KR20180086247A - 키나제 조절을 위한 화합물 및 방법과 이들에 대한 징후 - Google Patents

키나제 조절을 위한 화합물 및 방법과 이들에 대한 징후 Download PDF

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KR20180086247A
KR20180086247A KR1020187018381A KR20187018381A KR20180086247A KR 20180086247 A KR20180086247 A KR 20180086247A KR 1020187018381 A KR1020187018381 A KR 1020187018381A KR 20187018381 A KR20187018381 A KR 20187018381A KR 20180086247 A KR20180086247 A KR 20180086247A
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alkyl
cycloalkyl
disease
heterocycloalkyl
compound
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구오시안 우
제프리 우
카트리나 찬
켄 동
토드 에윙
프라바 엔. 이브라힘
잭 린
웨인 스페바크
잉 장
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플렉시콘 인코퍼레이티드
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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
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    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10Spiro-condensed systems
    • C07D491/107Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring

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  • Medicinal Chemistry (AREA)
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  • Molecular Biology (AREA)
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KR1020187018381A 2015-12-07 2016-12-06 키나제 조절을 위한 화합물 및 방법과 이들에 대한 징후 Withdrawn KR20180086247A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562264180P 2015-12-07 2015-12-07
US62/264,180 2015-12-07
PCT/US2016/065179 WO2017100201A1 (en) 2015-12-07 2016-12-06 Compounds and methods for kinase modulation, and indications therefor

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KR20180086247A true KR20180086247A (ko) 2018-07-30

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US (1) US9938273B2 (enExample)
EP (1) EP3386980B1 (enExample)
JP (1) JP6862468B2 (enExample)
KR (1) KR20180086247A (enExample)
CN (1) CN108368110A (enExample)
AU (1) AU2016367147B2 (enExample)
BR (1) BR112018011475A2 (enExample)
CA (1) CA3007462C (enExample)
CO (1) CO2018007052A2 (enExample)
ES (1) ES2899581T3 (enExample)
IL (1) IL259803A (enExample)
MX (1) MX2018006856A (enExample)
PH (1) PH12018501179A1 (enExample)
RU (1) RU2018123825A (enExample)
SG (1) SG11201804711RA (enExample)
WO (1) WO2017100201A1 (enExample)

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