NO325560B1 - Anvendelse av villtype p53-protein eller p53-kodende sekvens for fremstilling av et medikament for behandling av kreft. - Google Patents
Anvendelse av villtype p53-protein eller p53-kodende sekvens for fremstilling av et medikament for behandling av kreft. Download PDFInfo
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- NO325560B1 NO325560B1 NO19964527A NO964527A NO325560B1 NO 325560 B1 NO325560 B1 NO 325560B1 NO 19964527 A NO19964527 A NO 19964527A NO 964527 A NO964527 A NO 964527A NO 325560 B1 NO325560 B1 NO 325560B1
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- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
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- 108700026220 vif Genes Proteins 0.000 description 1
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Classifications
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- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
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- C07K—PEPTIDES
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- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4746—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used p53
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- A61K38/00—Medicinal preparations containing peptides
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10332—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/022—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from an adenovirus
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Oncology (AREA)
- Toxicology (AREA)
- Inorganic Chemistry (AREA)
- Virology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/233,002 US5747469A (en) | 1991-03-06 | 1994-04-25 | Methods and compositions comprising DNA damaging agents and p53 |
| PCT/US1995/004898 WO1995028948A1 (en) | 1994-04-25 | 1995-04-24 | Compositions comprising dna damaging agents and p53 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO964527D0 NO964527D0 (no) | 1996-10-24 |
| NO964527L NO964527L (no) | 1996-12-17 |
| NO325560B1 true NO325560B1 (no) | 2008-06-16 |
Family
ID=22875472
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19964527A NO325560B1 (no) | 1994-04-25 | 1996-10-24 | Anvendelse av villtype p53-protein eller p53-kodende sekvens for fremstilling av et medikament for behandling av kreft. |
| NO20074774A NO20074774L (no) | 1994-04-25 | 2007-09-19 | Blandinger omfattende DNA-odeleggende midler og P53 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20074774A NO20074774L (no) | 1994-04-25 | 2007-09-19 | Blandinger omfattende DNA-odeleggende midler og P53 |
Country Status (20)
| Country | Link |
|---|---|
| US (5) | US5747469A (hu) |
| EP (2) | EP0760675B2 (hu) |
| JP (2) | JP3847334B2 (hu) |
| KR (1) | KR100379174B1 (hu) |
| CN (1) | CN1209164C (hu) |
| AT (2) | ATE383167T1 (hu) |
| AU (1) | AU694216B2 (hu) |
| BR (1) | BR9507506A (hu) |
| CA (1) | CA2188560C (hu) |
| CZ (1) | CZ295144B6 (hu) |
| DE (2) | DE69521994T3 (hu) |
| ES (2) | ES2160707T5 (hu) |
| HU (1) | HU221279B1 (hu) |
| NO (2) | NO325560B1 (hu) |
| NZ (1) | NZ284709A (hu) |
| PL (1) | PL185749B1 (hu) |
| RU (1) | RU2146149C1 (hu) |
| SK (1) | SK283364B6 (hu) |
| UA (1) | UA43917C2 (hu) |
| WO (1) | WO1995028948A1 (hu) |
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| US5705334A (en) * | 1988-09-22 | 1998-01-06 | Massachusetts Institute Of Technology | Uses for DNA structure-specific recognition protein |
| US5747469A (en) | 1991-03-06 | 1998-05-05 | Board Of Regents, The University Of Texas System | Methods and compositions comprising DNA damaging agents and p53 |
| CA2108144A1 (en) | 1991-03-06 | 1992-09-07 | Jack A. Roth | Methods and compositions for the selective inhibition of gene expression |
| US6410010B1 (en) | 1992-10-13 | 2002-06-25 | Board Of Regents, The University Of Texas System | Recombinant P53 adenovirus compositions |
| US6524812B1 (en) | 1993-10-07 | 2003-02-25 | Regents Of The University Of Minnesota | Genes encoding resistance to DNA alkylating agents |
| US6495348B1 (en) * | 1993-10-07 | 2002-12-17 | Regents Of The University Of Minnesota | Mitomycin biosynthetic gene cluster |
| CN1263864C (zh) * | 1993-10-25 | 2006-07-12 | 坎吉公司 | 重组腺病毒载体及其使用方法 |
| US20010006629A1 (en) * | 1993-10-25 | 2001-07-05 | Richard J. Gregory | Recombinant adenoviral vector and methods of use |
| US20060275261A1 (en) * | 1993-10-25 | 2006-12-07 | Canji, Inc. | Adenoviral vectors having a protein IX deletion |
| US20050031590A9 (en) * | 1993-10-25 | 2005-02-10 | Richard Gregory | Adenoviral vectors having a protein IX deletion |
| US20020010144A1 (en) * | 1994-04-29 | 2002-01-24 | Robert Sobol | Enhancing the sensitivity of tumor cells to therapies |
| US5998205A (en) * | 1994-11-28 | 1999-12-07 | Genetic Therapy, Inc. | Vectors for tissue-specific replication |
| US6638762B1 (en) | 1994-11-28 | 2003-10-28 | Genetic Therapy, Inc. | Tissue-vectors specific replication and gene expression |
| FR2729295A1 (fr) * | 1995-01-17 | 1996-07-19 | Rhone Poulenc Rorer Sa | Traitement therapeutique combine des pathologies hyperproliferatives |
| US20020068049A1 (en) * | 1998-09-10 | 2002-06-06 | Henderson Daniel R. | Tissue specific adenoviral vectors |
| JPH11510380A (ja) | 1995-07-17 | 1999-09-14 | ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム | ｐ１６発現構築物および癌治療におけるその適用 |
| US7163925B1 (en) | 1995-07-17 | 2007-01-16 | Board Of Regents, The University Of Texas System | p16 expression constructs and their application in cancer therapy |
| US5763415A (en) * | 1995-08-03 | 1998-06-09 | John Hopkins University School Of Medicine | Destruction of the epithelium of an exocrine gland in the prophylactic and therapeutic treatment of cancer |
| CA2230852A1 (en) * | 1995-08-30 | 1997-03-06 | The Regents Of The University Of California | Therapy for cellular accumulation in chronic inflammatory diseases |
| CA2234060A1 (en) * | 1995-10-06 | 1997-04-10 | Arch Development Corporation | Methods and compositions for viral enhancement of cell killing |
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| EP1724350A1 (en) * | 1995-11-30 | 2006-11-22 | The Board Of Regents, The University Of Texas System | Method and compositions for the diagnosis and treatment of cancer |
| US5952221A (en) * | 1996-03-06 | 1999-09-14 | Avigen, Inc. | Adeno-associated virus vectors comprising a first and second nucleic acid sequence |
| WO1997039135A1 (en) * | 1996-04-17 | 1997-10-23 | Board Of Regents, The University Of Texas System | Enhanced expression of transgenes |
| US6054467A (en) * | 1996-07-05 | 2000-04-25 | Sidney Kimmel Cancer Center | Down-regulation of DNA repair to enhance sensitivity to P53-mediated apoptosis |
| US5728541A (en) | 1996-07-12 | 1998-03-17 | Precision Therapeutics, Inc. | Method for preparing cell cultures from biologial specimens for chemotherapeutic and other assays |
| US20040023375A1 (en) * | 2002-07-30 | 2004-02-05 | Precision Therapeutics, Inc. | Method for preparing cell cultures from biological specimens for chemotherapeutic and other assays |
| AU3731397A (en) * | 1996-07-18 | 1998-02-10 | Arch Development Corporation | Methods and compositions for modulation of growth response |
| US5958892A (en) * | 1996-07-30 | 1999-09-28 | Board Of Regents, The University Of Texas System | 2-methoxyestradiol-induced apoptosis in cancer cells |
| WO1998022608A2 (en) * | 1996-11-18 | 1998-05-28 | Mcgill University | Post-mitotic neurons containing adenovirus vectors that modulate apoptosis and growth |
| US6183752B1 (en) * | 1997-02-05 | 2001-02-06 | Pasteur Merieux Serums Et Vaccins | Restenosis/atherosclerosis diagnosis, prophylaxis and therapy |
| US20030064949A1 (en) * | 1998-02-17 | 2003-04-03 | Loretta Nielsen | Combined tumor suppressor gene therapy and chemotherapy in the treatment of neoplasms |
| US20030060434A1 (en) * | 1997-02-18 | 2003-03-27 | Loretta Nielsen | Combined tumor suppressor gene therapy and chemotherapy in the treatment of neoplasms |
| SK285969B6 (sk) * | 1997-02-18 | 2007-12-06 | Canji, Inc. | Prípravky na liečenie cicavčích nádorových alebo hyperproliferatívnych buniek |
| US6020191A (en) * | 1997-04-14 | 2000-02-01 | Genzyme Corporation | Adenoviral vectors capable of facilitating increased persistence of transgene expression |
| US6642045B1 (en) | 1997-04-14 | 2003-11-04 | Breonics, Inc. | System for exsanguinous metabolic support of an organ or tissue |
| KR19980077401A (ko) * | 1997-04-18 | 1998-11-16 | 문우철 | 와일드타입 p53 유전자벡터와 양이온성 리포솜을 함유하는 암의 유전자 치료제 |
| US6635623B1 (en) * | 1997-06-13 | 2003-10-21 | Baylor College Of Medicine | Lipoproteins as nucleic acid vectors |
| US20050096288A1 (en) * | 1997-06-13 | 2005-05-05 | Aragene, Inc. | Lipoproteins as nucleic acid vectors |
| US6749863B1 (en) * | 1997-11-19 | 2004-06-15 | Georgetown University | Targeted liposome gene delivery |
| US6841537B1 (en) * | 1998-04-22 | 2005-01-11 | Protiva Biotherapeutics Inc. | Combination therapy using nucleic acids and conventional drugs |
| US6841538B1 (en) | 1998-04-22 | 2005-01-11 | Inex Pharmaceuticals Corporation | Combination therapy using nucleic acids and radio therapy |
| US5972640A (en) * | 1998-05-12 | 1999-10-26 | The Regents Of The University Of California | Methods for identifying antimitotic agents |
| AU771224B2 (en) | 1998-07-13 | 2004-03-18 | Board Of Regents, The University Of Texas System | Cancer treatment methods using antibodies to aminophospholipids |
| WO2000015648A1 (en) * | 1998-09-10 | 2000-03-23 | The Uab Research Foundation | Adenoviral vector encoding pro-apoptotic bax gene and uses thereof |
| US6649158B1 (en) * | 1998-10-15 | 2003-11-18 | Canji, Inc. | Methods and compositions to induce antitumor response |
| US7094533B1 (en) * | 1999-01-21 | 2006-08-22 | Board Of Regents Of The University Of Nebraska | Therapeutic and diagnostic applications of prostatic acid phosphatase in prostate cancer |
| ES2366100T3 (es) * | 1999-02-22 | 2011-10-17 | Georgetown University | Inmunoliposomas dirigidos mediante un fragmento de anticuerpo para la administración sistémica de genes. |
| AU3004700A (en) * | 1999-02-24 | 2000-09-14 | University Of Iowa Research Foundation, The | Methods and compositions for delivery of and specific immune response to nucleotide expression systems |
| EP1165144A2 (en) * | 1999-03-15 | 2002-01-02 | Introgen Therapeutics, Inc. | Dendritic cells transduced with a wild-type self gene elicit potent antitumor immune responses |
| AU4345400A (en) * | 1999-04-14 | 2000-11-14 | Breonics, Inc. | System for exsanguinous metabolic support of an organ or tissue |
| US20040038193A1 (en) * | 1999-04-14 | 2004-02-26 | Breonics, Inc. | System for exsanguinous metabolic support of an organ or tissue |
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