AU2016367147B2 - Compounds and methods for kinase modulation, and indications therefor - Google Patents

Compounds and methods for kinase modulation, and indications therefor Download PDF

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AU2016367147B2
AU2016367147B2 AU2016367147A AU2016367147A AU2016367147B2 AU 2016367147 B2 AU2016367147 B2 AU 2016367147B2 AU 2016367147 A AU2016367147 A AU 2016367147A AU 2016367147 A AU2016367147 A AU 2016367147A AU 2016367147 B2 AU2016367147 B2 AU 2016367147B2
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pyridin
pyrrolo
methyl
pyridine
cyano
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AU2016367147A1 (en
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Katrina Chan
Ken Dong
Todd Ewing
Prabha N. Ibrahim
Jack Lin
Wayne Spevak
Guoxian Wu
Jeffrey Wu
Ying Zhang
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Plexxikon Inc
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Plexxikon Inc
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring

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  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
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AU2016367147A 2015-12-07 2016-12-06 Compounds and methods for kinase modulation, and indications therefor Active AU2016367147B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562264180P 2015-12-07 2015-12-07
US62/264,180 2015-12-07
PCT/US2016/065179 WO2017100201A1 (en) 2015-12-07 2016-12-06 Compounds and methods for kinase modulation, and indications therefor

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AU2016367147A1 AU2016367147A1 (en) 2018-07-05
AU2016367147B2 true AU2016367147B2 (en) 2021-04-08

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US (1) US9938273B2 (enExample)
EP (1) EP3386980B1 (enExample)
JP (1) JP6862468B2 (enExample)
KR (1) KR20180086247A (enExample)
CN (1) CN108368110A (enExample)
AU (1) AU2016367147B2 (enExample)
BR (1) BR112018011475A2 (enExample)
CA (1) CA3007462C (enExample)
CO (1) CO2018007052A2 (enExample)
ES (1) ES2899581T3 (enExample)
IL (1) IL259803A (enExample)
MX (1) MX2018006856A (enExample)
PH (1) PH12018501179A1 (enExample)
RU (1) RU2018123825A (enExample)
SG (1) SG11201804711RA (enExample)
WO (1) WO2017100201A1 (enExample)

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