KR101629181B1 - 피롤 화합물 - Google Patents

피롤 화합물 Download PDF

Info

Publication number
KR101629181B1
KR101629181B1 KR1020117006779A KR20117006779A KR101629181B1 KR 101629181 B1 KR101629181 B1 KR 101629181B1 KR 1020117006779 A KR1020117006779 A KR 1020117006779A KR 20117006779 A KR20117006779 A KR 20117006779A KR 101629181 B1 KR101629181 B1 KR 101629181B1
Authority
KR
South Korea
Prior art keywords
compound
ethyl acetate
halogen
sulfonyl
salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
KR1020117006779A
Other languages
English (en)
Korean (ko)
Other versions
KR20110071067A (ko
Inventor
하루유키 니시다
야스요시 아리카와
이쿠오 후지모리
Original Assignee
다케다 야쿠힌 고교 가부시키가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41508823&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR101629181(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 다케다 야쿠힌 고교 가부시키가이샤 filed Critical 다케다 야쿠힌 고교 가부시키가이샤
Publication of KR20110071067A publication Critical patent/KR20110071067A/ko
Application granted granted Critical
Publication of KR101629181B1 publication Critical patent/KR101629181B1/ko
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1020117006779A 2008-08-27 2009-08-26 피롤 화합물 Active KR101629181B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2008218851 2008-08-27
JPJP-P-2008-218851 2008-08-27
JP2008269099 2008-10-17
JPJP-P-2008-269099 2008-10-17

Publications (2)

Publication Number Publication Date
KR20110071067A KR20110071067A (ko) 2011-06-28
KR101629181B1 true KR101629181B1 (ko) 2016-06-13

Family

ID=41508823

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020117006779A Active KR101629181B1 (ko) 2008-08-27 2009-08-26 피롤 화합물

Country Status (38)

Country Link
US (3) US8592597B2 (enExample)
EP (1) EP2318390B1 (enExample)
JP (1) JP5638515B2 (enExample)
KR (1) KR101629181B1 (enExample)
CN (1) CN102197033B (enExample)
AR (1) AR073136A1 (enExample)
AU (1) AU2009284867B2 (enExample)
BR (1) BRPI0917705A2 (enExample)
CA (1) CA2735162C (enExample)
CL (1) CL2011000402A1 (enExample)
CO (1) CO6321166A2 (enExample)
CR (1) CR20110169A (enExample)
CY (1) CY1114452T1 (enExample)
DK (1) DK2318390T3 (enExample)
DO (1) DOP2011000061A (enExample)
EA (1) EA019741B1 (enExample)
EC (1) ECSP11010912A (enExample)
ES (1) ES2423289T3 (enExample)
GE (1) GEP20135786B (enExample)
HR (1) HRP20130653T1 (enExample)
IL (1) IL211335A (enExample)
JO (1) JO2871B1 (enExample)
MA (1) MA32647B1 (enExample)
ME (1) ME01598B (enExample)
MX (1) MX2011001955A (enExample)
MY (1) MY152008A (enExample)
NZ (1) NZ591793A (enExample)
PE (2) PE20141174A1 (enExample)
PL (1) PL2318390T3 (enExample)
PT (1) PT2318390E (enExample)
RS (1) RS52872B (enExample)
SI (1) SI2318390T1 (enExample)
SM (1) SMT201300085B (enExample)
TW (1) TWI473798B (enExample)
UA (1) UA105185C2 (enExample)
UY (1) UY32074A (enExample)
WO (1) WO2010024451A1 (enExample)
ZA (1) ZA201101774B (enExample)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8592597B2 (en) 2008-08-27 2013-11-26 Takeda Pharmaceutical Company Limited Pyrrole compounds
US20110229879A1 (en) * 2010-03-19 2011-09-22 University Of Rochester Methods and compositions for nuclear staining
CN102452979B (zh) * 2010-11-03 2015-04-01 天津药明康德新药开发有限公司 5-氟-3-吡啶磺酰氯的合成方法
CN102863371B (zh) * 2011-07-06 2016-04-13 中国科学院上海有机化学研究所 氟代二氢吡咯或氟代吡咯
US10039813B2 (en) 2012-02-07 2018-08-07 Massachusetts Institute Of Technology Use of antagonists of ghrelin or ghrelin receptor to prevent or treat stress-sensitive psychiatric illness
CA2877619C (en) 2012-06-27 2020-09-22 Takeda Pharmaceutical Company Limited Liquid preparations of amines and organic acids stabilized by salts
CA2902624C (en) * 2013-02-28 2021-05-18 Takeda Pharmaceutical Company Limited Method for producing sulfonyl chloride compound
US9724396B2 (en) 2013-03-15 2017-08-08 Massachusetts Institute Of Technology Use of antagonists of growth hormone or growth hormone receptor to prevent or treat stress-sensitive psychiatric illness
KR102084185B1 (ko) 2013-08-29 2020-03-04 주식회사 대웅제약 테트라히드로사이클로펜타피롤 유도체 및 이의 제조방법
CN105367550A (zh) * 2014-08-11 2016-03-02 江苏柯菲平医药股份有限公司 四氢环戊二烯并[c]吡咯类衍生物、其制备方法及其在医药上的应用
UY36547A (es) 2015-02-05 2016-06-01 Bayer Cropscience Ag Derivados heterocíclicos condensados bicíclicos sustituidos por 2-(het)arilo como pesticidas
US10317418B2 (en) 2015-02-24 2019-06-11 Massachusetts Institute Of Technology Use of ghrelin or functional ghrelin receptor agonists to prevent and treat stress-sensitive psychiatric illness
UA124663C2 (uk) 2015-07-30 2021-10-27 Такеда Фармасьютікал Компані Лімітед Таблетка
JP6913076B2 (ja) 2015-08-07 2021-08-04 バイエル・クロップサイエンス・アクチェンゲゼルシャフト 有害生物防除剤としての２−（ヘタ）アリール−置換縮合ヘテロ環誘導体
CN106430006B (zh) * 2016-08-18 2018-06-12 国网湖南省电力公司带电作业中心 配电线路移动式绝缘登高作业装置及方法
CN108203430A (zh) * 2016-12-16 2018-06-26 天地人和生物科技有限公司 一种新型可逆性质子泵抑制剂及其制备方法和用途
ES2921931T3 (es) 2017-07-10 2022-09-02 Takeda Pharmaceuticals Co Preparación que comprende vonoprazán
KR102126576B1 (ko) 2018-09-19 2020-06-24 주식회사 대웅제약 4-메톡시 피롤 유도체의 제조 방법
CN113527536B (zh) * 2020-04-21 2024-03-22 杭州德柯医疗科技有限公司 一种含氟多糖高分子化合物及其制备方法
ES3014815T3 (en) * 2020-06-17 2025-04-25 Ildong Pharmaceutical Co Ltd Novel acid secretion inhibitor and use thereof
EP4074317A1 (en) 2021-04-14 2022-10-19 Bayer AG Phosphorus derivatives as novel sos1 inhibitors
CN113620930B (zh) * 2021-07-12 2022-08-16 南京烁慧医药科技有限公司 一种含磺酰胺结构的化合物及其制备方法和应用、一种药物组合物及应用
CN118541361A (zh) * 2021-12-15 2024-08-23 日东制药株式会社 1-磺酰基吡咯衍生物的新型盐、其制备方法和包括其的药物组合物
CN118401510A (zh) * 2021-12-15 2024-07-26 日东制药株式会社 1-磺酰基吡咯衍生物的新颖盐类、其制备方法及包含其的药物组合物
KR20230102353A (ko) * 2021-12-30 2023-07-07 주식회사 대웅제약 삼중음성유방암의 예방 또는 치료용 약학적 조성물

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007026916A1 (en) 2005-08-30 2007-03-08 Takeda Pharmaceutical Company Limited 1-heterocyclylsulfonyl, 2-aminomethyl, 5- (hetero-) aryl substituted 1-h-pyrrole derivatives as acid secretion inhibitors

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3772301D1 (de) 1986-08-29 1991-09-26 Pfizer 2-guanidino-4-aryl-thiazole fuer die behandlung von peptischen geschwueren.
US5128366A (en) 1990-07-05 1992-07-07 Shinogi & Co., Ltd. Pyrrole derivatives
WO1992004025A1 (en) 1990-08-31 1992-03-19 Warner-Lambert Company Amino acid analogs as cck antagonists
US5331006A (en) * 1990-08-31 1994-07-19 Warner-Lambert Company Amino acid analogs as CCK antagonists
WO1993007751A1 (en) 1991-10-18 1993-04-29 Monsanto Company Fungicides for the control of take-all disease of plants
MX9205392A (es) 1991-10-29 1993-04-01 Du Pont Triazolcarbozamidas herbicidas y procedimiento para su obtencion.
JPH06135961A (ja) 1992-10-23 1994-05-17 Nippon Iyakuhin Kogyo Kk 新規ジフェニルピロリルフラン誘導体
US5286742A (en) * 1992-11-03 1994-02-15 American Cyanamid Company Pyrrole thiocarboxamide insecticidal and acaricidal agents
US5480902A (en) * 1993-08-31 1996-01-02 American Cyanamid Company Thienylpyrrole fungicidal agents
JPH08119936A (ja) 1994-10-18 1996-05-14 Fujisawa Pharmaceut Co Ltd 複素環式誘導体
JPH0930967A (ja) 1995-07-17 1997-02-04 Chugai Pharmaceut Co Ltd 抗潰瘍剤
DE69716449T2 (de) 1996-08-28 2003-08-07 The Procter & Gamble Company, Cincinnati Substituierte zyklische amine als metalloproteaseinhibitoren
ES2331860T3 (es) 1996-12-23 2010-01-18 Bristol-Myers Squibb Pharma Company Compuestos heteroaromaticos que contienen nitrogeno como inhibidores del factor xa.
JPH11209344A (ja) 1998-01-26 1999-08-03 Kyowa Hakko Kogyo Co Ltd 含窒素複素環化合物
GB9817548D0 (en) 1998-08-12 1998-10-07 Novartis Ag Organic compounds
EP1176139B1 (en) 1999-03-10 2005-05-18 Shionogi & Co., Ltd. Medicinal compositions with 2.2.1] and 3.1.1] bicycloskeleton antagonistic to both of pgd 2?/txa 2? receptors
TW575561B (en) 1999-03-25 2004-02-11 Hoffmann La Roche 1-arenesulfonyl-2-aryl-pyrrolidine and piperidine derivatives
AU3783100A (en) 1999-06-14 2000-12-21 Dow Agrosciences Llc Substituted triazoles, imidazoles and pyrazoles as herbicides
ATE309995T1 (de) * 1999-08-26 2005-12-15 Aventis Pharma Inc Substituierte (aminoiminomethyl oder aminomethyl) dihydrobenzofurane und benozopyrane
EP1284260A4 (en) 2000-05-22 2004-03-31 Takeda Chemical Industries Ltd TYROSIN PHOSPHATASE INHIBITORS
US6589978B2 (en) 2000-06-30 2003-07-08 Hoffman-La Roche Inc. 1-sulfonyl pyrrolidine derivatives
GB0016453D0 (en) 2000-07-04 2000-08-23 Hoffmann La Roche Pyrrole derivatives
US7544690B2 (en) 2001-10-01 2009-06-09 Taisho Pharmaceutical Co., Ltd. MCH receptor antagonists
WO2003040147A1 (en) 2001-11-08 2003-05-15 Pharmacia & Upjohn Company Azabicyclic-substituted-heteroaryl compounds for the treatment of disease__________________________________________________________________________________________________________________________
EP1451179A1 (en) 2001-11-22 2004-09-01 Ciba SC Holding AG Pyrrole synthesis
EP1466902A4 (en) 2001-12-28 2005-11-09 Takeda Pharmaceutical ANTAGONISTS OF THE ANDROGEN RECEPTOR
WO2003068738A1 (en) 2002-02-11 2003-08-21 Neurocrine Biosciences, Inc. Pyrrole derivatives as ligands of melanocortin receptors
AU2003209114A1 (en) * 2002-02-14 2003-09-04 Wyeth Pyrrolylalkylidene-hydrazinecarboximidamide derivatives as 5-hydroxytryptamine-6 ligands
TW200306191A (en) 2002-02-22 2003-11-16 Teijin Ltd Pyrrolopyrimidine derivatives
AU2003245464A1 (en) 2002-06-13 2003-12-31 E.I. Du Pont De Nemours And Company Pyrazole and pyrrole carboxamide insecticides
BR0313396A (pt) * 2002-08-12 2005-06-28 Sugen Inc 3-pirrolil-piridopirazóis e 3-pirrolil-indazóis, como inibidores de quinase
JP2004315511A (ja) 2003-03-31 2004-11-11 Taisho Pharmaceut Co Ltd Ｍｃｈ受容体アンタゴニスト
WO2004103968A1 (en) 2003-05-26 2004-12-02 Aponetics Ag Sulfopyrroles
WO2006036024A1 (ja) 2004-09-30 2006-04-06 Takeda Pharmaceutical Company Limited プロトンポンプ阻害薬
EP1655284A1 (en) 2004-10-26 2006-05-10 Aponetics AG 2-Phenylsulfopyrroles
US8512761B2 (en) * 2006-01-27 2013-08-20 Yale University Fast acting inhibitor of gastric acid secretion
JP5207964B2 (ja) 2006-03-31 2013-06-12 武田薬品工業株式会社 酸分泌抑制薬
US8933105B2 (en) * 2007-02-28 2015-01-13 Takeda Pharmaceutical Company Limited Pyrrole compounds
AR068538A1 (es) 2007-09-28 2009-11-18 Takeda Pharmaceutical Compuesto heterociclico de 5 miembros con actividad supresora de la secrecion de acido
US20090318429A1 (en) 2008-04-28 2009-12-24 Institute For Oneworld Health Compounds, Compositions and Methods Comprising Heteroaromatic Derivatives
US8563730B2 (en) 2008-05-16 2013-10-22 Takeda San Diego, Inc. Pyrazole and fused pyrazole glucokinase activators
US8592597B2 (en) 2008-08-27 2013-11-26 Takeda Pharmaceutical Company Limited Pyrrole compounds

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007026916A1 (en) 2005-08-30 2007-03-08 Takeda Pharmaceutical Company Limited 1-heterocyclylsulfonyl, 2-aminomethyl, 5- (hetero-) aryl substituted 1-h-pyrrole derivatives as acid secretion inhibitors

Also Published As

Publication number Publication date
EA201170384A1 (ru) 2011-10-31
ES2423289T3 (es) 2013-09-19
CA2735162A1 (en) 2010-03-04
BRPI0917705A2 (pt) 2016-02-16
US20110172275A1 (en) 2011-07-14
CA2735162C (en) 2015-06-23
UY32074A (es) 2010-03-26
PE20110300A1 (es) 2011-06-16
GEP20135786B (en) 2013-03-11
TW201010993A (en) 2010-03-16
EP2318390B1 (en) 2013-05-01
AU2009284867B2 (en) 2014-08-28
IL211335A (en) 2013-12-31
HRP20130653T1 (en) 2013-08-31
US20140031393A1 (en) 2014-01-30
US8993598B2 (en) 2015-03-31
WO2010024451A1 (en) 2010-03-04
CL2011000402A1 (es) 2011-07-29
CR20110169A (es) 2011-05-16
US8969387B2 (en) 2015-03-03
ECSP11010912A (es) 2011-04-29
NZ591793A (en) 2012-11-30
HK1157756A1 (en) 2012-07-06
KR20110071067A (ko) 2011-06-28
US8592597B2 (en) 2013-11-26
MX2011001955A (es) 2011-03-29
JP5638515B2 (ja) 2014-12-10
DK2318390T3 (da) 2013-07-08
PT2318390E (pt) 2013-07-10
CN102197033B (zh) 2014-07-16
IL211335A0 (en) 2011-04-28
JP2012501296A (ja) 2012-01-19
MY152008A (en) 2014-08-15
CY1114452T1 (el) 2016-10-05
EA019741B1 (ru) 2014-05-30
TWI473798B (zh) 2015-02-21
DOP2011000061A (es) 2011-04-15
MA32647B1 (fr) 2011-09-01
US20100056577A1 (en) 2010-03-04
AU2009284867A2 (en) 2011-04-21
EP2318390A1 (en) 2011-05-11
PL2318390T3 (pl) 2013-09-30
ZA201101774B (en) 2012-06-27
SMT201300085B (it) 2013-09-06
PE20141174A1 (es) 2014-09-19
SI2318390T1 (sl) 2013-08-30
UA105185C2 (uk) 2014-04-25
CN102197033A (zh) 2011-09-21
AU2009284867A1 (en) 2010-03-04
RS52872B (sr) 2013-12-31
AR073136A1 (es) 2010-10-13
ME01598B (me) 2014-09-20
CO6321166A2 (es) 2011-09-20
JO2871B1 (en) 2015-03-15

Similar Documents

Publication Publication Date Title
KR101629181B1 (ko) 피롤 화합물
EP2114917B1 (en) Pyrrole compounds
KR101408561B1 (ko) 산 분비 억제제로서 1-헤테로시클릴술포닐, 2-아미노메틸, 5-(헤테로-) 아릴 치환된 1-ｈ-피롤 유도체
KR101656906B1 (ko) 피라졸 화합물
HK1157756B (en) Pyrrole compounds
HK1114516B (en) Substituted sulfoxide compounds, methods for preparing the same and use thereof
HK1114516A1 (en) Substituted sulfoxide compounds, methods for preparing the same and use thereof

Legal Events

Date Code Title Description
PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

A201 Request for examination
P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U12-oth-PR1002

Fee payment year number: 1

PG1601 Publication of registration

St.27 status event code: A-4-4-Q10-Q13-nap-PG1601

FPAY Annual fee payment

Payment date: 20190515

Year of fee payment: 4

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 4

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 5

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 6

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 7

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 8

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 9

R18-X000 Changes to party contact information recorded

St.27 status event code: A-5-5-R10-R18-oth-X000