DK1059092T3 - Anvendelse af komplekser af kationiske liposomer og polydeoxyribonukleotider som medikamenter - Google Patents
Anvendelse af komplekser af kationiske liposomer og polydeoxyribonukleotider som medikamenterInfo
- Publication number
- DK1059092T3 DK1059092T3 DK99111118T DK99111118T DK1059092T3 DK 1059092 T3 DK1059092 T3 DK 1059092T3 DK 99111118 T DK99111118 T DK 99111118T DK 99111118 T DK99111118 T DK 99111118T DK 1059092 T3 DK1059092 T3 DK 1059092T3
- Authority
- DK
- Denmark
- Prior art keywords
- complexes
- polydeoxyribonucleotides
- cationic liposomes
- drugs
- polydeoxyribonucletoides
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
- A61K47/6911—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP99111118A EP1059092B1 (en) | 1999-06-08 | 1999-06-08 | Use of complexes among cationic liposomes and polydeoxyribonucleotides as medicaments |
| CA002274419A CA2274419A1 (en) | 1999-06-08 | 1999-06-11 | Use of complexes among cationic liposomes and polydeoxyribonucleotides as medicaments |
| AU35010/99A AU776014B2 (en) | 1999-06-11 | 1999-06-11 | Use of complexes among cationic liposomes and polydeoxyribonucleotides as medicaments |
| US09/330,215 US6767554B2 (en) | 1999-06-08 | 1999-06-11 | Use of complexes among cationic liposomes and polydeoxyribonucleotides and medicaments |
| KR1019990021947A KR100676492B1 (ko) | 1999-06-08 | 1999-06-12 | 양이온성 리포솜 및 폴리데옥시리보누클레오티드 사이의 복합체의 약제로서의 용도 |
| JP16700999A JP4598908B2 (ja) | 1999-06-08 | 1999-06-14 | カチオン性リポソームとポリデオキシリボヌクレオチドとの複合体 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1059092T3 true DK1059092T3 (da) | 2006-03-27 |
Family
ID=32330163
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK99111118T DK1059092T3 (da) | 1999-06-08 | 1999-06-08 | Anvendelse af komplekser af kationiske liposomer og polydeoxyribonukleotider som medikamenter |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6767554B2 (da) |
| EP (1) | EP1059092B1 (da) |
| JP (1) | JP4598908B2 (da) |
| KR (1) | KR100676492B1 (da) |
| AT (1) | ATE311907T1 (da) |
| CA (1) | CA2274419A1 (da) |
| DE (1) | DE69928778T2 (da) |
| DK (1) | DK1059092T3 (da) |
| ES (1) | ES2251134T3 (da) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4115833B2 (ja) | 2000-10-12 | 2008-07-09 | ユニバーシティー、オブ、メディシン、アンド、デンティストリー、オブ、ニュージャージー | オリゴヌクレオチドが促進する合体 |
| CA2491216C (en) * | 2002-06-26 | 2012-01-03 | Medigene Oncology Gmbh | Method of producing a cationic liposomal preparation comprising a lipophilic compound |
| JP2006193461A (ja) * | 2005-01-13 | 2006-07-27 | Pola Chem Ind Inc | 毛髪用の洗浄料 |
| ITMI20051303A1 (it) * | 2005-07-08 | 2007-01-09 | Inxel S R L | Metodo per la produzione di vernici in polvere termoindurenti particolarmente per l'applicazione mediante impianti elettrostatici |
| EP1872787A1 (en) * | 2006-06-27 | 2008-01-02 | Gentium S.p.A. | Use of defibrotide for the inhibition of heparanase |
| JPWO2008093848A1 (ja) * | 2007-02-02 | 2010-05-20 | サンスター株式会社 | ホスファチジルコリンを含有する炎症マーカー低減組成物 |
| EP2103689A1 (en) * | 2008-03-19 | 2009-09-23 | Gentium S.p.A. | Synthetic phosphodiester oligonucleotides and therapeutical uses thereof |
| US20100279353A1 (en) * | 2009-04-30 | 2010-11-04 | Shiu Nan Chen | Process of producing fibrinolytic enzyme from mushroom |
| JP5142295B2 (ja) * | 2009-05-08 | 2013-02-13 | 独立行政法人農業・食品産業技術総合研究機構 | ベシクル及びその製法 |
| WO2010135714A2 (en) | 2009-05-22 | 2010-11-25 | The Methodist Hospital Research Institute | Methods for modulating adipocyte expression using microrna compositions |
| ES2694239T3 (es) | 2010-11-12 | 2018-12-19 | Gentium S.R.L. | Defibrótido para su uso en profilaxis y/o tratamiento de la enfermedad de Injerto contra huésped (GVHD) |
| GB201204632D0 (en) * | 2012-03-16 | 2012-05-02 | Univ Belfast | Delivery system |
| KR102038357B1 (ko) | 2012-06-22 | 2019-10-31 | 젠티엄 에스알엘 | 디파이브로타이드의 생물학적 활성 측정을 위한 유우글로불린에 기초한 방법 |
| US11086970B2 (en) | 2013-03-13 | 2021-08-10 | Blue Belt Technologies, Inc. | Systems and methods for using generic anatomy models in surgical planning |
| KR101534276B1 (ko) * | 2014-07-18 | 2015-07-07 | 주식회사 에스씨301테라피 | 지방 이식 수술 후 지방세포 성장 및 생착 증진을 위한 조성물 |
| EP3026122A1 (en) | 2014-11-27 | 2016-06-01 | Gentium S.p.A. | Cellular-based method for determining the potency of defibrotide |
| TW201909904A (zh) | 2017-08-03 | 2019-03-16 | 愛爾蘭商爵士製藥愛爾蘭有限責任公司 | 高濃度調配物 |
| WO2019200251A1 (en) | 2018-04-12 | 2019-10-17 | Jazz Pharmaceuticals, Inc. | Defibrotide for the prevention and treatment of cytokine release syndrome and neurotoxicity associated with immunodepletion |
| KR102144615B1 (ko) * | 2018-08-09 | 2020-08-13 | 장건주 | 폴리데옥시리보뉴클레오타이드를 포함하는 마이셀, 약물 전달체 및 이의 제조방법 |
| KR102132478B1 (ko) * | 2018-11-15 | 2020-07-10 | (주)진우바이오 | 히알루론산-폴리데옥시리보뉴클레오타이드 복합체와 이를 활용한 필름 및 이의 제조방법 |
| WO2020118165A1 (en) | 2018-12-07 | 2020-06-11 | Jazz Pharmaceuticals Ireland Limited | Subcutaneous delivery of high concentration formulations |
| WO2021060440A1 (ja) | 2019-09-26 | 2021-04-01 | 日油株式会社 | 脂質ナノ粒子の凍結乾燥組成物 |
| WO2021174039A1 (en) | 2020-02-28 | 2021-09-02 | Jazz Pharmaceuticals Ireland Limited | Delivery of low viscosity formulations |
| WO2022234101A1 (en) | 2021-05-06 | 2022-11-10 | Jazz Pharmaceuticals Ireland Limited | Defibrotide for the treatment and prevention of acute respiratory distress syndrome |
| CN115737470A (zh) * | 2022-11-25 | 2023-03-07 | 润辉生物技术（威海）有限公司 | 一种肌肽-pdrn复合物及其制备方法和应用 |
| CN115836982B (zh) * | 2022-12-30 | 2024-02-06 | 南京乐韬生物科技有限公司 | 一种含pdrn的纳米乳液及其制备方法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1043823B (it) | 1970-11-03 | 1980-02-29 | Prephar | Procedimento per l estrazione di acidi nucleici da organi animali |
| DE3017154A1 (de) | 1980-05-05 | 1981-11-12 | Hoechst Ag, 6000 Frankfurt | Verfahren zur herstellung von 2-chlor-1,1,1,2,3,3,3,-heptafluor-propan |
| HU192909B (en) * | 1985-01-17 | 1987-07-28 | Chinoin Gyogyszer Es Vegyeszet | Process for producing interfuranylene-prostacycline derivatives |
| IT1190313B (it) * | 1986-04-17 | 1988-02-16 | Crinos Industria Farmaco | Procedimento per l'ottenimento di polidesossiribonucleotidi chimicamente definiti e riproducibili e prodotto farmacologicamente attivo risultante |
| WO1990003795A1 (en) * | 1988-10-05 | 1990-04-19 | Vestar, Inc. | Method of making liposomes with improved stability during drying |
| JPH04503957A (ja) * | 1989-03-07 | 1992-07-16 | ジェネンテク，インコーポレイテッド | 脂質とオリゴヌクレオチドの共有結合コンジュゲート |
| EP0451791A2 (de) * | 1990-04-12 | 1991-10-16 | Hoechst Aktiengesellschaft | Langwirksame Liposomenpräparate von Peptidarzneistoffen und Verfahren zu ihrer Herstellung |
| EP0539989B1 (de) | 1991-11-01 | 1997-06-18 | SOLVAY (Société Anonyme) | Verfahren zur Herstellung von 1,1,1,2,3,3,3-Heptafluorpropan (R 227) |
| IT1252174B (it) * | 1991-12-09 | 1995-06-05 | Crinos Industria Farmaco | Oligodesossimibonucleotidi ad attivita' antiischemica e procedimenti per il loro ottenimento |
| DE59303465D1 (de) | 1992-03-26 | 1996-09-26 | Hoechst Ag | Verfahren zur Reaktivierung eines bei der Herstellung von 1,1,1,2,3,3,3-Heptafluorpropan (R 227) eingesetzten Aktivkohle-Katalysators |
| US5395619A (en) * | 1993-03-03 | 1995-03-07 | Liposome Technology, Inc. | Lipid-polymer conjugates and liposomes |
| DE4323054A1 (de) | 1993-07-14 | 1995-01-19 | Hoechst Ag | Verfahren zur Herstellung von 2-H-Heptafluorpropan |
| US6071890A (en) * | 1994-12-09 | 2000-06-06 | Genzyme Corporation | Organ-specific targeting of cationic amphiphile/DNA complexes for gene therapy |
| US5908777A (en) * | 1995-06-23 | 1999-06-01 | University Of Pittsburgh | Lipidic vector for nucleic acid delivery |
| DE69629702T2 (de) * | 1995-08-01 | 2004-06-17 | Isis Pharmaceuticals, Inc., Carlsbad | Liposomale oligonukleotidzusammensetzungen |
| US5837283A (en) * | 1997-03-12 | 1998-11-17 | The Regents Of The University Of California | Cationic lipid compositions targeting angiogenic endothelial cells |
-
1999
- 1999-06-08 DE DE69928778T patent/DE69928778T2/de not_active Expired - Lifetime
- 1999-06-08 EP EP99111118A patent/EP1059092B1/en not_active Expired - Lifetime
- 1999-06-08 ES ES99111118T patent/ES2251134T3/es not_active Expired - Lifetime
- 1999-06-08 DK DK99111118T patent/DK1059092T3/da active
- 1999-06-08 AT AT99111118T patent/ATE311907T1/de active
- 1999-06-11 CA CA002274419A patent/CA2274419A1/en not_active Abandoned
- 1999-06-11 US US09/330,215 patent/US6767554B2/en not_active Expired - Lifetime
- 1999-06-12 KR KR1019990021947A patent/KR100676492B1/ko not_active IP Right Cessation
- 1999-06-14 JP JP16700999A patent/JP4598908B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JP4598908B2 (ja) | 2010-12-15 |
| KR20010002244A (ko) | 2001-01-15 |
| JP2001002565A (ja) | 2001-01-09 |
| US20020142029A1 (en) | 2002-10-03 |
| ES2251134T3 (es) | 2006-04-16 |
| CA2274419A1 (en) | 2000-12-11 |
| US6767554B2 (en) | 2004-07-27 |
| KR100676492B1 (ko) | 2007-01-30 |
| EP1059092A1 (en) | 2000-12-13 |
| DE69928778D1 (de) | 2006-01-12 |
| DE69928778T2 (de) | 2006-07-06 |
| ATE311907T1 (de) | 2005-12-15 |
| EP1059092B1 (en) | 2005-12-07 |
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