RS51561B - Formulacija male doze entekavira i upotreba - Google Patents

Formulacija male doze entekavira i upotreba

Info

Publication number
RS51561B
RS51561B YU63002A YUP63002A RS51561B RS 51561 B RS51561 B RS 51561B YU 63002 A YU63002 A YU 63002A YU P63002 A YUP63002 A YU P63002A RS 51561 B RS51561 B RS 51561B
Authority
RS
Serbia
Prior art keywords
entecavir
povidone
solvent
substrate
carrier
Prior art date
Application number
YU63002A
Other languages
English (en)
Inventor
Richard J. Colonno
Omar L. Sprockel
Divyakant Desai
Michael G. Fakes
Abizer Harianawala
Original Assignee
Bristol-Myers Squibb Co.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26881354&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=RS51561(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bristol-Myers Squibb Co. filed Critical Bristol-Myers Squibb Co.
Publication of YU63002A publication Critical patent/YU63002A/sh
Publication of RS51561B publication Critical patent/RS51561B/sr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/485—Inorganic compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

Upotreba male doze entekavira za pripremu farmaceutskog preparata u obliku tablete ili kapsule za primenu jednom dnevno, u lečenju infekcije hepatitisom B kod odraslog pacijenta - čoveka, naznačena time što navedeni preparat sadrži od 0,001 do 10 mg entekavira vezanog za farmaceutski prihvatljiv nosilac - supstrat pomoću povidona kao vezivne supstance, te što navedeni farmaceutski preparat može da se dobije u procesu koji podrazumeva korake:(a) rastvaranja entekavira i supstance povidona u rastvaraču, kako bi se dobio rastvor koji sadrži entekavir i povidon na temperaturi u opsegu od oko 25°C do oko 80°C, gde je navedeni rastvarač voda ili voda sa podešenom pH vrednošću,(b) prskanja navedenog rastvora iz koraka (a) na supstrat - nosilac, dok se dati supstrat -nosilac kreće, pod uslovima koji se kontrolišu tako da se aglomeracija čestica smanji na najmanju moguću meru,(c) sušenja navedenog nosioca obloženog entekavirom iz koraka (b) kako bi se uklonio navedeni rastvarač, i(d) spajanja navedenog osušenog supstrata obloženog entekavirom iz koraka (c) sa drugim poželjnim sastojcima kako bi se dobio navedeni farmaceutski preparat.Prijava sadrži još 8 patentnih zahteva.
YU63002A 2000-02-29 2001-01-26 Formulacija male doze entekavira i upotreba RS51561B (sr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US18567200P 2000-02-29 2000-02-29
US22131300P 2000-07-28 2000-07-28
PCT/US2001/002630 WO2001064221A1 (en) 2000-02-29 2001-01-26 Low dose entecavir formulation and use

Publications (2)

Publication Number Publication Date
YU63002A YU63002A (sh) 2005-03-15
RS51561B true RS51561B (sr) 2011-08-31

Family

ID=26881354

Family Applications (1)

Application Number Title Priority Date Filing Date
YU63002A RS51561B (sr) 2000-02-29 2001-01-26 Formulacija male doze entekavira i upotreba

Country Status (35)

Country Link
US (1) US6627224B2 (sr)
EP (2) EP1267880B2 (sr)
JP (3) JP5140222B2 (sr)
KR (1) KR100757155B1 (sr)
AR (1) AR027965A1 (sr)
AT (1) ATE312613T1 (sr)
AU (1) AU2001229775A1 (sr)
BG (1) BG65815B1 (sr)
BR (1) BRPI0108435B8 (sr)
CA (1) CA2401569C (sr)
CO (1) CO5261593A1 (sr)
CZ (1) CZ303395B6 (sr)
DE (1) DE60115870T3 (sr)
DK (1) DK1267880T4 (sr)
EA (1) EA006181B1 (sr)
EE (1) EE05442B1 (sr)
EG (1) EG24408A (sr)
ES (1) ES2253403T5 (sr)
GE (1) GEP20053504B (sr)
HK (1) HK1048771A1 (sr)
HR (1) HRP20020649A2 (sr)
HU (1) HU230698B1 (sr)
IL (1) IL150447A0 (sr)
MX (1) MXPA02008359A (sr)
MY (1) MY127422A (sr)
NO (1) NO324014B1 (sr)
NZ (1) NZ520024A (sr)
PE (1) PE20020770A1 (sr)
PL (1) PL201411B1 (sr)
RS (1) RS51561B (sr)
SI (1) SI1267880T2 (sr)
SK (1) SK288008B6 (sr)
TW (1) TWI287988B (sr)
UA (1) UA84534C2 (sr)
WO (1) WO2001064221A1 (sr)

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SI1267880T2 (sl) * 2000-02-29 2010-04-30 Bristol Myers Squibb Co Formulacija z nizko dozo entekavirja in uporaba
MY131488A (en) * 2002-04-08 2007-08-30 Bristol Myers Squibb Co Low dose liquid entecavir formulations and use
AR040588A1 (es) 2002-07-26 2005-04-13 Schering Corp Formulacion farmaceutica que comprende un inhibidor de la absorcion del colesterol y un inhibidor de una hmg- co a reductasa
EP2433941A1 (en) * 2002-12-11 2012-03-28 Bristol-Myers Squibb Company Process for isolating the antiviral agent [1S-(1alpha, 3alpha, 4beta)]-2-amino-1,9-dihydro-9-[4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one
AU2004206821C1 (en) 2003-01-14 2009-10-01 Gilead Sciences, Inc. Compositions and methods for combination antiviral therapy
ES2596827T3 (es) 2003-11-17 2017-01-12 Biomarin Pharmaceutical Inc. Tratamiento de la fenilcetonuria con BH4
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US7511139B2 (en) * 2004-06-04 2009-03-31 Bristol-Myers Squibb Company Process for the preparation of entecavir and novel intermediates thereof via carbon-silicon oxidation
JP4756153B2 (ja) * 2004-08-27 2011-08-24 富士製薬工業株式会社 低成分含量の錠剤の製造方法
US20060127451A1 (en) * 2004-09-23 2006-06-15 Michael Augello Coating composition
TWI375560B (en) 2005-06-13 2012-11-01 Gilead Sciences Inc Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same
TWI471145B (zh) 2005-06-13 2015-02-01 Bristol Myers Squibb & Gilead Sciences Llc 單一式藥學劑量型
CN101245068A (zh) * 2007-02-14 2008-08-20 浙江医药股份有限公司新昌制药厂 结晶型态的恩替卡韦及其制备方法和其药物组合物及用途
AR065809A1 (es) 2007-03-22 2009-07-01 Bristol Myers Squibb Co Formulaciones farmaceuticas que contienen un inhibidor sglt2
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EA201290556A1 (ru) * 2009-12-23 2013-01-30 Рациофарм Гмбх Оральная лекарственная форма, включающая энтекавир
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KR101594820B1 (ko) * 2011-06-16 2016-02-17 건일제약 주식회사 엔테카비르를 함유하는 미립구 및 이의 제조방법
KR101439635B1 (ko) 2011-11-01 2014-09-11 대원제약주식회사 안정성이 향상된 엔테카비어를 함유하는 약학적 조성물 및 그 제조방법
IN2011CH03893A (sr) * 2011-11-14 2015-08-21 Hetero Research Foundation
EP2644197A1 (en) * 2012-03-26 2013-10-02 Sanovel Ilac Sanayi ve Ticaret A.S. Novel Pharmaceutical Compositions of Entecavir
EP2644196B1 (en) * 2012-03-26 2019-09-18 Arven Ilac Sanayi ve Ticaret A.S. Pharmaceutical compositions of Entecavir
KR101285008B1 (ko) * 2012-04-18 2013-07-10 제일약품주식회사 저용량 엔테카비어의 경구투여 제제의 제조방법
CA2779052A1 (en) * 2012-05-31 2013-11-30 Pharmascience Inc. Pharmaceutical composition of entecavir and process of manufacturing
CN103908436B (zh) * 2012-12-29 2016-02-10 安徽贝克生物制药有限公司 一种速释型恩替卡韦组合物
KR101512895B1 (ko) 2013-08-09 2015-04-16 대화제약 주식회사 엔테카비어를 포함하는 약학적 조성물의 제조방법
WO2015194923A1 (ko) * 2014-06-20 2015-12-23 주식회사 씨티씨바이오 엔테카비르를 유효성분으로 포함하는 약학 제제 및 이의 제조방법
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KR20230112817A (ko) 2022-01-21 2023-07-28 한림대학교 산학협력단 피루브산 및 pdk 억제제를 포함하는 뇌질환의 예방 또는 치료용 조성물

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Also Published As

Publication number Publication date
EE200200484A (et) 2004-04-15
UA84534C2 (uk) 2008-11-10
BG106905A (bg) 2003-04-30
JP5921746B2 (ja) 2016-05-24
EE05442B1 (et) 2011-08-15
MXPA02008359A (es) 2003-02-12
JP2004503467A (ja) 2004-02-05
DE60115870T2 (de) 2006-08-17
GEP20053504B (en) 2005-05-10
BR0108435A (pt) 2004-06-15
US6627224B2 (en) 2003-09-30
EP1267880A1 (en) 2003-01-02
BG65815B1 (bg) 2010-01-29
NO20024099L (no) 2002-08-28
ES2253403T5 (es) 2010-04-22
PE20020770A1 (es) 2002-09-06
HU230698B1 (hu) 2017-09-28
HK1048771A1 (zh) 2003-04-17
NO324014B1 (no) 2007-07-30
PL201411B1 (pl) 2009-04-30
EP1267880B2 (en) 2010-01-20
NZ520024A (en) 2005-03-24
SK11652002A3 (sk) 2003-09-11
JP5140222B2 (ja) 2013-02-06
DE60115870D1 (de) 2006-01-19
EA200200812A1 (ru) 2003-12-25
MY127422A (en) 2006-11-30
DK1267880T3 (da) 2006-03-06
YU63002A (sh) 2005-03-15
EG24408A (en) 2009-05-20
JP2012255017A (ja) 2012-12-27
CO5261593A1 (es) 2003-03-31
AR027965A1 (es) 2003-04-16
SI1267880T2 (sl) 2010-04-30
WO2001064221A1 (en) 2001-09-07
BRPI0108435B1 (pt) 2019-02-05
DE60115870T3 (de) 2010-07-29
AU2001229775A1 (en) 2001-09-12
IL150447A0 (en) 2002-12-01
HUP0500558A3 (en) 2012-08-28
SK288008B6 (sk) 2012-10-02
DK1267880T4 (da) 2010-05-17
TWI287988B (en) 2007-10-11
EP1642582A1 (en) 2006-04-05
NO20024099D0 (no) 2002-08-28
KR20020082230A (ko) 2002-10-30
ES2253403T3 (es) 2006-06-01
CA2401569C (en) 2009-08-18
EP1267880B1 (en) 2005-12-14
HUP0500558A2 (hu) 2005-09-28
HRP20020649A2 (en) 2004-12-31
CZ303395B6 (cs) 2012-08-29
EA006181B1 (ru) 2005-10-27
JP2015178523A (ja) 2015-10-08
SI1267880T1 (sl) 2006-06-30
KR100757155B1 (ko) 2007-09-07
BRPI0108435B8 (pt) 2021-05-25
CA2401569A1 (en) 2001-09-07
ATE312613T1 (de) 2005-12-15
PL366102A1 (en) 2005-01-24
US20010033864A1 (en) 2001-10-25

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