EA201792501A1 - Вакцины для лечения и профилактики рака - Google Patents
Вакцины для лечения и профилактики ракаInfo
- Publication number
- EA201792501A1 EA201792501A1 EA201792501A EA201792501A EA201792501A1 EA 201792501 A1 EA201792501 A1 EA 201792501A1 EA 201792501 A EA201792501 A EA 201792501A EA 201792501 A EA201792501 A EA 201792501A EA 201792501 A1 EA201792501 A1 EA 201792501A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- vaccines
- cancer
- prevention
- treatment
- compositions
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 3
- 201000011510 cancer Diseases 0.000 title abstract 2
- 230000002265 prevention Effects 0.000 title 1
- 229960005486 vaccine Drugs 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 3
- 108010001441 Phosphopeptides Proteins 0.000 abstract 2
- 102000002812 Heat-Shock Proteins Human genes 0.000 abstract 1
- 108010004889 Heat-Shock Proteins Proteins 0.000 abstract 1
- 229940022399 cancer vaccine Drugs 0.000 abstract 1
- 230000035772 mutation Effects 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 229940021747 therapeutic vaccine Drugs 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001102—Receptors, cell surface antigens or cell surface determinants
- A61K39/001103—Receptors for growth factors
- A61K39/001104—Epidermal growth factor receptors [EGFR]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001102—Receptors, cell surface antigens or cell surface determinants
- A61K39/001103—Receptors for growth factors
- A61K39/001107—Fibroblast growth factor receptors [FGFR]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001102—Receptors, cell surface antigens or cell surface determinants
- A61K39/001103—Receptors for growth factors
- A61K39/001108—Platelet-derived growth factor receptors [PDGFR]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001102—Receptors, cell surface antigens or cell surface determinants
- A61K39/001103—Receptors for growth factors
- A61K39/00111—Hepatocyte growth factor receptor [HGFR or c-met]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001102—Receptors, cell surface antigens or cell surface determinants
- A61K39/001111—Immunoglobulin superfamily
- A61K39/001114—CD74, Ii, MHC class II invariant chain or MHC class II gamma chain
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001152—Transcription factors, e.g. SOX or c-MYC
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001154—Enzymes
- A61K39/001164—GTPases, e.g. Ras or Rho
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70539—MHC-molecules, e.g. HLA-molecules
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55516—Proteins; Peptides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55522—Cytokines; Lymphokines; Interferons
- A61K2039/55527—Interleukins
- A61K2039/55533—IL-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6043—Heat shock proteins
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
- Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Organic Chemistry (AREA)
- Cell Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Wood Science & Technology (AREA)
- Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- General Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Hospice & Palliative Care (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Изобретение относится к композициям, которые могут быть использованы в качестве терапевтических вакцин (например, противоопухолевых вакцин), и к способам получения таких композиций. В композициях, раскрытых в настоящей заявке, обычно используют белок стресса и по меньшей мере один синтетический пептид, который может быть фосфопептидом или фосфопептидным миметиком, включающим опухолеспецифическую мутацию, присутствующую в раковой опухоли пациента.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562161053P | 2015-05-13 | 2015-05-13 | |
US201562205591P | 2015-08-14 | 2015-08-14 | |
US201562257458P | 2015-11-19 | 2015-11-19 | |
US201662307592P | 2016-03-14 | 2016-03-14 | |
PCT/US2016/032465 WO2016183486A1 (en) | 2015-05-13 | 2016-05-13 | Vaccines for treatment and prevention of cancer |
Publications (1)
Publication Number | Publication Date |
---|---|
EA201792501A1 true EA201792501A1 (ru) | 2018-10-31 |
Family
ID=56072474
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201792501A EA201792501A1 (ru) | 2015-05-13 | 2016-05-13 | Вакцины для лечения и профилактики рака |
Country Status (14)
Country | Link |
---|---|
US (2) | US10568948B2 (ru) |
EP (1) | EP3294324A1 (ru) |
JP (2) | JP6925980B2 (ru) |
KR (1) | KR20180006945A (ru) |
CN (1) | CN107847572A (ru) |
AU (2) | AU2016260540B2 (ru) |
CA (1) | CA2984643A1 (ru) |
EA (1) | EA201792501A1 (ru) |
HK (1) | HK1252873A1 (ru) |
IL (2) | IL293135A (ru) |
MA (1) | MA42420A (ru) |
MX (2) | MX2017014532A (ru) |
SG (1) | SG10201912485PA (ru) |
WO (1) | WO2016183486A1 (ru) |
Families Citing this family (31)
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CA2984643A1 (en) * | 2015-05-13 | 2016-11-17 | Agenus Inc. | Vaccines for treatment and prevention of cancer |
TWI765875B (zh) | 2015-12-16 | 2022-06-01 | 美商磨石生物公司 | 新抗原辨識、製造及用途 |
SG11201810023QA (en) | 2016-05-27 | 2018-12-28 | Agenus Inc | Anti-tim-3 antibodies and methods of use thereof |
WO2018094569A1 (zh) * | 2016-11-22 | 2018-05-31 | 深圳华大基因研究院 | 多肽及其应用 |
ES2928773T3 (es) | 2017-01-17 | 2022-11-22 | Heparegenix Gmbh | Inhibidores de proteína cinasas para fomentar la regeneración hepática o reducir o prevenir la muerte de hepatocitos |
BR112019017241A2 (pt) | 2017-04-13 | 2020-04-14 | Agenus Inc | anticorpos anti-cd137 e métodos de uso dos mesmos |
CA3062061A1 (en) | 2017-05-01 | 2018-11-08 | Agenus Inc. | Anti-tigit antibodies and methods of use thereof |
EP3622071A4 (en) * | 2017-05-10 | 2020-05-20 | Nantomics, LLC | CIRCULATING RNA FOR DETECTING, PREDICTING AND MONITORING CANCER |
EP3694532A4 (en) | 2017-10-10 | 2021-07-14 | Gritstone Oncology, Inc. | IDENTIFICATION OF NEOANTIGENS BY MEANS OF HOT SPOTS |
JP2021503897A (ja) | 2017-11-22 | 2021-02-15 | グリットストーン オンコロジー インコーポレイテッド | 新生抗原のためのジャンクションエピトープ提示の低減 |
CA3096909A1 (en) | 2018-04-26 | 2019-10-31 | Agenus Inc. | Heat shock protein-binding peptide compositions and methods of use thereof |
US20210233610A1 (en) * | 2018-08-28 | 2021-07-29 | CeCaVa GmbH & Co. KG | Methods for ranking and/or selecting tumor-specific neoantigens |
EP3618071A1 (en) * | 2018-08-28 | 2020-03-04 | CeCaVa GmbH & Co. KG | Methods for selecting tumor-specific neoantigens |
CN110917341A (zh) * | 2018-09-20 | 2020-03-27 | 天津贝罗尼生物科技有限公司 | 一种小鼠肿瘤疫苗及其制备方法 |
WO2020065023A1 (en) * | 2018-09-27 | 2020-04-02 | Vaccibody As | Method for selecting neoepitopes |
CN109438570B (zh) * | 2018-11-28 | 2021-07-20 | 生命谷(海南)生物科技股份有限公司 | 肿瘤相关基因fgfr3突变短肽及其应用 |
CN109517053B (zh) * | 2018-11-28 | 2021-10-08 | 生命谷(海南)生物科技股份有限公司 | 肿瘤相关基因ret突变短肽及其应用 |
CN112767998A (zh) * | 2019-01-29 | 2021-05-07 | 杭州纽安津生物科技有限公司 | 针对靶向药物达拉菲尼、派姆单抗、威罗菲尼、司美替尼的多肽疫苗组合及其设计方法 |
WO2020221783A1 (en) * | 2019-04-29 | 2020-11-05 | Vaccibody As | Methods for pre-selection of neoepitopes |
KR20220038742A (ko) * | 2019-07-24 | 2022-03-29 | 아게누스 인코포레이티드 | 항원성 폴리펩티드 및 이의 사용 방법 |
AU2020335928A1 (en) | 2019-08-30 | 2022-02-17 | Agenus Inc. | Anti-CD96 antibodies and methods of use thereof |
CN112002374B (zh) * | 2020-06-14 | 2022-04-22 | 北京臻知医学科技有限责任公司 | 基于深度学习的mhc-i表位亲和力预测方法 |
US11421015B2 (en) | 2020-12-07 | 2022-08-23 | Think Therapeutics, Inc. | Method of compact peptide vaccines using residue optimization |
JP2023551204A (ja) * | 2020-11-20 | 2023-12-07 | シンク・セラピューティクス・インコーポレイテッド | 最適化ペプチドワクチンの組成物および方法 |
US11058751B1 (en) | 2020-11-20 | 2021-07-13 | Think Therapeutics, Inc. | Compositions for optimized RAS peptide vaccines |
US20240002795A1 (en) * | 2020-11-24 | 2024-01-04 | Providence Health & Services - Oregon | T cell receptors specific for a mutant form of the ret oncogene and uses thereof |
CN112608992B (zh) * | 2020-12-21 | 2022-05-10 | 黄志玲 | 一种msh6突变基因及其应用 |
CN113173985A (zh) * | 2021-03-24 | 2021-07-27 | 深圳市新靶向生物科技有限公司 | 一种与结直肠癌驱动基因突变相关的抗原肽及其应用 |
US11464842B1 (en) | 2021-04-28 | 2022-10-11 | Think Therapeutics, Inc. | Compositions and method for optimized peptide vaccines using residue optimization |
WO2024036068A1 (en) * | 2022-08-12 | 2024-02-15 | Amazon Technologies, Inc. | Tumor cell identification by mapping mutations in bulk dna sequences to single cell rna sequences |
WO2024054892A1 (en) * | 2022-09-09 | 2024-03-14 | Shape Therapeutics Inc. | Therapeutic peptides |
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-
2016
- 2016-05-13 CA CA2984643A patent/CA2984643A1/en not_active Abandoned
- 2016-05-13 CN CN201680040668.6A patent/CN107847572A/zh active Pending
- 2016-05-13 AU AU2016260540A patent/AU2016260540B2/en not_active Ceased
- 2016-05-13 MA MA042420A patent/MA42420A/fr unknown
- 2016-05-13 EP EP16724828.5A patent/EP3294324A1/en not_active Withdrawn
- 2016-05-13 IL IL293135A patent/IL293135A/en unknown
- 2016-05-13 JP JP2017558945A patent/JP6925980B2/ja active Active
- 2016-05-13 MX MX2017014532A patent/MX2017014532A/es unknown
- 2016-05-13 SG SG10201912485PA patent/SG10201912485PA/en unknown
- 2016-05-13 US US15/154,543 patent/US10568948B2/en not_active Expired - Fee Related
- 2016-05-13 KR KR1020177035671A patent/KR20180006945A/ko not_active Application Discontinuation
- 2016-05-13 EA EA201792501A patent/EA201792501A1/ru unknown
- 2016-05-13 WO PCT/US2016/032465 patent/WO2016183486A1/en active Application Filing
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2017
- 2017-10-30 IL IL255333A patent/IL255333B/en unknown
- 2017-11-13 MX MX2022005291A patent/MX2022005291A/es unknown
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2018
- 2018-09-21 HK HK18112217.2A patent/HK1252873A1/zh unknown
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2020
- 2020-01-09 US US16/738,637 patent/US20200237885A1/en not_active Abandoned
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2021
- 2021-04-01 AU AU2021202037A patent/AU2021202037A1/en not_active Abandoned
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AU2016260540B2 (en) | 2021-01-07 |
JP2018515519A (ja) | 2018-06-14 |
SG10201912485PA (en) | 2020-02-27 |
JP2021178854A (ja) | 2021-11-18 |
IL255333A0 (en) | 2017-12-31 |
KR20180006945A (ko) | 2018-01-19 |
CA2984643A1 (en) | 2016-11-17 |
CN107847572A (zh) | 2018-03-27 |
MA42420A (fr) | 2018-05-23 |
EP3294324A1 (en) | 2018-03-21 |
MX2022005291A (es) | 2022-05-24 |
WO2016183486A1 (en) | 2016-11-17 |
IL255333B (en) | 2022-06-01 |
HK1252873A1 (zh) | 2019-06-06 |
IL293135A (en) | 2022-07-01 |
JP6925980B2 (ja) | 2021-08-25 |
AU2021202037A1 (en) | 2021-04-29 |
AU2016260540A1 (en) | 2017-11-30 |
MX2017014532A (es) | 2018-02-21 |
US20160331821A1 (en) | 2016-11-17 |
US10568948B2 (en) | 2020-02-25 |
US20200237885A1 (en) | 2020-07-30 |
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