NO834765L - Fremgangsmaate for rensing av antra-cyclinon-glukosider ved adsorpsjon paa harpikser - Google Patents
Fremgangsmaate for rensing av antra-cyclinon-glukosider ved adsorpsjon paa harpikserInfo
- Publication number
- NO834765L NO834765L NO834765A NO834765A NO834765L NO 834765 L NO834765 L NO 834765L NO 834765 A NO834765 A NO 834765A NO 834765 A NO834765 A NO 834765A NO 834765 L NO834765 L NO 834765L
- Authority
- NO
- Norway
- Prior art keywords
- resin
- adsorption
- purification
- water
- product
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 17
- 238000001179 sorption measurement Methods 0.000 title claims description 13
- 238000000746 purification Methods 0.000 title claims description 12
- 229930182478 glucoside Natural products 0.000 title 1
- 150000008131 glucosides Chemical class 0.000 title 1
- 229920005989 resin Polymers 0.000 claims description 26
- 239000011347 resin Substances 0.000 claims description 26
- 239000012535 impurity Substances 0.000 claims description 25
- 239000000047 product Substances 0.000 claims description 22
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 22
- 239000000243 solution Substances 0.000 claims description 17
- 239000000203 mixture Substances 0.000 claims description 12
- 229930182470 glycoside Natural products 0.000 claims description 5
- 150000002338 glycosides Chemical class 0.000 claims description 5
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 4
- 230000002378 acidificating effect Effects 0.000 claims description 4
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 4
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 4
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims description 4
- 238000010828 elution Methods 0.000 claims description 4
- 239000000126 substance Substances 0.000 claims description 4
- 238000003795 desorption Methods 0.000 claims description 3
- 239000007864 aqueous solution Substances 0.000 claims description 2
- 239000012043 crude product Substances 0.000 claims description 2
- 238000005342 ion exchange Methods 0.000 claims description 2
- 150000001875 compounds Chemical class 0.000 claims 1
- 238000000855 fermentation Methods 0.000 claims 1
- 230000004151 fermentation Effects 0.000 claims 1
- 239000002798 polar solvent Substances 0.000 claims 1
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 26
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 19
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 15
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 description 10
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 8
- 229960004679 doxorubicin Drugs 0.000 description 5
- AOJJSUZBOXZQNB-VTZDEGQISA-N 4'-epidoxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-VTZDEGQISA-N 0.000 description 4
- XDXDZDZNSLXDNA-TZNDIEGXSA-N Idarubicin Chemical compound C1[C@H](N)[C@H](O)[C@H](C)O[C@H]1O[C@@H]1C2=C(O)C(C(=O)C3=CC=CC=C3C3=O)=C3C(O)=C2C[C@@](O)(C(C)=O)C1 XDXDZDZNSLXDNA-TZNDIEGXSA-N 0.000 description 4
- XDXDZDZNSLXDNA-UHFFFAOYSA-N Idarubicin Natural products C1C(N)C(O)C(C)OC1OC1C2=C(O)C(C(=O)C3=CC=CC=C3C3=O)=C3C(O)=C2CC(O)(C(C)=O)C1 XDXDZDZNSLXDNA-UHFFFAOYSA-N 0.000 description 4
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 4
- 229920001429 chelating resin Polymers 0.000 description 4
- 229960000975 daunorubicin Drugs 0.000 description 4
- STQGQHZAVUOBTE-VGBVRHCVSA-N daunorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(C)=O)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 STQGQHZAVUOBTE-VGBVRHCVSA-N 0.000 description 4
- ITSGNOIFAJAQHJ-BMFNZSJVSA-N esorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)C[C@H](C)O1 ITSGNOIFAJAQHJ-BMFNZSJVSA-N 0.000 description 4
- 229960000908 idarubicin Drugs 0.000 description 4
- 239000001632 sodium acetate Substances 0.000 description 4
- 235000017281 sodium acetate Nutrition 0.000 description 4
- STQGQHZAVUOBTE-UHFFFAOYSA-N 7-Cyan-hept-2t-en-4,6-diinsaeure Natural products C1=2C(O)=C3C(=O)C=4C(OC)=CC=CC=4C(=O)C3=C(O)C=2CC(O)(C(C)=O)CC1OC1CC(N)C(O)C(C)O1 STQGQHZAVUOBTE-UHFFFAOYSA-N 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 239000000872 buffer Substances 0.000 description 3
- 239000012467 final product Substances 0.000 description 3
- 239000002244 precipitate Substances 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- XVXGYZFARCOVHS-BINOZUKVSA-N (7s,9s)-7-[(2r,4s,5s,6s)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-8,10-dihydro-7h-tetracene-5,12-dione Chemical compound C1[C@H](N)[C@H](O)[C@H](C)O[C@H]1O[C@@H]1C2=C(O)C(C(=O)C3=CC=CC=C3C3=O)=C3C(O)=C2C[C@@](O)(C(=O)CO)C1 XVXGYZFARCOVHS-BINOZUKVSA-N 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 239000004280 Sodium formate Substances 0.000 description 2
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 230000008030 elimination Effects 0.000 description 2
- 238000003379 elimination reaction Methods 0.000 description 2
- 229960001904 epirubicin Drugs 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- HLBBKKJFGFRGMU-UHFFFAOYSA-M sodium formate Chemical compound [Na+].[O-]C=O HLBBKKJFGFRGMU-UHFFFAOYSA-M 0.000 description 2
- 235000019254 sodium formate Nutrition 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- 229920002684 Sepharose Polymers 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000003929 acidic solution Substances 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 239000013043 chemical agent Substances 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 238000011097 chromatography purification Methods 0.000 description 1
- 238000012790 confirmation Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000012262 fermentative production Methods 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- GBMDVOWEEQVZKZ-UHFFFAOYSA-N methanol;hydrate Chemical compound O.OC GBMDVOWEEQVZKZ-UHFFFAOYSA-N 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 235000011121 sodium hydroxide Nutrition 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000925 very toxic Toxicity 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT24939/82A IT1155446B (it) | 1982-12-23 | 1982-12-23 | Procedimento per la purificazione di glucosidi antraciclinonici mediante adsobimento selettivo su resine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO834765L true NO834765L (no) | 1984-06-25 |
Family
ID=11215200
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO834765A NO834765L (no) | 1982-12-23 | 1983-12-22 | Fremgangsmaate for rensing av antra-cyclinon-glukosider ved adsorpsjon paa harpikser |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US4861870A (de) |
| JP (2) | JPS59118797A (de) |
| KR (1) | KR900008743B1 (de) |
| AT (1) | AT383601B (de) |
| AU (1) | AU570935B2 (de) |
| BE (1) | BE898506A (de) |
| CA (1) | CA1204738A (de) |
| CH (1) | CH657623A5 (de) |
| CS (1) | CS258114B2 (de) |
| DE (1) | DE3345445C2 (de) |
| DK (1) | DK594083A (de) |
| ES (1) | ES8504758A1 (de) |
| FI (1) | FI834650A (de) |
| FR (1) | FR2538394B1 (de) |
| GB (1) | GB2133005B (de) |
| GR (1) | GR79135B (de) |
| HK (1) | HK74887A (de) |
| HU (1) | HU197917B (de) |
| IE (1) | IE56678B1 (de) |
| IL (1) | IL70500A (de) |
| IT (1) | IT1155446B (de) |
| NL (1) | NL193108C (de) |
| NO (1) | NO834765L (de) |
| NZ (1) | NZ206605A (de) |
| PT (1) | PT77883B (de) |
| SE (1) | SE8307134L (de) |
| SG (1) | SG34587G (de) |
| SU (6) | SU1440350A3 (de) |
| YU (1) | YU247183A (de) |
| ZA (1) | ZA839564B (de) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5977082A (en) * | 1985-08-02 | 1999-11-02 | Pharmacia & Upjohn Company | Injectable ready-to-use solutions containing an antitumor anthracycline glycoside |
| US5124317A (en) * | 1985-08-02 | 1992-06-23 | Farmitalia Carlo Erba S.P.A. | Injectable ready-to-use solutions containing an antitumor anthracycline glycoside |
| DK356087A (da) * | 1987-07-09 | 1989-01-10 | Biogal Gyogyszergyar | Fremgangsmaade til isolering af et antibiotikum |
| US5188945A (en) * | 1991-09-09 | 1993-02-23 | American Cyanamid Company | Recovery process for antibiotics ll-e19020 alpha and beta |
| US5437861A (en) * | 1993-03-16 | 1995-08-01 | Applied Immune Sciences, Inc. | Removal of selected factors from whole blood or its components; and prevention and treatment of septic shock syndrome |
| DE19521419C2 (de) * | 1995-06-14 | 1997-11-27 | Plasma Applikation Mbh Ges | Verdampfereinheit zur Verdampfung von Materialien im elektrischen Vakuumbogen |
| WO1999011650A1 (fr) * | 1997-08-28 | 1999-03-11 | Mercian Corporation | Procede de purification de daunomycine |
| DE69842005D1 (de) * | 1997-12-05 | 2010-12-30 | Mercian Corp | Kristallines anthracyclin antibiotikum und seine herstellung |
| KR100274787B1 (ko) * | 1998-05-08 | 2003-10-22 | 보령제약 주식회사 | 독소루비신및이의염산염의제조정제방법 |
| CN1188424C (zh) * | 1998-10-16 | 2005-02-09 | 美露香株式会社 | 盐酸阿霉素的结晶 |
| KR100351718B1 (ko) * | 1999-11-02 | 2002-09-11 | 보령제약 주식회사 | 4'-에피-독소루비신의 정제방법 |
| WO2005004805A2 (en) | 2003-07-02 | 2005-01-20 | Solux Corporation | Thermally stable crystalline epirubicin hydrochloride and method of making the same |
| US20090099346A1 (en) * | 2003-07-02 | 2009-04-16 | Victor Matvienko | Thermally stable crystalline epirubicin hydrochloride |
| TW200510719A (en) * | 2003-08-06 | 2005-03-16 | Pharmacia Italia Spa | Method for detecting contaminants in pharmaceutical products |
| US7388083B2 (en) * | 2005-03-07 | 2008-06-17 | Solux Corporation | Epimerization of 4′-C bond and modification of 14-CH3-(CO)-fragment in anthracyclin antibiotics |
| US9035032B2 (en) * | 2005-12-13 | 2015-05-19 | Solux Corporation | Method for preparing 4-demethyldaunorubicin |
| US8802830B2 (en) * | 2005-12-20 | 2014-08-12 | Solux Corporation | Synthesis of epirubicin from 13-dihydrodaunorubicine |
| US8357785B2 (en) * | 2008-01-08 | 2013-01-22 | Solux Corporation | Method of aralkylation of 4′-hydroxyl group of anthracylins |
| US8173621B2 (en) | 2008-06-11 | 2012-05-08 | Gilead Pharmasset Llc | Nucleoside cyclicphosphates |
| US8551973B2 (en) | 2008-12-23 | 2013-10-08 | Gilead Pharmasset Llc | Nucleoside analogs |
| PA8855601A1 (es) | 2008-12-23 | 2010-07-27 | Forformidatos de nucleósidos | |
| KR20110104074A (ko) | 2008-12-23 | 2011-09-21 | 파마셋 인코포레이티드 | 퓨린 뉴클레오시드의 합성 |
| EP2636676A3 (de) | 2009-09-08 | 2014-01-01 | Heraeus Precious Metals GmbH & Co. KG | Kristallisierung von Epidaunorubicin x HCI |
| CA2794671C (en) | 2010-03-31 | 2018-05-01 | Gilead Pharmasset Llc | Stereoselective synthesis of phosphorus containing actives |
| CN102120750B (zh) * | 2011-01-30 | 2013-04-03 | 山东新时代药业有限公司 | 一种盐酸表柔比星的纯化方法 |
| DE102011103751A1 (de) | 2011-05-31 | 2012-12-06 | Heraeus Precious Metals Gmbh & Co. Kg | Kristallisierung von Epirubicinhydrochlorid |
| CN103087124B (zh) * | 2012-11-21 | 2016-01-13 | 浙江海正药业股份有限公司 | 一种制备阿霉素的方法 |
| EP2778171A1 (de) | 2013-03-15 | 2014-09-17 | Synbias Pharma Ltd. | Kristallines Monohydrat von Epirubicinhydrochlorid |
| CN108350015A (zh) * | 2015-11-05 | 2018-07-31 | 浙江海正药业股份有限公司 | 一种表柔比星或其盐酸盐的分离纯化方法 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE639897A (de) * | ||||
| US2960437A (en) * | 1954-09-03 | 1960-11-15 | Pfizer & Co C | Ion exchange purification of basic antibiotics |
| US2827417A (en) * | 1954-09-03 | 1958-03-18 | Pfizer & Co C | Ion exchange purification of basic antibiotics |
| US2793978A (en) * | 1955-06-27 | 1957-05-28 | Olin Mathieson | Ion exchange purification of neomycin |
| US3221008A (en) * | 1962-01-30 | 1965-11-30 | Merck & Co Inc | Ion exchange process for the recovery of ionic organic substances |
| FR1533151A (fr) * | 1962-05-18 | 1968-07-19 | Rhone Poulenc Sa | Nouvel antibiotique et sa préparation |
| FR1527892A (fr) * | 1967-03-15 | 1968-06-07 | Rhone Poulenc Sa | Nouveau procédé de préparation de l'antibiotique 13057 r.p. |
| FR1593235A (de) * | 1968-11-18 | 1970-05-25 | ||
| JPS4944347A (de) * | 1972-09-01 | 1974-04-26 | ||
| US3882195A (en) * | 1973-05-16 | 1975-05-06 | Air Prod & Chem | Pre-emulsification-delayed initiation suspension pearl polymerization process |
| JPS5134915B2 (de) * | 1974-07-27 | 1976-09-29 | ||
| AU519670B2 (en) * | 1975-01-22 | 1981-12-17 | Farmitalia Carlo Erba S.R.L. | Optically active daunosaminyl derivatives of anthracyclin- /nes |
| NL7602342A (nl) * | 1975-03-13 | 1976-09-15 | Rhone Poulenc Ind | Naftaceenderivaat met antibiotische activiteit. |
| US4029548A (en) * | 1976-05-07 | 1977-06-14 | The Upjohn Company | Process for producing antibiotics U-50,147 and U-51,738 |
| IT1098212B (it) * | 1978-05-09 | 1985-09-07 | Farmaceutici Italia | Antracioline antitumorali sostituite |
| JPS5543012A (en) * | 1978-09-20 | 1980-03-26 | Sanraku Inc | Novel anthracycline derivatine and its preparation |
| JPS6023679B2 (ja) * | 1979-07-13 | 1985-06-08 | メルシャン株式会社 | ロドマイシン群抗生物質とその製造法 |
| JPS5750994A (en) * | 1980-09-12 | 1982-03-25 | Microbial Chem Res Found | Novel antibiotic mf266 substance and its preparation |
| JPS57159496A (en) * | 1981-03-28 | 1982-10-01 | Sanraku Inc | Preparation of adriamycin |
| IT1210476B (it) * | 1981-05-28 | 1989-09-14 | Erba Farmitalia | Antracicline. |
-
1982
- 1982-12-23 IT IT24939/82A patent/IT1155446B/it active
-
1983
- 1983-12-15 AU AU22455/83A patent/AU570935B2/en not_active Expired
- 1983-12-15 DE DE3345445A patent/DE3345445C2/de not_active Expired - Lifetime
- 1983-12-15 NL NL8304327A patent/NL193108C/nl not_active IP Right Cessation
- 1983-12-16 CA CA000443557A patent/CA1204738A/en not_active Expired
- 1983-12-16 NZ NZ206605A patent/NZ206605A/en unknown
- 1983-12-16 AT AT0440083A patent/AT383601B/de not_active IP Right Cessation
- 1983-12-16 GB GB08333511A patent/GB2133005B/en not_active Expired
- 1983-12-16 FI FI834650A patent/FI834650A/fi not_active Application Discontinuation
- 1983-12-16 SU SU833674607A patent/SU1440350A3/ru active
- 1983-12-20 IL IL70500A patent/IL70500A/xx not_active IP Right Cessation
- 1983-12-20 GR GR73292A patent/GR79135B/el unknown
- 1983-12-20 FR FR8320378A patent/FR2538394B1/fr not_active Expired
- 1983-12-20 ES ES528226A patent/ES8504758A1/es not_active Expired
- 1983-12-20 CH CH6767/83A patent/CH657623A5/it not_active IP Right Cessation
- 1983-12-20 BE BE0/212079A patent/BE898506A/fr not_active IP Right Cessation
- 1983-12-20 YU YU02471/83A patent/YU247183A/xx unknown
- 1983-12-22 HU HU834427A patent/HU197917B/hu unknown
- 1983-12-22 PT PT77883A patent/PT77883B/pt unknown
- 1983-12-22 DK DK594083A patent/DK594083A/da not_active Application Discontinuation
- 1983-12-22 CS CS839802A patent/CS258114B2/cs unknown
- 1983-12-22 SE SE8307134A patent/SE8307134L/xx not_active Application Discontinuation
- 1983-12-22 ZA ZA839564A patent/ZA839564B/xx unknown
- 1983-12-22 KR KR1019830006090A patent/KR900008743B1/ko not_active IP Right Cessation
- 1983-12-22 NO NO834765A patent/NO834765L/no unknown
- 1983-12-22 JP JP58241118A patent/JPS59118797A/ja active Granted
- 1983-12-23 IE IE3060/83A patent/IE56678B1/en not_active IP Right Cessation
-
1987
- 1987-01-14 SU SU874028798A patent/SU1447287A3/ru active
- 1987-01-14 SU SU874028799A patent/SU1450747A3/ru active
- 1987-01-20 SU SU874028832A patent/SU1470197A3/ru active
- 1987-01-20 SU SU874028823A patent/SU1450748A3/ru active
- 1987-01-23 SU SU874028858A patent/SU1575943A3/ru active
- 1987-02-02 US US07/009,550 patent/US4861870A/en not_active Expired - Lifetime
- 1987-04-14 SG SG345/87A patent/SG34587G/en unknown
- 1987-10-15 HK HK748/87A patent/HK74887A/xx not_active IP Right Cessation
-
1994
- 1994-11-30 JP JP6296499A patent/JP2749272B2/ja not_active Expired - Lifetime
Also Published As
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