OA12028A - Immunostimulatory nucleic acids. - Google Patents

Immunostimulatory nucleic acids. Download PDF

Info

Publication number
OA12028A
OA12028A OA1200200083A OA1200200083A OA12028A OA 12028 A OA12028 A OA 12028A OA 1200200083 A OA1200200083 A OA 1200200083A OA 1200200083 A OA1200200083 A OA 1200200083A OA 12028 A OA12028 A OA 12028A
Authority
OA
OAPI
Prior art keywords
nucleic acid
cancer
immunostimulatory nucleic
rich
antigen
Prior art date
Application number
OA1200200083A
Other languages
English (en)
Inventor
Arthur M Krieg
Christian Schetter
Jorg Vollmer
Original Assignee
Univ Iowa Res Found
Coley Pharm Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27387805&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=OA12028(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ Iowa Res Found, Coley Pharm Gmbh filed Critical Univ Iowa Res Found
Publication of OA12028A publication Critical patent/OA12028A/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • A61K31/7105Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • A61K31/7125Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/39Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55561CpG containing adjuvants; Oligonucleotide containing adjuvants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Pulmonology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Virology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Neurosurgery (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
OA1200200083A 1999-09-25 2000-09-25 Immunostimulatory nucleic acids. OA12028A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15611399P 1999-09-25 1999-09-25
US15613599P 1999-09-27 1999-09-27
US22743600P 2000-08-23 2000-08-23

Publications (1)

Publication Number Publication Date
OA12028A true OA12028A (en) 2006-04-28

Family

ID=27387805

Family Applications (1)

Application Number Title Priority Date Filing Date
OA1200200083A OA12028A (en) 1999-09-25 2000-09-25 Immunostimulatory nucleic acids.

Country Status (32)

Country Link
US (3) US7271156B2 (fr)
EP (2) EP1700603A3 (fr)
JP (1) JP2003510282A (fr)
KR (1) KR100863630B1 (fr)
CN (3) CN101543507A (fr)
AP (2) AP2006003503A0 (fr)
AT (1) ATE304361T1 (fr)
AU (2) AU780979B2 (fr)
BG (1) BG65736B1 (fr)
BR (1) BR0014236A (fr)
CA (1) CA2388055A1 (fr)
CZ (1) CZ301488B6 (fr)
DE (1) DE60022665T2 (fr)
DK (1) DK1221955T3 (fr)
EE (1) EE200200158A (fr)
ES (1) ES2248126T3 (fr)
HK (1) HK1047697B (fr)
HR (1) HRP20020249A2 (fr)
HU (1) HUP0202639A2 (fr)
IL (1) IL148843A0 (fr)
MX (1) MXPA02003108A (fr)
NO (1) NO20021453L (fr)
NZ (1) NZ517929A (fr)
OA (1) OA12028A (fr)
PL (1) PL354997A1 (fr)
RS (1) RS50325B (fr)
RU (1) RU2245149C2 (fr)
SK (1) SK287400B6 (fr)
TR (2) TR200503031T2 (fr)
UA (1) UA77152C2 (fr)
WO (1) WO2001022972A2 (fr)
ZA (1) ZA200201963B (fr)

Families Citing this family (250)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7189834B2 (en) * 1993-05-11 2007-03-13 Marshall William E Oligoribonucleotides alert the immune system of animals to the imminence of microbial infection
US20030109469A1 (en) * 1993-08-26 2003-06-12 Carson Dennis A. Recombinant gene expression vectors and methods for use of same to enhance the immune response of a host to an antigen
US6727230B1 (en) * 1994-03-25 2004-04-27 Coley Pharmaceutical Group, Inc. Immune stimulation by phosphorothioate oligonucleotide analogs
US6239116B1 (en) 1994-07-15 2001-05-29 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
US7935675B1 (en) 1994-07-15 2011-05-03 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
US20030026782A1 (en) 1995-02-07 2003-02-06 Arthur M. Krieg Immunomodulatory oligonucleotides
US6429199B1 (en) * 1994-07-15 2002-08-06 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules for activating dendritic cells
US6207646B1 (en) 1994-07-15 2001-03-27 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
US7422902B1 (en) * 1995-06-07 2008-09-09 The University Of British Columbia Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer
US5981501A (en) * 1995-06-07 1999-11-09 Inex Pharmaceuticals Corp. Methods for encapsulating plasmids in lipid bilayers
EP0855184A1 (fr) 1997-01-23 1998-07-29 Grayson B. Dr. Lipford Composition pharmaceutique comprenant un polynucléotide et un antigène notamment pour la vaccination
US6406705B1 (en) 1997-03-10 2002-06-18 University Of Iowa Research Foundation Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant
US6287591B1 (en) * 1997-05-14 2001-09-11 Inex Pharmaceuticals Corp. Charged therapeutic agents encapsulated in lipid particles containing four lipid components
WO1999058118A2 (fr) * 1998-05-14 1999-11-18 Cpg Immunopharmaceuticals Gmbh PROCEDES DE REGULATION DE L'HEMATOPOIESE AU MOYEN D'OLIGONUCLEOTIDES A CpG
SI1077722T1 (sl) * 1998-05-22 2007-02-28 Ottawa Health Research Inst Metode in produkti za induciranje sluznicne imunosti
US20030022854A1 (en) 1998-06-25 2003-01-30 Dow Steven W. Vaccines using nucleic acid-lipid complexes
NZ513935A (en) 1999-02-17 2004-02-27 Csl Ltd Immunogenic complexes and methods relating thereto
US6977245B2 (en) 1999-04-12 2005-12-20 The United States Of America As Represented By The Department Of Health And Human Services Oligodeoxynucleotide and its use to induce an immune response
US20050002958A1 (en) * 1999-06-29 2005-01-06 Smithkline Beecham Biologicals Sa Vaccines
JP2003507341A (ja) 1999-08-19 2003-02-25 ダイナバックス テクノロジーズ コーポレイション 免疫刺激配列およびそれを使用するための組成物を用いて免疫応答を調節するための方法およびそれを使用するための組成物
UA77152C2 (en) * 1999-09-25 2006-11-15 Method for stimulation of immune response using nucleic acid-containing immunostimulating compositions, method for treatment of cancer and method for treatment or prophylaxis of allergy or asthma
US6949520B1 (en) 1999-09-27 2005-09-27 Coley Pharmaceutical Group, Inc. Methods related to immunostimulatory nucleic acid-induced interferon
HUP0300627A3 (en) * 1999-12-13 2005-11-28 Bioniche Life Sciences Inc Bel Therapeutically useful synthetic oligonucleotides
EP1322655B1 (fr) * 2000-01-14 2007-11-14 The Government of the United States of America, as represented by the Secretary of the Department of Health and Human Services Oligonucleotide synthetique et son utilisation pour induire une reaction immunitaire
CA2398756A1 (fr) 2000-01-31 2001-08-02 Eyal Raz Polynucleotides immunomodulateurs dans le traitement d'une infection par un pathogene intracellulaire
US7585847B2 (en) * 2000-02-03 2009-09-08 Coley Pharmaceutical Group, Inc. Immunostimulatory nucleic acids for the treatment of asthma and allergy
US6613751B2 (en) 2000-02-23 2003-09-02 The Regents Of The University Of California Method for treating inflammatory bowel disease and other forms of gastrointestinal inflammation
US20030129251A1 (en) 2000-03-10 2003-07-10 Gary Van Nest Biodegradable immunomodulatory formulations and methods for use thereof
US7129222B2 (en) 2000-03-10 2006-10-31 Dynavax Technologies Corporation Immunomodulatory formulations and methods for use thereof
SK288201B6 (sk) 2000-03-31 2014-06-03 Purdue Research Foundation Farmaceutický prostriedok
IL152959A0 (en) 2000-06-08 2003-06-24 Intercell Biomedizinische Forschungs & Entwicklungs Gmbh Immunostimulatory oligodeoxynucleotides
US7767197B2 (en) 2000-06-22 2010-08-03 Endo Pharmaceuticals Colorado LLC Delivery vehicle composition and methods for delivering antigens and other drugs
DK1296714T3 (da) * 2000-06-22 2009-12-07 Coley Pharm Gmbh Kombination af CpG og antistoffer, der er rettet mod CD19, CD20, CD22 eller CD40 til behandling eller forebyggelse af kræft
KR100917101B1 (ko) * 2000-08-04 2009-09-15 도요 보세키 가부시키가이샤 플렉시블 금속적층체 및 그 제조방법
WO2002022809A2 (fr) 2000-09-15 2002-03-21 Coley Pharmaceutical Gmbh Procede de criblage a haut rendement d'immuno-agoniste/antagoniste base sur cpg
DE60134421D1 (de) * 2000-12-08 2008-07-24 Coley Pharmaceuticals Gmbh Cpg-artige nukleinsäuren und verfahren zu ihrer verwendung
US20030049266A1 (en) 2000-12-27 2003-03-13 Fearon Karen L. Immunomodulatory polynucleotides and methods of using the same
AU2002345847B2 (en) * 2001-06-21 2008-05-29 Dynavax Technologies Corporation Chimeric immunomodulatory compounds and methods of using the same
US7785610B2 (en) * 2001-06-21 2010-08-31 Dynavax Technologies Corporation Chimeric immunomodulatory compounds and methods of using the same—III
US20040132677A1 (en) * 2001-06-21 2004-07-08 Fearon Karen L. Chimeric immunomodulatory compounds and methods of using the same-IV
EP1572124A4 (fr) * 2001-06-29 2007-11-28 Novartis Vaccines & Diagnostic Compositions de vaccin vhc e1e2
US7666674B2 (en) 2001-07-27 2010-02-23 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Use of sterically stabilized cationic liposomes to efficiently deliver CPG oligonucleotides in vivo
AU2002326561B2 (en) 2001-08-07 2008-04-03 Dynavax Technologies Corporation Immunomodulatory compositions, formulations, and methods for use thereof
US7354909B2 (en) * 2001-08-14 2008-04-08 The United States Of America As Represented By Secretary Of The Department Of Health And Human Services Method for rapid generation of mature dendritic cells
US8834900B2 (en) * 2001-08-17 2014-09-16 University Of Iowa Research Foundation Combination motif immune stimulatory oligonucleotides with improved activity
AU2008200021A1 (en) * 2001-08-17 2008-01-31 Coley Pharmaceutical Gmbh Combination motif immune stimulatory oligonucleotides with improved activity
WO2003022296A1 (fr) * 2001-09-07 2003-03-20 The Trustees Of Boston University Procede et composition pour traiter les troubles lies aux complexes immuns
DE60234375D1 (de) 2001-09-14 2009-12-24 Cytos Biotechnology Ag VERPACKUNG VON IMMUNSTIMULIERENDEM CpG IN VIRUSÄHNLICHEN PARTIKELN: HERSTELLUNGSVERFAHREN UND VERWENDUNG
JP2005523878A (ja) * 2001-09-28 2005-08-11 パーデュー・リサーチ・ファウンデーション リガンド・免疫原物質複合体を用いた処置方法
EP1455593B1 (fr) 2001-10-06 2013-07-24 Merial Limited Procedes et compositions pour favoriser la croissance et l'immunite naturelle chez de jeunes animaux
US20030139364A1 (en) * 2001-10-12 2003-07-24 University Of Iowa Research Foundation Methods and products for enhancing immune responses using imidazoquinoline compounds
US7276489B2 (en) * 2002-10-24 2007-10-02 Idera Pharmaceuticals, Inc. Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5′ ends
JP2005516897A (ja) * 2001-11-07 2005-06-09 イネックス ファーマシューティカルズ コーポレイション 改善された粘膜のワクチン及びその使用方法
US8466116B2 (en) 2001-12-20 2013-06-18 The Unites States Of America As Represented By The Secretary Of The Department Of Health And Human Services Use of CpG oligodeoxynucleotides to induce epithelial cell growth
WO2003054161A2 (fr) * 2001-12-20 2003-07-03 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Utilisation d'oligodeoxynucleotides cpg en vue d'induire l'angiogenese
EP1467755A1 (fr) 2001-12-21 2004-10-20 Antigenics Inc. Compositions comprenant des reactifs immunoreactifs et des saponosides et techniques d'utilisation de ces compositions
US8088388B2 (en) * 2002-02-14 2012-01-03 United Biomedical, Inc. Stabilized synthetic immunogen delivery system
AU2003230806B2 (en) 2002-04-04 2009-05-07 Zoetis Belgium S.A. Immunostimulatory G,U-containing oligoribonucleotides
KR20050009697A (ko) * 2002-04-22 2005-01-25 바이오니취 라이프 사이언시즈 인코포레이티드 올리고뉴클레오티드 조성물 및 면역 반응 조절시 이의 용도
US20040009943A1 (en) * 2002-05-10 2004-01-15 Inex Pharmaceuticals Corporation Pathogen vaccines and methods for using the same
US20040009944A1 (en) * 2002-05-10 2004-01-15 Inex Pharmaceuticals Corporation Methylated immunostimulatory oligonucleotides and methods of using the same
US20040013649A1 (en) * 2002-05-10 2004-01-22 Inex Pharmaceuticals Corporation Cancer vaccines and methods of using the same
KR100456681B1 (ko) 2002-05-22 2004-11-10 주식회사 대웅 박테리아의 염색체 dna 파쇄물과 비독성리포폴리사카라이드를 포함하는 면역강화 및 조절 조성물
CA2388049A1 (fr) * 2002-05-30 2003-11-30 Immunotech S.A. Oligonucleotides immunostimulateurs et utilisations connexes
EP1513552B1 (fr) * 2002-06-20 2010-12-01 Cytos Biotechnology AG Particules pseudo-virales enveloppees combinees au cpg destinees a etre utilisees en tant qu'adjuvants avec des allergenes: procede de preparation et utilisation de celles-ci
JP2005535627A (ja) * 2002-06-25 2005-11-24 シティ・オブ・ホープ アジュバント不含ペプチド・ワクチン
US7807803B2 (en) 2002-07-03 2010-10-05 Coley Pharmaceutical Group, Inc. Nucleic acid compositions for stimulating immune responses
US7605138B2 (en) 2002-07-03 2009-10-20 Coley Pharmaceutical Group, Inc. Nucleic acid compositions for stimulating immune responses
US7569553B2 (en) 2002-07-03 2009-08-04 Coley Pharmaceutical Group, Inc. Nucleic acid compositions for stimulating immune responses
US7576066B2 (en) 2002-07-03 2009-08-18 Coley Pharmaceutical Group, Inc. Nucleic acid compositions for stimulating immune responses
US20040053880A1 (en) 2002-07-03 2004-03-18 Coley Pharmaceutical Group, Inc. Nucleic acid compositions for stimulating immune responses
AU2003247880B2 (en) * 2002-07-03 2010-09-02 Coley Pharmaceutical Group, Inc. Nucleic acid compositions for stimulating immune responses
AR040996A1 (es) * 2002-08-19 2005-04-27 Coley Pharm Group Inc Acidos nucleicos inmunoestimuladores
SG166673A1 (en) * 2002-08-19 2010-12-29 Coley Pharm Group Inc Immunostimulatory nucleic acids
CN1694959B (zh) * 2002-09-13 2013-09-18 雷普利瑟公司 非序列互补的抗病毒寡核苷酸
US8263091B2 (en) 2002-09-18 2012-09-11 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Method of treating and preventing infections in immunocompromised subjects with immunostimulatory CpG oligonucleotides
NZ540098A (en) 2002-10-29 2008-09-26 Coley Pharmaceutical Group Ltd Use of CPG oligonucleotides in the treatment of hepatitis C virus infection
CA2504493C (fr) * 2002-11-01 2015-12-29 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Procede de prevention d'infections a partir d'agents de terrorisme biologique avec des oligonucleotides cpg immunostimulateurs
CA2502015A1 (fr) 2002-12-11 2004-06-24 Coley Pharmaceutical Group, Inc. Acides nucleiques 5'cpg et leurs methodes d'utilisation
US7317142B2 (en) * 2002-12-13 2008-01-08 Prodi Gene, Inc. Immunization of fish with plant-expressed recombinant proteins
SI1575977T1 (sl) * 2002-12-23 2010-01-29 Dynavax Tech Corp Imunostimulirni sekvenčni polinukleotidi in postopki za njihovo uporabo
US8158768B2 (en) 2002-12-23 2012-04-17 Dynavax Technologies Corporation Immunostimulatory sequence oligonucleotides and methods of using the same
US7625872B2 (en) 2002-12-23 2009-12-01 Dynavax Technologies Corporation Branched immunomodulatory compounds and methods of using the same
ES2385933T3 (es) 2003-02-20 2012-08-03 University Of Connecticut Health Center Métodos para la producción de complejos de moléculas antígenas de alfa (2) macroglobulina.
RU2351362C2 (ru) 2003-03-26 2009-04-10 Цитос Байотекнолоджи Аг КОНЪЮГАТЫ ПЕПТИДА Melan-A, АНАЛОГА ВИРУСОПОДОБНОЙ ЧАСТИЦЫ
US7537767B2 (en) 2003-03-26 2009-05-26 Cytis Biotechnology Ag Melan-A- carrier conjugates
US20040235770A1 (en) * 2003-04-02 2004-11-25 Coley Pharmaceutical Group, Ltd. Immunostimulatory nucleic acid oil-in-water formulations and related methods of use
PT1610850E (pt) * 2003-04-09 2012-06-15 Novartis Ag Dispositivo para gerar um aerossol com protecção da entrada de ar
CN1798563A (zh) * 2003-05-15 2006-07-05 独立行政法人科学技术振兴机构 免疫刺激剂
WO2005007672A2 (fr) * 2003-06-20 2005-01-27 Coley Pharmaceutical Gmbh Antagonistes des recepteurs toll (tlr) pour petites molecules
DE602004031017D1 (de) 2003-07-10 2011-02-24 Cytos Biotechnology Ag Zusammensetzung verpackte virusartige teilchen umfassend zur verstärkung einer immunantwort
AU2004263037B2 (en) * 2003-08-11 2011-02-10 Japan As Represented By The Director-General Of National Institute Of Infectious Diseases Novel vaccine containing adjuvant capable of inducing mucosal immunity
GB2388581A (en) 2003-08-22 2003-11-19 Danisco Coated aqueous beads
JP4926707B2 (ja) 2003-08-22 2012-05-09 ダニスコ エイ/エス 封入化抗菌材料
EP1670507A4 (fr) 2003-09-12 2007-10-17 Antigenics Inc Vaccin pour le traitement et la prevention de l'infection provoquee par le virus de l'herpes simplex
US7615539B2 (en) 2003-09-25 2009-11-10 Coley Pharmaceutical Group, Inc. Nucleic acid-lipophilic conjugates
CA2542099A1 (fr) * 2003-10-11 2005-04-21 Inex Pharmaceuticals Corporation Procedes et compositions permettant de renforcer l'immunite innee et la cytotoxicite cellulaire dependant des anticorps
AP2006003611A0 (en) 2003-10-30 2006-06-30 Coley Pharm Gmbh C-class oligonucleotide analogs with enhanced immunostimulatory potency
US20050239733A1 (en) * 2003-10-31 2005-10-27 Coley Pharmaceutical Gmbh Sequence requirements for inhibitory oligonucleotides
US20050100983A1 (en) * 2003-11-06 2005-05-12 Coley Pharmaceutical Gmbh Cell-free methods for identifying compounds that affect toll-like receptor 9 (TLR9) signaling
AU2004304770B2 (en) * 2003-12-08 2010-05-06 Idera Pharmaceuticals, Inc. Modulation of immunostimulatory properties by small oligonucleotide-based compounds
DE10361502A1 (de) * 2003-12-23 2005-07-28 Phenion Gmbh & Co. Kg Kosmetische oder pharmazeutische Zubereitungen enthaltend Superstruktur-bildende Nukleinsäure-Sequenzen
KR100558851B1 (ko) * 2004-01-08 2006-03-10 학교법인연세대학교 면역조절능력이 증가된 CpG 올리고데옥시뉴클레오티드변형체
US7973016B2 (en) * 2004-01-23 2011-07-05 Joslin Diebetes Center Methods of treating, reducing, or preventing autoimmune conditions
EP2415481A3 (fr) * 2004-02-19 2012-04-18 Coley Pharmaceutical Group, Inc. Oligonucléotides d'ARN viral immunostimulateurs
EP1730281A2 (fr) * 2004-04-02 2006-12-13 Coley Pharmaceutical Group, Inc. Acides nucleiques immunostimulateurs destines a induire des reactions d'il-10
EP1753453A2 (fr) * 2004-06-08 2007-02-21 Coley Pharmaceutical GmbH Oligonucleotide abasique utilise en tant que plate-forme support pour un antigene ainsi qu'un agoniste et un antagoniste immunostimulatoire
US7674456B2 (en) * 2004-06-14 2010-03-09 Charles Wiseman Breast cancer cell lines and uses thereof
EP1781325A2 (fr) 2004-07-18 2007-05-09 CSL Limited Formulations a base de complexes immunostimulants et d'oligonucleotides permettant d'induire des reponses d'interferon-gamma ameliorees
BRPI0513081A (pt) 2004-08-03 2008-04-22 Geneart Ag método para modular a expressão gênica pela alteração do conteúdo de cpg, sistema de expressão, medicamento que o compreende e respectivos usos
ES2543207T3 (es) 2004-09-01 2015-08-17 Dynavax Technologies Corporation Métodos y composiciones para la inhibición de respuestas inmunes innatas y autoinmunidad
MY159370A (en) 2004-10-20 2016-12-30 Coley Pharm Group Inc Semi-soft-class immunostimulatory oligonucleotides
EP1657307A1 (fr) * 2004-11-16 2006-05-17 Immunotech S.A. Oligonucléotides induisant la sécrétion de GM-CSF
US20080009455A9 (en) * 2005-02-24 2008-01-10 Coley Pharmaceutical Group, Inc. Immunostimulatory oligonucleotides
JP5403457B2 (ja) * 2005-02-28 2014-01-29 株式会社明治 Atオリゴヌクレオチドを有効成分とする免疫応答増強性薬剤及び食品組成物
EP2007421A2 (fr) * 2005-03-04 2008-12-31 Dynavax Technologies Corporation Vaccins comprenant des oligonucleotides immunostimulateurs (iss), desquels iss sont conjugues a des antigenes et stabilises dans des conditions de tampon et par d'autres excipients
US7767212B2 (en) 2005-03-18 2010-08-03 Cytos Biotechnology Ag CAT allergen conjugates and uses thereof
JP2008535862A (ja) 2005-04-08 2008-09-04 キメリクス,インコーポレイテッド ポックスウイルス感染の治療のための化合物、組成物および方法
JP2008535859A (ja) * 2005-04-08 2008-09-04 コーリー ファーマシューティカル グループ,インコーポレイテッド 感染症によって悪化した喘息を治療するための方法
AU2006239117A1 (en) 2005-04-28 2006-11-02 Novo Nordisk Health Care Ag A closed container comprising an activated factor VII polypeptide, processes for the preparation of the same, and a kit and a method for use of the kit
DE102005022290A1 (de) * 2005-05-13 2006-11-16 Universitätsklinikum Schleswig-Holstein Hexanukleotid-Wirkstoffe
CN1865275B (zh) 2005-05-17 2011-06-15 长春华普生物技术有限公司 对人b细胞肿瘤有治疗作用的人工合成的单链脱氧核苷酸
CA2612162C (fr) 2005-07-01 2016-05-17 Index Pharmaceuticals Ab Utilisation d'oligonucleotides dans des etats inflammatoires refractairees aux steroides ou dependantes des steroides
EP2179737B1 (fr) 2005-07-01 2013-08-14 Index Pharmaceuticals AB Modulation de la réponse aux steroides
BRPI0612408A2 (pt) * 2005-07-07 2010-11-03 Pfizer terapia para tratamento de cáncer em combinação com anticorpo anti-ctla-4 e oligodesoxinucleotìdeo sintético contendo o motivo cpg
KR20080048067A (ko) * 2005-09-16 2008-05-30 콜리 파마슈티칼 게엠베하 포스포디에스테르 주쇄를 갖는 면역자극성 단일가닥리보핵산
SG165394A1 (en) * 2005-09-16 2010-10-28 Coley Pharm Gmbh Modulation of immunostimulatory properties of short interfering ribonucleic acid (sirna) by nucleotide modification
WO2007050034A1 (fr) 2005-10-28 2007-05-03 Index Pharmaceuticals Ab Composition et procede pour la prevention, le traitement et/ou l’attenuation d’une maladie inflammatoire
AU2006312013B2 (en) * 2005-11-02 2012-10-04 Duke University Concurrent chemotherapy and immunotherapy
NZ567978A (en) 2005-11-04 2011-09-30 Novartis Vaccines & Diagnostic Influenza vaccine with reduced amount of oil-in-water emulsion as adjuvant
EP2368572B1 (fr) 2005-11-04 2020-03-04 Seqirus UK Limited Vaccins avec adjuvants dotés d'antigènes non virioniques préparés à partir de virus de la grippe cultivés dans une culture cellulaire
US20110180430A1 (en) 2005-11-04 2011-07-28 Novartis Vaccines And Diagnostics Srl Adjuvanted influenza vaccines including cytokine-inducing agents
NZ568211A (en) 2005-11-04 2011-11-25 Novartis Vaccines & Diagnostic Influenza vaccines including combinations of particulate adjuvants and immunopotentiators
CN102864152B (zh) * 2005-11-07 2015-11-18 艾德拉药物股份有限公司 包含经修饰的免疫刺激性二核苷酸的基于寡核苷酸的化合物之免疫刺激特性
DK1957647T3 (en) 2005-11-25 2015-04-07 Zoetis Belgium S A Immunostimulatory oligoribonucleotides
EP1973608A1 (fr) 2005-12-14 2008-10-01 Cytos Biotechnology AG Particules emballees avec des acides nucleiques immunostimulateurs pour le traitement de l hypersensibilite
JP6087041B2 (ja) 2006-01-27 2017-03-08 ノバルティス アーゲー 血球凝集素およびマトリックスタンパク質を含むインフルエンザウイルスワクチン
MX2008009970A (es) * 2006-02-01 2008-11-19 Univ Johns Hopkins Conjugados de polipeptido-acido nucleico para inmunoprofilaxis o inmunoterapia para desordenes neoplasicos o infecciosos.
US8168164B2 (en) 2006-02-03 2012-05-01 Purdue Research Foundation Targeted conjugates and radiation
EP2405002B1 (fr) * 2006-02-15 2014-09-24 AdiuTide Pharmaceuticals GmbH Compositions et procédés pour formulations d'oligonucléotides
CN100418583C (zh) * 2006-02-21 2008-09-17 朱鸿飞 预防和治疗乳腺炎的药物组合物
EP2382987A1 (fr) 2006-03-24 2011-11-02 Novartis Vaccines and Diagnostics GmbH Stockage de vaccins contre la grippe sans réfrigération
US9107863B2 (en) * 2006-03-27 2015-08-18 The Buck Institute For Age Reasearch Reagents and methods for cancer treatment and prevention
SG173336A1 (en) 2006-03-31 2011-08-29 Novartis Ag Combined mucosal and parenteral immunization against hiv
ATE513912T1 (de) 2006-05-05 2011-07-15 Isis Pharmaceuticals Inc Verbindungen und verfahren zur modulation der expression von sglt2
RU2464030C2 (ru) * 2006-05-26 2012-10-20 Регадо Байосайенсиз, Инк. Введение противосвертывающей системы reg1
DK2054431T3 (da) 2006-06-09 2012-01-02 Novartis Ag Konformere af bakterielle adhæsiner
WO2007144150A1 (fr) 2006-06-12 2007-12-21 Cytos Biotechnology Ag Procédé pour le conditionnement d'oligonucléotides dans des particules analogues à des virus de bactériophages à arn
AU2007263281B2 (en) 2006-06-20 2012-12-06 Transgene S.A. Recombinant viral vaccine
GB0614460D0 (en) 2006-07-20 2006-08-30 Novartis Ag Vaccines
EP2497495B3 (fr) 2006-09-11 2021-02-17 Seqirus UK Limited Fabrication de vaccins contre la grippe sans utiliser d'oeufs
CN101517082B (zh) 2006-09-27 2014-01-22 科勒制药有限责任公司 具有增强的免疫刺激活性的含疏水性T类似物的CpG寡聚核苷酸类似物
WO2008057529A2 (fr) * 2006-11-06 2008-05-15 Coley Pharmaceutical Group, Inc. Compositions de vaccins à base de peptides contre la protéine de transfert d'ester de cholestéryle (cetp) endogène
EP2679240A1 (fr) 2006-12-06 2014-01-01 Novartis AG Vaccins comprenant un antigène issu de quatre souches du virus grippal
UA100370C2 (uk) 2006-12-11 2012-12-25 Мериал Лимитед Спосіб вакцинації птахів проти salmonella
CA2671873C (fr) 2006-12-12 2018-10-09 Brian Stephen Sproat Oligonucleotides contenant des concentrations elevees en monomeres de guanine
GB0700562D0 (en) 2007-01-11 2007-02-21 Novartis Vaccines & Diagnostic Modified Saccharides
CN101784283A (zh) 2007-06-27 2010-07-21 诺华有限公司 低添加流感疫苗
US20090123467A1 (en) * 2007-07-31 2009-05-14 The Johns Hopkins University Polypeptide-Nucleic Acid Conjugate for Immunoprophylaxis or Immunotherapy for Neoplastic or Infectious Disorders
GB0714963D0 (en) 2007-08-01 2007-09-12 Novartis Ag Compositions comprising antigens
WO2009055076A2 (fr) * 2007-10-26 2009-04-30 Dynavax Technologies Corporation Procédés et compositions pour inhiber les réponses immunitaires et l'auto-immunité
GB0810305D0 (en) 2008-06-05 2008-07-09 Novartis Ag Influenza vaccination
GB0818453D0 (en) 2008-10-08 2008-11-12 Novartis Ag Fermentation processes for cultivating streptococci and purification processes for obtaining cps therefrom
CN105055432A (zh) 2008-01-25 2015-11-18 奇默里克斯公司 治疗病毒感染的方法
JP5518041B2 (ja) 2008-03-18 2014-06-11 ノバルティス アーゲー インフルエンザウイルスワクチン抗原の調製における改良
MX2010012069A (es) 2008-05-08 2010-12-14 Merial Ltd Vacuna de la leishmaniasis con el uso del inmunogeno salival de la mosca de la arena.
TWI351288B (en) * 2008-07-04 2011-11-01 Univ Nat Pingtung Sci & Tech Cpg dna adjuvant in avian vaccines
CA2744987C (fr) 2008-12-02 2018-01-16 Chiralgen, Ltd. Procede pour la synthese d'acides nucleiques modifies par des atomes de phosphore
EP2370582B1 (fr) * 2008-12-04 2017-05-10 CuRNA, Inc. Traitement de maladies liées à un gène suppresseur de tumeur par inhibition d'un transcrit antisens naturel du gène
US8552165B2 (en) * 2008-12-09 2013-10-08 Heather Davis Immunostimulatory oligonucleotides
PE20110998A1 (es) 2008-12-09 2012-02-10 Coley Pharm Group Inc Oligonucleotidos inmunoestimuladores
EP2396408B1 (fr) * 2009-02-12 2017-09-20 CuRNA, Inc. Traitement des maladies associées au facteur neurotrophique dérivé des cellules gliales (gdnf) par inhibition du produit antisens naturel de la transcription vers gdnf
JP5766126B2 (ja) * 2009-02-12 2015-08-19 クルナ・インコーポレーテッド 脳由来神経栄養因子(bdnf)関連疾病の、bdnfに対する天然アンチセンス転写物の抑制による治療
US8568732B2 (en) 2009-03-06 2013-10-29 Novartis Ag Chlamydia antigens
KR101730351B1 (ko) 2009-03-25 2017-04-28 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 병원체에 대한 포유동물의 선천성 면역 저항성의 자극을 위한 조성물
EP2413953B1 (fr) 2009-04-03 2017-11-08 Agenus Inc. Procédés de préparation et d'utilisation de complexes chaperons multiples-antigène
NZ612315A (en) 2009-04-14 2014-10-31 Novartis Ag Compositions for immunising against staphylococcus aureus
EP2424565A1 (fr) 2009-04-27 2012-03-07 Novartis AG Vaccins avec adjuvants pour protéger du virus de la grippe
CA2767253A1 (fr) 2009-07-06 2011-01-13 Ontorii, Inc. Nouveaux precurseurs d'acide nucleique et leurs methodes d'utilisation
CA2767536A1 (fr) 2009-07-07 2011-01-13 Novartis Ag Immunogenes d' escherichia coli conserves
WO2011008974A2 (fr) 2009-07-15 2011-01-20 Novartis Ag Compositions à base de protéine f du vrs et procédés de fabrication associés
PL2464658T3 (pl) 2009-07-16 2015-03-31 Novartis Ag Immunogeny z Escherichia coli o zniesionej toksyczności
JP2013500017A (ja) * 2009-07-24 2013-01-07 カッパーアールエヌエー,インコーポレイテッド サ−チュイン(sirt)への天然アンチセンス転写物の阻止によるサ−チュイン(sirt)関連疾患の治療
ES2664591T3 (es) * 2009-09-25 2018-04-20 Curna, Inc. Tratamiento de enfermedades relacionadas con la filagrina (flg) mediante la modulación de la expresión y actividad del gen FLG
GB0918392D0 (en) 2009-10-20 2009-12-02 Novartis Ag Diagnostic and therapeutic methods
GB0919690D0 (en) 2009-11-10 2009-12-23 Guy S And St Thomas S Nhs Foun compositions for immunising against staphylococcus aureus
WO2011062997A2 (fr) 2009-11-17 2011-05-26 Musc Foundation For Research Development Anticorps monoclonaux humains pour nucléoline humaine
AU2010321584C1 (en) 2009-11-23 2016-12-22 BASF Agricultural Solutions Seed US LLC Elite event EE-GM3 and methods and kits for identifying such event in biological samples
MX2012005932A (es) 2009-11-23 2012-09-12 Bayer Cropscience Nv Plantas de soya tolerantes a herbicidas y metodos para indentificar las mismas.
US9173954B2 (en) 2009-12-30 2015-11-03 Glaxosmithkline Biologicals Sa Polysaccharide immunogens conjugated to E. coli carrier proteins
US9006218B2 (en) 2010-02-12 2015-04-14 Chimerix Inc. Nucleoside phosphonate salts
CA2797601A1 (fr) 2010-04-26 2011-11-10 Chimerix, Inc. Methodes de traitement d'infections retrovirales et regimes posologiques associes
EA201500857A1 (ru) 2010-05-26 2016-06-30 Селекта Байосайенсиз, Инк. Комбинированные вакцины с синтетическими наноносителями
GB201009861D0 (en) 2010-06-11 2010-07-21 Novartis Ag OMV vaccines
AU2011268211B2 (en) 2010-06-16 2015-07-16 Dynavax Technologies Corporation Methods of treatment using TLR7 and/or TLR9 inhibitors
CN103025873B (zh) * 2010-06-23 2018-05-08 库尔纳公司 通过抑制电压门控钠通道α亚基(SCNA)的天然反义转录物而治疗SCNA相关疾病
ES2557382T3 (es) * 2010-07-06 2016-01-25 Glaxosmithkline Biologicals Sa Liposomas con lípidos que tienen un valor de pKa ventajoso para el suministro de ARN
EP2620428B1 (fr) 2010-09-24 2019-05-22 Wave Life Sciences Ltd. Groupe auxiliaire asymétrique
EP2640190A4 (fr) 2010-11-05 2016-05-11 Selecta Biosciences Inc Composés nicotiniques modifiés et procédés associés
EP2667892B1 (fr) 2011-01-26 2019-03-27 GlaxoSmithKline Biologicals SA Régime d'immunisation contre le vrs
US10941399B2 (en) * 2011-04-14 2021-03-09 Beth Israel Deaconess Medical Center, Inc. Methods and compositions for gene-specific demethylation by DNA methyltransferase (DNMT)-RNA interaction
LT3275892T (lt) 2011-05-13 2020-04-10 Glaxosmithkline Biologicals S.A. Struktūros prieš suliejimą rsv f antigenai
BR112013029959A8 (pt) * 2011-05-20 2021-09-08 Alderbio Holdings Llc Anticorpos anti-cgrp e anti-cgrpr e seu uso para prevenir ou inibir fotofobia ou aversão à luz, composição farmacêutica compreendendo os referidos anticorpos, bem como sequência de ácido nucleico e célula recombinante
EP3662932B1 (fr) 2011-05-20 2021-04-07 H. Lundbeck A/S Compositions anti-cgrp et leur utilisation
EP2709662B1 (fr) 2011-05-20 2019-07-31 AlderBio Holdings LLC Utilisation d'anticorps ou de fragments d'anticorps anti-cgrp ou anti-cgrp-r dans le traitement ou la prévention de formes chroniques et aiguës de la diarrhée
CN103796639B (zh) * 2011-07-06 2017-05-31 诺华股份有限公司 阳离子水包油乳液
CN103764171B (zh) 2011-07-08 2016-08-17 诺华股份有限公司 酪氨酸连接方法
JP6049712B2 (ja) 2011-07-08 2016-12-21 ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒルThe University Of North Carolina At Chapel Hill 抗癌治療及び画像化並びに骨障害治療のための金属ビスホスホネートナノ粒子
EP3248982A1 (fr) 2011-07-19 2017-11-29 Wave Life Sciences Ltd. Reactifs de type thiosulfonate pour la synthèse d'acides nucléiques fonctionnalisés
CN103957932B (zh) 2011-07-20 2017-06-23 梅里亚有限公司 包含最优化的猫白血病病毒包膜基因的重组猫白血病病毒疫苗
EA201490381A1 (ru) 2011-07-29 2014-06-30 Селекта Байосайенсиз, Инк. Синтетические наноносители, которые стимулируют формирование гуморального иммунного ответа и иммунного ответа, опосредованного цитотоксическими т-лимфоцитами (ctl)
JP6170932B2 (ja) 2011-11-07 2017-07-26 ノバルティス アーゲー spr0096抗原およびspr2021抗原を含むキャリア分子
WO2013129603A1 (fr) * 2012-02-28 2013-09-06 国立大学法人東京農工大学 Procédé permettant de désigner une maladie en relation avec la quantité de tdp-43 présent dans les cellules
WO2013142371A1 (fr) 2012-03-20 2013-09-26 Merial Limited Vaccin contre l'herpèsvirus équin 1 recombinant contenant une glycoprotéine c mutée et utilisations associées
JP2014012650A (ja) * 2012-07-05 2014-01-23 Nihon Univ 上皮バリア機能の増強方法及び増強剤
WO2014010718A1 (fr) * 2012-07-13 2014-01-16 株式会社新日本科学 Adjuvant d'acide nucléique chiral
SG11201500239VA (en) 2012-07-13 2015-03-30 Wave Life Sciences Japan Asymmetric auxiliary group
EP4219516A3 (fr) 2012-07-13 2024-01-10 Wave Life Sciences Ltd. Controle chiral
MX2015002701A (es) 2012-08-30 2015-12-01 Merial Inc Dispositivo hiperbarico y metodos para producir vacunas inactivadas y para replegar/solubilizar proteinas recombinates.
EA201590427A1 (ru) 2012-10-02 2015-09-30 Глаксосмитклайн Байолоджикалс С.А. Нелинейные сахаридные конъюгаты
SG11201504258RA (en) 2012-11-30 2015-07-30 Glaxosmithkline Biolog Sa Pseudomonas antigens and antigen combinations
DK3521312T3 (da) 2013-02-20 2021-06-28 Innate Pharma Forbindelse, der binder specifikt til kir3dl2, til anvendelse til behandling af perifert t-cellelymfom
US9427647B2 (en) * 2013-04-26 2016-08-30 Russell I. Moy Climbing hold assembly having load dissipative effect
JP6865582B2 (ja) * 2013-05-29 2021-04-28 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル Kir3dl2は皮膚及び非皮膚末梢t細胞リンパ腫のサブセットをそれぞれ予防及び治療するために有用なバイオマーカー及び治療標的である
WO2014201245A1 (fr) 2013-06-12 2014-12-18 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Agoniste de tlr-9 comportant un agoniste de tlr-7 et/ou de tlr-8 pour traiter des tumeurs
US20170114122A1 (en) 2015-10-23 2017-04-27 Alderbio Holdings Llc Regulation of glucose metabolism using anti-cgrp antibodies
CA2919268C (fr) 2013-07-25 2023-09-05 Exicure, Inc. Constructions a partir d'acides nucleiques spheriques utilisees en tant qu'agents immunostimulants a des fins prophylactiques et therapeutiques
EP2870974A1 (fr) 2013-11-08 2015-05-13 Novartis AG Vaccins conjugués de salmonelle
US10144933B2 (en) 2014-01-15 2018-12-04 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant having immunity induction activity, and immunity induction activator
JPWO2015108048A1 (ja) 2014-01-15 2017-03-23 株式会社新日本科学 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤
WO2015108046A1 (fr) 2014-01-15 2015-07-23 株式会社新日本科学 Adjuvant d'acide nucléique chiral ayant une activité anti-allergique, et agent anti-allergique
RU2016133035A (ru) 2014-01-16 2018-02-21 Уэйв Лайф Сайенсес Лтд. Хиральный дизайн
KR102290205B1 (ko) 2014-06-04 2021-08-20 엑시큐어, 인크. 예방 또는 치료 용도를 위한 리포솜성 구형 핵산에 의한 면역 조절인자의 다가 전달
WO2016044839A2 (fr) 2014-09-19 2016-03-24 The Board Of Regents Of The University Of Texas System Compositions et méthodes pour traiter des infections virales par le biais de l'immunité innée stimulée en combinaison avec des composés antiviraux
CA2968531A1 (fr) 2014-11-21 2016-05-26 Northwestern University Absorption cellulaire specifique a une sequence de conjugues nanoparticulaires d'acides nucleiques spheriques
EA201792501A1 (ru) 2015-05-13 2018-10-31 Эйдженус Инк. Вакцины для лечения и профилактики рака
EP3313439A2 (fr) 2015-06-26 2018-05-02 Seqirus UK Limited Vaccins contre la grippe à correspondance antigénique
CN114807152A (zh) 2016-06-08 2022-07-29 哈佛学院院长及董事 工程化病毒载体减少了炎症和免疫反应的诱导
CA3031778A1 (fr) * 2016-07-26 2018-02-01 Bayer Animal Health Gmbh Augmentation de la fertilite chez les especes bovines
US11364304B2 (en) 2016-08-25 2022-06-21 Northwestern University Crosslinked micellar spherical nucleic acids
WO2018201090A1 (fr) 2017-04-28 2018-11-01 Exicure, Inc. Synthèse d'acides nucléiques sphériques à l'aide de fractions lipophiles
US11433131B2 (en) 2017-05-11 2022-09-06 Northwestern University Adoptive cell therapy using spherical nucleic acids (SNAs)
US11826426B2 (en) 2017-08-02 2023-11-28 The University Of Chicago Nanoscale metal-organic layers and metal-organic nanoplates for x-ray induced photodynamic therapy, radiotherapy, radiodynamic therapy, chemotherapy, immunotherapy, and any combination thereof
EP3707262A1 (fr) 2017-11-08 2020-09-16 President and Fellows of Harvard College Compositions et procédés d'inhibition de réponses inflammatoires induites par un vecteur viral
CN111801116A (zh) * 2017-12-15 2020-10-20 拜耳动物保健有限责任公司 免疫刺激性组合物
TWI839435B (zh) 2019-01-08 2024-04-21 丹麥商H.朗德貝克公司 使用抗cgrp 抗體急性治療和快速治療頭痛
CN112972672B (zh) * 2019-12-13 2024-04-19 远大赛威信生命科学(南京)有限公司 药物组合物及其用途
WO2021154745A1 (fr) 2020-01-27 2021-08-05 Oregon State University Vaccin sous-unitaire contre la blennorragie
CN114181888B (zh) * 2021-11-24 2023-12-08 汕头大学 一种浅色黄姑鱼鱼鳔细胞系的建立方法及应用
CN115252603A (zh) * 2022-07-08 2022-11-01 深圳市第二人民医院(深圳市转化医学研究院) indisulam在制备治疗膀胱癌的药物中的应用

Family Cites Families (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0368594A (ja) * 1989-08-09 1991-03-25 Shiratori Seiyaku Kk ポリヌクレオチドの製造法
WO1995026204A1 (fr) * 1994-03-25 1995-10-05 Isis Pharmaceuticals, Inc. Stimulation immunitaire par des analogues d'oligonucleotides de phosphorothioate
US6727230B1 (en) * 1994-03-25 2004-04-27 Coley Pharmaceutical Group, Inc. Immune stimulation by phosphorothioate oligonucleotide analogs
US20030026782A1 (en) * 1995-02-07 2003-02-06 Arthur M. Krieg Immunomodulatory oligonucleotides
US20030050263A1 (en) * 1994-07-15 2003-03-13 The University Of Iowa Research Foundation Methods and products for treating HIV infection
CA2194761C (fr) 1994-07-15 2006-12-19 Arthur M. Krieg Oligonucleotides immunomodulateurs
US6239116B1 (en) * 1994-07-15 2001-05-29 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
US6207646B1 (en) * 1994-07-15 2001-03-27 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
US6429199B1 (en) * 1994-07-15 2002-08-06 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules for activating dendritic cells
US7935675B1 (en) * 1994-07-15 2011-05-03 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
EP0855184A1 (fr) * 1997-01-23 1998-07-29 Grayson B. Dr. Lipford Composition pharmaceutique comprenant un polynucléotide et un antigène notamment pour la vaccination
JP2001513776A (ja) * 1997-02-28 2001-09-04 ユニバーシティ オブ アイオワ リサーチ ファウンデーション LPS関連障害の処置における非メチル化CpGジヌクレオチドを含む核酸の使用
US6406705B1 (en) * 1997-03-10 2002-06-18 University Of Iowa Research Foundation Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant
AU753688B2 (en) * 1997-03-10 2002-10-24 Ottawa Civic Loeb Research Institute Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant
WO1998052581A1 (fr) * 1997-05-20 1998-11-26 Ottawa Civic Hospital Loeb Research Institute Vecteurs et procedes destines a l'immunisation et a des protocoles therapeutiques
EP1009440B1 (fr) 1997-07-03 2008-09-17 MacFarlane, Donald E. Procedes d'inhibition de reponses associees a l'adn immunostimulateur
CA2323929C (fr) * 1998-04-03 2004-03-09 University Of Iowa Research Foundation Procedes et produits servant a stimuler le systeme immunitaire au moyen d'oligonucleotides et de cytokines immunotherapeutiques
EP1077708A1 (fr) 1998-05-06 2001-02-28 University Of Iowa Research Foundation Methodes de prevention et de traitement des parasitoses et maladies associees a l'aide d'oligonucleotides cpg
WO1999058118A2 (fr) * 1998-05-14 1999-11-18 Cpg Immunopharmaceuticals Gmbh PROCEDES DE REGULATION DE L'HEMATOPOIESE AU MOYEN D'OLIGONUCLEOTIDES A CpG
SI1077722T1 (sl) 1998-05-22 2007-02-28 Ottawa Health Research Inst Metode in produkti za induciranje sluznicne imunosti
AU764532B2 (en) 1998-07-27 2003-08-21 University Of Iowa Research Foundation, The Stereoisomers of CpG oligonucleotides and related methods
WO2000046365A1 (fr) * 1999-02-02 2000-08-10 Biocache Pharmaceuticals, Inc. Plate-forme perfectionnee de presentation d'antigenes
AU3760100A (en) * 1999-03-16 2000-10-04 Panacea Pharmaceuticals, Llc Immunostimulatory nucleic acids and antigens
KR100922031B1 (ko) * 1999-04-19 2009-10-19 글락소스미스클라인 바이오로지칼즈 에스.에이. 백신
DE60013591T2 (de) * 1999-04-29 2005-02-03 Coley Pharmaceutical Gmbh Screening nach modulatoren der funktion von immunstimulatorischer dna
AU776268B2 (en) 1999-06-08 2004-09-02 Aventis Pasteur Immunostimulant oligonucleotide
AU6051800A (en) * 1999-06-16 2001-01-02 University Of Iowa Research Foundation, The Antagonism of immunostimulatory cpg-oligonucleotides by 4-aminoquinolines and other weak bases
UA77152C2 (en) * 1999-09-25 2006-11-15 Method for stimulation of immune response using nucleic acid-containing immunostimulating compositions, method for treatment of cancer and method for treatment or prophylaxis of allergy or asthma
US6949520B1 (en) * 1999-09-27 2005-09-27 Coley Pharmaceutical Group, Inc. Methods related to immunostimulatory nucleic acid-induced interferon
CA2396871A1 (fr) * 2000-01-20 2001-12-20 Ottawa Health Research Institute Acides nucleiques immunostimulateurs permettant d'induire une reponse immunitaire th2
US7585847B2 (en) * 2000-02-03 2009-09-08 Coley Pharmaceutical Group, Inc. Immunostimulatory nucleic acids for the treatment of asthma and allergy
FR2805265B1 (fr) 2000-02-18 2002-04-12 Aventis Pasteur Oligonucleotides immunostimulants
US20020156033A1 (en) * 2000-03-03 2002-10-24 Bratzler Robert L. Immunostimulatory nucleic acids and cancer medicament combination therapy for the treatment of cancer
US20040131628A1 (en) * 2000-03-08 2004-07-08 Bratzler Robert L. Nucleic acids for the treatment of disorders associated with microorganisms
US6339630B1 (en) * 2000-05-18 2002-01-15 The United States Of America As Represented By The United States Department Of Energy Sealed drive screw operator
DK1296714T3 (da) * 2000-06-22 2009-12-07 Coley Pharm Gmbh Kombination af CpG og antistoffer, der er rettet mod CD19, CD20, CD22 eller CD40 til behandling eller forebyggelse af kræft
US20020165178A1 (en) * 2000-06-28 2002-11-07 Christian Schetter Immunostimulatory nucleic acids for the treatment of anemia, thrombocytopenia, and neutropenia
US20020198165A1 (en) 2000-08-01 2002-12-26 Bratzler Robert L. Nucleic acids for the prevention and treatment of gastric ulcers
US20020091097A1 (en) * 2000-09-07 2002-07-11 Bratzler Robert L. Nucleic acids for the prevention and treatment of sexually transmitted diseases
WO2002022809A2 (fr) * 2000-09-15 2002-03-21 Coley Pharmaceutical Gmbh Procede de criblage a haut rendement d'immuno-agoniste/antagoniste base sur cpg
DE60134421D1 (de) * 2000-12-08 2008-07-24 Coley Pharmaceuticals Gmbh Cpg-artige nukleinsäuren und verfahren zu ihrer verwendung
AU2002248185A1 (en) * 2000-12-14 2002-07-16 Coley Pharmaceutical Group, Inc. Inhibition of angiogenesis by nucleic acids
GB0105360D0 (en) * 2001-03-03 2001-04-18 Glaxo Group Ltd Chimaeric immunogens
US20030050268A1 (en) * 2001-03-29 2003-03-13 Krieg Arthur M. Immunostimulatory nucleic acid for treatment of non-allergic inflammatory diseases
US20030148316A1 (en) * 2001-08-01 2003-08-07 Lipford Grayson B. Methods and compositions relating to plasmacytoid dendritic cells
US8834900B2 (en) * 2001-08-17 2014-09-16 University Of Iowa Research Foundation Combination motif immune stimulatory oligonucleotides with improved activity
CN1633598A (zh) * 2001-10-05 2005-06-29 科勒制药股份公司 Toll样受体3信号传导的激动剂和拮抗剂
US20030139364A1 (en) * 2001-10-12 2003-07-24 University Of Iowa Research Foundation Methods and products for enhancing immune responses using imidazoquinoline compounds
CA2466612A1 (fr) * 2001-11-30 2003-06-12 Exxonmobil Chemical Patents Inc. Catalyseurs bimetalliques presentant une activite superieure
JP2005519035A (ja) * 2001-12-07 2005-06-30 インターツェル・アクチェンゲゼルシャフト 免疫促進性オリゴデオキシヌクレオチド
AU2003230806B2 (en) 2002-04-04 2009-05-07 Zoetis Belgium S.A. Immunostimulatory G,U-containing oligoribonucleotides
WO2003103586A2 (fr) * 2002-06-05 2003-12-18 Coley Pharmaceutical Group, Inc. Methode de traitement de maladies auto-immunes ou inflammatoires a l'aide de combinaisons d'oligonucleotides inhibiteurs et de petites molecules antagonistes d'acides nucleiques cpg immunostimulateurs
US20040053880A1 (en) * 2002-07-03 2004-03-18 Coley Pharmaceutical Group, Inc. Nucleic acid compositions for stimulating immune responses
US7605138B2 (en) * 2002-07-03 2009-10-20 Coley Pharmaceutical Group, Inc. Nucleic acid compositions for stimulating immune responses
US7569553B2 (en) * 2002-07-03 2009-08-04 Coley Pharmaceutical Group, Inc. Nucleic acid compositions for stimulating immune responses
US7576066B2 (en) * 2002-07-03 2009-08-18 Coley Pharmaceutical Group, Inc. Nucleic acid compositions for stimulating immune responses
US7807803B2 (en) * 2002-07-03 2010-10-05 Coley Pharmaceutical Group, Inc. Nucleic acid compositions for stimulating immune responses
AU2003255969A1 (en) 2002-07-17 2004-02-02 Coley Pharmaceutical Gmbh Use of cpg nucleic acids in prion-disease
AR040996A1 (es) * 2002-08-19 2005-04-27 Coley Pharm Group Inc Acidos nucleicos inmunoestimuladores
JP4173861B2 (ja) * 2002-09-13 2008-10-29 イデニクス(ケイマン)リミテツド 耐性HBV菌株の治療のためのβ−L−2’−デオキシヌクレオシド及び併用療法
WO2004026888A2 (fr) 2002-09-19 2004-04-01 Coley Pharmaceutical Gmbh Recepteur tlr9 derive de diverses especes mammaliennes
CA2502015A1 (fr) * 2002-12-11 2004-06-24 Coley Pharmaceutical Group, Inc. Acides nucleiques 5'cpg et leurs methodes d'utilisation
US20040235770A1 (en) * 2003-04-02 2004-11-25 Coley Pharmaceutical Group, Ltd. Immunostimulatory nucleic acid oil-in-water formulations and related methods of use
WO2004094671A2 (fr) 2003-04-22 2004-11-04 Coley Pharmaceutical Gmbh Procedes et produits pour identifier et evaluer des ligands des tlr
WO2005007672A2 (fr) * 2003-06-20 2005-01-27 Coley Pharmaceutical Gmbh Antagonistes des recepteurs toll (tlr) pour petites molecules
US7615539B2 (en) * 2003-09-25 2009-11-10 Coley Pharmaceutical Group, Inc. Nucleic acid-lipophilic conjugates
US20050215501A1 (en) * 2003-10-24 2005-09-29 Coley Pharmaceutical Group, Inc. Methods and products for enhancing epitope spreading
US20050100983A1 (en) * 2003-11-06 2005-05-12 Coley Pharmaceutical Gmbh Cell-free methods for identifying compounds that affect toll-like receptor 9 (TLR9) signaling
US20050181035A1 (en) * 2004-02-17 2005-08-18 Dow Steven W. Systemic immune activation method using non CpG nucleic acids
US20050244410A1 (en) * 2004-04-29 2005-11-03 Ashlyn Bassiri Toll-like receptor 9 effector agents and uses thereof
JP2008535859A (ja) * 2005-04-08 2008-09-04 コーリー ファーマシューティカル グループ,インコーポレイテッド 感染症によって悪化した喘息を治療するための方法
US20060241076A1 (en) * 2005-04-26 2006-10-26 Coley Pharmaceutical Gmbh Modified oligoribonucleotide analogs with enhanced immunostimulatory activity

Also Published As

Publication number Publication date
RU2002111006A (ru) 2004-01-10
BG65736B1 (bg) 2009-09-30
CZ20021050A3 (cs) 2003-01-15
AU7615300A (en) 2001-04-30
KR20020068509A (ko) 2002-08-27
NZ517929A (en) 2004-02-27
TR200503031T2 (tr) 2005-09-21
CN1454091A (zh) 2003-11-05
AU780979B2 (en) 2005-04-28
EE200200158A (et) 2003-06-16
JP2003510282A (ja) 2003-03-18
US20070066554A1 (en) 2007-03-22
NO20021453L (no) 2002-05-27
DK1221955T3 (da) 2006-01-30
SK3962002A3 (en) 2003-04-01
EP1700603A2 (fr) 2006-09-13
UA77152C2 (en) 2006-11-15
US20030212026A1 (en) 2003-11-13
AP2002002484A0 (en) 2002-06-30
CZ301488B6 (cs) 2010-03-24
EP1221955B9 (fr) 2005-11-30
SK287400B6 (sk) 2010-08-09
AP1775A (en) 2007-08-28
WO2001022972A2 (fr) 2001-04-05
HRP20020249A2 (en) 2005-06-30
EP1221955A2 (fr) 2002-07-17
BG106538A (en) 2002-12-29
YU27102A (sh) 2005-11-28
EP1221955B1 (fr) 2005-09-14
CN101543507A (zh) 2009-09-30
ATE304361T1 (de) 2005-09-15
TR200200797T2 (tr) 2002-10-21
RS50325B (sr) 2009-09-08
NO20021453D0 (no) 2002-03-22
US7271156B2 (en) 2007-09-18
US20090191188A1 (en) 2009-07-30
HK1047697A1 (en) 2003-03-07
PL354997A1 (en) 2004-03-22
WO2001022972A3 (fr) 2002-01-17
AU2005203408B2 (en) 2008-10-23
HK1047697B (zh) 2005-12-02
CA2388055A1 (fr) 2001-04-05
BR0014236A (pt) 2002-10-15
DE60022665D1 (de) 2005-10-20
WO2001022972A9 (fr) 2006-12-14
EP1700603A3 (fr) 2007-06-13
DE60022665T2 (de) 2006-06-22
RU2245149C2 (ru) 2005-01-27
IL148843A0 (en) 2002-09-12
HUP0202639A2 (en) 2002-12-28
KR100863630B1 (ko) 2008-10-15
AP2006003503A0 (en) 2006-02-28
CN1939541A (zh) 2007-04-04
AU2005203408A1 (en) 2005-08-25
ES2248126T3 (es) 2006-03-16
MXPA02003108A (es) 2003-10-14
ZA200201963B (en) 2003-03-10

Similar Documents

Publication Publication Date Title
EP1221955B9 (fr) Acides nucleiques immunostimulateurs
US7605138B2 (en) Nucleic acid compositions for stimulating immune responses
US7569553B2 (en) Nucleic acid compositions for stimulating immune responses
US7807803B2 (en) Nucleic acid compositions for stimulating immune responses
US7576066B2 (en) Nucleic acid compositions for stimulating immune responses
US8114419B2 (en) Nucleic acid compositions for stimulating immune responses
US20010044416A1 (en) Immunostimulatory nucleic acids for inducing a Th2 immune response
AU2003247880B2 (en) Nucleic acid compositions for stimulating immune responses