PT1412357E - Beta-amino-tetra-hidroimidazo (1,2-a) pirazinas e beta-aminotetra-hidrotriazolo (4,3-a) pirazinas como inibidores da dipeptidil-peptidase para o tratamento ou prevencao de diabetes - Google Patents

Beta-amino-tetra-hidroimidazo (1,2-a) pirazinas e beta-aminotetra-hidrotriazolo (4,3-a) pirazinas como inibidores da dipeptidil-peptidase para o tratamento ou prevencao de diabetes

Info

Publication number
PT1412357E
PT1412357E PT02749813T PT02749813T PT1412357E PT 1412357 E PT1412357 E PT 1412357E PT 02749813 T PT02749813 T PT 02749813T PT 02749813 T PT02749813 T PT 02749813T PT 1412357 E PT1412357 E PT 1412357E
Authority
PT
Portugal
Prior art keywords
pyrazines
beta
diabetes
prevention
treatment
Prior art date
Application number
PT02749813T
Other languages
English (en)
Portuguese (pt)
Inventor
Scott D Edmondson
Michael H Fisher
Kim Dooseop
Maccoss Malcolm
Emma R Parmee
Ann E Weber
Xu Jinyou
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23172273&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT1412357(E) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of PT1412357E publication Critical patent/PT1412357E/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07—ORGANIC CHEMISTRY
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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
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  • Hematology (AREA)
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  • Obesity (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
  • Molecular Biology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Reproductive Health (AREA)
  • Psychiatry (AREA)
PT02749813T 2001-07-06 2002-07-05 Beta-amino-tetra-hidroimidazo (1,2-a) pirazinas e beta-aminotetra-hidrotriazolo (4,3-a) pirazinas como inibidores da dipeptidil-peptidase para o tratamento ou prevencao de diabetes PT1412357E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US30347401P 2001-07-06 2001-07-06

Publications (1)

Publication Number Publication Date
PT1412357E true PT1412357E (pt) 2006-07-31

Family

ID=23172273

Family Applications (2)

Application Number Title Priority Date Filing Date
PT05077584T PT1625847E (pt) 2001-07-06 2002-07-05 Utilização médica de uma tetra-hidrotrioazolo [4,3-a]pirazina
PT02749813T PT1412357E (pt) 2001-07-06 2002-07-05 Beta-amino-tetra-hidroimidazo (1,2-a) pirazinas e beta-aminotetra-hidrotriazolo (4,3-a) pirazinas como inibidores da dipeptidil-peptidase para o tratamento ou prevencao de diabetes

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PT05077584T PT1625847E (pt) 2001-07-06 2002-07-05 Utilização médica de uma tetra-hidrotrioazolo [4,3-a]pirazina

Country Status (45)

Country Link
US (9) US7125873B2 (en:Method)
EP (4) EP1625847B1 (en:Method)
JP (1) JP3762407B2 (en:Method)
KR (1) KR100606871B1 (en:Method)
CN (2) CN1861077A (en:Method)
AR (1) AR036114A1 (en:Method)
AT (2) ATE471148T1 (en:Method)
AU (1) AU2002320303B2 (en:Method)
BE (1) BE2007C047I2 (en:Method)
BG (1) BG108493A (en:Method)
BR (1) BRPI0210866B8 (en:Method)
CA (1) CA2450740C (en:Method)
CR (1) CR7235A (en:Method)
CY (3) CY2007019I2 (en:Method)
DE (4) DE122008000046I1 (en:Method)
DK (2) DK1625847T3 (en:Method)
DO (1) DOP2002000438A (en:Method)
EA (2) EA012701B1 (en:Method)
EC (1) ECSP044935A (en:Method)
ES (2) ES2259713T3 (en:Method)
FR (2) FR07C0041I2 (en:Method)
GE (2) GEP20053734B (en:Method)
HR (1) HRP20031098B1 (en:Method)
HU (2) HU225695B1 (en:Method)
IL (3) IL159109A0 (en:Method)
IS (2) IS2218B (en:Method)
JO (1) JO2230B1 (en:Method)
LT (1) LTC1412357I2 (en:Method)
LU (2) LUC91360I2 (en:Method)
MA (1) MA27053A1 (en:Method)
ME (1) ME00439B (en:Method)
MX (1) MXPA04000018A (en:Method)
MY (1) MY127961A (en:Method)
NL (2) NL300287I2 (en:Method)
NO (4) NO321999B1 (en:Method)
NZ (1) NZ529833A (en:Method)
PE (1) PE20030654A1 (en:Method)
PL (1) PL196278B6 (en:Method)
PT (2) PT1625847E (en:Method)
RS (1) RS50737B (en:Method)
SI (1) SI1412357T1 (en:Method)
TW (1) TWI226331B (en:Method)
UA (1) UA74912C2 (en:Method)
WO (1) WO2003004498A1 (en:Method)
ZA (1) ZA200309294B (en:Method)

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