NO20100656L - Modifiserte chimaere polypeptider med forbedrede farmakokinetiske egenskaper - Google Patents

Modifiserte chimaere polypeptider med forbedrede farmakokinetiske egenskaper

Info

Publication number
NO20100656L
NO20100656L NO20100656A NO20100656A NO20100656L NO 20100656 L NO20100656 L NO 20100656L NO 20100656 A NO20100656 A NO 20100656A NO 20100656 A NO20100656 A NO 20100656A NO 20100656 L NO20100656 L NO 20100656L
Authority
NO
Norway
Prior art keywords
vegf
pharmacokinetic properties
chimeric polypeptides
improved pharmacokinetic
modified chimeric
Prior art date
Application number
NO20100656A
Other languages
English (en)
Other versions
NO332559B1 (no
Inventor
George D Yancopoulos
Nicholas J Papadopoulos
Samuel Davis
Original Assignee
Regeneron Pharma
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22480568&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20100656(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Publication of NO20100656L publication Critical patent/NO20100656L/no
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of NO332559B1 publication Critical patent/NO332559B1/no

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Rheumatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)

Abstract

Det er beskrevet anvendelse av et fusjonspolypeptid som er i stand til å binde vaskulær endotelial vekstfaktor (VEGF) for fremstilling av et medikament til behandling av en øyesykdom eller artritt, hvor fusjonspolypeptidet består i hovedsak av et immunoglobulinliknende (Ig) domene 2 av en første VEGF-reseptor og Ig-domene 3 av en andre VEGF-reseptor samt en multimeriserende komponent. Særskilte sykdommer som kan behandles med de aktuelle medikamenter er diabetisk retinopati eller reumatoid artritt.
NO20100656A 1999-06-08 2010-05-06 Anvendelse av fusjonspolypeptid for fremstilling av medikamenter til behandling av oyesykdommer NO332559B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13813399P 1999-06-08 1999-06-08
PCT/US2000/014142 WO2000075319A1 (en) 1999-06-08 2000-05-23 Modified chimeric polypeptides with improved pharmacokinetic properties

Publications (2)

Publication Number Publication Date
NO20100656L true NO20100656L (no) 2002-02-08
NO332559B1 NO332559B1 (no) 2012-10-29

Family

ID=22480568

Family Applications (3)

Application Number Title Priority Date Filing Date
NO20016036A NO330775B1 (no) 1999-06-08 2001-12-10 Isolert nukleinsyremolekyl som koder for vaskulaer endotelial vekstfaktor med immunoglobulin-domener, fusjonspolypeptid kodet av dette, fremgangsmate for fremstilling derav samt anvendelse derav
NO20100656A NO332559B1 (no) 1999-06-08 2010-05-06 Anvendelse av fusjonspolypeptid for fremstilling av medikamenter til behandling av oyesykdommer
NO2013010C NO2013010I1 (no) 1999-06-08 2013-05-15 Aflibercept

Family Applications Before (1)

Application Number Title Priority Date Filing Date
NO20016036A NO330775B1 (no) 1999-06-08 2001-12-10 Isolert nukleinsyremolekyl som koder for vaskulaer endotelial vekstfaktor med immunoglobulin-domener, fusjonspolypeptid kodet av dette, fremgangsmate for fremstilling derav samt anvendelse derav

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO2013010C NO2013010I1 (no) 1999-06-08 2013-05-15 Aflibercept

Country Status (33)

Country Link
EP (2) EP1544299B1 (no)
JP (2) JP4723140B2 (no)
KR (1) KR100659477B1 (no)
CN (3) CN103349781B (no)
AT (2) ATE417928T1 (no)
AU (2) AU779303B2 (no)
BE (1) BE2013C029I2 (no)
BR (2) BR0011407A (no)
CA (1) CA2376379C (no)
CY (2) CY1108883T1 (no)
CZ (2) CZ303656B6 (no)
DE (2) DE60019415T2 (no)
DK (2) DK1544299T3 (no)
ES (2) ES2237429T3 (no)
FR (1) FR13C0028I2 (no)
HK (3) HK1043388A1 (no)
HR (1) HRP20010908B1 (no)
HU (3) HU230159B1 (no)
IL (3) IL146890A0 (no)
LT (1) LTC1183353I2 (no)
LU (1) LU92195I2 (no)
ME (2) ME00024B (no)
MX (1) MXPA01012630A (no)
NO (3) NO330775B1 (no)
NZ (1) NZ515913A (no)
PL (1) PL208247B1 (no)
PT (2) PT1183353E (no)
RS (1) RS50073B (no)
RU (1) RU2265661C2 (no)
SK (1) SK287332B6 (no)
UA (1) UA74146C2 (no)
WO (1) WO2000075319A1 (no)
ZA (1) ZA200110068B (no)

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