PL2470499T3 - Nowe pochodne kolchicyny, sposoby i ich zastosowania - Google Patents
Nowe pochodne kolchicyny, sposoby i ich zastosowaniaInfo
- Publication number
- PL2470499T3 PL2470499T3 PL10811047T PL10811047T PL2470499T3 PL 2470499 T3 PL2470499 T3 PL 2470499T3 PL 10811047 T PL10811047 T PL 10811047T PL 10811047 T PL10811047 T PL 10811047T PL 2470499 T3 PL2470499 T3 PL 2470499T3
- Authority
- PL
- Poland
- Prior art keywords
- methods
- colchicine derivatives
- novel colchicine
- novel
- derivatives
- Prior art date
Links
- IAKHMKGGTNLKSZ-INIZCTEOSA-N (S)-colchicine Chemical class C1([C@@H](NC(C)=O)CC2)=CC(=O)C(OC)=CC=C1C1=C2C=C(OC)C(OC)=C1OC IAKHMKGGTNLKSZ-INIZCTEOSA-N 0.000 title 1
- 229940045695 antineooplastic colchicine derivative Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
- C07C323/40—Y being a hydrogen or a carbon atom
- C07C323/41—Y being a hydrogen or an acyclic carbon atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/30—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms
- C07C233/32—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/24—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/61—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5082—Supracellular entities, e.g. tissue, organisms
- G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/30—Ortho- or ortho- and peri-condensed systems containing three rings containing seven-membered rings
- C07C2603/34—Benzoheptalenes; Hydrogenated benzoheptalenes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/10—Screening for compounds of potential therapeutic value involving cells
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Food Science & Technology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23714209P | 2009-08-26 | 2009-08-26 | |
| US24013209P | 2009-09-04 | 2009-09-04 | |
| PCT/CA2010/001199 WO2011022805A1 (en) | 2009-08-26 | 2010-07-30 | Novel colchicine derivatives, methods and uses thereof |
| EP10811047.9A EP2470499B1 (en) | 2009-08-26 | 2010-07-30 | Novel colchicine derivatives, methods and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2470499T3 true PL2470499T3 (pl) | 2019-11-29 |
Family
ID=43627104
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL10811047T PL2470499T3 (pl) | 2009-08-26 | 2010-07-30 | Nowe pochodne kolchicyny, sposoby i ich zastosowania |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US9458101B2 (pl) |
| EP (1) | EP2470499B1 (pl) |
| JP (1) | JP2013502441A (pl) |
| CA (1) | CA2808277C (pl) |
| DK (1) | DK2470499T3 (pl) |
| ES (1) | ES2745255T3 (pl) |
| PL (1) | PL2470499T3 (pl) |
| WO (1) | WO2011022805A1 (pl) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2500670C1 (ru) * | 2012-08-07 | 2013-12-10 | Федеральное Государственное Бюджетное Образовательное Учреждение Высшего Профессионального Образования "Нижегородский Государственный Университет Им. Н.И. Лобачевского" | ПРОИЗВОДНОЕ 1',2',3'-ТРИМЕТОКСИБЕНЗО[4',5':4,5]-6,7-ДИГИДРОЦИКЛОГЕПТА-[2,3-e]-1H-1-МЕТИЛИНДОЛА И ЕГО ПРИМЕНЕНИЕ |
| RU2500671C1 (ru) * | 2012-08-07 | 2013-12-10 | Федеральное Государственное Бюджетное Образовательное Учреждение Высшего Профессионального Образования "Нижегородский Государственный Университет Им. Н.И. Лобачевского" | ПРОИЗВОДНОЕ 1',2',3'-ТРИМЕТОКСИБЕНЗО[4',5':4,5]-6,7-ДИГИДРОЦИКЛОГЕПТА-[3,2-f]-1H-1-МЕТИЛИНДОЛА И ЕГО ПРИМЕНЕНИЕ |
| US10265281B2 (en) | 2012-11-02 | 2019-04-23 | Murray And Poole Enterprises Ltd | Treatment or prevention of cardiovascular events via the administration of a colchicine derivative |
| RU2538982C1 (ru) * | 2013-11-19 | 2015-01-10 | Федеральное Государственное Бюджетное Образовательное Учреждение Высшего Профессионального Образования "Нижегородский Государственный Университет Им. Н.И. Лобачевского" | Производное n-(1s)-1',2',3'-триметокси-6,7-дигидро-1н-бензо[5',6':5,4]циклогепта-[3,2-f]бензофуран-1-ил)ацетамида и его применение |
| EP3207026B1 (en) | 2014-10-14 | 2018-12-12 | Council of Scientific and Industrial Research | 10-substituted colchicinoids as potent anticancer agents |
| RU2593998C1 (ru) * | 2015-06-23 | 2016-08-10 | федеральное государственное автономное образовательное учреждение высшего образования "Нижегородский государственный университет им. Н.И. Лобачевского" | ПРОИЗВОДНОЕ 1', 2', 3'-ТРИМЕТОКСИБЕНЗО[5', 6:5, 4]-1H-6, 7-ДИГИДРОЦИКЛОГЕПТА[3, 2-f]БЕНЗОФУРАНА И ЕГО ПРИМЕНЕНИЕ |
| RU2630303C1 (ru) * | 2016-11-30 | 2017-09-08 | Федеральное государственное автономное образовательное учреждение высшего образования "Национальный исследовательский Нижегородский государственный университет им. Н.И. Лобачевского" | Производное 1'-бромо-2',3',4'-триметоксибензо[5',6':4,5]-(aR, 1S)-1-ацетамидо-6,7-дигидроциклогепта-[3,4-f]-1Н-индола и его применение |
| EP3641741B1 (en) * | 2017-06-19 | 2024-03-20 | University of Maryland, Baltimore | Microtubule polymerization inhibitor prodrugs and methods of using the same |
| KR20210027408A (ko) * | 2018-06-29 | 2021-03-10 | 알버타 헬스 서비시즈 | 콜히친 유도체의 방법 및 용도 |
| RU2678440C1 (ru) * | 2018-07-23 | 2019-01-29 | Федеральное государственное автономное образовательное учреждение высшего образования "Национальный исследовательский Нижегородский государственный университет им. Н.И. Лобачевского" | ПРОИЗВОДНОЕ 1",2",3"-ТРИМЕТОКСИБЕНЗО[5",6":5',4']1H-(aR,1S)-1-АЦЕТАМИДО-6',7'-ДИГИДРОЦИКЛОГЕПТА[2',3'-f]-2,3-ДИГИДРОФУРАНА И ЕГО ПРИМЕНЕНИЕ |
| WO2021089715A1 (en) * | 2019-11-06 | 2021-05-14 | Murray And Poole Enterprises, Ltd. | Use of colchicine in the treatment and prevention of lung cancer |
| CN116082182A (zh) * | 2021-11-08 | 2023-05-09 | 天津市昕晨投资发展有限公司 | 秋水仙碱衍生物的制备方法及其用途 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB763217A (en) * | 1954-02-10 | 1956-12-12 | Roussel Uclaf | Colchiceine derivatives |
| FR1344474A (fr) | 1962-10-18 | 1963-11-29 | Roussel Uclaf | Dérivés de la colchicine et de la thiocolchicine et procédé de préparation |
| US4533675A (en) * | 1984-04-17 | 1985-08-06 | The United States Of America As Represented By The Department Of Health And Human Services | Carbamates of colchicine for treatment of gout |
| US5175342A (en) | 1988-08-24 | 1992-12-29 | The United States Of America As Represented By The Department Of Health And Human Services | Esters of 3-demethylthiocolchicine and n-acyl analogs |
| US5747469A (en) | 1991-03-06 | 1998-05-05 | Board Of Regents, The University Of Texas System | Methods and compositions comprising DNA damaging agents and p53 |
| IT1270124B (it) | 1994-10-05 | 1997-04-28 | Indena Spa | Derivati della colchicina e loro impiego terapeutico |
| FR2731217B1 (fr) * | 1995-03-03 | 1997-06-13 | Roussel Uclaf | Nouveaux derives tricycliques, leur preparation, leur application a la preparation de la colchicine et de la thiocolchicine optiquement actives ou racemiques et d'analogues ou derives et intermediaires |
| IT1276996B1 (it) | 1995-06-27 | 1997-11-04 | Indena Spa | Derivati della colchicina, loro uso e formulazioni che li contengono |
| GB9904387D0 (en) | 1999-02-25 | 1999-04-21 | Pharmacia & Upjohn Spa | Antitumour synergistic composition |
| US7622612B2 (en) * | 2001-05-28 | 2009-11-24 | Chemtech Research Incorporation | Tricyclic derivatives and their use |
| US6825236B2 (en) * | 2003-04-14 | 2004-11-30 | California Pacific Medical Center | Colchicine derivatives |
| CN100393698C (zh) | 2003-06-25 | 2008-06-11 | 第一药品(株) | 三环衍生物或其药学上可接受的盐、其制备以及包含它们的药物组合物 |
| KR101077609B1 (ko) * | 2009-07-08 | 2011-10-27 | 제일약품주식회사 | 트리사이클릭 유도체의 제조방법 |
| WO2011021397A1 (ja) | 2009-08-20 | 2011-02-24 | 国立大学法人千葉大学 | コルヒチン誘導体 |
-
2010
- 2010-07-30 JP JP2012525826A patent/JP2013502441A/ja active Pending
- 2010-07-30 CA CA2808277A patent/CA2808277C/en active Active
- 2010-07-30 US US13/392,454 patent/US9458101B2/en active Active
- 2010-07-30 DK DK10811047.9T patent/DK2470499T3/da active
- 2010-07-30 WO PCT/CA2010/001199 patent/WO2011022805A1/en active Application Filing
- 2010-07-30 ES ES10811047T patent/ES2745255T3/es active Active
- 2010-07-30 EP EP10811047.9A patent/EP2470499B1/en active Active
- 2010-07-30 PL PL10811047T patent/PL2470499T3/pl unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2808277C (en) | 2018-01-16 |
| DK2470499T3 (da) | 2019-09-23 |
| US20120225912A1 (en) | 2012-09-06 |
| ES2745255T3 (es) | 2020-02-28 |
| EP2470499A1 (en) | 2012-07-04 |
| WO2011022805A1 (en) | 2011-03-03 |
| JP2013502441A (ja) | 2013-01-24 |
| CA2808277A1 (en) | 2011-03-03 |
| US9458101B2 (en) | 2016-10-04 |
| EP2470499B1 (en) | 2019-06-12 |
| EP2470499A4 (en) | 2013-03-27 |
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