA-N 0.000 claims 1
- YOCFTDIRUIVHSI-UHFFFAOYSA-N N-[1-[5-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-indazole-3-carbonyl]piperidin-4-yl]acetamide Chemical compound C1(=CC=CC=C1)C1=CC=2C(=NC=C(C=2)C=2C=C3C(=NNC3=CC=2)C(=O)N2CCC(CC2)NC(C)=O)N1 YOCFTDIRUIVHSI-UHFFFAOYSA-N 0.000 claims 1
- NWAZQAMYQOISIC-UHFFFAOYSA-N N-[1-[6-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyridine-2-carbonyl]piperidin-4-yl]acetamide Chemical compound C1(=CC=CC=C1)C1=CC=2C(=NC=C(C=2)C2=CC=CC(=N2)C(=O)N2CCC(CC2)NC(C)=O)N1 NWAZQAMYQOISIC-UHFFFAOYSA-N 0.000 claims 1
- OFFNEBOUBCRWKE-UHFFFAOYSA-N N-[1-[6-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyridine-2-carbonyl]piperidin-4-yl]methanesulfonamide Chemical compound C1(=CC=CC=C1)C1=CC=2C(=NC=C(C=2)C2=CC=CC(=N2)C(=O)N2CCC(CC2)NS(=O)(=O)C)N1 OFFNEBOUBCRWKE-UHFFFAOYSA-N 0.000 claims 1
- VFHYETRTTZPINK-UHFFFAOYSA-N N-[1-[6-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyridine-2-carbonyl]pyrrolidin-3-yl]methanesulfonamide Chemical compound C1(=CC=CC=C1)C1=CC=2C(=NC=C(C=2)C2=CC=CC(=N2)C(=O)N2CC(CC2)NS(=O)(=O)C)N1 VFHYETRTTZPINK-UHFFFAOYSA-N 0.000 claims 1
- JCKKCSLCTACCDP-UHFFFAOYSA-N N-[6-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyridin-2-yl]azetidine-3-carboxamide Chemical compound C1(=CC=CC=C1)C1=CC=2C(=NC=C(C=2)C2=CC=CC(=N2)NC(=O)C2CNC2)N1 JCKKCSLCTACCDP-UHFFFAOYSA-N 0.000 claims 1
- WPXHKYXQFKOBBH-UHFFFAOYSA-N N-cyclopropyl-3-(2-ethynyl-1H-pyrrolo[2,3-b]pyridin-5-yl)benzenesulfonamide Chemical compound C1(CC1)NS(=O)(=O)C1=CC(=CC=C1)C=1C=C2C(=NC=1)NC(=C2)C#C WPXHKYXQFKOBBH-UHFFFAOYSA-N 0.000 claims 1
- PONLSSCMJKJRMY-UHFFFAOYSA-N N-cyclopropyl-3-[2-(2-phenylethynyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]benzenesulfonamide Chemical compound C1(CC1)NS(=O)(=O)C1=CC(=CC=C1)C=1C=C2C(=NC=1)NC(=C2)C#CC1=CC=CC=C1 PONLSSCMJKJRMY-UHFFFAOYSA-N 0.000 claims 1
- NAGPXYIHSMZRLO-UHFFFAOYSA-N N-cyclopropyl-3-[2-(3-hydroxyprop-1-ynyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]benzenesulfonamide Chemical compound C1(CC1)NS(=O)(=O)C1=CC(=CC=C1)C=1C=C2C(=NC=1)NC(=C2)C#CCO NAGPXYIHSMZRLO-UHFFFAOYSA-N 0.000 claims 1
- PUEVQLSGRQFGPP-UHFFFAOYSA-N N-cyclopropyl-3-[2-[3-(dimethylamino)prop-1-ynyl]-1H-pyrrolo[2,3-b]pyridin-5-yl]benzenesulfonamide Chemical compound C1(CC1)NS(=O)(=O)C1=CC(=CC=C1)C=1C=C2C(=NC=1)NC(=C2)C#CCN(C)C PUEVQLSGRQFGPP-UHFFFAOYSA-N 0.000 claims 1
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims 1
- OVNJGRGEQLHHSA-UHFFFAOYSA-N N-methoxy-3-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)benzamide Chemical compound CONC(C1=CC(=CC=C1)C=1C=C2C(=NC=1)NC(=C2)C1=CC=CC=C1)=O OVNJGRGEQLHHSA-UHFFFAOYSA-N 0.000 claims 1
- RAKNXGOXIKNKPD-UHFFFAOYSA-N N-methoxy-N-methyl-3-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)benzamide Chemical compound CON(C(C1=CC(=CC=C1)C=1C=C2C(=NC=1)NC(=C2)C1=CC=CC=C1)=O)C RAKNXGOXIKNKPD-UHFFFAOYSA-N 0.000 claims 1
- WTJHUNMXHXAKOC-UHFFFAOYSA-N N-methyl-1-[6-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyridin-2-yl]sulfonylpyrrolidin-3-amine Chemical compound CNC1CN(CC1)S(=O)(=O)C1=NC(=CC=C1)C=1C=C2C(=NC=1)NC(=C2)C1=CC=CC=C1 WTJHUNMXHXAKOC-UHFFFAOYSA-N 0.000 claims 1
- RDGBHTYBYUSLFZ-UHFFFAOYSA-N N-methyl-1-[[6-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyridin-2-yl]methyl]pyrrolidin-3-amine Chemical compound CNC1CN(CC1)CC1=NC(=CC=C1)C=1C=C2C(=NC=1)NC(=C2)C1=CC=CC=C1 RDGBHTYBYUSLFZ-UHFFFAOYSA-N 0.000 claims 1
- 108010072915 NAc-Sar-Gly-Val-(d-allo-Ile)-Thr-Nva-Ile-Arg-ProNEt Proteins 0.000 claims 1
- 206010030113 Oedema Diseases 0.000 claims 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
- 239000012828 PI3K inhibitor Substances 0.000 claims 1
- 229930012538 Paclitaxel Natural products 0.000 claims 1
- 206010033701 Papillary thyroid cancer Diseases 0.000 claims 1
- 208000005228 Pericardial Effusion Diseases 0.000 claims 1
- 102000016971 Proto-Oncogene Proteins c-kit Human genes 0.000 claims 1
- 108010014608 Proto-Oncogene Proteins c-kit Proteins 0.000 claims 1
- 206010052276 Pseudodementia Diseases 0.000 claims 1
- 201000001947 Reflex Sympathetic Dystrophy Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 208000021811 Sandhoff disease Diseases 0.000 claims 1
- 206010039491 Sarcoma Diseases 0.000 claims 1
- 208000017460 Sialidosis type 2 Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 208000037913 T-cell disorder Diseases 0.000 claims 1
- 206010042971 T-cell lymphoma Diseases 0.000 claims 1
- 208000027585 T-cell non-Hodgkin lymphoma Diseases 0.000 claims 1
- NAVMQTYZDKMPEU-UHFFFAOYSA-N Targretin Chemical compound CC1=CC(C(CCC2(C)C)(C)C)=C2C=C1C(=C)C1=CC=C(C(O)=O)C=C1 NAVMQTYZDKMPEU-UHFFFAOYSA-N 0.000 claims 1
- 229940123237 Taxane Drugs 0.000 claims 1
- 208000022292 Tay-Sachs disease Diseases 0.000 claims 1
- BPEGJWRSRHCHSN-UHFFFAOYSA-N Temozolomide Chemical compound O=C1N(C)N=NC2=C(C(N)=O)N=CN21 BPEGJWRSRHCHSN-UHFFFAOYSA-N 0.000 claims 1
- FOCVUCIESVLUNU-UHFFFAOYSA-N Thiotepa Chemical compound C1CN1P(N1CC1)(=S)N1CC1 FOCVUCIESVLUNU-UHFFFAOYSA-N 0.000 claims 1
- 102000004887 Transforming Growth Factor beta Human genes 0.000 claims 1
- 108090001012 Transforming Growth Factor beta Proteins 0.000 claims 1
- 206010044565 Tremor Diseases 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 206010046798 Uterine leiomyoma Diseases 0.000 claims 1
- JXLYSJRDGCGARV-WWYNWVTFSA-N Vinblastine Natural products O=C(O[C@H]1[C@](O)(C(=O)OC)[C@@H]2N(C)c3c(cc(c(OC)c3)[C@]3(C(=O)OC)c4[nH]c5c(c4CCN4C[C@](O)(CC)C[C@H](C3)C4)cccc5)[C@@]32[C@H]2[C@@]1(CC)C=CCN2CC3)C JXLYSJRDGCGARV-WWYNWVTFSA-N 0.000 claims 1
- 208000018839 Wilson disease Diseases 0.000 claims 1
- BJILFKUFNWCMFA-GOSISDBHSA-N [(3R)-3-(methylamino)pyrrolidin-1-yl]-[5-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)thiophen-2-yl]methanone Chemical compound CN[C@H]1CN(CC1)C(=O)C=1SC(=CC=1)C=1C=C2C(=NC=1)NC(=C2)C1=CC=CC=C1 BJILFKUFNWCMFA-GOSISDBHSA-N 0.000 claims 1
- JGKBORLDNDLWOG-LJQANCHMSA-N [(3R)-3-(methylamino)pyrrolidin-1-yl]-[6-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyridin-2-yl]methanone Chemical compound CN[C@H]1CN(CC1)C(=O)C1=NC(=CC=C1)C=1C=C2C(=NC=1)NC(=C2)C1=CC=CC=C1 JGKBORLDNDLWOG-LJQANCHMSA-N 0.000 claims 1
- JGKBORLDNDLWOG-IBGZPJMESA-N [(3S)-3-(methylamino)pyrrolidin-1-yl]-[6-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyridin-2-yl]methanone Chemical compound CN[C@@H]1CN(CC1)C(=O)C1=NC(=CC=C1)C=1C=C2C(=NC=1)NC(=C2)C1=CC=CC=C1 JGKBORLDNDLWOG-IBGZPJMESA-N 0.000 claims 1
- NOASSQFHSZANSW-INIZCTEOSA-N [(3S)-3-aminopyrrolidin-1-yl]-[2-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-1,3-thiazol-4-yl]methanone Chemical compound N[C@@H]1CN(CC1)C(=O)C=1N=C(SC=1)C=1C=C2C(=NC=1)NC(=C2)C1=CC=CC=C1 NOASSQFHSZANSW-INIZCTEOSA-N 0.000 claims 1
- JEUYSYQACAZIHS-NRFANRHFSA-N [(3S)-3-aminopyrrolidin-1-yl]-[3-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl]methanone Chemical compound N[C@@H]1CN(CC1)C(=O)C1=CC(=CC=C1)C=1C=C2C(=NC=1)NC(=C2)C1=CC=CC=C1 JEUYSYQACAZIHS-NRFANRHFSA-N 0.000 claims 1
- FIFBAMUXPKKTMG-IBGZPJMESA-N [(3S)-3-aminopyrrolidin-1-yl]-[4-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyridin-2-yl]methanone Chemical compound N[C@@H]1CN(CC1)C(=O)C1=NC=CC(=C1)C=1C=C2C(=NC=1)NC(=C2)C1=CC=CC=C1 FIFBAMUXPKKTMG-IBGZPJMESA-N 0.000 claims 1
- WOHCIGMBCLQWKK-INIZCTEOSA-N [(3S)-3-aminopyrrolidin-1-yl]-[5-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-1,3-thiazol-2-yl]methanone Chemical compound N[C@@H]1CN(CC1)C(=O)C=1SC(=CN=1)C=1C=C2C(=NC=1)NC(=C2)C1=CC=CC=C1 WOHCIGMBCLQWKK-INIZCTEOSA-N 0.000 claims 1
- DIHXKBNLZNOQRS-SFHVURJKSA-N [(3S)-3-aminopyrrolidin-1-yl]-[6-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyridin-2-yl]methanone Chemical compound N[C@@H]1CN(CC1)C(=O)C1=NC(=CC=C1)C=1C=C2C(=NC=1)NC(=C2)C1=CC=CC=C1 DIHXKBNLZNOQRS-SFHVURJKSA-N 0.000 claims 1
- LUJZZYWHBDHDQX-QFIPXVFZSA-N [(3s)-morpholin-3-yl]methyl n-[4-[[1-[(3-fluorophenyl)methyl]indazol-5-yl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]carbamate Chemical compound C=1N2N=CN=C(NC=3C=C4C=NN(CC=5C=C(F)C=CC=5)C4=CC=3)C2=C(C)C=1NC(=O)OC[C@@H]1COCCN1 LUJZZYWHBDHDQX-QFIPXVFZSA-N 0.000 claims 1
- NTEUKAGVAGOPJZ-JOCHJYFZSA-N [(7S)-7-amino-5-azaspiro[2.4]heptan-5-yl]-[6-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyridin-2-yl]methanone Chemical compound N[C@@H]1CN(CC11CC1)C(=O)C1=NC(=CC=C1)C=1C=C2C(=NC=1)NC(=C2)C1=CC=CC=C1 NTEUKAGVAGOPJZ-JOCHJYFZSA-N 0.000 claims 1
- BNQOIWGXUVOYBQ-UHFFFAOYSA-N [3-(cyclopropylamino)pyrrolidin-1-yl]-[6-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyridin-2-yl]methanone Chemical compound C1(CC1)NC1CN(CC1)C(=O)C1=NC(=CC=C1)C=1C=C2C(=NC=1)NC(=C2)C1=CC=CC=C1 BNQOIWGXUVOYBQ-UHFFFAOYSA-N 0.000 claims 1
- VPDJRWXBZJWAGN-UHFFFAOYSA-N [3-(dimethylamino)pyrrolidin-1-yl]-[6-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyridin-2-yl]methanone Chemical compound CN(C1CN(CC1)C(=O)C1=NC(=CC=C1)C=1C=C2C(=NC=1)NC(=C2)C1=CC=CC=C1)C VPDJRWXBZJWAGN-UHFFFAOYSA-N 0.000 claims 1
- HBJKVKUUKRDDND-UHFFFAOYSA-N [3-(methylamino)azetidin-1-yl]-[6-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyridin-2-yl]methanone Chemical compound CNC1CN(C1)C(=O)C1=NC(=CC=C1)C=1C=C2C(=NC=1)NC(=C2)C1=CC=CC=C1 HBJKVKUUKRDDND-UHFFFAOYSA-N 0.000 claims 1
- GYAAWDZJYHOLKY-UHFFFAOYSA-N [3-(methylamino)piperidin-1-yl]-[6-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyridin-2-yl]methanone Chemical compound CNC1CN(CCC1)C(=O)C1=NC(=CC=C1)C=1C=C2C(=NC=1)NC(=C2)C1=CC=CC=C1 GYAAWDZJYHOLKY-UHFFFAOYSA-N 0.000 claims 1
- WSFNFABNFHUSTL-UHFFFAOYSA-N [3-(methylamino)pyrrolidin-1-yl]-[5-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-indazol-3-yl]methanone Chemical compound CNC1CN(CC1)C(=O)C1=NNC2=CC=C(C=C12)C=1C=C2C(=NC=1)NC(=C2)C1=CC=CC=C1 WSFNFABNFHUSTL-UHFFFAOYSA-N 0.000 claims 1
- JGKBORLDNDLWOG-UHFFFAOYSA-N [3-(methylamino)pyrrolidin-1-yl]-[6-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyridin-2-yl]methanone Chemical compound CNC1CN(CC1)C(=O)C1=NC(=CC=C1)C=1C=C2C(=NC=1)NC(=C2)C1=CC=CC=C1 JGKBORLDNDLWOG-UHFFFAOYSA-N 0.000 claims 1
- GZOLDMZAXRMITF-UHFFFAOYSA-N [3-(methylamino)pyrrolidin-1-yl]-[6-[2-[1-(2,2,2-trifluoroethyl)pyrazol-4-yl]-1H-pyrrolo[2,3-b]pyridin-5-yl]pyridin-2-yl]methanone Chemical compound CNC1CN(CC1)C(=O)C1=NC(=CC=C1)C=1C=C2C(=NC=1)NC(=C2)C=1C=NN(C=1)CC(F)(F)F GZOLDMZAXRMITF-UHFFFAOYSA-N 0.000 claims 1
- CUXKHRHTHRAINF-UHFFFAOYSA-N [3-(methylaminomethyl)pyrrolidin-1-yl]-[6-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyridin-2-yl]methanone Chemical compound CNCC1CN(CC1)C(=O)C1=NC(=CC=C1)C=1C=C2C(=NC=1)NC(=C2)C1=CC=CC=C1 CUXKHRHTHRAINF-UHFFFAOYSA-N 0.000 claims 1
- KEKQWWWOPAHITC-UHFFFAOYSA-N [3-[5-[3-(4-aminopiperidine-1-carbonyl)-1H-indazol-5-yl]-1H-pyrrolo[2,3-b]pyridin-2-yl]-2,5-dihydropyrrol-1-yl]-cyclopropylmethanone Chemical compound NC1CCN(CC1)C(=O)C1=NNC2=CC=C(C=C12)C=1C=C2C(=NC=1)NC(=C2)C=1CN(CC=1)C(=O)C1CC1 KEKQWWWOPAHITC-UHFFFAOYSA-N 0.000 claims 1
- XPEKKXJUWCQCTP-UHFFFAOYSA-N [3-amino-3-(trifluoromethyl)pyrrolidin-1-yl]-[6-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyridin-2-yl]methanone Chemical compound NC1(CN(CC1)C(=O)C1=NC(=CC=C1)C=1C=C2C(=NC=1)NC(=C2)C1=CC=CC=C1)C(F)(F)F XPEKKXJUWCQCTP-UHFFFAOYSA-N 0.000 claims 1
- ADENLUQCJQAJHB-UHFFFAOYSA-N [4-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl]urea Chemical compound C1(=CC=CC=C1)C1=CC=2C(=NC=C(C=2)C2=CC=C(C=C2)NC(=O)N)N1 ADENLUQCJQAJHB-UHFFFAOYSA-N 0.000 claims 1
- XIUXKTINOKHBTF-UHFFFAOYSA-N [4-(aminomethyl)piperidin-1-yl]-[6-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyridin-2-yl]methanone Chemical compound NCC1CCN(CC1)C(=O)C1=NC(=CC=C1)C=1C=C2C(=NC=1)NC(=C2)C1=CC=CC=C1 XIUXKTINOKHBTF-UHFFFAOYSA-N 0.000 claims 1
- VTJFISLOQWXZHS-UHFFFAOYSA-N [4-(hydroxymethyl)piperidin-1-yl]-[6-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyridin-2-yl]methanone Chemical compound OCC1CCN(CC1)C(=O)C1=NC(=CC=C1)C=1C=C2C(=NC=1)NC(=C2)C1=CC=CC=C1 VTJFISLOQWXZHS-UHFFFAOYSA-N 0.000 claims 1
- FLTQXGJXLXGWFY-UHFFFAOYSA-N [4-(methylamino)piperidin-1-yl]-[5-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-indazol-3-yl]methanone Chemical compound CNC1CCN(CC1)C(=O)C1=NNC2=CC=C(C=C12)C=1C=C2C(=NC=1)NC(=C2)C1=CC=CC=C1 FLTQXGJXLXGWFY-UHFFFAOYSA-N 0.000 claims 1
- TUGDGWOCELORHH-UHFFFAOYSA-N [4-(methylamino)piperidin-1-yl]-[6-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyridin-2-yl]methanone Chemical compound CNC1CCN(CC1)C(=O)C1=NC(=CC=C1)C=1C=C2C(=NC=1)NC(=C2)C1=CC=CC=C1 TUGDGWOCELORHH-UHFFFAOYSA-N 0.000 claims 1
- RUPMDPVWCQPMCE-UHFFFAOYSA-N [6-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyridin-2-yl]-[3-(trifluoromethyl)pyrrolidin-1-yl]methanone Chemical compound C1(=CC=CC=C1)C1=CC=2C(=NC=C(C=2)C2=CC=CC(=N2)C(=O)N2CC(CC2)C(F)(F)F)N1 RUPMDPVWCQPMCE-UHFFFAOYSA-N 0.000 claims 1
- GBOMBHDTOPPUIU-UHFFFAOYSA-N [6-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyridin-2-yl]-piperidin-4-ylmethanone Chemical compound C1(=CC=CC=C1)C1=CC=2C(=NC=C(C=2)C2=CC=CC(=N2)C(=O)C2CCNCC2)N1 GBOMBHDTOPPUIU-UHFFFAOYSA-N 0.000 claims 1
- ORRZOIVNXKQKEL-UHFFFAOYSA-N [6-[2-(2-methoxypyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl]pyridin-2-yl]-[3-(methylamino)pyrrolidin-1-yl]methanone Chemical compound COC1=NC=CC(=C1)C1=CC=2C(=NC=C(C=2)C2=CC=CC(=N2)C(=O)N2CC(CC2)NC)N1 ORRZOIVNXKQKEL-UHFFFAOYSA-N 0.000 claims 1
- DPTZUZYDGUSPBZ-UHFFFAOYSA-N [6-[2-(4-fluorophenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]pyridin-2-yl]-[3-(methylamino)pyrrolidin-1-yl]methanone Chemical compound FC1=CC=C(C=C1)C1=CC=2C(=NC=C(C=2)C2=CC=CC(=N2)C(=O)N2CC(CC2)NC)N1 DPTZUZYDGUSPBZ-UHFFFAOYSA-N 0.000 claims 1
- 210000001015 abdomen Anatomy 0.000 claims 1
- 238000002679 ablation Methods 0.000 claims 1
- RJURFGZVJUQBHK-IIXSONLDSA-N actinomycin D Chemical compound C[C@H]1OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@@H]2CCCN2C(=O)[C@@H](C(C)C)NC(=O)[C@H]1NC(=O)C1=C(N)C(=O)C(C)=C2OC(C(C)=CC=C3C(=O)N[C@@H]4C(=O)N[C@@H](C(N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)=O)C(C)C)=C3N=C21 RJURFGZVJUQBHK-IIXSONLDSA-N 0.000 claims 1
- 201000007930 alcohol dependence Diseases 0.000 claims 1
- 229960000548 alemtuzumab Drugs 0.000 claims 1
- 229960001445 alitretinoin Drugs 0.000 claims 1
- 229930013930 alkaloid Natural products 0.000 claims 1
- 150000003797 alkaloid derivatives Chemical class 0.000 claims 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 1
- 125000000278 alkyl amino alkyl group Chemical group 0.000 claims 1
- 125000003282 alkyl amino group Chemical group 0.000 claims 1
- 125000004471 alkyl aminosulfonyl group Chemical group 0.000 claims 1
- 125000004688 alkyl sulfonyl alkyl group Chemical group 0.000 claims 1
- 229940100198 alkylating agent Drugs 0.000 claims 1
- 239000002168 alkylating agent Substances 0.000 claims 1
- SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 claims 1
- 201000008333 alpha-mannosidosis Diseases 0.000 claims 1
- 229960000473 altretamine Drugs 0.000 claims 1
- 125000005097 aminocarbonylalkyl group Chemical group 0.000 claims 1
- ROBVIMPUHSLWNV-UHFFFAOYSA-N aminoglutethimide Chemical compound C=1C=C(N)C=CC=1C1(CC)CCC(=O)NC1=O ROBVIMPUHSLWNV-UHFFFAOYSA-N 0.000 claims 1
- 229960003437 aminoglutethimide Drugs 0.000 claims 1
- 229960001220 amsacrine Drugs 0.000 claims 1
- XCPGHVQEEXUHNC-UHFFFAOYSA-N amsacrine Chemical compound COC1=CC(NS(C)(=O)=O)=CC=C1NC1=C(C=CC=C2)C2=NC2=CC=CC=C12 XCPGHVQEEXUHNC-UHFFFAOYSA-N 0.000 claims 1
- 229960001694 anagrelide Drugs 0.000 claims 1
- OTBXOEAOVRKTNQ-UHFFFAOYSA-N anagrelide Chemical compound N1=C2NC(=O)CN2CC2=C(Cl)C(Cl)=CC=C21 OTBXOEAOVRKTNQ-UHFFFAOYSA-N 0.000 claims 1
- 239000003098 androgen Substances 0.000 claims 1
- 229940030486 androgens Drugs 0.000 claims 1
- 239000004037 angiogenesis inhibitor Substances 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 239000002260 anti-inflammatory agent Substances 0.000 claims 1
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 1
- 230000000340 anti-metabolite Effects 0.000 claims 1
- 230000001028 anti-proliverative effect Effects 0.000 claims 1
- 229940100197 antimetabolite Drugs 0.000 claims 1
- 239000002256 antimetabolite Substances 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 239000003886 aromatase inhibitor Substances 0.000 claims 1
- 125000003710 aryl alkyl group Chemical group 0.000 claims 1
- 125000000732 arylene group Chemical group 0.000 claims 1
- 210000003567 ascitic fluid Anatomy 0.000 claims 1
- 229960003272 asparaginase Drugs 0.000 claims 1
- DCXYFEDJOCDNAF-UHFFFAOYSA-M asparaginate Chemical compound [O-]C(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-M 0.000 claims 1
- 229950010993 atrasentan Drugs 0.000 claims 1
- MOTJMGVDPWRKOC-QPVYNBJUSA-N atrasentan Chemical compound C1([C@H]2[C@@H]([C@H](CN2CC(=O)N(CCCC)CCCC)C=2C=C3OCOC3=CC=2)C(O)=O)=CC=C(OC)C=C1 MOTJMGVDPWRKOC-QPVYNBJUSA-N 0.000 claims 1
- 229960003005 axitinib Drugs 0.000 claims 1
- RITAVMQDGBJQJZ-FMIVXFBMSA-N axitinib Chemical compound CNC(=O)C1=CC=CC=C1SC1=CC=C(C(\C=C\C=2N=CC=CC=2)=NN2)C2=C1 RITAVMQDGBJQJZ-FMIVXFBMSA-N 0.000 claims 1
- 229960002756 azacitidine Drugs 0.000 claims 1
- VSRXQHXAPYXROS-UHFFFAOYSA-N azanide;cyclobutane-1,1-dicarboxylic acid;platinum(2+) Chemical compound [NH2-].[NH2-].[Pt+2].OC(=O)C1(C(O)=O)CCC1 VSRXQHXAPYXROS-UHFFFAOYSA-N 0.000 claims 1
- 125000004567 azetidin-3-yl group Chemical group N1CC(C1)* 0.000 claims 1
- SQVRNKJHWKZAKO-UHFFFAOYSA-N beta-N-Acetyl-D-neuraminic acid Natural products CC(=O)NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO SQVRNKJHWKZAKO-UHFFFAOYSA-N 0.000 claims 1
- 229960000397 bevacizumab Drugs 0.000 claims 1
- 229960002938 bexarotene Drugs 0.000 claims 1
- 230000003115 biocidal effect Effects 0.000 claims 1
- 230000008512 biological response Effects 0.000 claims 1
- 229960001561 bleomycin Drugs 0.000 claims 1
- OYVAGSVQBOHSSS-UAPAGMARSA-O bleomycin A2 Chemical compound N([C@H](C(=O)N[C@H](C)[C@@H](O)[C@H](C)C(=O)N[C@@H]([C@H](O)C)C(=O)NCCC=1SC=C(N=1)C=1SC=C(N=1)C(=O)NCCC[S+](C)C)[C@@H](O[C@H]1[C@H]([C@@H](O)[C@H](O)[C@H](CO)O1)O[C@@H]1[C@H]([C@@H](OC(N)=O)[C@H](O)[C@@H](CO)O1)O)C=1N=CNC=1)C(=O)C1=NC([C@H](CC(N)=O)NC[C@H](N)C(N)=O)=NC(N)=C1C OYVAGSVQBOHSSS-UAPAGMARSA-O 0.000 claims 1
- 210000000988 bone and bone Anatomy 0.000 claims 1
- GXJABQQUPOEUTA-RDJZCZTQSA-N bortezomib Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)B(O)O)NC(=O)C=1N=CC=NC=1)C1=CC=CC=C1 GXJABQQUPOEUTA-RDJZCZTQSA-N 0.000 claims 1
- 229960001467 bortezomib Drugs 0.000 claims 1
- 229960005539 bryostatin 1 Drugs 0.000 claims 1
- MJQUEDHRCUIRLF-TVIXENOKSA-N bryostatin 1 Chemical compound C([C@@H]1CC(/[C@@H]([C@@](C(C)(C)/C=C/2)(O)O1)OC(=O)/C=C/C=C/CCC)=C\C(=O)OC)[C@H]([C@@H](C)O)OC(=O)C[C@H](O)C[C@@H](O1)C[C@H](OC(C)=O)C(C)(C)[C@]1(O)C[C@@H]1C\C(=C\C(=O)OC)C[C@H]\2O1 MJQUEDHRCUIRLF-TVIXENOKSA-N 0.000 claims 1
- CUWODFFVMXJOKD-UVLQAERKSA-N buserelin Chemical compound CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](COC(C)(C)C)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H]1NC(=O)CC1)CC1=CC=C(O)C=C1 CUWODFFVMXJOKD-UVLQAERKSA-N 0.000 claims 1
- 229960002719 buserelin Drugs 0.000 claims 1
- 229960002092 busulfan Drugs 0.000 claims 1
- 229960004117 capecitabine Drugs 0.000 claims 1
- 229960004562 carboplatin Drugs 0.000 claims 1
- 201000011529 cardiovascular cancer Diseases 0.000 claims 1
- 229960005243 carmustine Drugs 0.000 claims 1
- 206010008129 cerebral palsy Diseases 0.000 claims 1
- 229960005395 cetuximab Drugs 0.000 claims 1
- 229960004630 chlorambucil Drugs 0.000 claims 1
- JCKYGMPEJWAADB-UHFFFAOYSA-N chlorambucil Chemical compound OC(=O)CCCC1=CC=C(N(CCCl)CCCl)C=C1 JCKYGMPEJWAADB-UHFFFAOYSA-N 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 208000007118 chronic progressive multiple sclerosis Diseases 0.000 claims 1
- 229960004316 cisplatin Drugs 0.000 claims 1
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 claims 1
- 229960002436 cladribine Drugs 0.000 claims 1
- 229960002271 cobimetinib Drugs 0.000 claims 1
- RESIMIUSNACMNW-BXRWSSRYSA-N cobimetinib fumarate Chemical compound OC(=O)\C=C\C(O)=O.C1C(O)([C@H]2NCCCC2)CN1C(=O)C1=CC=C(F)C(F)=C1NC1=CC=C(I)C=C1F.C1C(O)([C@H]2NCCCC2)CN1C(=O)C1=CC=C(F)C(F)=C1NC1=CC=C(I)C=C1F RESIMIUSNACMNW-BXRWSSRYSA-N 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 125000004966 cyanoalkyl group Chemical group 0.000 claims 1
- 125000000596 cyclohexenyl group Chemical group C1(=CCCCC1)* 0.000 claims 1
- 229960004397 cyclophosphamide Drugs 0.000 claims 1
- 229960000684 cytarabine Drugs 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 229960002465 dabrafenib Drugs 0.000 claims 1
- BFSMGDJOXZAERB-UHFFFAOYSA-N dabrafenib Chemical compound S1C(C(C)(C)C)=NC(C=2C(=C(NS(=O)(=O)C=3C(=CC=CC=3F)F)C=CC=2)F)=C1C1=CC=NC(N)=N1 BFSMGDJOXZAERB-UHFFFAOYSA-N 0.000 claims 1
- 229960003901 dacarbazine Drugs 0.000 claims 1
- 229960000640 dactinomycin Drugs 0.000 claims 1
- 229960002448 dasatinib Drugs 0.000 claims 1
- 229960000975 daunorubicin Drugs 0.000 claims 1
- STQGQHZAVUOBTE-VGBVRHCVSA-N daunorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(C)=O)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 STQGQHZAVUOBTE-VGBVRHCVSA-N 0.000 claims 1
- 229960003603 decitabine Drugs 0.000 claims 1
- LRCZQSDQZJBHAF-PUBGEWHCSA-N dha-paclitaxel Chemical compound N([C@H]([C@@H](OC(=O)CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CC)C(=O)O[C@@H]1C(=C2[C@@H](OC(C)=O)C(=O)[C@]3(C)[C@@H](O)C[C@H]4OC[C@]4([C@H]3[C@H](OC(=O)C=3C=CC=CC=3)[C@](C2(C)C)(O)C1)OC(C)=O)C)C=1C=CC=CC=1)C(=O)C1=CC=CC=C1 LRCZQSDQZJBHAF-PUBGEWHCSA-N 0.000 claims 1
- 125000004663 dialkyl amino group Chemical group 0.000 claims 1
- RGLYKWWBQGJZGM-ISLYRVAYSA-N diethylstilbestrol Chemical compound C=1C=C(O)C=CC=1C(/CC)=C(\CC)C1=CC=C(O)C=C1 RGLYKWWBQGJZGM-ISLYRVAYSA-N 0.000 claims 1
- 229960000452 diethylstilbestrol Drugs 0.000 claims 1
- 125000001028 difluoromethyl group Chemical group [H]C(F)(F)* 0.000 claims 1
- 125000005043 dihydropyranyl group Chemical group O1C(CCC=C1)* 0.000 claims 1
- 125000005054 dihydropyrrolyl group Chemical group [H]C1=C([H])C([H])([H])C([H])([H])N1* 0.000 claims 1
- 239000003534 dna topoisomerase inhibitor Substances 0.000 claims 1
- 229960003668 docetaxel Drugs 0.000 claims 1
- 229960004679 doxorubicin Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 229950001287 edotecarin Drugs 0.000 claims 1
- 229940121647 egfr inhibitor Drugs 0.000 claims 1
- 229960001904 epirubicin Drugs 0.000 claims 1
- 229960000439 eribulin mesylate Drugs 0.000 claims 1
- QAMYWGZHLCQOOJ-PWIVHLLHSA-N eribulin mesylate Chemical compound CS(O)(=O)=O.C([C@H]1CC[C@@H]2O[C@@H]3[C@H]4O[C@H]5C[C@](O[C@H]4[C@H]2O1)(O[C@@H]53)CC[C@@H]1O[C@H](C(C1)=C)CC1)C(=O)C[C@@H]2[C@@H](OC)[C@@H](C[C@H](O)CN)O[C@H]2C[C@@H]2C(=C)[C@H](C)C[C@H]1O2 QAMYWGZHLCQOOJ-PWIVHLLHSA-N 0.000 claims 1
- 229960001433 erlotinib Drugs 0.000 claims 1
- AAKJLRGGTJKAMG-UHFFFAOYSA-N erlotinib Chemical compound C=12C=C(OCCOC)C(OCCOC)=CC2=NC=NC=1NC1=CC=CC(C#C)=C1 AAKJLRGGTJKAMG-UHFFFAOYSA-N 0.000 claims 1
- 201000004101 esophageal cancer Diseases 0.000 claims 1
- 125000005677 ethinylene group Chemical group [*:2]C#C[*:1] 0.000 claims 1
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- VJJPUSNTGOMMGY-MRVIYFEKSA-N etoposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@H](C)OC[C@H]4O3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 VJJPUSNTGOMMGY-MRVIYFEKSA-N 0.000 claims 1
- 229960005420 etoposide Drugs 0.000 claims 1
- 229950009429 exatecan Drugs 0.000 claims 1
- ZVYVPGLRVWUPMP-FYSMJZIKSA-N exatecan Chemical compound C1C[C@H](N)C2=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC3=CC(F)=C(C)C1=C32 ZVYVPGLRVWUPMP-FYSMJZIKSA-N 0.000 claims 1
- 206010016629 fibroma Diseases 0.000 claims 1
- 230000004761 fibrosis Effects 0.000 claims 1
- 229960000961 floxuridine Drugs 0.000 claims 1
- ODKNJVUHOIMIIZ-RRKCRQDMSA-N floxuridine Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(F)=C1 ODKNJVUHOIMIIZ-RRKCRQDMSA-N 0.000 claims 1
- 229960000390 fludarabine Drugs 0.000 claims 1
- GIUYCYHIANZCFB-FJFJXFQQSA-N fludarabine phosphate Chemical compound C1=NC=2C(N)=NC(F)=NC=2N1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]1O GIUYCYHIANZCFB-FJFJXFQQSA-N 0.000 claims 1
- 229910052731 fluorine Inorganic materials 0.000 claims 1
- 239000011737 fluorine Substances 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 229960002949 fluorouracil Drugs 0.000 claims 1
- MKXKFYHWDHIYRV-UHFFFAOYSA-N flutamide Chemical compound CC(C)C(=O)NC1=CC=C([N+]([O-])=O)C(C(F)(F)F)=C1 MKXKFYHWDHIYRV-UHFFFAOYSA-N 0.000 claims 1
- 229960002074 flutamide Drugs 0.000 claims 1
- 229960002258 fulvestrant Drugs 0.000 claims 1
- 229950001109 galiximab Drugs 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 229960002584 gefitinib Drugs 0.000 claims 1
- XGALLCVXEZPNRQ-UHFFFAOYSA-N gefitinib Chemical compound C=12C=C(OCCCN3CCOCC3)C(OC)=CC2=NC=NC=1NC1=CC=C(F)C(Cl)=C1 XGALLCVXEZPNRQ-UHFFFAOYSA-N 0.000 claims 1
- QTQAWLPCGQOSGP-GBTDJJJQSA-N geldanamycin Chemical compound N1C(=O)\C(C)=C/C=C\[C@@H](OC)[C@H](OC(N)=O)\C(C)=C/[C@@H](C)[C@@H](O)[C@H](OC)C[C@@H](C)CC2=C(OC)C(=O)C=C1C2=O QTQAWLPCGQOSGP-GBTDJJJQSA-N 0.000 claims 1
- 229960005277 gemcitabine Drugs 0.000 claims 1
- SDUQYLNIPVEERB-QPPQHZFASA-N gemcitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 claims 1
- 229960000578 gemtuzumab Drugs 0.000 claims 1
- 230000000762 glandular Effects 0.000 claims 1
- 229940096919 glycogen Drugs 0.000 claims 1
- 201000004502 glycogen storage disease II Diseases 0.000 claims 1
- 229960002913 goserelin Drugs 0.000 claims 1
- 239000003481 heat shock protein 90 inhibitor Substances 0.000 claims 1
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims 1
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims 1
- 125000005549 heteroarylene group Chemical group 0.000 claims 1
- 125000006588 heterocycloalkylene group Chemical group 0.000 claims 1
- UUVWYPNAQBNQJQ-UHFFFAOYSA-N hexamethylmelamine Chemical compound CN(C)C1=NC(N(C)C)=NC(N(C)C)=N1 UUVWYPNAQBNQJQ-UHFFFAOYSA-N 0.000 claims 1
- 229940088597 hormone Drugs 0.000 claims 1
- 239000005556 hormone Substances 0.000 claims 1
- 239000003667 hormone antagonist Substances 0.000 claims 1
- 208000003906 hydrocephalus Diseases 0.000 claims 1
- 229960000908 idarubicin Drugs 0.000 claims 1
- 229950002248 idoxifene Drugs 0.000 claims 1
- 229960001101 ifosfamide Drugs 0.000 claims 1
- HOMGKSMUEGBAAB-UHFFFAOYSA-N ifosfamide Chemical compound ClCCNP1(=O)OCCCN1CCCl HOMGKSMUEGBAAB-UHFFFAOYSA-N 0.000 claims 1
- 229960003685 imatinib mesylate Drugs 0.000 claims 1
- YLMAHDNUQAMNNX-UHFFFAOYSA-N imatinib methanesulfonate Chemical compound CS(O)(=O)=O.C1CN(C)CCN1CC1=CC=C(C(=O)NC=2C=C(NC=3N=C(C=CN=3)C=3C=NC=CC=3)C(C)=CC=2)C=C1 YLMAHDNUQAMNNX-UHFFFAOYSA-N 0.000 claims 1
- 125000002883 imidazolyl group Chemical group 0.000 claims 1
- DOUYETYNHWVLEO-UHFFFAOYSA-N imiquimod Chemical compound C1=CC=CC2=C3N(CC(C)C)C=NC3=C(N)N=C21 DOUYETYNHWVLEO-UHFFFAOYSA-N 0.000 claims 1
- 229960002751 imiquimod Drugs 0.000 claims 1
- 230000002519 immonomodulatory effect Effects 0.000 claims 1
- 229940125721 immunosuppressive agent Drugs 0.000 claims 1
- 239000003018 immunosuppressive agent Substances 0.000 claims 1
- 230000001771 impaired effect Effects 0.000 claims 1
- 229950008097 improsulfan Drugs 0.000 claims 1
- DBIGHPPNXATHOF-UHFFFAOYSA-N improsulfan Chemical compound CS(=O)(=O)OCCCNCCCOS(C)(=O)=O DBIGHPPNXATHOF-UHFFFAOYSA-N 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 230000002757 inflammatory effect Effects 0.000 claims 1
- 229960004768 irinotecan Drugs 0.000 claims 1
- UWKQSNNFCGGAFS-XIFFEERXSA-N irinotecan Chemical compound C1=C2C(CC)=C3CN(C(C4=C([C@@](C(=O)OC4)(O)CC)C=4)=O)C=4C3=NC2=CC=C1OC(=O)N(CC1)CCC1N1CCCCC1 UWKQSNNFCGGAFS-XIFFEERXSA-N 0.000 claims 1
- 229950005254 irofulven Drugs 0.000 claims 1
- NICJCIQSJJKZAH-AWEZNQCLSA-N irofulven Chemical compound O=C([C@@]1(O)C)C2=CC(C)=C(CO)C2=C(C)C21CC2 NICJCIQSJJKZAH-AWEZNQCLSA-N 0.000 claims 1
- 125000004594 isoindolinyl group Chemical group C1(NCC2=CC=CC=C12)* 0.000 claims 1
- 229960005280 isotretinoin Drugs 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 229940043355 kinase inhibitor Drugs 0.000 claims 1
- 229960004891 lapatinib Drugs 0.000 claims 1
- BCFGMOOMADDAQU-UHFFFAOYSA-N lapatinib Chemical compound O1C(CNCCS(=O)(=O)C)=CC=C1C1=CC=C(N=CN=C2NC=3C=C(Cl)C(OCC=4C=C(F)C=CC=4)=CC=3)C2=C1 BCFGMOOMADDAQU-UHFFFAOYSA-N 0.000 claims 1
- 201000005264 laryngeal carcinoma Diseases 0.000 claims 1
- 201000010260 leiomyoma Diseases 0.000 claims 1
- GOTYRUGSSMKFNF-UHFFFAOYSA-N lenalidomide Chemical compound C1C=2C(N)=CC=CC=2C(=O)N1C1CCC(=O)NC1=O GOTYRUGSSMKFNF-UHFFFAOYSA-N 0.000 claims 1
- 229960004942 lenalidomide Drugs 0.000 claims 1
- GFIJNRVAKGFPGQ-LIJARHBVSA-N leuprolide Chemical compound CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)CC1=CC=C(O)C=C1 GFIJNRVAKGFPGQ-LIJARHBVSA-N 0.000 claims 1
- 229960004338 leuprorelin Drugs 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 229960002247 lomustine Drugs 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 229940124302 mTOR inhibitor Drugs 0.000 claims 1
- 230000036210 malignancy Effects 0.000 claims 1
- 239000003628 mammalian target of rapamycin inhibitor Substances 0.000 claims 1
- 229960004961 mechlorethamine Drugs 0.000 claims 1
- HAWPXGHAZFHHAD-UHFFFAOYSA-N mechlorethamine Chemical compound ClCCN(C)CCCl HAWPXGHAZFHHAD-UHFFFAOYSA-N 0.000 claims 1
- 208000023356 medullary thyroid gland carcinoma Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 229960001924 melphalan Drugs 0.000 claims 1
- SGDBTWWWUNNDEQ-LBPRGKRZSA-N melphalan Chemical compound OC(=O)[C@@H](N)CC1=CC=C(N(CCCl)CCCl)C=C1 SGDBTWWWUNNDEQ-LBPRGKRZSA-N 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 206010027175 memory impairment Diseases 0.000 claims 1
- 229950002676 menogaril Drugs 0.000 claims 1
- LWYJUZBXGAFFLP-OCNCTQISSA-N menogaril Chemical compound O1[C@@]2(C)[C@H](O)[C@@H](N(C)C)[C@H](O)[C@@H]1OC1=C3C(=O)C(C=C4C[C@@](C)(O)C[C@H](C4=C4O)OC)=C4C(=O)C3=C(O)C=C12 LWYJUZBXGAFFLP-OCNCTQISSA-N 0.000 claims 1
- GLVAUDGFNGKCSF-UHFFFAOYSA-N mercaptopurine Chemical compound S=C1NC=NC2=C1NC=N2 GLVAUDGFNGKCSF-UHFFFAOYSA-N 0.000 claims 1
- 229960001428 mercaptopurine Drugs 0.000 claims 1
- 229960000485 methotrexate Drugs 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 1
- CFCUWKMKBJTWLW-BKHRDMLASA-N mithramycin Chemical compound O([C@@H]1C[C@@H](O[C@H](C)[C@H]1O)OC=1C=C2C=C3C[C@H]([C@@H](C(=O)C3=C(O)C2=C(O)C=1C)O[C@@H]1O[C@H](C)[C@@H](O)[C@H](O[C@@H]2O[C@H](C)[C@H](O)[C@H](O[C@@H]3O[C@H](C)[C@@H](O)[C@@](C)(O)C3)C2)C1)[C@H](OC)C(=O)[C@@H](O)[C@@H](C)O)[C@H]1C[C@@H](O)[C@H](O)[C@@H](C)O1 CFCUWKMKBJTWLW-BKHRDMLASA-N 0.000 claims 1
- 239000002829 mitogen activated protein kinase inhibitor Substances 0.000 claims 1
- 229960004857 mitomycin Drugs 0.000 claims 1
- 229960001156 mitoxantrone Drugs 0.000 claims 1
- KKZJGLLVHKMTCM-UHFFFAOYSA-N mitoxantrone Chemical compound O=C1C2=C(O)C=CC(O)=C2C(=O)C2=C1C(NCCNCCO)=CC=C2NCCNCCO KKZJGLLVHKMTCM-UHFFFAOYSA-N 0.000 claims 1
- 239000003607 modifier Substances 0.000 claims 1
- 201000006894 monocytic leukemia Diseases 0.000 claims 1
- RAHBGWKEPAQNFF-UHFFFAOYSA-N motesanib Chemical compound C=1C=C2C(C)(C)CNC2=CC=1NC(=O)C1=CC=CN=C1NCC1=CC=NC=C1 RAHBGWKEPAQNFF-UHFFFAOYSA-N 0.000 claims 1
- 201000007769 mucolipidosis Diseases 0.000 claims 1
- 201000006938 muscular dystrophy Diseases 0.000 claims 1
- LBWFXVZLPYTWQI-IPOVEDGCSA-N n-[2-(diethylamino)ethyl]-5-[(z)-(5-fluoro-2-oxo-1h-indol-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide;(2s)-2-hydroxybutanedioic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O.CCN(CC)CCNC(=O)C1=C(C)NC(\C=C/2C3=CC(F)=CC=C3NC\2=O)=C1C LBWFXVZLPYTWQI-IPOVEDGCSA-N 0.000 claims 1
- 229960000801 nelarabine Drugs 0.000 claims 1
- IXOXBSCIXZEQEQ-UHTZMRCNSA-N nelarabine Chemical compound C1=NC=2C(OC)=NC(N)=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1O IXOXBSCIXZEQEQ-UHTZMRCNSA-N 0.000 claims 1
- QZGIWPZCWHMVQL-UIYAJPBUSA-N neocarzinostatin chromophore Chemical compound O1[C@H](C)[C@H](O)[C@H](O)[C@@H](NC)[C@H]1O[C@@H]1C/2=C/C#C[C@H]3O[C@@]3([C@@H]3OC(=O)OC3)C#CC\2=C[C@H]1OC(=O)C1=C(O)C=CC2=C(C)C=C(OC)C=C12 QZGIWPZCWHMVQL-UIYAJPBUSA-N 0.000 claims 1
- HHZIURLSWUIHRB-UHFFFAOYSA-N nilotinib Chemical compound C1=NC(C)=CN1C1=CC(NC(=O)C=2C=C(NC=3N=C(C=CN=3)C=3C=NC=CC=3)C(C)=CC=2)=CC(C(F)(F)F)=C1 HHZIURLSWUIHRB-UHFFFAOYSA-N 0.000 claims 1
- 229960000435 oblimersen Drugs 0.000 claims 1
- MIMNFCVQODTQDP-NDLVEFNKSA-N oblimersen Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](COP(S)(=O)O[C@@H]2[C@H](O[C@H](C2)N2C3=NC=NC(N)=C3N=C2)COP(O)(=S)O[C@@H]2[C@H](O[C@H](C2)N2C(N=C(N)C=C2)=O)COP(O)(=S)O[C@@H]2[C@H](O[C@H](C2)N2C(N=C(N)C=C2)=O)COP(O)(=S)O[C@@H]2[C@H](O[C@H](C2)N2C3=C(C(NC(N)=N3)=O)N=C2)COP(O)(=S)O[C@@H]2[C@H](O[C@H](C2)N2C(N=C(N)C=C2)=O)COP(O)(=S)O[C@@H]2[C@H](O[C@H](C2)N2C3=C(C(NC(N)=N3)=O)N=C2)COP(O)(=S)O[C@@H]2[C@H](O[C@H](C2)N2C(NC(=O)C(C)=C2)=O)COP(O)(=S)O[C@@H]2[C@H](O[C@H](C2)N2C3=C(C(NC(N)=N3)=O)N=C2)COP(O)(=S)O[C@@H]2[C@H](O[C@H](C2)N2C(N=C(N)C=C2)=O)COP(O)(=S)O[C@@H]2[C@H](O[C@H](C2)N2C3=C(C(NC(N)=N3)=O)N=C2)COP(O)(=S)O[C@@H]2[C@H](O[C@H](C2)N2C3=NC=NC(N)=C3N=C2)COP(O)(=S)O[C@@H]2[C@H](O[C@H](C2)N2C(N=C(N)C=C2)=O)COP(O)(=S)O[C@@H]2[C@H](O[C@H](C2)N2C(N=C(N)C=C2)=O)COP(O)(=S)O[C@@H]2[C@H](O[C@H](C2)N2C(N=C(N)C=C2)=O)COP(O)(=S)O[C@@H]2[C@H](O[C@H](C2)N2C(NC(=O)C(C)=C2)=O)COP(O)(=S)O[C@@H]2[C@H](O[C@H](C2)N2C(N=C(N)C=C2)=O)COP(O)(=S)O[C@@H]2[C@H](O[C@H](C2)N2C(NC(=O)C(C)=C2)=O)CO)[C@@H](O)C1 MIMNFCVQODTQDP-NDLVEFNKSA-N 0.000 claims 1
- 229960001756 oxaliplatin Drugs 0.000 claims 1
- DWAFYCQODLXJNR-BNTLRKBRSA-L oxaliplatin Chemical compound O1C(=O)C(=O)O[Pt]11N[C@@H]2CCCC[C@H]2N1 DWAFYCQODLXJNR-BNTLRKBRSA-L 0.000 claims 1
- 229960001592 paclitaxel Drugs 0.000 claims 1
- 229960001972 panitumumab Drugs 0.000 claims 1
- 230000003076 paracrine Effects 0.000 claims 1
- 229960002621 pembrolizumab Drugs 0.000 claims 1
- 229960005079 pemetrexed Drugs 0.000 claims 1
- QOFFJEBXNKRSPX-ZDUSSCGKSA-N pemetrexed Chemical compound C1=N[C]2NC(N)=NC(=O)C2=C1CCC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 QOFFJEBXNKRSPX-ZDUSSCGKSA-N 0.000 claims 1
- 229960002087 pertuzumab Drugs 0.000 claims 1
- 208000028591 pheochromocytoma Diseases 0.000 claims 1
- 229940043441 phosphoinositide 3-kinase inhibitor Drugs 0.000 claims 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 claims 1
- BCIIMDOZSUCSEN-UHFFFAOYSA-N piperidin-4-amine Chemical compound NC1CCNCC1 BCIIMDOZSUCSEN-UHFFFAOYSA-N 0.000 claims 1
- 125000003386 piperidinyl group Chemical group 0.000 claims 1
- 229950001100 piposulfan Drugs 0.000 claims 1
- NUKCGLDCWQXYOQ-UHFFFAOYSA-N piposulfan Chemical compound CS(=O)(=O)OCCC(=O)N1CCN(C(=O)CCOS(C)(=O)=O)CC1 NUKCGLDCWQXYOQ-UHFFFAOYSA-N 0.000 claims 1
- 208000004748 plexiform neurofibroma Diseases 0.000 claims 1
- 229960003171 plicamycin Drugs 0.000 claims 1
- 206010063401 primary progressive multiple sclerosis Diseases 0.000 claims 1
- 201000002212 progressive supranuclear palsy Diseases 0.000 claims 1
- 239000003528 protein farnesyltransferase inhibitor Substances 0.000 claims 1
- 239000003197 protein kinase B inhibitor Substances 0.000 claims 1
- 201000010108 pycnodysostosis Diseases 0.000 claims 1
- 125000003226 pyrazolyl group Chemical group 0.000 claims 1
- 125000002098 pyridazinyl group Chemical group 0.000 claims 1
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 1
- 125000000168 pyrrolyl group Chemical group 0.000 claims 1
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims 1
- 229960004622 raloxifene Drugs 0.000 claims 1
- GZUITABIAKMVPG-UHFFFAOYSA-N raloxifene Chemical compound C1=CC(O)=CC=C1C1=C(C(=O)C=2C=CC(OCCN3CCCCC3)=CC=2)C2=CC=C(O)C=C2S1 GZUITABIAKMVPG-UHFFFAOYSA-N 0.000 claims 1
- ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 150000004492 retinoid derivatives Chemical class 0.000 claims 1
- 229960004641 rituximab Drugs 0.000 claims 1
- 229950009213 rubitecan Drugs 0.000 claims 1
- VHXNKPBCCMUMSW-FQEVSTJZSA-N rubitecan Chemical compound C1=CC([N+]([O-])=O)=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VHXNKPBCCMUMSW-FQEVSTJZSA-N 0.000 claims 1
- 210000003079 salivary gland Anatomy 0.000 claims 1
- 229950010746 selumetinib Drugs 0.000 claims 1
- CYOHGALHFOKKQC-UHFFFAOYSA-N selumetinib Chemical compound OCCONC(=O)C=1C=C2N(C)C=NC2=C(F)C=1NC1=CC=C(Br)C=C1Cl CYOHGALHFOKKQC-UHFFFAOYSA-N 0.000 claims 1
- 229960003440 semustine Drugs 0.000 claims 1
- SQVRNKJHWKZAKO-OQPLDHBCSA-N sialic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)OC1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-OQPLDHBCSA-N 0.000 claims 1
- 208000011985 sialidosis Diseases 0.000 claims 1
- 230000019491 signal transduction Effects 0.000 claims 1
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 claims 1
- 229960002930 sirolimus Drugs 0.000 claims 1
- 239000010802 sludge Substances 0.000 claims 1
- 229960003787 sorafenib Drugs 0.000 claims 1
- 206010041823 squamous cell carcinoma Diseases 0.000 claims 1
- 208000017572 squamous cell neoplasm Diseases 0.000 claims 1
- 210000000130 stem cell Anatomy 0.000 claims 1
- 238000011476 stem cell transplantation Methods 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 229960001052 streptozocin Drugs 0.000 claims 1
- ZSJLQEPLLKMAKR-GKHCUFPYSA-N streptozocin Chemical compound O=NN(C)C(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O ZSJLQEPLLKMAKR-GKHCUFPYSA-N 0.000 claims 1
- 229960000894 sulindac Drugs 0.000 claims 1
- MLKXDPUZXIRXEP-MFOYZWKCSA-N sulindac Chemical compound CC1=C(CC(O)=O)C2=CC(F)=CC=C2\C1=C/C1=CC=C(S(C)=O)C=C1 MLKXDPUZXIRXEP-MFOYZWKCSA-N 0.000 claims 1
- 229960002812 sunitinib malate Drugs 0.000 claims 1
- 229960001603 tamoxifen Drugs 0.000 claims 1
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 claims 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 1
- 229960004964 temozolomide Drugs 0.000 claims 1
- NRUKOCRGYNPUPR-QBPJDGROSA-N teniposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@@H](OC[C@H]4O3)C=3SC=CC=3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 NRUKOCRGYNPUPR-QBPJDGROSA-N 0.000 claims 1
- 229960001278 teniposide Drugs 0.000 claims 1
- SFQBOKKRNOXYEC-UHFFFAOYSA-N tert-butyl 3-[5-[6-(3-cyanopyrrolidine-1-carbonyl)pyridin-2-yl]-1H-pyrrolo[2,3-b]pyridin-2-yl]-2,5-dihydropyrrole-1-carboxylate Chemical compound C(#N)C1CN(CC1)C(=O)C1=CC=CC(=N1)C=1C=C2C(=NC=1)NC(=C2)C=1CN(CC=1)C(=O)OC(C)(C)C SFQBOKKRNOXYEC-UHFFFAOYSA-N 0.000 claims 1
- MODVSQKJJIBWPZ-VLLPJHQWSA-N tesetaxel Chemical compound O([C@H]1[C@@H]2[C@]3(OC(C)=O)CO[C@@H]3CC[C@@]2(C)[C@H]2[C@@H](C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C(=CC=CN=4)F)C[C@]1(O)C3(C)C)O[C@H](O2)CN(C)C)C(=O)C1=CC=CC=C1 MODVSQKJJIBWPZ-VLLPJHQWSA-N 0.000 claims 1
- BPEWUONYVDABNZ-DZBHQSCQSA-N testolactone Chemical compound O=C1C=C[C@]2(C)[C@H]3CC[C@](C)(OC(=O)CC4)[C@@H]4[C@@H]3CCC2=C1 BPEWUONYVDABNZ-DZBHQSCQSA-N 0.000 claims 1
- 229960005353 testolactone Drugs 0.000 claims 1
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims 1
- 125000005942 tetrahydropyridyl group Chemical group 0.000 claims 1
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 claims 1
- 229960003433 thalidomide Drugs 0.000 claims 1
- 125000000335 thiazolyl group Chemical group 0.000 claims 1
- 125000001544 thienyl group Chemical group 0.000 claims 1
- SRVJKTDHMYAMHA-WUXMJOGZSA-N thioacetazone Chemical compound CC(=O)NC1=CC=C(\C=N\NC(N)=S)C=C1 SRVJKTDHMYAMHA-WUXMJOGZSA-N 0.000 claims 1
- 208000030901 thyroid gland follicular carcinoma Diseases 0.000 claims 1
- 208000030045 thyroid gland papillary carcinoma Diseases 0.000 claims 1
- 208000019179 thyroid gland undifferentiated (anaplastic) carcinoma Diseases 0.000 claims 1
- 229960003087 tioguanine Drugs 0.000 claims 1
- MNRILEROXIRVNJ-UHFFFAOYSA-N tioguanine Chemical compound N1C(N)=NC(=S)C2=NC=N[C]21 MNRILEROXIRVNJ-UHFFFAOYSA-N 0.000 claims 1
- 229940044693 topoisomerase inhibitor Drugs 0.000 claims 1
- 229960000303 topotecan Drugs 0.000 claims 1
- UCFGDBYHRUNTLO-QHCPKHFHSA-N topotecan Chemical compound C1=C(O)C(CN(C)C)=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 UCFGDBYHRUNTLO-QHCPKHFHSA-N 0.000 claims 1
- 229960005267 tositumomab Drugs 0.000 claims 1
- FDTAUJJRHBRHIJ-FDJAAIFISA-N tpi-287 Chemical compound O([C@@H]1[C@]2(O)C[C@@H](C(=C([C@H](OC(C)=O)[C@@H]3OC(O[C@H]4C[C@H]5OC[C@]5([C@@H]1[C@]34C)OC(C)=O)C=C)C2(C)C)C)OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)CC(C)C)C(=O)C1=CC=CC=C1 FDTAUJJRHBRHIJ-FDJAAIFISA-N 0.000 claims 1
- 229960004066 trametinib Drugs 0.000 claims 1
- LIRYPHYGHXZJBZ-UHFFFAOYSA-N trametinib Chemical compound CC(=O)NC1=CC=CC(N2C(N(C3CC3)C(=O)C3=C(NC=4C(=CC(I)=CC=4)F)N(C)C(=O)C(C)=C32)=O)=C1 LIRYPHYGHXZJBZ-UHFFFAOYSA-N 0.000 claims 1
- 229960000575 trastuzumab Drugs 0.000 claims 1
- 229960001727 tretinoin Drugs 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
- 229960001099 trimetrexate Drugs 0.000 claims 1
- NOYPYLRCIDNJJB-UHFFFAOYSA-N trimetrexate Chemical compound COC1=C(OC)C(OC)=CC(NCC=2C(=C3C(N)=NC(N)=NC3=CC=2)C)=C1 NOYPYLRCIDNJJB-UHFFFAOYSA-N 0.000 claims 1
- 230000005747 tumor angiogenesis Effects 0.000 claims 1
- 230000004614 tumor growth Effects 0.000 claims 1
- 208000025444 tumor of salivary gland Diseases 0.000 claims 1
- 229940121358 tyrosine kinase inhibitor Drugs 0.000 claims 1
- 239000005483 tyrosine kinase inhibitor Substances 0.000 claims 1
- 150000004917 tyrosine kinase inhibitor derivatives Chemical class 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
- 229950000578 vatalanib Drugs 0.000 claims 1
- YCOYDOIWSSHVCK-UHFFFAOYSA-N vatalanib Chemical compound C1=CC(Cl)=CC=C1NC(C1=CC=CC=C11)=NN=C1CC1=CC=NC=C1 YCOYDOIWSSHVCK-UHFFFAOYSA-N 0.000 claims 1
- 229960003862 vemurafenib Drugs 0.000 claims 1
- GPXBXXGIAQBQNI-UHFFFAOYSA-N vemurafenib Chemical compound CCCS(=O)(=O)NC1=CC=C(F)C(C(=O)C=2C3=CC(=CN=C3NC=2)C=2C=CC(Cl)=CC=2)=C1F GPXBXXGIAQBQNI-UHFFFAOYSA-N 0.000 claims 1
- 229960003048 vinblastine Drugs 0.000 claims 1
- JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 claims 1
- 229960004528 vincristine Drugs 0.000 claims 1
- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 claims 1
- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 claims 1
- 229960004355 vindesine Drugs 0.000 claims 1
- UGGWPQSBPIFKDZ-KOTLKJBCSA-N vindesine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(N)=O)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1N=C1[C]2C=CC=C1 UGGWPQSBPIFKDZ-KOTLKJBCSA-N 0.000 claims 1
- 229960002066 vinorelbine Drugs 0.000 claims 1
- GBABOYUKABKIAF-GHYRFKGUSA-N vinorelbine Chemical compound C1N(CC=2C3=CC=CC=C3NC=22)CC(CC)=C[C@H]1C[C@]2(C(=O)OC)C1=CC([C@]23[C@H]([C@]([C@H](OC(C)=O)[C@]4(CC)C=CCN([C@H]34)CC2)(O)C(=O)OC)N2C)=C2C=C1OC GBABOYUKABKIAF-GHYRFKGUSA-N 0.000 claims 1
- 229950009268 zinostatin Drugs 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Immunology (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Virology (AREA)
- Transplantation (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- AIDS & HIV (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Rheumatology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562264180P | 2015-12-07 | 2015-12-07 | |
| US62/264,180 | 2015-12-07 | ||
| PCT/US2016/065179 WO2017100201A1 (en) | 2015-12-07 | 2016-12-06 | Compounds and methods for kinase modulation, and indications therefor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2018123825A true RU2018123825A (ru) | 2020-01-15 |
Family
ID=57796966
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2018123825A RU2018123825A (ru) | 2015-12-07 | 2016-12-06 | Соединения и способы для модуляции киназ, и показания для этого |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US9938273B2 (enExample) |
| EP (1) | EP3386980B1 (enExample) |
| JP (1) | JP6862468B2 (enExample) |
| KR (1) | KR20180086247A (enExample) |
| CN (1) | CN108368110A (enExample) |
| AU (1) | AU2016367147B2 (enExample) |
| BR (1) | BR112018011475A2 (enExample) |
| CA (1) | CA3007462C (enExample) |
| CO (1) | CO2018007052A2 (enExample) |
| ES (1) | ES2899581T3 (enExample) |
| IL (1) | IL259803A (enExample) |
| MX (1) | MX2018006856A (enExample) |
| PH (1) | PH12018501179A1 (enExample) |
| RU (1) | RU2018123825A (enExample) |
| SG (1) | SG11201804711RA (enExample) |
| WO (1) | WO2017100201A1 (enExample) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG183036A1 (en) | 2007-07-17 | 2012-08-30 | Plexxikon Inc | Compounds and methods for kinase modulation, and indications therefor |
| JP5941069B2 (ja) | 2011-02-07 | 2016-06-29 | プレキシコン インコーポレーテッドＰｌｅｘｘｉｋｏｎ Ｉｎｃ． | キナーゼ調節のための化合物および方法、ならびにそれに対する適応症 |
| US9358235B2 (en) | 2012-03-19 | 2016-06-07 | Plexxikon Inc. | Kinase modulation, and indications therefor |
| AU2013312477B2 (en) | 2012-09-06 | 2018-05-31 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| EP2935248B1 (en) | 2012-12-21 | 2018-02-28 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| US20140303121A1 (en) | 2013-03-15 | 2014-10-09 | Plexxikon Inc. | Heterocyclic compounds and uses thereof |
| KR102244719B1 (ko) | 2013-03-15 | 2021-04-26 | 플렉시콘 인코퍼레이티드 | 헤테로시클릭 화합물 및 그의 용도 |
| BR112015028845A2 (pt) | 2013-05-30 | 2017-07-25 | Plexxikon Inc | compostos para a modulação da quinase e indicações da mesma |
| CN112574196A (zh) | 2015-05-06 | 2021-03-30 | 普莱希科公司 | 调节激酶的1H-吡咯并[2,3-b]吡啶衍生物的合成 |
| EP3292123B1 (en) | 2015-05-06 | 2020-07-22 | Plexxikon Inc. | Solid forms of a compound modulating kinases |
| TWI658042B (zh) | 2015-05-22 | 2019-05-01 | 美商普雷辛肯公司 | 雜環化合物的合成 |
| US10829484B2 (en) | 2015-07-28 | 2020-11-10 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| CN108137585B (zh) | 2015-09-21 | 2021-10-22 | 普莱希科公司 | 杂环化合物及其应用 |
| WO2017156071A1 (en) | 2016-03-09 | 2017-09-14 | Blade Therapeutics, Inc. | Cyclic keto-amide compounds as calpain modulators and methods of production and use thereof |
| AU2017292646A1 (en) | 2016-07-05 | 2019-02-07 | Blade Therapeutics, Inc. | Calpain modulators and therapeutic uses thereof |
| TW201815766A (zh) | 2016-09-22 | 2018-05-01 | 美商普雷辛肯公司 | 用於ｉｄｏ及ｔｄｏ調節之化合物及方法以及其適應症 |
| WO2018064119A1 (en) * | 2016-09-28 | 2018-04-05 | Blade Therapeutics, Inc. | Calpain modulators and therapeutic uses thereof |
| JP7193460B2 (ja) | 2016-12-23 | 2022-12-20 | プレキシコン インコーポレーテッド | Ｃｄｋ８調節およびその適応症のための化合物および方法 |
| US11040027B2 (en) | 2017-01-17 | 2021-06-22 | Heparegenix Gmbh | Protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death |
| WO2018175311A1 (en) | 2017-03-20 | 2018-09-27 | Plexxikon Inc. | Crystalline forms of 4-(1-(1,1-di(pyridin-2-yl)ethyl)-6-(3,5-dimethylisoxazol-4-yl)-1h- pyrrolo[3,2-b]pyridin-3-yl)benzoic acid that inhibits bromodomain |
| US10428067B2 (en) | 2017-06-07 | 2019-10-01 | Plexxikon Inc. | Compounds and methods for kinase modulation |
| US11548867B2 (en) | 2017-07-19 | 2023-01-10 | Idea Ya Biosciences, Inc. | Amido compounds as AhR modulators |
| KR102615829B1 (ko) | 2017-07-25 | 2023-12-20 | 플렉시콘 인코퍼레이티드 | 키나제를 조정하는 화합물의 제제 |
| RU2739489C2 (ru) * | 2018-03-06 | 2020-12-24 | Закрытое Акционерное Общество "Биокад" | Новые гетероциклические соединения как ингибиторы CDK8/19 |
| AU2018312836B2 (en) * | 2017-08-07 | 2022-12-08 | Joint Stock Company "Biocad" | Novel heterocyclic compounds as CDK8/19 inhibitors |
| AU2018348241B2 (en) | 2017-10-13 | 2023-01-12 | Opna Bio SA | Solid forms of a compound for modulating kinases |
| JP7175309B2 (ja) | 2017-10-27 | 2022-11-18 | プレキシコン インコーポレーテッド | キナーゼを調節する化合物の製剤 |
| WO2019183145A1 (en) | 2018-03-20 | 2019-09-26 | Plexxikon Inc. | Compounds and methods for ido and tdo modulation, and indications therefor |
| CN110833548A (zh) * | 2018-08-15 | 2020-02-25 | 广西梧州制药（集团）股份有限公司 | 吡唑并嘧啶衍生物在治疗肝肺综合征的用途 |
| CN111434661B (zh) * | 2019-01-11 | 2023-09-12 | 爱科诺生物医药(香港)有限公司 | 具有细胞坏死抑制活性的芳香杂环化合物及其应用 |
| CA3136224A1 (en) | 2019-04-09 | 2020-10-15 | Plexxikon Inc. | Condensed azines for ep300 or cbp modulation and indications therefor |
| TWI759829B (zh) | 2019-08-23 | 2022-04-01 | 財團法人生物技術開發中心 | 作為第iii型受體酪胺酸激酶抑制劑之雜環吡唑衍生物 |
| JP2023503470A (ja) * | 2019-11-25 | 2023-01-30 | ゲイン セラピューティクス エスアー | ガラクトセレブロシダーゼの活性の変質に関連する状態におけるアリールおよびヘテロアリール化合物、ならびにそれらの治療的使用 |
| CN118767143A (zh) | 2019-12-12 | 2024-10-15 | 听治疗有限责任公司 | 用于预防和治疗听力损失的组合物和方法 |
| WO2021216898A1 (en) | 2020-04-23 | 2021-10-28 | Plexxikon Inc. | Compounds and methods for cd73 modulation and indications therefor |
| IL297645B1 (en) | 2020-04-29 | 2025-09-01 | Plexxikon Inc | Synthesis of heterocyclic compounds |
| EP4178982A1 (en) | 2020-07-13 | 2023-05-17 | Precirix N.V. | Antibody fragment against folr1 |
| EP4199926A1 (en) | 2020-08-21 | 2023-06-28 | Plexxikon Inc. | Combinational drug anticancer therapies |
| CN114230565B (zh) * | 2020-09-09 | 2023-10-27 | 成都奥睿药业有限公司 | 5-取代吲哚3-酰胺衍生物及其制备方法和用途 |
| WO2023203135A1 (en) | 2022-04-22 | 2023-10-26 | Precirix N.V. | Improved radiolabelled antibody |
| AU2023264245A1 (en) | 2022-05-02 | 2024-12-19 | Precirix N.V. | Pre-targeting |
| JP2025524358A (ja) * | 2022-06-08 | 2025-07-30 | ブロッサムヒル・セラピューティクス・インコーポレイテッド | インダゾール大員環およびその使用 |
| WO2023245329A1 (en) * | 2022-06-20 | 2023-12-28 | Biofront Ltd | Multi-kinase inhibitors, compositions thereof, and methods of using the same |
| EP4574144A1 (en) * | 2023-12-19 | 2025-06-25 | Gongwin Biopharm Co., Ltd. | Method for treating peripheral nerve sheath tumor |
Family Cites Families (125)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US878589A (en) | 1907-01-19 | 1908-02-11 | Rail Joint Co | Reinforced angle-bar for rail-joints. |
| GB1573212A (en) | 1976-04-15 | 1980-08-20 | Technicon Instr | Immunoassay for gentamicin |
| US4568649A (en) | 1983-02-22 | 1986-02-04 | Immunex Corporation | Immediate ligand detection assay |
| US4626513A (en) | 1983-11-10 | 1986-12-02 | Massachusetts General Hospital | Method and apparatus for ligand detection |
| ATE56096T1 (de) | 1984-03-15 | 1990-09-15 | Immunex Corp | Test zur sofortigen feststellung von liganden, testsatz und seine herstellung. |
| US6054270A (en) | 1988-05-03 | 2000-04-25 | Oxford Gene Technology Limited | Analying polynucleotide sequences |
| US5700637A (en) | 1988-05-03 | 1997-12-23 | Isis Innovation Limited | Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays |
| US5658775A (en) | 1988-05-17 | 1997-08-19 | Sloan-Kettering Institute For Cancer Research | Double copy retroviral vector |
| WO1990002806A1 (en) | 1988-09-01 | 1990-03-22 | Whitehead Institute For Biomedical Research | Recombinant retroviruses with amphotropic and ecotropic host ranges |
| US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| US5527681A (en) | 1989-06-07 | 1996-06-18 | Affymax Technologies N.V. | Immobilized molecular synthesis of systematically substituted compounds |
| US5800992A (en) | 1989-06-07 | 1998-09-01 | Fodor; Stephen P.A. | Method of detecting nucleic acids |
| US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
| US5744101A (en) | 1989-06-07 | 1998-04-28 | Affymax Technologies N.V. | Photolabile nucleoside protecting groups |
| AU7906691A (en) | 1990-05-23 | 1991-12-10 | United States of America, as represented by the Secretary, U.S. Department of Commerce, The | Adeno-associated virus (aav)-based eucaryotic vectors |
| EP0659209A1 (en) | 1991-07-26 | 1995-06-28 | The University Of Rochester | Cancer therapy utilizing malignant cells |
| US5632957A (en) | 1993-11-01 | 1997-05-27 | Nanogen | Molecular biological diagnostic systems including electrodes |
| JPH05236997A (ja) | 1992-02-28 | 1993-09-17 | Hitachi Ltd | ポリヌクレオチド捕捉用チップ |
| US5631236A (en) | 1993-08-26 | 1997-05-20 | Baylor College Of Medicine | Gene therapy for solid tumors, using a DNA sequence encoding HSV-Tk or VZV-Tk |
| US5426039A (en) | 1993-09-08 | 1995-06-20 | Bio-Rad Laboratories, Inc. | Direct molecular cloning of primer extended DNA containing an alkane diol |
| US6045996A (en) | 1993-10-26 | 2000-04-04 | Affymetrix, Inc. | Hybridization assays on oligonucleotide arrays |
| US5965452A (en) | 1996-07-09 | 1999-10-12 | Nanogen, Inc. | Multiplexed active biologic array |
| US6468742B2 (en) | 1993-11-01 | 2002-10-22 | Nanogen, Inc. | Methods for determination of single nucleic acid polymorphisms using bioelectronic microchip |
| US5807522A (en) | 1994-06-17 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for fabricating microarrays of biological samples |
| US5556752A (en) | 1994-10-24 | 1996-09-17 | Affymetrix, Inc. | Surface-bound, unimolecular, double-stranded DNA |
| US5830645A (en) | 1994-12-09 | 1998-11-03 | The Regents Of The University Of California | Comparative fluorescence hybridization to nucleic acid arrays |
| US5959098A (en) | 1996-04-17 | 1999-09-28 | Affymetrix, Inc. | Substrate preparation process |
| US6117681A (en) | 1995-03-29 | 2000-09-12 | Bavarian Nordic Research Inst. A/S | Pseudotyped retroviral particles |
| US6110456A (en) | 1995-06-07 | 2000-08-29 | Yale University | Oral delivery or adeno-associated viral vectors |
| US5856174A (en) | 1995-06-29 | 1999-01-05 | Affymetrix, Inc. | Integrated nucleic acid diagnostic device |
| US5866411A (en) | 1995-09-08 | 1999-02-02 | Pedersen; Finn Skou | Retroviral vector, a replication system for said vector and avian or mammalian cells transfected with said vector |
| US5721118A (en) | 1995-10-31 | 1998-02-24 | The Regents Of The University Of California, San Diego | Mammalian artificial chromosomes and methods of using same |
| US6022963A (en) | 1995-12-15 | 2000-02-08 | Affymetrix, Inc. | Synthesis of oligonucleotide arrays using photocleavable protecting groups |
| US6013440A (en) | 1996-03-11 | 2000-01-11 | Affymetrix, Inc. | Nucleic acid affinity columns |
| US6025155A (en) | 1996-04-10 | 2000-02-15 | Chromos Molecular Systems, Inc. | Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes |
| AU3568897A (en) | 1996-06-07 | 1998-01-05 | Eos Biotechnology, Inc. | Immobilised linear oligonucleotide arrays |
| US6846630B2 (en) | 1996-10-18 | 2005-01-25 | Takara Shuzo Co., Ltd. | Nucleic acid encoding receptor type protein kinase |
| US6096718A (en) | 1997-06-05 | 2000-08-01 | Gene Targeting Corp. | Tissue specific adenovirus vectors for breast cancer treatment |
| US6826296B2 (en) | 1997-07-25 | 2004-11-30 | Affymetrix, Inc. | Method and system for providing a probe array chip design database |
| AU8908198A (en) | 1997-08-15 | 1999-03-08 | Hyseq, Inc. | Methods and compositions for detection or quantification of nucleic acid species |
| ES2225407T3 (es) | 1997-09-11 | 2005-03-16 | Bioventures, Inc. | Metodo para producir disposiciones ordenadas de alta densidad. |
| US6465178B2 (en) | 1997-09-30 | 2002-10-15 | Surmodics, Inc. | Target molecule attachment to surfaces |
| WO1999051773A1 (en) | 1998-04-03 | 1999-10-14 | Phylos, Inc. | Addressable protein arrays |
| US6048695A (en) | 1998-05-04 | 2000-04-11 | Baylor College Of Medicine | Chemically modified nucleic acids and methods for coupling nucleic acids to solid support |
| ATE482945T1 (de) * | 1998-05-26 | 2010-10-15 | Chugai Pharmaceutical Co Ltd | Heterozyklische indolderivate und mono- oder diazaindol-derivate |
| US6113913A (en) | 1998-06-26 | 2000-09-05 | Genvec, Inc. | Recombinant adenovirus |
| US6277628B1 (en) | 1998-10-02 | 2001-08-21 | Incyte Genomics, Inc. | Linear microarrays |
| US6277489B1 (en) | 1998-12-04 | 2001-08-21 | The Regents Of The University Of California | Support for high performance affinity chromatography and other uses |
| US6221653B1 (en) | 1999-04-27 | 2001-04-24 | Agilent Technologies, Inc. | Method of performing array-based hybridization assays using thermal inkjet deposition of sample fluids |
| US6653151B2 (en) | 1999-07-30 | 2003-11-25 | Large Scale Proteomics Corporation | Dry deposition of materials for microarrays using matrix displacement |
| US20010008765A1 (en) | 1999-12-06 | 2001-07-19 | Fuji Photo Film Co., Ltd. | DNA chip and reactive solid carrier |
| CN1615873A (zh) | 1999-12-24 | 2005-05-18 | 阿文蒂斯药物有限公司 | 氮杂吲哚类化合物 |
| GB0115109D0 (en) * | 2001-06-21 | 2001-08-15 | Aventis Pharma Ltd | Chemical compounds |
| US20040171062A1 (en) | 2002-02-28 | 2004-09-02 | Plexxikon, Inc. | Methods for the design of molecular scaffolds and ligands |
| AU2003272548A1 (en) | 2002-09-16 | 2004-04-30 | Plexxikon, Inc. | Crystal structure of pim-1 kinase |
| US20050048573A1 (en) | 2003-02-03 | 2005-03-03 | Plexxikon, Inc. | PDE5A crystal structure and uses |
| JP2007524374A (ja) | 2003-02-28 | 2007-08-30 | プレキシコン，インコーポレーテッド | Ｐｙｋ２結晶構造および使用 |
| US20050079548A1 (en) | 2003-07-07 | 2005-04-14 | Plexxikon, Inc. | Ligand development using PDE4B crystal structures |
| WO2005009958A1 (en) | 2003-07-17 | 2005-02-03 | Plexxikon, Inc. | Ppar active compounds |
| US7348338B2 (en) | 2003-07-17 | 2008-03-25 | Plexxikon, Inc. | PPAR active compounds |
| WO2005028624A2 (en) | 2003-09-15 | 2005-03-31 | Plexxikon, Inc. | Molecular scaffolds for kinase ligand development |
| ES2527118T3 (es) | 2003-12-19 | 2015-01-20 | Plexxikon Inc. | Compuestos y procedimientos de desarrollo de moduladores de Ret |
| US7517970B2 (en) | 2003-12-19 | 2009-04-14 | Plexxikon, Inc. | Nucleic acids encoding kinase and phosphatase enzymes, expression vectors and cells containing same |
| US20070066641A1 (en) | 2003-12-19 | 2007-03-22 | Prabha Ibrahim | Compounds and methods for development of RET modulators |
| WO2006078287A2 (en) | 2004-05-06 | 2006-07-27 | Plexxikon, Inc. | Pde4b inhibitors and uses therefor |
| US7498342B2 (en) | 2004-06-17 | 2009-03-03 | Plexxikon, Inc. | Compounds modulating c-kit activity |
| TW200616632A (en) | 2004-06-17 | 2006-06-01 | Plexxikon Inc | Compounds modulating c-kit activity and uses therefor |
| KR20070053237A (ko) * | 2004-07-27 | 2007-05-23 | 에스지엑스 파마슈티컬스, 인코포레이티드 | 피롤로-피리딘 키나제 조절제 |
| WO2006026754A2 (en) | 2004-09-03 | 2006-03-09 | Plexxikon, Inc. | Bicyclic heteroaryl pde4b inhibitors |
| US7531568B2 (en) | 2004-11-30 | 2009-05-12 | Plexxikon, Inc. | PPAR active compounds |
| EP1833787A2 (en) | 2004-11-30 | 2007-09-19 | Plexxikon, Inc. | Indole derivatives for use as ppar active compounds |
| US20060160135A1 (en) | 2004-12-08 | 2006-07-20 | Weiru Wang | SF-1 and LRH-1 modulator development |
| NZ563444A (en) | 2005-05-17 | 2011-04-29 | Plexxikon Inc | Pyrrolo(2,3-b)pyridine derivatives as protein kinase inhibitors |
| UA95244C2 (ru) | 2005-06-22 | 2011-07-25 | Плексикон, Инк. | Соединения и способ модулирования активности киназ, и показания для их применения |
| TW200800872A (en) | 2005-09-07 | 2008-01-01 | Plexxikon Inc | PPAR active compounds |
| AU2006287528A1 (en) | 2005-09-07 | 2007-03-15 | Plexxikon, Inc. | 1 , 4 and 1 , 5-disubstituted indole derivatives for use as PPAR active compounds |
| EP1943245A2 (en) | 2005-09-07 | 2008-07-16 | Plexxikon, Inc. | 1,3-disubstituted indole derivatives for use as ppar modulators |
| EP2041139B1 (en) * | 2006-04-26 | 2011-11-09 | F. Hoffmann-La Roche AG | Pharmaceutical compounds |
| WO2008063888A2 (en) | 2006-11-22 | 2008-05-29 | Plexxikon, Inc. | Compounds modulating c-fms and/or c-kit activity and uses therefor |
| WO2008079909A1 (en) | 2006-12-21 | 2008-07-03 | Plexxikon, Inc. | Pyrrolo [2,3-b] pyridines as kinase modulators |
| RU2009122670A (ru) | 2006-12-21 | 2011-01-27 | Плекссикон, Инк. (Us) | Соединения и способы для модуляции киназ и показания к их применению |
| PE20081581A1 (es) | 2006-12-21 | 2008-11-12 | Plexxikon Inc | COMPUESTOS PIRROLO[2,3-b]PIRIDINAS COMO MODULADORES DE QUINASA |
| BRPI0808196A2 (pt) | 2007-03-08 | 2014-07-08 | Plexxikon Inc | Compostos ativos de ppar |
| PE20090159A1 (es) | 2007-03-08 | 2009-02-21 | Plexxikon Inc | COMPUESTOS DERIVADOS DE ACIDO INDOL-PROPIONICO COMO MODULADORES PPARs |
| SG183036A1 (en) | 2007-07-17 | 2012-08-30 | Plexxikon Inc | Compounds and methods for kinase modulation, and indications therefor |
| US8158636B2 (en) | 2008-05-19 | 2012-04-17 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| PE20091846A1 (es) | 2008-05-19 | 2009-12-16 | Plexxikon Inc | DERIVADOS DE PIRROLO[2,3-d]-PIRIMIDINA COMO MODULADORES DE CINASAS |
| EP2313411A1 (en) | 2008-06-10 | 2011-04-27 | Plexxikon, Inc. | 5h-pyrr0l0 [2,3-b]pyrazine derivatives for kinase modulation, and indications therefor |
| WO2009152087A1 (en) | 2008-06-10 | 2009-12-17 | Plexxikon, Inc. | Bicyclic heteroaryl compounds and methods for kinase modulation, and indications therefor |
| US8785489B2 (en) | 2008-10-17 | 2014-07-22 | Boehringer Ingelheim International Gmbh | Heteroaryl substituted indole compounds useful as MMP-13 inhibitors |
| TW201036972A (en) | 2009-03-11 | 2010-10-16 | Plexxikon Inc | Compounds and uses thereof |
| AU2010224245B2 (en) | 2009-03-11 | 2016-07-21 | Plexxikon, Inc. | Pyrrolo [2, 3-b] pyridine derivatives for the inhibition of Raf kinases |
| WO2010111527A1 (en) | 2009-03-26 | 2010-09-30 | Plexxikon, Inc. | Pyrazolo [ 3, 4 -b] pyridines as kinase inhibitors and their medical use |
| EA022924B1 (ru) | 2009-04-03 | 2016-03-31 | Ф.Хоффманн-Ля Рош Аг | ТВЁРДАЯ ФОРМА {3-[5-(4-ХЛОРФЕНИЛ)-1Н-ПИРРОЛО[2,3-b]ПИРИДИН-3-КАРБОНИЛ]-2,4-ДИФТОРФЕНИЛ}АМИДА ПРОПАН-1-СУЛЬФОНОВОЙ КИСЛОТЫ И ЕЁ ПРИМЕНЕНИЕ |
| MX2011011735A (es) | 2009-05-04 | 2011-11-29 | Plexxikon Inc | Compuestos y metodos para la inhibicion de renina, e indicaciones para ello. |
| TW201041888A (en) | 2009-05-06 | 2010-12-01 | Plexxikon Inc | Compounds and methods for kinase modulation, and indications therefor |
| MA33975B1 (fr) | 2009-11-06 | 2013-02-01 | Plexxikon Inc | Composés et méthodes de modulation des kinases et leurs indications d'emploi |
| CN105906631A (zh) | 2009-11-18 | 2016-08-31 | 普莱希科公司 | 用于激酶调节的化合物和方法及其适应症 |
| RU2012131373A (ru) | 2009-12-23 | 2014-01-27 | Плексксикон, Инк. | Соединения и способы модулирования киназы, а также показания для такого модулирования |
| TWI510487B (zh) | 2010-04-21 | 2015-12-01 | Plexxikon Inc | 用於激酶調節的化合物和方法及其適應症 |
| US8642606B2 (en) | 2010-09-29 | 2014-02-04 | Plexxikon Inc. | ZAP-70 active compounds |
| JP5941069B2 (ja) | 2011-02-07 | 2016-06-29 | プレキシコン インコーポレーテッドＰｌｅｘｘｉｋｏｎ Ｉｎｃ． | キナーゼ調節のための化合物および方法、ならびにそれに対する適応症 |
| TWI558702B (zh) | 2011-02-21 | 2016-11-21 | 普雷辛肯公司 | 醫藥活性物質的固態形式 |
| AU2012255275B2 (en) | 2011-05-17 | 2016-01-28 | Plexxikon Inc. | Kinase modulation and indications therefor |
| DE102011111400A1 (de) * | 2011-08-23 | 2013-02-28 | Merck Patent Gmbh | Bicyclische heteroaromatische Verbindungen |
| US20130158049A1 (en) | 2011-12-20 | 2013-06-20 | Hoffmann-La Roche Inc. | 7-azaindole inhibitors of crac |
| US9358235B2 (en) | 2012-03-19 | 2016-06-07 | Plexxikon Inc. | Kinase modulation, and indications therefor |
| US9150570B2 (en) | 2012-05-31 | 2015-10-06 | Plexxikon Inc. | Synthesis of heterocyclic compounds |
| AU2013312477B2 (en) | 2012-09-06 | 2018-05-31 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| EP2738172A1 (en) * | 2012-11-28 | 2014-06-04 | Almirall, S.A. | New bicyclic compounds as crac channel modulators |
| EP2935248B1 (en) | 2012-12-21 | 2018-02-28 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| US20140303121A1 (en) | 2013-03-15 | 2014-10-09 | Plexxikon Inc. | Heterocyclic compounds and uses thereof |
| KR102244719B1 (ko) | 2013-03-15 | 2021-04-26 | 플렉시콘 인코퍼레이티드 | 헤테로시클릭 화합물 및 그의 용도 |
| BR112015028845A2 (pt) | 2013-05-30 | 2017-07-25 | Plexxikon Inc | compostos para a modulação da quinase e indicações da mesma |
| WO2015134536A1 (en) | 2014-03-04 | 2015-09-11 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| ES2688554T3 (es) * | 2014-03-21 | 2018-11-05 | Bristol-Myers Squibb Company | Compuestos de azabenzofurano que contienen ciano para el tratamiento de la hepatitis C |
| AU2015318233B2 (en) | 2014-09-15 | 2020-03-12 | Plexxikon Inc. | Heterocyclic compounds and uses thereof |
| WO2016164641A1 (en) | 2015-04-08 | 2016-10-13 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| CN112574196A (zh) | 2015-05-06 | 2021-03-30 | 普莱希科公司 | 调节激酶的1H-吡咯并[2,3-b]吡啶衍生物的合成 |
| EP3292123B1 (en) | 2015-05-06 | 2020-07-22 | Plexxikon Inc. | Solid forms of a compound modulating kinases |
| TWI658042B (zh) | 2015-05-22 | 2019-05-01 | 美商普雷辛肯公司 | 雜環化合物的合成 |
| US9814714B2 (en) | 2015-05-22 | 2017-11-14 | Plexxikon Inc. | Kinase modulation, and indications therefor |
| US10829484B2 (en) | 2015-07-28 | 2020-11-10 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| CN108137585B (zh) | 2015-09-21 | 2021-10-22 | 普莱希科公司 | 杂环化合物及其应用 |
| EP3430005B1 (en) | 2016-03-16 | 2021-12-08 | Plexxikon Inc. | Compounds and methods for kinase modulation and indications therefore |
-
2016
- 2016-12-06 US US15/370,631 patent/US9938273B2/en active Active
- 2016-12-06 WO PCT/US2016/065179 patent/WO2017100201A1/en not_active Ceased
- 2016-12-06 CA CA3007462A patent/CA3007462C/en active Active
- 2016-12-06 RU RU2018123825A patent/RU2018123825A/ru not_active Application Discontinuation
- 2016-12-06 EP EP16826214.5A patent/EP3386980B1/en active Active
- 2016-12-06 BR BR112018011475A patent/BR112018011475A2/pt not_active Application Discontinuation
- 2016-12-06 KR KR1020187018381A patent/KR20180086247A/ko not_active Withdrawn
- 2016-12-06 SG SG11201804711RA patent/SG11201804711RA/en unknown
- 2016-12-06 ES ES16826214T patent/ES2899581T3/es active Active
- 2016-12-06 MX MX2018006856A patent/MX2018006856A/es unknown
- 2016-12-06 CN CN201680071952.XA patent/CN108368110A/zh active Pending
- 2016-12-06 JP JP2018549138A patent/JP6862468B2/ja active Active
- 2016-12-06 AU AU2016367147A patent/AU2016367147B2/en active Active
-
2018
- 2018-06-04 PH PH12018501179A patent/PH12018501179A1/en unknown
- 2018-06-04 IL IL259803A patent/IL259803A/en unknown
- 2018-07-05 CO CONC2018/0007052A patent/CO2018007052A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20170158690A1 (en) | 2017-06-08 |
| EP3386980A1 (en) | 2018-10-17 |
| KR20180086247A (ko) | 2018-07-30 |
| MX2018006856A (es) | 2018-08-01 |
| IL259803A (en) | 2018-07-31 |
| ES2899581T3 (es) | 2022-03-14 |
| JP6862468B2 (ja) | 2021-04-21 |
| EP3386980B1 (en) | 2021-10-13 |
| CO2018007052A2 (es) | 2018-07-19 |
| CA3007462C (en) | 2023-10-24 |
| WO2017100201A1 (en) | 2017-06-15 |
| AU2016367147A1 (en) | 2018-07-05 |
| BR112018011475A2 (pt) | 2018-12-04 |
| CA3007462A1 (en) | 2017-06-15 |
| US9938273B2 (en) | 2018-04-10 |
| AU2016367147B2 (en) | 2021-04-08 |
| JP2018537533A (ja) | 2018-12-20 |
| SG11201804711RA (en) | 2018-07-30 |
| CN108368110A (zh) | 2018-08-03 |
| PH12018501179A1 (en) | 2019-02-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2018123825A (ru) | Соединения и способы для модуляции киназ, и показания для этого | |
| JP6461263B2 (ja) | Ｃ−ｆｍｓおよび／またはｃ−ｋｉｔ活性を調節する化合物およびその用途 | |
| US20230346927A1 (en) | COMBINATION of ATR KINASE INHIBITORS and PD-1/PD-L1 INHIBITORS | |
| JP6117235B2 (ja) | Ｐｉ３ｋの活性または機能の阻害剤の使用 | |
| TWI896747B (zh) | 快速加速纖維肉瘤蛋白質降解之化合物及包含其之組成物 | |
| JP2023546054A (ja) | ヘテロ環ｇｌｐ－１アゴニスト | |
| EP3846800A1 (en) | Compounds for the degradation of brd9 or mth1 | |
| UA125032C2 (uk) | ЗАМІЩЕНІ ПІРАЗОЛО[1,5-a]ПІРИДИНОВІ СПОЛУКИ ЯК ІНГІБІТОРИ RЕТ-КІНАЗИ | |
| CA2984259A1 (en) | Combinations of inhibitors of irak4 with inhibitors of btk | |
| CA3174245A1 (en) | Therapeutics for the degradation of mutant braf | |
| MX2008006979A (es) | Compuestos de urea utiles en el tratamiento contra el cancer. | |
| KR20140003436A (ko) | 과증식성 장애 및 혈관형성과 관련된 질환 치료에 유용한 아미노알코올 치환된 2,3-디하이드로이미다조[1,2-ｃ]퀴나졸린 유도체 | |
| CZ292707B6 (cs) | Imidazolové deriváty a farmaceutický prostředek s jejich obsahem | |
| JP7716777B2 (ja) | 窒素含有多環式縮合環系化合物、その医薬組成物、製造方法及び用途 | |
| WO2018206547A1 (en) | Combination of bub1 and atr inhibitors | |
| US20200216439A1 (en) | Hetero-1,5,6,7-tetrahydro-4h-indol-4-ones | |
| HK1191007A (en) | Compounds modulating c-fms and/or c-kit activity and uses therefor | |
| HK1191007B (en) | Compounds modulating c-fms and/or c-kit activity and uses therefor | |
| HK1139927A (en) | Compounds modulating c-fms and/or c-kit activity and uses therefor | |
| HK1133649B (en) | Compounds modulating c-fms and/or c-kit activity and uses therefor |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA93 | Acknowledgement of application withdrawn (no request for examination) |
Effective date: 20191209 |