ES2055907T3 - Conjugados covalentes de lipidos y oligonucleotidos. - Google Patents

Conjugados covalentes de lipidos y oligonucleotidos.

Info

Publication number
ES2055907T3
ES2055907T3 ES90904028T ES90904028T ES2055907T3 ES 2055907 T3 ES2055907 T3 ES 2055907T3 ES 90904028 T ES90904028 T ES 90904028T ES 90904028 T ES90904028 T ES 90904028T ES 2055907 T3 ES2055907 T3 ES 2055907T3
Authority
ES
Spain
Prior art keywords
nucleotide sequence
oligonucleotides
lipids
conjugate
interest
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90904028T
Other languages
English (en)
Inventor
Norbert W Bischofberger
Regan G Shea
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Application granted granted Critical
Publication of ES2055907T3 publication Critical patent/ES2055907T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
    • A61K47/544—Phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
    • A61K47/6911—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Dispersion Chemistry (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Fats And Perfumes (AREA)

Abstract

SE PRESENTA UN CONJUGADO DONDE SE ACOPLA DE FORMA COVALENTE UN LIPIDO A UNA SECUENCIA DE OLIGONUCLEOTIDO QUE ES BIEN DE INTERES O BIEN SUSTANCIALMENTE COMPLEMENTARIA A UNA SECUENCIA DE NUCLEOTIDO DE INTERES. EL CONJUGADO ES UTIL PARA LA PURIFICACION DE ACIDO NUCLEICO, METODOS DE DIAGNOSTICO, Y APLICACIONES TERAPEUTICAS. EL ASPECTO TERAPEUTICO INCLUYE CONJUGADOS EN LOS QUE EL OLIGONUCLEOTIDO CONTIENE UNA SECUENCIA DE NUCLEOTIDO DE SENTIDO CONTRARIO A UNA SECUENCIA QUE CODIFICA UN POLIPEPTIDO RESPONSABLE DE TRASTORNO PATOGENICO.
ES90904028T 1989-03-07 1990-02-23 Conjugados covalentes de lipidos y oligonucleotidos. Expired - Lifetime ES2055907T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US32020289A 1989-03-07 1989-03-07

Publications (1)

Publication Number Publication Date
ES2055907T3 true ES2055907T3 (es) 1994-09-01

Family

ID=23245339

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90904028T Expired - Lifetime ES2055907T3 (es) 1989-03-07 1990-02-23 Conjugados covalentes de lipidos y oligonucleotidos.

Country Status (8)

Country Link
EP (1) EP0462145B1 (es)
JP (1) JPH04503957A (es)
AT (1) ATE104857T1 (es)
CA (1) CA2049028A1 (es)
DE (1) DE69008521T2 (es)
DK (1) DK0462145T3 (es)
ES (1) ES2055907T3 (es)
WO (1) WO1990010448A2 (es)

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EP0462145A1 (en) 1991-12-27
DE69008521T2 (de) 1994-10-20
CA2049028A1 (en) 1990-09-08
WO1990010448A2 (en) 1990-09-20
DK0462145T3 (da) 1994-08-08
ATE104857T1 (de) 1994-05-15
DE69008521D1 (de) 1994-06-01
WO1990010448A3 (en) 1990-11-29
EP0462145B1 (en) 1994-04-27

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