|
DK2347775T3
(da)
|
2005-12-13 |
2020-07-13 |
Harvard College |
Skabeloner til celletransplantation
|
|
PL2624873T3
(pl)
|
2010-10-06 |
2020-12-14 |
President And Fellows Of Harvard College |
Nadające się do wstrzykiwania hydrożele tworzące pory do terapii komórkowych opartych na materiałach
|
|
US9675561B2
(en)
|
2011-04-28 |
2017-06-13 |
President And Fellows Of Harvard College |
Injectable cryogel vaccine devices and methods of use thereof
|
|
PL2838515T3
(pl)
|
2012-04-16 |
2020-06-29 |
President And Fellows Of Harvard College |
Kompozycje mezoporowatego krzemu do modulowania odpowiedzi odpornościowych
|
|
SG11201407875UA
(en)
|
2012-06-08 |
2014-12-30 |
Aduro Biotech |
Compostions and methods for cancer immunotherapy
|
|
AU2013358892B2
(en)
|
2012-12-13 |
2018-06-21 |
Aduro Biotech, Inc. |
Compositions comprising cyclic purine dinucleotides having defined stereochemistries and methods for their preparation and use
|
|
CA2908154C
(en)
|
2013-04-29 |
2023-11-28 |
Memorial Sloan Kettering Cancer Center |
Compositions and methods for altering second messenger signaling
|
|
JP2016518140A
(ja)
|
2013-05-03 |
2016-06-23 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア |
I型インターフェロンの環状ジヌクレオチド誘導法
|
|
US9549944B2
(en)
|
2013-05-18 |
2017-01-24 |
Aduro Biotech, Inc. |
Compositions and methods for inhibiting “stimulator of interferon gene”—dependent signalling
|
|
DK2996473T3
(da)
|
2013-05-18 |
2019-11-04 |
Aduro Biotech Inc |
Sammensætninger og fremgangsmåder til aktivering af "stimulator af interferon-gen"-afhængig signalering
|
|
EP3027227A4
(en)
*
|
2013-07-31 |
2018-05-23 |
Memorial Sloan Kettering Cancer Center |
Sting crystals and modulators
|
|
US10570204B2
(en)
|
2013-09-26 |
2020-02-25 |
The Medical College Of Wisconsin, Inc. |
Methods for treating hematologic cancers
|
|
JP2016538344A
(ja)
*
|
2013-11-19 |
2016-12-08 |
ザ・ユニバーシティ・オブ・シカゴThe University Of Chicago |
癌処置としてのstingアゴニストの使用
|
|
JOP20200094A1
(ar)
|
2014-01-24 |
2017-06-16 |
Dana Farber Cancer Inst Inc |
جزيئات جسم مضاد لـ pd-1 واستخداماتها
|
|
WO2015109391A1
(en)
|
2014-01-24 |
2015-07-30 |
Children's Hospital Of Eastern Ontario Research Institute Inc. |
Smc combination therapy for the treatment of cancer
|
|
JOP20200096A1
(ar)
|
2014-01-31 |
2017-06-16 |
Children’S Medical Center Corp |
جزيئات جسم مضاد لـ tim-3 واستخداماتها
|
|
LT3116909T
(lt)
|
2014-03-14 |
2020-02-10 |
Novartis Ag |
Antikūno molekulės prieš lag-3 ir jų panaudojimas
|
|
CN107073090A
(zh)
|
2014-04-30 |
2017-08-18 |
哈佛学院董事会 |
结合的疫苗装置和杀死癌细胞的方法
|
|
CA2950033A1
(en)
|
2014-06-04 |
2015-12-10 |
Glaxosmithkline Intellectual Property Development Limited |
Cyclic di-nucleotides as modulators of sting
|
|
BR112017004826A2
(pt)
|
2014-09-13 |
2017-12-12 |
Novartis Ag |
terapias de combinação de inibidores de alk
|
|
MA41044A
(fr)
|
2014-10-08 |
2017-08-15 |
Novartis Ag |
Compositions et procédés d'utilisation pour une réponse immunitaire accrue et traitement contre le cancer
|
|
EP3206711B1
(en)
|
2014-10-14 |
2023-05-31 |
Novartis AG |
Antibody molecules to pd-l1 and uses thereof
|
|
US11058758B2
(en)
*
|
2014-11-20 |
2021-07-13 |
National Institutes Of Biomedical Innovation, Health And Nutrition |
TH1-inducing adjuvant comprising combination of different nucleic acid adjuvants, and use of same
|
|
PL3233882T3
(pl)
|
2014-12-16 |
2020-04-30 |
Kayla Therapeutics |
Fluorowane cykliczne dinukleotydy do indukcji cytokin
|
|
GB201501462D0
(en)
|
2015-01-29 |
2015-03-18 |
Glaxosmithkline Ip Dev Ltd |
Novel compounds
|
|
WO2016123573A1
(en)
|
2015-01-30 |
2016-08-04 |
President And Fellows Of Harvard College |
Peritumoral and intratumoral materials for cancer therapy
|
|
WO2016130616A1
(en)
|
2015-02-11 |
2016-08-18 |
The Johns Hopkins University |
Bacteria over-expressing c-di-amp and therapeutic methods
|
|
PE20171448A1
(es)
|
2015-03-10 |
2017-10-02 |
Aduro Biotech Inc |
Composiciones y metodos para activar la senalizacion dependiente del estimulador del gen de interferon
|
|
JP7094533B2
(ja)
|
2015-04-10 |
2022-07-04 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
免疫細胞捕捉デバイスおよびその製造および使用方法
|
|
RU2749113C2
(ru)
|
2015-04-22 |
2021-06-04 |
Куревак Аг |
Содержащая рнк композиция для лечения опухолевых заболеваний
|
|
CN114272371A
(zh)
*
|
2015-07-29 |
2022-04-05 |
诺华股份有限公司 |
包含抗pd-1抗体分子的联合疗法
|
|
EP3317301B1
(en)
|
2015-07-29 |
2021-04-07 |
Novartis AG |
Combination therapies comprising antibody molecules to lag-3
|
|
WO2017019897A1
(en)
|
2015-07-29 |
2017-02-02 |
Novartis Ag |
Combination therapies comprising antibody molecules to tim-3
|
|
CN106692967A
(zh)
*
|
2015-08-12 |
2017-05-24 |
聊城市奥润生物医药科技有限公司 |
环二核苷酸cGAMP联合PD1的抗体(Nivolumab)在制备抗肿瘤药物中的应用
|
|
US11453697B1
(en)
|
2015-08-13 |
2022-09-27 |
Merck Sharp & Dohme Llc |
Cyclic di-nucleotide compounds as sting agonists
|
|
MX2018001814A
(es)
*
|
2015-08-13 |
2018-05-07 |
Merck Sharp & Dohme |
Compuestos dinucleotidos ciclicos como agonistas del estimulador de genes de interferon.
|
|
CN106540255A
(zh)
*
|
2015-09-18 |
2017-03-29 |
聊城市奥润生物医药科技有限公司 |
环二核苷酸cGAMP联合贝伐珠单抗在抗肿瘤中的应用
|
|
TW201726700A
(zh)
|
2015-10-28 |
2017-08-01 |
艾杜諾生物科技公司 |
用於活化「干擾素基因刺激子」依賴性訊號之組合物及方法
|
|
MA44334A
(fr)
|
2015-10-29 |
2018-09-05 |
Novartis Ag |
Conjugués d'anticorps comprenant un agoniste du récepteur de type toll
|
|
NZ738202A
(en)
|
2015-12-03 |
2019-07-26 |
Glaxosmithkline Ip Dev Ltd |
Cyclic purine dinucleotides as modulators of sting
|
|
MX2018007204A
(es)
|
2015-12-16 |
2018-12-11 |
Gritstone Oncology Inc |
Identificacion, fabricacion y uso de neoantigeno.
|
|
US20180369268A1
(en)
*
|
2015-12-16 |
2018-12-27 |
Aduro Biotech, Inc. |
Methods for identifying inhibitors of "stimulator of interferon gene"- dependent interferon production
|
|
ES2986067T3
(es)
|
2015-12-17 |
2024-11-08 |
Novartis Ag |
Moléculas de anticuerpos frente a PD-1 y usos de las mismas
|
|
MA43859A
(fr)
|
2016-01-11 |
2018-11-21 |
Novartis Ag |
Anticorps monoclonaux humainisés immunostimulants dirigés contre l'interleukine -2 humaine, et leurs protéines de fusion
|
|
HRP20251050T1
(hr)
|
2016-01-11 |
2025-11-07 |
Innate Tumor Immunity, Inc. |
Ciklični dinukleotidi za liječenje stanja povezanih s aktivnošću sting kao što je rak
|
|
US10723756B2
(en)
|
2016-01-11 |
2020-07-28 |
Innate Tumor Immunity Inc. |
Cyclic dinucleotides for treating conditions associated with STING activity such as cancer
|
|
CN106544319A
(zh)
*
|
2016-01-24 |
2017-03-29 |
聊城市奥润生物医药科技有限公司 |
一种用于刺激树突状细胞成熟的组合物及其用于刺激树突状细胞成熟的方法
|
|
US11752238B2
(en)
|
2016-02-06 |
2023-09-12 |
President And Fellows Of Harvard College |
Recapitulating the hematopoietic niche to reconstitute immunity
|
|
CN114751950B
(zh)
*
|
2016-03-18 |
2025-04-18 |
免疫传感器公司 |
环二核苷酸化合物及使用方法
|
|
CN106540256A
(zh)
*
|
2016-03-27 |
2017-03-29 |
聊城市奥润生物医药科技有限公司 |
环二核苷酸-脂质体偶联单克隆抗体在抗肿瘤中的应用
|
|
SI3440076T1
(sl)
|
2016-04-07 |
2022-09-30 |
Glaxosmithkline Intellectual Property Development Limited |
Heterociklični amidi uporabni kot proteinski modulatorji
|
|
CN109563081A
(zh)
|
2016-04-07 |
2019-04-02 |
葛兰素史克知识产权开发有限公司 |
可用作蛋白调节剂的杂环酰胺类
|
|
KR20180134395A
(ko)
|
2016-04-19 |
2018-12-18 |
인네이트 튜머 이뮤니티, 인코포레이티드 |
Nlrp3 조정제
|
|
WO2017184735A1
(en)
|
2016-04-19 |
2017-10-26 |
Ifm Therapeutics, Inc |
Nlrp3 modulators
|
|
US10696985B1
(en)
|
2016-06-06 |
2020-06-30 |
Vanderbilt University |
Reversibly crosslinked endosomolytic polymer vesicles for cytosolic drug delivery
|
|
WO2018009466A1
(en)
|
2016-07-05 |
2018-01-11 |
Aduro Biotech, Inc. |
Locked nucleic acid cyclic dinucleotide compounds and uses thereof
|
|
WO2018009652A1
(en)
*
|
2016-07-06 |
2018-01-11 |
Sperovie Biosciences, Inc. |
Compounds, compositions, and methods for the treatment of disease
|
|
MX392605B
(es)
|
2016-07-06 |
2025-03-11 |
Invox Pharma Ltd |
Compuestos, composiciones y metodos para el tratamiento de enfermedades.
|
|
JP2019522486A
(ja)
|
2016-07-13 |
2019-08-15 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
抗原提示細胞模倣足場およびそれを作製および使用するための方法
|
|
NL2017267B1
(en)
|
2016-07-29 |
2018-02-01 |
Aduro Biotech Holdings Europe B V |
Anti-pd-1 antibodies
|
|
NL2017270B1
(en)
|
2016-08-02 |
2018-02-09 |
Aduro Biotech Holdings Europe B V |
New anti-hCTLA-4 antibodies
|
|
KR102638898B1
(ko)
|
2016-08-02 |
2024-02-22 |
프레지던트 앤드 펠로우즈 오브 하바드 칼리지 |
면역 반응을 조정하기 위한 생체재료
|
|
CA3069780A1
(en)
|
2016-08-09 |
2018-02-15 |
Aarhus Universitet |
Modulation of ifi16 and sting activity
|
|
FI3506884T4
(fi)
|
2016-08-30 |
2024-12-23 |
Dana Farber Cancer Inst Inc |
Lääkkeenantokoostumuksia ja niiden käyttötapoja
|
|
US11052149B2
(en)
|
2016-09-19 |
2021-07-06 |
The University Of North Carolina At Chapel Hill |
Methods and compositions for inducing an immune response
|
|
US10537590B2
(en)
|
2016-09-30 |
2020-01-21 |
Boehringer Ingelheim International Gmbh |
Cyclic dinucleotide compounds
|
|
GEP20217285B
(en)
|
2016-10-04 |
2021-08-10 |
Merck Sharp & Dohme |
BENZO[b]THIOPHENE COMPOUNDS AS STING AGONISTS
|
|
US11001605B2
(en)
|
2016-10-07 |
2021-05-11 |
Biolog Life Science Institute Gmbh & Co. Kg |
Cyclic dinucleotides containing benzimidazole, method for the production of same, and use of same to activate stimulator of interferon genes (sting)-dependent signaling pathways
|
|
CN110381996A
(zh)
*
|
2016-10-11 |
2019-10-25 |
艾伯塔大学理事会 |
包含环状二核苷酸或古细菌脂质体作为佐剂的丙型肝炎病毒免疫原性组合物及其使用方法
|
|
JOP20170188A1
(ar)
|
2016-11-25 |
2019-01-30 |
Janssen Biotech Inc |
ثنائي النوكليوتيدات الحلقية كمنبهات ستينغ (sting)
|
|
JP2018090562A
(ja)
*
|
2016-12-01 |
2018-06-14 |
武田薬品工業株式会社 |
環状ジヌクレオチド
|
|
JOP20170192A1
(ar)
*
|
2016-12-01 |
2019-01-30 |
Takeda Pharmaceuticals Co |
داي نوكليوتيد حلقي
|
|
WO2018118665A1
(en)
*
|
2016-12-20 |
2018-06-28 |
Merck Sharp & Dohme Corp. |
Cyclic dinucleotide sting agonists for cancer treatment
|
|
RU2019122602A
(ru)
*
|
2016-12-20 |
2021-01-22 |
Мерк Шарп И Доум Корп. |
Комбинации антагонистов pd-1 и циклических динуклеотидных агонистов sting для лечения рака
|
|
EP3573718B1
(en)
*
|
2017-01-27 |
2022-06-01 |
Janssen Biotech, Inc. |
Cyclic dinucleotides as sting agonists
|
|
WO2018138684A1
(en)
|
2017-01-27 |
2018-08-02 |
Janssen Biotech, Inc. |
Cyclic dinucleotides as sting agonists
|
|
EA201991804A1
(ru)
|
2017-02-01 |
2020-02-07 |
МОДЕРНАТиЭкс, ИНК. |
ИММУНОМОДУЛИРУЮЩИЕ ТЕРАПЕВТИЧЕСКИЕ КОМПОЗИЦИИ мРНК, КОДИРУЮЩЕЙ ПЕПТИДЫ С АКТИВИРУЮЩЕЙ ОНКОГЕННОЙ МУТАЦИЕЙ
|
|
TWI674261B
(zh)
|
2017-02-17 |
2019-10-11 |
美商英能腫瘤免疫股份有限公司 |
Nlrp3 調節劑
|
|
JP2018131427A
(ja)
*
|
2017-02-17 |
2018-08-23 |
国立研究開発法人理化学研究所 |
免疫細胞の制御技術
|
|
US20200055883A1
(en)
|
2017-02-17 |
2020-02-20 |
Eisai R&D Management Co., Ltd. |
Cyclic di-nucleotides derivative for the treatment of cancer
|
|
CA3053568A1
(en)
|
2017-02-21 |
2018-08-30 |
Board Of Regents, The University Of Texas System |
Cyclic dinucleotides as agonists of stimulator of interferon gene dependent signalling
|
|
CN106727331B
(zh)
*
|
2017-03-13 |
2022-02-01 |
杭州星鳌生物科技有限公司 |
免疫脂质体-环二核苷酸的组成、制备方法及其在抗肿瘤中的应用
|
|
CA3055791A1
(en)
|
2017-03-20 |
2018-09-27 |
Genocea Biosciences, Inc. |
Treatment methods
|
|
JOP20190218A1
(ar)
|
2017-03-22 |
2019-09-22 |
Boehringer Ingelheim Int |
مركبات ثنائية النيوكليوتيدات حلقية معدلة
|
|
CA3058134A1
(en)
|
2017-04-13 |
2018-10-18 |
Aduro Biotech Holdings, Europe B.V. |
Anti-sirp alpha antibodies
|
|
CN110770345A
(zh)
|
2017-04-14 |
2020-02-07 |
托尔奈公司 |
免疫调节多核苷酸、抗体缀合物及其使用方法
|
|
AR111651A1
(es)
|
2017-04-28 |
2019-08-07 |
Novartis Ag |
Conjugados de anticuerpos que comprenden agonistas del receptor de tipo toll y terapias de combinación
|
|
UY37695A
(es)
|
2017-04-28 |
2018-11-30 |
Novartis Ag |
Compuesto dinucleótido cíclico bis 2’-5’-rr-(3’f-a)(3’f-a) y usos del mismo
|
|
AR113224A1
(es)
|
2017-04-28 |
2020-02-19 |
Novartis Ag |
Conjugados de anticuerpo que comprenden un agonista de sting
|
|
WO2018208667A1
(en)
*
|
2017-05-12 |
2018-11-15 |
Merck Sharp & Dohme Corp. |
Cyclic di-nucleotide compounds as sting agonists
|
|
CN108853144A
(zh)
*
|
2017-05-16 |
2018-11-23 |
科济生物医药(上海)有限公司 |
Toll样受体激动剂与免疫效应细胞的联用
|
|
WO2018229715A1
(en)
|
2017-06-16 |
2018-12-20 |
Novartis Ag |
Compositions comprising anti-cd32b antibodies and methods of use thereof
|
|
US20200172628A1
(en)
|
2017-06-22 |
2020-06-04 |
Novartis Ag |
Antibody molecules to cd73 and uses thereof
|
|
MA49457A
(fr)
|
2017-06-22 |
2020-04-29 |
Novartis Ag |
Molécules d'anticorps se liant à cd73 et leurs utilisations
|
|
WO2019014402A1
(en)
|
2017-07-14 |
2019-01-17 |
Innate Tumor Immunity, Inc. |
MODULATORS OF NLRP3
|
|
EP3431484A1
(en)
*
|
2017-07-21 |
2019-01-23 |
Ludwig-Maximilians-Universität München |
A fluorescent cyclic dinucleotide and its use in methods of identifying substances having an ability to modulate the cgas/sting pathway
|
|
EP3658565B1
(en)
|
2017-07-28 |
2022-11-09 |
Bristol-Myers Squibb Company |
Cyclic dinucleotides as anticancer agents
|
|
US11285131B2
(en)
|
2017-08-04 |
2022-03-29 |
Merck Sharp & Dohme Corp. |
Benzo[b]thiophene STING agonists for cancer treatment
|
|
JP2020529421A
(ja)
|
2017-08-04 |
2020-10-08 |
メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. |
がんの処置のためのPD−1アンタゴニストおよびベンゾ[b]チオフェンSTINGアゴニストの組み合わせ
|
|
KR102782200B1
(ko)
|
2017-08-30 |
2025-03-17 |
에이제이 사이언시즈 (이씽) 코., 엘티디 |
인터페론 유전자 조절인자의 자극제로서의 환식 다이-뉴클레오타이드
|
|
CN111051327B
(zh)
*
|
2017-08-31 |
2023-11-03 |
百时美施贵宝公司 |
作为抗癌剂的环二核苷酸
|
|
CN111051328B
(zh)
*
|
2017-08-31 |
2023-11-03 |
百时美施贵宝公司 |
作为抗癌剂的环二核苷酸
|
|
WO2019046511A1
(en)
|
2017-08-31 |
2019-03-07 |
Sperovie Biosciences, Inc. |
COMPOUNDS, COMPOSITIONS AND METHODS FOR THE TREATMENT OF DISEASE
|
|
HUE066413T2
(hu)
|
2017-09-08 |
2024-08-28 |
Univ Leland Stanford Junior |
ENPP1 inhibitorok és alkalmazásuk rák kezelésére
|
|
US11707531B2
(en)
|
2017-09-11 |
2023-07-25 |
F-star Therapeutics, Inc. |
Compounds, compositions, and methods for the treatment of disease
|
|
US11584774B2
(en)
|
2017-09-11 |
2023-02-21 |
F-star Therapeutics, Inc. |
Compounds, compositions, and methods for the treatment of disease
|
|
WO2019069270A1
(en)
|
2017-10-05 |
2019-04-11 |
Glaxosmithkline Intellectual Property Development Limited |
GENERATOR STIMULATOR MODULATORS (STING) INTERFERON
|
|
JP2020536106A
(ja)
|
2017-10-05 |
2020-12-10 |
グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドGlaxosmithkline Intellectual Property Development Limited |
Hivの処置に有用なインターフェロン遺伝子の刺激物質(sting)の調節物質
|
|
AU2018348165B2
(en)
|
2017-10-10 |
2025-09-04 |
Seattle Project Corp. |
Neoantigen identification using hotspots
|
|
US20210040205A1
(en)
|
2017-10-25 |
2021-02-11 |
Novartis Ag |
Antibodies targeting cd32b and methods of use thereof
|
|
KR20200098511A
(ko)
|
2017-11-10 |
2020-08-20 |
다케다 야쿠힌 고교 가부시키가이샤 |
Sting 조절제 화합물, 및 제조 및 사용 방법
|
|
EA038805B1
(ru)
*
|
2017-11-21 |
2021-10-21 |
Такеда Фармасьютикал Компани Лимитед |
Циклические динуклеотиды в качестве агонистов sting (стимулятор генов интерферона)
|
|
US11885815B2
(en)
|
2017-11-22 |
2024-01-30 |
Gritstone Bio, Inc. |
Reducing junction epitope presentation for neoantigens
|
|
US11633473B2
(en)
|
2017-11-27 |
2023-04-25 |
Children's Medical Center Corporation |
Stimulator of Interferon Genes (STING) ligands and uses thereof
|
|
JP7317014B2
(ja)
*
|
2017-12-15 |
2023-07-28 |
ヤンセン バイオテツク,インコーポレーテツド |
Stingアゴニストとしての環状ジヌクレオチド
|
|
JP7098748B2
(ja)
|
2017-12-20 |
2022-07-11 |
インスティチュート オブ オーガニック ケミストリー アンド バイオケミストリー エーエスシーアール,ヴイ.ヴイ.アイ. |
Stingアダプタータンパク質を活性化するホスホン酸結合を有する2’3’環状ジヌクレオチド
|
|
US11685761B2
(en)
|
2017-12-20 |
2023-06-27 |
Merck Sharp & Dohme Llc |
Cyclic di-nucleotide compounds as sting agonists
|
|
CN111566120B
(zh)
|
2017-12-20 |
2023-09-29 |
捷克共和国有机化学与生物化学研究所 |
活化sting转接蛋白的具有膦酸酯键的3’3’环状二核苷酸
|
|
US11813326B2
(en)
*
|
2018-01-04 |
2023-11-14 |
Academia Sinica |
Cell-associating immunologic adjuvants for treatment enhancement
|
|
EP3743103A4
(en)
*
|
2018-01-26 |
2021-03-17 |
The Regents of The University of California |
INTRANASAL ADMINISTRATION OF CYCLIC DI-NUCLEOTIDE ADJUVED VACCINE FOR TUBERCULOSIS
|
|
CA3090171A1
(en)
|
2018-02-02 |
2019-08-08 |
Novartis Ag |
Combination of sting agonist and il-15/il15-ra for the treatment of cancer
|
|
EP3749681A1
(en)
*
|
2018-02-06 |
2020-12-16 |
STipe Therapeutics ApS |
Modulation of p62 and sting activity
|
|
US12220462B1
(en)
|
2018-02-13 |
2025-02-11 |
Abionyx Pharma Sa |
Complexes for delivery of cyclic dinucleotides
|
|
WO2019175145A1
(en)
|
2018-03-12 |
2019-09-19 |
Janssen Vaccines & Prevention B.V. |
Vaccines against urinary tract infections
|
|
CN110272462B
(zh)
*
|
2018-03-15 |
2023-03-10 |
南开大学 |
制备化合物的方法
|
|
WO2019183578A1
(en)
|
2018-03-23 |
2019-09-26 |
Codiak Biosciences, Inc. |
Extracellular vesicles comprising sting-agonist
|
|
WO2019185477A1
(en)
|
2018-03-27 |
2019-10-03 |
Boehringer Ingelheim International Gmbh |
Cyclic dinucleotide compounds containing 2-aza-hypoxanthine or 6h-pytazolo[1,5-d][1,2,4]triazin-7-one as sting agonists
|
|
EP3774833A1
(en)
|
2018-03-27 |
2021-02-17 |
Boehringer Ingelheim International GmbH |
Modified cyclic dinucleotide compounds
|
|
EP3774765A4
(en)
|
2018-04-03 |
2021-12-29 |
Merck Sharp & Dohme Corp. |
Aza-benzothiophene compounds as sting agonists
|
|
JP7326319B2
(ja)
|
2018-04-03 |
2023-08-15 |
メルク・シャープ・アンド・ドーム・エルエルシー |
Stingアゴニストとしてのベンゾチオフェン類及び関連する化合物
|
|
WO2019195658A1
(en)
|
2018-04-05 |
2019-10-10 |
Dana-Farber Cancer Institute, Inc. |
Sting levels as a biomarker for cancer immunotherapy
|
|
TWI818007B
(zh)
*
|
2018-04-06 |
2023-10-11 |
捷克科學院有機化學與生物化學研究所 |
2'3'-環二核苷酸
|
|
TWI833744B
(zh)
|
2018-04-06 |
2024-03-01 |
捷克科學院有機化學與生物化學研究所 |
3'3'-環二核苷酸
|
|
TW202005654A
(zh)
|
2018-04-06 |
2020-02-01 |
捷克科學院有機化學與生物化學研究所 |
2,2,─環二核苷酸
|
|
NZ769136A
(en)
|
2018-04-25 |
2024-04-26 |
Innate Tumor Immunity Inc |
Nlrp3 modulators
|
|
CN108310378A
(zh)
*
|
2018-04-28 |
2018-07-24 |
杭州星鳌生物科技有限公司 |
一类新型免疫联体抗肿瘤创新药物的制备及其应用
|
|
WO2019211799A1
(en)
|
2018-05-03 |
2019-11-07 |
Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. |
2'3'-cyclic dinucleotide analogue comprising a cyclopentanyl modified nucleotide
|
|
GB201807924D0
(en)
|
2018-05-16 |
2018-06-27 |
Ctxt Pty Ltd |
Compounds
|
|
WO2019232244A2
(en)
|
2018-05-31 |
2019-12-05 |
Novartis Ag |
Antibody molecules to cd73 and uses thereof
|
|
WO2019232392A1
(en)
|
2018-06-01 |
2019-12-05 |
Eisai R&D Management Co., Ltd. |
Methods for the treatment of bladder cancer
|
|
WO2019246450A1
(en)
*
|
2018-06-20 |
2019-12-26 |
Yale University |
Rig-i agonists and treatments using same
|
|
EP3818044A1
(en)
|
2018-07-03 |
2021-05-12 |
IFM Due, Inc. |
Compounds and compositions for treating conditions associated with sting activity
|
|
US11618749B2
(en)
|
2018-07-03 |
2023-04-04 |
Ifm Due, Inc. |
Compounds and compositions for treating conditions associated with STING activity
|
|
US12291548B2
(en)
|
2018-07-10 |
2025-05-06 |
Sperovie Biosciences, Inc. |
Compounds, compositions, and methods for the treatment of disease
|
|
NZ771198A
(en)
*
|
2018-07-11 |
2024-11-29 |
Actym Therapeutics Inc |
Engineered immunostimulatory bacterial strains and uses thereof
|
|
US12201627B2
(en)
|
2018-08-16 |
2025-01-21 |
Innate Tumor Immunity, Inc. |
NLRP3 modulators
|
|
US11691990B2
(en)
|
2018-08-16 |
2023-07-04 |
Eisai R&D Management Co., Ltd |
Salts of compounds and crystals thereof
|
|
WO2020037092A1
(en)
|
2018-08-16 |
2020-02-20 |
Innate Tumor Immunity, Inc. |
Imidazo[4,5-c]quinoline derived nlrp3-modulators
|
|
BR112021002642A2
(pt)
|
2018-08-16 |
2021-05-04 |
Innate Tumor Immunity, Inc. |
compostos de 4-amino-1h-imidazo[4,5-c]quinolina substituídos e métodos aprimorados para a preparação dos mesmos
|
|
MA53438A
(fr)
|
2018-08-24 |
2021-09-15 |
Codiak Biosciences Inc |
Vésicules extracellulaires ciblant des cellules dendritiques et utilisations associées
|
|
PT3848054T
(pt)
|
2018-09-06 |
2025-04-03 |
Daiichi Sankyo Co Ltd |
Conjugados anticorpo-fármaco de derivados de dinucleótidos cíclicos
|
|
WO2020049534A1
(en)
|
2018-09-07 |
2020-03-12 |
Novartis Ag |
Sting agonist and combination therapy thereof for the treatment of cancer
|
|
WO2020059895A1
(ko)
*
|
2018-09-17 |
2020-03-26 |
주식회사 큐라티스 |
스팅 작용자를 포함하는 면역항원보강제 및 백신 조성물
|
|
WO2020061129A1
(en)
|
2018-09-19 |
2020-03-26 |
President And Fellows Of Harvard College |
Compositions and methods for labeling and modulation of cells in vitro and in vivo
|
|
WO2020057546A1
(zh)
|
2018-09-21 |
2020-03-26 |
上海迪诺医药科技有限公司 |
环状二核苷酸类似物、其药物组合物及应用
|
|
US11161864B2
(en)
|
2018-10-29 |
2021-11-02 |
Venenum Biodesign, LLC |
Sting agonists
|
|
US11110106B2
(en)
|
2018-10-29 |
2021-09-07 |
Venenum Biodesign, LLC |
Sting agonists for treating bladder cancer and solid tumors
|
|
CN113272015A
(zh)
|
2018-10-29 |
2021-08-17 |
健诺西生物科学公司 |
治疗方法
|
|
WO2020092633A1
(en)
|
2018-10-30 |
2020-05-07 |
Vanderbilt University |
Graft copolymers, methods of forming graft copolymers, and methods of use thereof
|
|
EP3873938A1
(en)
|
2018-10-31 |
2021-09-08 |
Novartis AG |
Dc-sign antibody conjugates comprising sting agonists
|
|
US11596692B1
(en)
|
2018-11-21 |
2023-03-07 |
Incyte Corporation |
PD-L1/STING conjugates and methods of use
|
|
WO2020117623A1
(en)
*
|
2018-12-07 |
2020-06-11 |
Merck Sharp & Dohme Corp. |
Cyclic di-nucleotide compounds as sting agonists
|
|
EP3891166A4
(en)
*
|
2018-12-07 |
2022-08-24 |
Merck Sharp & Dohme Corp. |
CYCLIC DI-NUCLEOTIDE COMPOUNDS AS STING AGONISTS
|
|
WO2020117625A1
(en)
*
|
2018-12-07 |
2020-06-11 |
Merck Sharp & Dohme Corp. |
Cyclic di-nucleotide compounds as sting agonists
|
|
CN111423483B
(zh)
*
|
2019-01-10 |
2025-01-17 |
英诺生物制药(深圳)有限公司 |
环二核苷酸前药分子及其制备方法和应用
|
|
WO2020150113A1
(en)
|
2019-01-14 |
2020-07-23 |
Innate Tumor Immunity, Inc. |
Substituted quinazolines as nlrp3 modulators, for use in the treatment of cancer
|
|
ES2930151T3
(es)
|
2019-01-14 |
2022-12-07 |
Innate Tumor Immunity Inc |
Moduladores heterocíclicos de NLRP3, para su uso en el tratamiento del cáncer
|
|
KR102865929B1
(ko)
|
2019-01-14 |
2025-09-29 |
인네이트 튜머 이뮤니티, 인코포레이티드 |
Nlrp3 조정제
|
|
US12338228B2
(en)
|
2019-01-14 |
2025-06-24 |
Innate Tumor Immunity, Inc. |
NLRP3 modulators
|
|
TW202043198A
(zh)
|
2019-01-17 |
2020-12-01 |
美商Ifm Due有限公司 |
用於治療與sting活性相關之病況的化合物及組合物
|
|
US10998091B2
(en)
|
2019-02-07 |
2021-05-04 |
Sandeep Patil |
Systems for monitoring compliance with a patch dosage regimen and methods of using the same
|
|
US12024709B2
(en)
|
2019-02-27 |
2024-07-02 |
Actym Therapeutics, Inc. |
Immunostimulatory bacteria engineered to colonize tumors, tumor-resident immune cells, and the tumor microenvironment
|
|
WO2020178768A1
(en)
|
2019-03-07 |
2020-09-10 |
Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. |
3'3'-cyclic dinucleotide analogue comprising a cyclopentanyl modified nucleotide as sting modulator
|
|
US12318403B2
(en)
|
2019-03-07 |
2025-06-03 |
Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. |
2′3′-cyclic dinucleotides and prodrugs thereof
|
|
US20220143061A1
(en)
*
|
2019-03-07 |
2022-05-12 |
Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. |
3'3'-cyclic dinucleotides and prodrugs thereof
|
|
US11446370B2
(en)
|
2019-03-18 |
2022-09-20 |
Janssen Pharmaceuticals, Inc. |
Bioconjugates of E. coli o-antigen polysaccharides, methods of production thereof, and methods of use thereof
|
|
IL286467B1
(he)
|
2019-03-18 |
2025-10-01 |
Janssen Pharmaceuticals Inc |
שיטות לייצור תצמידים ביולוגיים של פוליסכארידים e. coli o - אנטיגן, תכשירים שלהם ושיטות לשימוש בהם
|
|
PH12021552223A1
(en)
|
2019-03-21 |
2022-05-30 |
Codiak Biosciences Inc |
Extracellular vesicles for vaccine delivery
|
|
CN113747925B
(zh)
|
2019-03-21 |
2024-10-15 |
隆萨销售股份公司 |
胞外囊泡缀合物及其用途
|
|
US12233356B2
(en)
|
2019-03-21 |
2025-02-25 |
Lonza Sales Ag |
Process for preparing extracellular vesicles
|
|
WO2020205688A1
(en)
|
2019-04-04 |
2020-10-08 |
Merck Sharp & Dohme Corp. |
Inhibitors of histone deacetylase-3 useful for the treatment of cancer, inflammation, neurodegeneration diseases and diabetes
|
|
TW202104214A
(zh)
|
2019-04-05 |
2021-02-01 |
英商葛蘭素史密斯克藍智慧財產發展有限公司 |
化合物
|
|
MA55805A
(fr)
|
2019-05-03 |
2022-03-09 |
Flagship Pioneering Innovations V Inc |
Métodes de modulation de l'activité immunitaire
|
|
JP7621974B2
(ja)
*
|
2019-05-09 |
2025-01-27 |
アリゴス セラピューティクス インコーポレイテッド |
Stingモジュレータとしての修飾環状ジヌクレオシド化合物
|
|
WO2020229982A1
(en)
|
2019-05-10 |
2020-11-19 |
Takeda Pharmaceutical Company Limited |
Antibody drug conjugates
|
|
MA56047A
(fr)
|
2019-05-29 |
2022-04-06 |
Ifm Due Inc |
Composés et compositions destinés au traitement d'états pathologiques associés à une activité de sting
|
|
EP3994158A1
(en)
|
2019-07-03 |
2022-05-11 |
Codiak BioSciences, Inc. |
Extracellular vesicles targeting t cells and uses thereof
|
|
EP3993834A1
(en)
|
2019-07-05 |
2022-05-11 |
Tambo, Inc. |
Trans-cyclooctene bioorthogonal agents and uses in cancer and immunotherapy
|
|
GB201910304D0
(en)
|
2019-07-18 |
2019-09-04 |
Ctxt Pty Ltd |
Compounds
|
|
GB201910305D0
(en)
|
2019-07-18 |
2019-09-04 |
Ctxt Pty Ltd |
Compounds
|
|
CN114206898B
(zh)
|
2019-07-25 |
2024-06-25 |
百济神州有限公司 |
作为sting激动剂的环状二核苷酸
|
|
US11155567B2
(en)
|
2019-08-02 |
2021-10-26 |
Mersana Therapeutics, Inc. |
Sting agonist compounds and methods of use
|
|
KR20220061977A
(ko)
|
2019-08-12 |
2022-05-13 |
퓨리노미아 바이오테크, 아이엔씨. |
Cd39 발현 세포의 adcc 표적화를 통해 t 세포 매개 면역 반응을 촉진 및 강화하기 위한 방법 및 조성물
|
|
WO2021041532A1
(en)
|
2019-08-26 |
2021-03-04 |
Dana-Farber Cancer Institute, Inc. |
Use of heparin to promote type 1 interferon signaling
|
|
EP3785719A1
(en)
*
|
2019-08-28 |
2021-03-03 |
Helmholtz-Zentrum für Infektionsforschung GmbH |
New use of cyclic dinucleotides
|
|
WO2021062058A1
(en)
|
2019-09-25 |
2021-04-01 |
Codiak Biosciences, Inc. |
Sting agonist comprising exosomes for treating neuroimmunological disorders
|
|
US20220395465A1
(en)
|
2019-09-25 |
2022-12-15 |
Codiak Biosciences, Inc. |
Sting agonist comprising exosomes combined with il-12 displaying exosomes for treating a tumour
|
|
EP4034081A1
(en)
|
2019-09-25 |
2022-08-03 |
Codiak BioSciences, Inc. |
Extracellular vesicle compositions
|
|
US20230103726A1
(en)
|
2019-09-25 |
2023-04-06 |
Codiak Biosciences, Inc. |
Methods of producing extracellular vesicles
|
|
WO2021067785A1
(en)
|
2019-10-02 |
2021-04-08 |
Janssen Vaccines & Prevention B.V |
Staphylococcus peptides and methods of use
|
|
WO2021074695A1
(en)
|
2019-10-16 |
2021-04-22 |
Avacta Life Sciences Limited |
PD-L1 INHIBITOR - TGFβ INHIBITOR BISPECIFIC DRUG MOIETIES.
|
|
WO2021113679A1
(en)
|
2019-12-06 |
2021-06-10 |
Mersana Therapeutics, Inc. |
Dimeric compounds as sting agonists
|
|
JP7662644B2
(ja)
|
2019-12-18 |
2025-04-15 |
シーティーエックスティー・ピーティーワイ・リミテッド |
化合物
|
|
CN115244052A
(zh)
|
2020-01-10 |
2022-10-25 |
先天肿瘤免疫公司 |
Nlrp3调节剂
|
|
IL294445B2
(he)
|
2020-01-16 |
2023-10-01 |
Janssen Pharmaceuticals Inc |
מוטנט fimh , תכשירים שלו ושימוש בהם
|
|
WO2021174091A1
(en)
|
2020-02-28 |
2021-09-02 |
Tallac Therapeutics, Inc. |
Transglutaminase-mediated conjugation
|
|
JPWO2021177438A1
(he)
|
2020-03-06 |
2021-09-10 |
|
|
|
EP4117717A1
(en)
|
2020-03-13 |
2023-01-18 |
Codiak BioSciences, Inc. |
Extracellular vesicles for treating neurological disorders
|
|
EP4121450A2
(en)
|
2020-03-20 |
2023-01-25 |
Codiak BioSciences, Inc. |
Extracellular vesicles for therapy
|
|
MY210304A
(en)
|
2020-04-02 |
2025-09-10 |
Mersana Therapeutics Inc |
Antibody drug conjugates comprising sting agonists
|
|
US20230141284A1
(en)
|
2020-04-10 |
2023-05-11 |
Ono Pharmaceutical Co., Ltd. |
Cancer therapeutic method
|
|
US11857618B2
(en)
|
2020-04-17 |
2024-01-02 |
Emory University |
Boosting immunogenicity of vaccines using saponins and agonists of the intracellular stimulator of interferon genes pathway
|
|
CA3178260A1
(en)
|
2020-05-13 |
2021-11-18 |
Massachusetts Institute Of Technology |
Compositions of polymeric microdevices and their use in cancer immunotherapy
|
|
WO2021237100A1
(en)
|
2020-05-21 |
2021-11-25 |
Codiak Biosciences, Inc. |
Methods of targeting extracellular vesicles to lung
|
|
EP4295917A3
(en)
|
2020-08-07 |
2024-02-28 |
Tambo, Inc. |
Trans-cyclooctene bioorthogonal agents and uses in cancer and immunotherapy
|
|
TW202227479A
(zh)
|
2020-09-02 |
2022-07-16 |
日商第一三共股份有限公司 |
新穎內-β-N-乙醯葡萄糖胺苷酶
|
|
IL301190A
(he)
|
2020-09-08 |
2023-05-01 |
Univ Texas |
הרכבים רב-תכליתיים להפעלת עקיצה ושימושים בהם
|
|
BR112023004819A2
(pt)
|
2020-09-17 |
2023-04-18 |
Janssen Pharmaceuticals Inc |
Composições de vacinas multivalentes e seus usos
|
|
WO2022066934A2
(en)
|
2020-09-23 |
2022-03-31 |
Codiak Biosciences, Inc. |
Process for preparing extracellular vesicles
|
|
US20240241020A1
(en)
|
2020-09-23 |
2024-07-18 |
Lonza Sales Ag |
Process for preparing extracellular vesicles
|
|
US20240082389A1
(en)
|
2020-09-23 |
2024-03-14 |
Lonza Sales Ag |
Methods of producing extracellular vesicles
|
|
WO2022066883A1
(en)
|
2020-09-23 |
2022-03-31 |
Codiak Biosciences, Inc. |
Extracellular vesicles comprising kras antigens and uses thereof
|
|
JP2023545178A
(ja)
|
2020-10-14 |
2023-10-26 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
Stingアゴニストと、細胞透過性ペプチド、カーゴ、及びtlrペプチドアゴニストを含む複合体との組合せ
|
|
EP3984535A1
(en)
|
2020-10-16 |
2022-04-20 |
Albert-Ludwigs-Universität Freiburg |
Nlrp3 activators for use in the treatment of infectious diseases or cancer by activating nlrp3 inflammasome
|
|
CN115160392A
(zh)
*
|
2020-10-20 |
2022-10-11 |
泰励生物科技(上海)有限公司 |
多功能环二核苷酸及其用途
|
|
AU2021363267A1
(en)
|
2020-10-20 |
2023-06-22 |
Tyligand Bioscience (Shanghai) Limited |
Multifunctional cyclic dinucleotide and use thereof
|
|
WO2022094262A1
(en)
|
2020-10-30 |
2022-05-05 |
Avacta Life Sciences Limited |
Fap-activated serum extended half-life therapeutic conjugates
|
|
KR20230106606A
(ko)
|
2020-11-09 |
2023-07-13 |
다케다 야쿠힌 고교 가부시키가이샤 |
항체 약물 접합체
|
|
CN116981479A
(zh)
|
2020-12-17 |
2023-10-31 |
塔夫茨大学信托人 |
Fap激活的放射治疗诊断法以及与之相关的用途
|
|
JP2024502474A
(ja)
|
2021-01-08 |
2024-01-19 |
アイエフエム デュー インコーポレイテッド |
Sting活性に関連する状態を治療するための、尿素を有するヘテロ二環式化合物または類似体およびその組成物
|
|
KR20250007029A
(ko)
|
2021-01-12 |
2025-01-13 |
얀센 파마슈티칼즈, 인코포레이티드 |
FimH 돌연변이체, 이를 포함하는 조성물 및 이의 용도
|
|
TW202241454A
(zh)
|
2021-02-01 |
2022-11-01 |
日商第一三共股份有限公司 |
抗體-免疫賦活化劑共軛物之新穎製造方法
|
|
UY39710A
(es)
|
2021-04-01 |
2022-09-30 |
Janssen Pharmaceuticals Inc |
Producción de bioconjugados de o18 de e. coli
|
|
JP2024517131A
(ja)
|
2021-04-20 |
2024-04-19 |
アンスティテュ・クリー |
免疫療法における使用のための組成物及び方法
|
|
EP4326769A1
(en)
|
2021-04-20 |
2024-02-28 |
Institut Curie |
Compositions and methods for use in immunotherapy
|
|
WO2022234003A1
(en)
|
2021-05-07 |
2022-11-10 |
Avacta Life Sciences Limited |
Cd33 binding polypeptides with stefin a protein
|
|
US20220313724A1
(en)
*
|
2021-05-17 |
2022-10-06 |
Highlight Therapeutics, S.L. |
Compositions for intratumoral administration and related methods
|
|
CA3221699A1
(en)
*
|
2021-06-24 |
2022-12-29 |
Glen N. Barber |
Sting dependent adjuvants
|
|
WO2023056468A1
(en)
|
2021-09-30 |
2023-04-06 |
Codiak Biosciences, Inc. |
Extracellular vesicle comprising cholesterol tagged sting-agonist
|
|
EP4413038A1
(en)
|
2021-10-07 |
2024-08-14 |
Avacta Life Sciences Limited |
Pd-l1 binding affimers
|
|
CN114106140A
(zh)
*
|
2021-11-23 |
2022-03-01 |
哈尔滨医科大学附属肿瘤医院 |
一种表达特定sting异构体、细胞系、制备方法、用途
|
|
WO2023154799A1
(en)
|
2022-02-14 |
2023-08-17 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Combination immunotherapy for treating cancer
|
|
EP4488378A1
(en)
|
2022-03-02 |
2025-01-08 |
Daiichi Sankyo Company, Limited |
Method for producing fc-containing molecule
|
|
WO2023218243A1
(en)
|
2022-05-12 |
2023-11-16 |
Avacta Life Sciences Limited |
Lag-3/pd-l1 binding fusion proteins
|
|
CN119744182A
(zh)
|
2022-08-29 |
2025-04-01 |
第一三共株式会社 |
包含突变Fc区的抗体药物偶联物
|
|
WO2024211577A1
(en)
|
2023-04-05 |
2024-10-10 |
Massachusetts Institute Of Technology |
Hybrid polymeric systems and methods of use thereof
|