NZ596374A - 3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]octane- or heptane-nitrile as jak inhibitors - Google Patents

3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]octane- or heptane-nitrile as jak inhibitors

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Publication number
NZ596374A
NZ596374A NZ596374A NZ59637410A NZ596374A NZ 596374 A NZ596374 A NZ 596374A NZ 596374 A NZ596374 A NZ 596374A NZ 59637410 A NZ59637410 A NZ 59637410A NZ 596374 A NZ596374 A NZ 596374A
Authority
NZ
New Zealand
Prior art keywords
pyrrolo
pyrazol
pyrimidin
compounds
octane
Prior art date
Application number
NZ596374A
Other languages
English (en)
Inventor
James D Rodgers
Yun-Long Li
Original Assignee
Incyte Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42246359&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NZ596374(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Incyte Corp filed Critical Incyte Corp
Publication of NZ596374A publication Critical patent/NZ596374A/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/525—Isoalloxazines, e.g. riboflavins, vitamin B2
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    • A61P5/00—Drugs for disorders of the endocrine system
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Diabetes (AREA)
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  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
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  • Neurology (AREA)
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  • Obesity (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pain & Pain Management (AREA)
  • Biotechnology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Neurosurgery (AREA)
NZ596374A 2009-05-22 2010-05-21 3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]octane- or heptane-nitrile as jak inhibitors NZ596374A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18058209P 2009-05-22 2009-05-22
PCT/US2010/035728 WO2010135621A1 (en) 2009-05-22 2010-05-21 3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]octane- or heptane-nitrile as jak inhibitors

Publications (1)

Publication Number Publication Date
NZ596374A true NZ596374A (en) 2014-01-31

Family

ID=42246359

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ596374A NZ596374A (en) 2009-05-22 2010-05-21 3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]octane- or heptane-nitrile as jak inhibitors

Country Status (36)

Country Link
US (3) US8604043B2 (enExample)
EP (2) EP3643312A1 (enExample)
JP (2) JP6172939B2 (enExample)
KR (1) KR20120030447A (enExample)
CN (2) CN102458411A (enExample)
AR (1) AR076920A1 (enExample)
AU (1) AU2010249443B2 (enExample)
BR (1) BRPI1012108B8 (enExample)
CA (1) CA2761954C (enExample)
CL (1) CL2011002955A1 (enExample)
CO (1) CO6470876A2 (enExample)
CR (1) CR20110621A (enExample)
CY (1) CY1122425T1 (enExample)
DK (1) DK2432472T3 (enExample)
EA (1) EA020494B1 (enExample)
EC (1) ECSP11011534A (enExample)
ES (1) ES2761300T3 (enExample)
HR (1) HRP20192203T1 (enExample)
HU (1) HUE046493T2 (enExample)
IL (1) IL216359A (enExample)
LT (1) LT2432472T (enExample)
ME (1) ME03556B (enExample)
MX (1) MX2011012262A (enExample)
MY (1) MY161416A (enExample)
NZ (1) NZ596374A (enExample)
PE (1) PE20120371A1 (enExample)
PL (1) PL2432472T3 (enExample)
PT (1) PT2432472T (enExample)
RS (1) RS59632B1 (enExample)
SG (2) SG10201402492TA (enExample)
SI (1) SI2432472T1 (enExample)
SM (1) SMT201900698T1 (enExample)
TW (1) TWI484962B (enExample)
UA (1) UA106078C2 (enExample)
WO (1) WO2010135621A1 (enExample)
ZA (1) ZA201108541B (enExample)

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TW201406761A (zh) 2012-05-18 2014-02-16 Incyte Corp 做爲ｊａｋ抑制劑之哌啶基環丁基取代之吡咯并吡啶及吡咯并嘧啶衍生物
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CA2921568A1 (en) 2013-08-20 2015-02-25 Incyte Corporation Survival benefit in patients with solid tumors with elevated c-reactive protein levels
SI3129021T1 (sl) 2014-04-08 2021-07-30 Incyte Corporation Zdravljenje malignosti B-celic s kombinacijo zaviralcev JAK in PI3K
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TW201618775A (zh) 2014-08-11 2016-06-01 艾森塔製藥公司 Ｂｔｋ抑制劑、ｐｉ３ｋ抑制劑、ｊａｋ－２抑制劑、ｐｄ－１抑制劑及／或ｐｄ－ｌ１抑制劑之治療組合物
PL3179991T3 (pl) 2014-08-11 2022-02-14 Acerta Pharma B.V. Kombinacje terapeutyczne inhibitora btk i inhibitora bcl-2
AR101504A1 (es) 2014-08-11 2016-12-21 Acerta Pharma Bv Combinaciones terapéuticas de un inhibidor de la btk, un inhibidor de la pi3k, un inhibidor de la jak-2, y/o un inhibidor de la cdk4/6
EP3559003B1 (en) * 2016-12-21 2022-08-24 Japan Tobacco Inc. Crystalline forms of a janus kinase inhibitor
WO2018167283A1 (en) 2017-03-17 2018-09-20 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for the diagnosis and treatment of pancreatic ductal adenocarcinoma associated neural remodeling
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AR076920A1 (es) 2011-07-20
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UA106078C2 (uk) 2014-07-25
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EP3643312A1 (en) 2020-04-29
TWI484962B (zh) 2015-05-21
CA2761954C (en) 2018-07-31
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