NZ591793A - Substituted 1-(4-fluoro-5-(2-fluoropyridin-3-yl)-1-((pyrindin-2-yl)sulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine compounds - Google Patents
Substituted 1-(4-fluoro-5-(2-fluoropyridin-3-yl)-1-((pyrindin-2-yl)sulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine compoundsInfo
- Publication number
- NZ591793A NZ591793A NZ591793A NZ59179309A NZ591793A NZ 591793 A NZ591793 A NZ 591793A NZ 591793 A NZ591793 A NZ 591793A NZ 59179309 A NZ59179309 A NZ 59179309A NZ 591793 A NZ591793 A NZ 591793A
- Authority
- NZ
- New Zealand
- Prior art keywords
- compounds
- methylmethanamine
- fluoropyridin
- pyrrol
- sulfonyl
- Prior art date
Links
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 208000008469 Peptic Ulcer Diseases 0.000 abstract 2
- 208000021302 gastroesophageal reflux disease Diseases 0.000 abstract 2
- 208000011906 peptic ulcer disease Diseases 0.000 abstract 2
- 230000035882 stress Effects 0.000 abstract 2
- 231100000397 ulcer Toxicity 0.000 abstract 2
- DPRWORPFTHSTIE-UHFFFAOYSA-N 1-[4-fluoro-5-(2-fluoropyridin-3-yl)-1-(4-methoxypyridin-2-yl)sulfonylpyrrol-3-yl]-n-methylmethanamine Chemical compound FC=1C(CNC)=CN(S(=O)(=O)C=2N=CC=C(OC)C=2)C=1C1=CC=CN=C1F DPRWORPFTHSTIE-UHFFFAOYSA-N 0.000 abstract 1
- JDCBSVKVFVIKHL-UHFFFAOYSA-N 1-[4-fluoro-5-(2-fluoropyridin-3-yl)-1-(4-methylpyridin-2-yl)sulfonylpyrrol-3-yl]-n-methylmethanamine Chemical compound FC=1C(CNC)=CN(S(=O)(=O)C=2N=CC=C(C)C=2)C=1C1=CC=CN=C1F JDCBSVKVFVIKHL-UHFFFAOYSA-N 0.000 abstract 1
- 208000023514 Barrett esophagus Diseases 0.000 abstract 1
- 208000023665 Barrett oesophagus Diseases 0.000 abstract 1
- 208000007882 Gastritis Diseases 0.000 abstract 1
- 206010017866 Gastritis haemorrhagic Diseases 0.000 abstract 1
- 206010020601 Hyperchlorhydria Diseases 0.000 abstract 1
- 208000005718 Stomach Neoplasms Diseases 0.000 abstract 1
- 208000007107 Stomach Ulcer Diseases 0.000 abstract 1
- 206010042220 Stress ulcer Diseases 0.000 abstract 1
- 208000025865 Ulcer Diseases 0.000 abstract 1
- 206010046274 Upper gastrointestinal haemorrhage Diseases 0.000 abstract 1
- 201000008629 Zollinger-Ellison syndrome Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000009858 acid secretion Effects 0.000 abstract 1
- 230000037328 acute stress Effects 0.000 abstract 1
- 208000000718 duodenal ulcer Diseases 0.000 abstract 1
- 201000006549 dyspepsia Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 206010017758 gastric cancer Diseases 0.000 abstract 1
- 230000002496 gastric effect Effects 0.000 abstract 1
- 208000017215 gastric mucosa-associated lymphoid tissue lymphoma Diseases 0.000 abstract 1
- 201000005917 gastric ulcer Diseases 0.000 abstract 1
- 201000000052 gastrinoma Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 abstract 1
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 abstract 1
- 208000000689 peptic esophagitis Diseases 0.000 abstract 1
- 230000002980 postoperative effect Effects 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 125000000168 pyrrolyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 201000011549 stomach cancer Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2008218851 | 2008-08-27 | ||
| JP2008269099 | 2008-10-17 | ||
| PCT/JP2009/065279 WO2010024451A1 (en) | 2008-08-27 | 2009-08-26 | Pyrrole compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ591793A true NZ591793A (en) | 2012-11-30 |
Family
ID=41508823
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ591793A NZ591793A (en) | 2008-08-27 | 2009-08-26 | Substituted 1-(4-fluoro-5-(2-fluoropyridin-3-yl)-1-((pyrindin-2-yl)sulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine compounds |
Country Status (38)
Families Citing this family (25)
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| CA2735162C (en) * | 2008-08-27 | 2015-06-23 | Takeda Pharmaceutical Company Limited | Pyrrole compounds |
| US20110229879A1 (en) * | 2010-03-19 | 2011-09-22 | University Of Rochester | Methods and compositions for nuclear staining |
| CN102452979B (zh) * | 2010-11-03 | 2015-04-01 | 天津药明康德新药开发有限公司 | 5-氟-3-吡啶磺酰氯的合成方法 |
| CN102863371B (zh) * | 2011-07-06 | 2016-04-13 | 中国科学院上海有机化学研究所 | 氟代二氢吡咯或氟代吡咯 |
| US10039813B2 (en) | 2012-02-07 | 2018-08-07 | Massachusetts Institute Of Technology | Use of antagonists of ghrelin or ghrelin receptor to prevent or treat stress-sensitive psychiatric illness |
| KR102206928B1 (ko) | 2012-06-27 | 2021-01-22 | 다케다 야쿠힌 고교 가부시키가이샤 | 염에 의해 안정화된 아민과 유기산의 액상 제제 |
| WO2014133059A1 (ja) * | 2013-02-28 | 2014-09-04 | 武田薬品工業株式会社 | スルホニルクロライド化合物の製造法 |
| WO2014144231A1 (en) | 2013-03-15 | 2014-09-18 | Massachusetts Institute Of Technology | Use of antagonists of growth hormone or growth hormone receptor to prevent or treat stress-sensitive psychiatric illness |
| KR102084185B1 (ko) | 2013-08-29 | 2020-03-04 | 주식회사 대웅제약 | 테트라히드로사이클로펜타피롤 유도체 및 이의 제조방법 |
| CN105367550A (zh) * | 2014-08-11 | 2016-03-02 | 江苏柯菲平医药股份有限公司 | 四氢环戊二烯并[c]吡咯类衍生物、其制备方法及其在医药上的应用 |
| UY36547A (es) | 2015-02-05 | 2016-06-01 | Bayer Cropscience Ag | Derivados heterocíclicos condensados bicíclicos sustituidos por 2-(het)arilo como pesticidas |
| WO2016138099A1 (en) | 2015-02-24 | 2016-09-01 | Massachusetts Institute Of Technology | Use of ghrelin or functional ghrelin receptor agonists to prevent and treat stress-sensitive psychiatric illness |
| WO2017018473A1 (ja) | 2015-07-30 | 2017-02-02 | 武田薬品工業株式会社 | 錠剤 |
| TW201718514A (zh) | 2015-08-07 | 2017-06-01 | 拜耳作物科學股份有限公司 | 作為殺蟲劑之經2-(雜)芳基取代之稠合雜環衍生物 |
| CN106430006B (zh) * | 2016-08-18 | 2018-06-12 | 国网湖南省电力公司带电作业中心 | 配电线路移动式绝缘登高作业装置及方法 |
| CN108203430A (zh) * | 2016-12-16 | 2018-06-26 | 天地人和生物科技有限公司 | 一种新型可逆性质子泵抑制剂及其制备方法和用途 |
| EP3651735B1 (en) | 2017-07-10 | 2022-04-13 | Takeda Pharmaceutical Company Limited | Preparation comprising vonoprazan |
| KR102126576B1 (ko) | 2018-09-19 | 2020-06-24 | 주식회사 대웅제약 | 4-메톡시 피롤 유도체의 제조 방법 |
| CN113527536B (zh) * | 2020-04-21 | 2024-03-22 | 杭州德柯医疗科技有限公司 | 一种含氟多糖高分子化合物及其制备方法 |
| HUE070031T2 (hu) * | 2020-06-17 | 2025-05-28 | Ildong Pharmaceutical Co Ltd | Új savszekréciós inhibitor és alkalmazása |
| EP4074317A1 (en) | 2021-04-14 | 2022-10-19 | Bayer AG | Phosphorus derivatives as novel sos1 inhibitors |
| CN113620930B (zh) * | 2021-07-12 | 2022-08-16 | 南京烁慧医药科技有限公司 | 一种含磺酰胺结构的化合物及其制备方法和应用、一种药物组合物及应用 |
| CN118401510A (zh) * | 2021-12-15 | 2024-07-26 | 日东制药株式会社 | 1-磺酰基吡咯衍生物的新颖盐类、其制备方法及包含其的药物组合物 |
| KR20240119083A (ko) * | 2021-12-15 | 2024-08-06 | 일동제약(주) | 1-설포닐 피롤 유도체의 신규 염, 이의 제조 방법 및 이를 포함하는 약학 조성물 |
| KR20230102353A (ko) * | 2021-12-30 | 2023-07-07 | 주식회사 대웅제약 | 삼중음성유방암의 예방 또는 치료용 약학적 조성물 |
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2009
- 2009-08-26 CA CA2735162A patent/CA2735162C/en not_active Expired - Fee Related
- 2009-08-26 ME MEP-2013-90A patent/ME01598B/me unknown
- 2009-08-26 KR KR1020117006779A patent/KR101629181B1/ko active Active
- 2009-08-26 EA EA201170384A patent/EA019741B1/ru not_active IP Right Cessation
- 2009-08-26 DK DK09788053.8T patent/DK2318390T3/da active
- 2009-08-26 PE PE2011000194A patent/PE20110300A1/es not_active Application Discontinuation
- 2009-08-26 US US12/547,778 patent/US8969387B2/en active Active
- 2009-08-26 BR BRPI0917705A patent/BRPI0917705A2/pt not_active IP Right Cessation
- 2009-08-26 NZ NZ591793A patent/NZ591793A/xx not_active IP Right Cessation
- 2009-08-26 JO JO2009322A patent/JO2871B1/en active
- 2009-08-26 MX MX2011001955A patent/MX2011001955A/es active IP Right Grant
- 2009-08-26 HR HRP20130653AT patent/HRP20130653T1/hr unknown
- 2009-08-26 PE PE2013002359A patent/PE20141174A1/es not_active Application Discontinuation
- 2009-08-26 TW TW98128638A patent/TWI473798B/zh not_active IP Right Cessation
- 2009-08-26 AU AU2009284867A patent/AU2009284867B2/en not_active Ceased
- 2009-08-26 RS RS20130319A patent/RS52872B/sr unknown
- 2009-08-26 ES ES09788053T patent/ES2423289T3/es active Active
- 2009-08-26 MY MYPI20110861 patent/MY152008A/en unknown
- 2009-08-26 UA UAA201103600A patent/UA105185C2/uk unknown
- 2009-08-26 US US13/061,078 patent/US8592597B2/en active Active
- 2009-08-26 GE GEAP200912153A patent/GEP20135786B/en unknown
- 2009-08-26 CN CN200980142371.0A patent/CN102197033B/zh active Active
- 2009-08-26 SI SI200930654T patent/SI2318390T1/sl unknown
- 2009-08-26 PL PL09788053T patent/PL2318390T3/pl unknown
- 2009-08-26 EP EP09788053.8A patent/EP2318390B1/en active Active
- 2009-08-26 PT PT97880538T patent/PT2318390E/pt unknown
- 2009-08-26 AR ARP090103278A patent/AR073136A1/es unknown
- 2009-08-26 UY UY0001032074A patent/UY32074A/es not_active Application Discontinuation
- 2009-08-26 WO PCT/JP2009/065279 patent/WO2010024451A1/en not_active Ceased
- 2009-08-26 JP JP2011508745A patent/JP5638515B2/ja active Active
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2011
- 2011-02-21 IL IL211335A patent/IL211335A/en not_active IP Right Cessation
- 2011-02-24 CL CL2011000402A patent/CL2011000402A1/es unknown
- 2011-02-25 DO DO2011000061A patent/DOP2011000061A/es unknown
- 2011-03-08 ZA ZA2011/01774A patent/ZA201101774B/en unknown
- 2011-03-18 MA MA33715A patent/MA32647B1/fr unknown
- 2011-03-25 CR CR20110169A patent/CR20110169A/es unknown
- 2011-03-25 EC EC2011010912A patent/ECSP11010912A/es unknown
- 2011-03-25 CO CO11036583A patent/CO6321166A2/es active IP Right Grant
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2013
- 2013-07-26 CY CY20131100636T patent/CY1114452T1/el unknown
- 2013-07-26 SM SM201300085T patent/SMT201300085B/xx unknown
- 2013-10-01 US US14/043,018 patent/US8993598B2/en active Active
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