CA2761954C - 3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]octane- or heptane-nitrile as jak inhibitors - Google Patents

3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]octane- or heptane-nitrile as jak inhibitors Download PDF

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CA2761954C
CA2761954C CA2761954A CA2761954A CA2761954C CA 2761954 C CA2761954 C CA 2761954C CA 2761954 A CA2761954 A CA 2761954A CA 2761954 A CA2761954 A CA 2761954A CA 2761954 C CA2761954 C CA 2761954C
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salt
compound
pyrrolo
pyrazol
pyrimidin
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French (fr)
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CA2761954A1 (en
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Yun-Long Li
James D. Rodgers
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Incyte Holdings Corp
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Incyte Holdings Corp
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/525—Isoalloxazines, e.g. riboflavins, vitamin B2
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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CA2761954A 2009-05-22 2010-05-21 3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]octane- or heptane-nitrile as jak inhibitors Active CA2761954C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US18058209P 2009-05-22 2009-05-22
US61/180,582 2009-05-22
PCT/US2010/035728 WO2010135621A1 (en) 2009-05-22 2010-05-21 3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]octane- or heptane-nitrile as jak inhibitors

Publications (2)

Publication Number Publication Date
CA2761954A1 CA2761954A1 (en) 2010-11-25
CA2761954C true CA2761954C (en) 2018-07-31

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CA2761954A Active CA2761954C (en) 2009-05-22 2010-05-21 3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]octane- or heptane-nitrile as jak inhibitors

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US (3) US8604043B2 (enExample)
EP (2) EP2432472B1 (enExample)
JP (2) JP6172939B2 (enExample)
KR (1) KR20120030447A (enExample)
CN (2) CN102458411A (enExample)
AR (1) AR076920A1 (enExample)
AU (1) AU2010249443B2 (enExample)
BR (1) BRPI1012108B8 (enExample)
CA (1) CA2761954C (enExample)
CL (1) CL2011002955A1 (enExample)
CO (1) CO6470876A2 (enExample)
CR (1) CR20110621A (enExample)
CY (1) CY1122425T1 (enExample)
DK (1) DK2432472T3 (enExample)
EA (1) EA020494B1 (enExample)
EC (1) ECSP11011534A (enExample)
ES (1) ES2761300T3 (enExample)
HR (1) HRP20192203T1 (enExample)
HU (1) HUE046493T2 (enExample)
IL (1) IL216359A (enExample)
LT (1) LT2432472T (enExample)
ME (1) ME03556B (enExample)
MX (1) MX2011012262A (enExample)
MY (1) MY161416A (enExample)
NZ (1) NZ596374A (enExample)
PE (1) PE20120371A1 (enExample)
PL (1) PL2432472T3 (enExample)
PT (1) PT2432472T (enExample)
RS (1) RS59632B1 (enExample)
SG (2) SG176111A1 (enExample)
SI (1) SI2432472T1 (enExample)
SM (1) SMT201900698T1 (enExample)
TW (1) TWI484962B (enExample)
UA (1) UA106078C2 (enExample)
WO (1) WO2010135621A1 (enExample)
ZA (1) ZA201108541B (enExample)

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KR102242077B1 (ko) 2012-11-15 2021-04-20 인사이트 홀딩스 코포레이션 룩솔리티니브의 서방성 제형
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SMT201900698T1 (it) 2020-01-14
EA201101666A1 (ru) 2012-05-30
JP2016040271A (ja) 2016-03-24
ZA201108541B (en) 2018-11-28
SI2432472T1 (sl) 2019-11-29
TWI484962B (zh) 2015-05-21
WO2010135621A1 (en) 2010-11-25
LT2432472T (lt) 2020-02-10
US9623029B2 (en) 2017-04-18
JP6172939B2 (ja) 2017-08-02
AR076920A1 (es) 2011-07-20
US9216984B2 (en) 2015-12-22
BRPI1012108B8 (pt) 2021-05-25
JP2012527481A (ja) 2012-11-08
CA2761954A1 (en) 2010-11-25
ECSP11011534A (es) 2012-01-31
BRPI1012108B1 (pt) 2020-08-25
AU2010249443B2 (en) 2015-08-13
PE20120371A1 (es) 2012-05-17
KR20120030447A (ko) 2012-03-28
SG176111A1 (en) 2011-12-29

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