LU92195I2 - Aflibercept (EYLEA-ZALTRAP) - Google Patents
Aflibercept (EYLEA-ZALTRAP)Info
- Publication number
- LU92195I2 LU92195I2 LU92195C LU92195C LU92195I2 LU 92195 I2 LU92195 I2 LU 92195I2 LU 92195 C LU92195 C LU 92195C LU 92195 C LU92195 C LU 92195C LU 92195 I2 LU92195 I2 LU 92195I2
- Authority
- LU
- Luxembourg
- Prior art keywords
- zaltrap
- eylea
- aflibercept
- macular degeneration
- diabetic retinopathy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Dermatology (AREA)
- Biotechnology (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Gastroenterology & Hepatology (AREA)
- Cell Biology (AREA)
- Physical Education & Sports Medicine (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Physics & Mathematics (AREA)
- Toxicology (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13813399P | 1999-06-08 | 1999-06-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
LU92195I2 true LU92195I2 (fr) | 2013-07-15 |
Family
ID=22480568
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
LU92195C LU92195I2 (fr) | 1999-06-08 | 2013-05-14 | Aflibercept (EYLEA-ZALTRAP) |
Country Status (33)
Country | Link |
---|---|
EP (2) | EP1544299B1 (fr) |
JP (2) | JP4723140B2 (fr) |
KR (1) | KR100659477B1 (fr) |
CN (3) | CN100523187C (fr) |
AT (2) | ATE293164T1 (fr) |
AU (2) | AU779303B2 (fr) |
BE (1) | BE2013C029I2 (fr) |
BR (2) | BR0011407A (fr) |
CA (1) | CA2376379C (fr) |
CY (2) | CY1108883T1 (fr) |
CZ (2) | CZ303656B6 (fr) |
DE (2) | DE60041159D1 (fr) |
DK (2) | DK1544299T3 (fr) |
ES (2) | ES2319305T3 (fr) |
FR (1) | FR13C0028I2 (fr) |
HK (3) | HK1043388A1 (fr) |
HR (1) | HRP20010908B1 (fr) |
HU (3) | HU229156B1 (fr) |
IL (3) | IL146890A0 (fr) |
LT (1) | LTC1183353I2 (fr) |
LU (1) | LU92195I2 (fr) |
ME (2) | MEP3208A (fr) |
MX (1) | MXPA01012630A (fr) |
NO (4) | NO330775B1 (fr) |
NZ (1) | NZ515913A (fr) |
PL (1) | PL208247B1 (fr) |
PT (2) | PT1183353E (fr) |
RS (1) | RS50073B (fr) |
RU (1) | RU2265661C2 (fr) |
SK (1) | SK287332B6 (fr) |
UA (1) | UA74146C2 (fr) |
WO (1) | WO2000075319A1 (fr) |
ZA (1) | ZA200110068B (fr) |
Families Citing this family (101)
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US6710174B2 (en) | 2001-09-13 | 2004-03-23 | Isis Pharmaceuticals, Inc. | Antisense inhibition of vascular endothelial growth factor receptor-1 expression |
US6100071A (en) | 1996-05-07 | 2000-08-08 | Genentech, Inc. | Receptors as novel inhibitors of vascular endothelial growth factor activity and processes for their production |
US6833349B2 (en) * | 1999-06-08 | 2004-12-21 | Regeneron Pharmaceuticals, Inc. | Methods of treating inflammatory skin diseases |
US7396664B2 (en) | 1999-06-08 | 2008-07-08 | Regeneron Pharmaceuticals, Inc. | VEGF-binding fusion proteins and nucleic acids encoding the same |
US7070959B1 (en) | 1999-06-08 | 2006-07-04 | Regeneron Pharmaceuticals, Inc. | Modified chimeric polypeptides with improved pharmacokinetic properties |
US7087411B2 (en) * | 1999-06-08 | 2006-08-08 | Regeneron Pharmaceuticals, Inc. | Fusion protein capable of binding VEGF |
JP4669984B2 (ja) | 2001-01-19 | 2011-04-13 | ベジェニクス リミテッド | 腫瘍画像化のターゲットとしてのF1t4(VEGFR−3)および抗腫瘍療法 |
US6734017B2 (en) | 2001-09-28 | 2004-05-11 | Isis Pharmaceuticals, Inc. | Antisense modulation of vascular endothelial growth factor receptor-2 expression |
US8183350B2 (en) | 2002-05-04 | 2012-05-22 | Acorda Therapeutics, Inc. | Compositions and methods for promoting neuronal outgrowth |
US7052691B2 (en) | 2003-03-28 | 2006-05-30 | Regeneron Pharmaceuticals, Inc. | Methods of treating diabetes by blocking VEGF-mediated activity |
US7959914B2 (en) | 2003-05-16 | 2011-06-14 | Acorda Therapeutics, Inc. | Methods of reducing extravasation of inflammatory cells |
AU2004247025B8 (en) * | 2003-05-16 | 2011-06-30 | Acorda Therapeutics, Inc. | Fusion proteins for the treatment of CNS |
EP2460881B1 (fr) | 2003-05-16 | 2017-05-03 | Acorda Therapeutics, Inc. | Mutants de degradation du proteoglycane pour le traitement du systeme nerveux central |
WO2004106378A2 (fr) * | 2003-05-28 | 2004-12-09 | Regeneron Pharmaceuticals, Inc. | Methode de traitement du rejet de greffon corneen |
US7186699B2 (en) | 2003-06-03 | 2007-03-06 | Cell Genesys, Inc. | Method for treating cancer by vector-mediated delivery of one or more anti-angiogenic or pro-apoptotic genes |
JP2006527198A (ja) * | 2003-06-06 | 2006-11-30 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | Vegfインヒビターを用いる腫瘍退縮方法 |
US7399612B2 (en) | 2003-06-30 | 2008-07-15 | Regeneron Pharmaceuticals, Inc. | VEGF-binding fusion proteins and nucleic acids encoding the same |
AR046510A1 (es) * | 2003-07-25 | 2005-12-14 | Regeneron Pharma | Composicion de un antagonista de vegf y un agente anti-proliferativo |
CA2534197A1 (fr) * | 2003-08-06 | 2005-02-24 | Thomas Jefferson University | Utilisation d'un antagoniste des vegf en combinaison avec une radiotherapie |
MXPA06013345A (es) | 2004-05-18 | 2008-10-31 | Acorda Therapeutics Inc | Metodos para purificar condrointinasa y sus formulaciones estables. |
US7750138B2 (en) * | 2004-06-08 | 2010-07-06 | Chengdu Kanghong Biotechnologies Co. Ltd. | Angiogenesis-inhibiting chimeric protein and the use |
CN101102786A (zh) | 2004-06-10 | 2008-01-09 | 瑞泽恩制药公司 | 施用并利用vegf抑制剂治疗人类癌症的方法 |
EP1755645A2 (fr) * | 2004-06-18 | 2007-02-28 | Regeneron Pharmaceuticals, Inc. | Methode d'administration d'inhibiteurs de vegf pour le traitement d'un epanchement pleural malin |
AU2005267741A1 (en) | 2004-07-30 | 2006-02-09 | Regeneron Pharmaceuticals, Inc. | Methods of treating type I diabetes by blocking VEGF-mediated activity |
BRPI0515264B1 (pt) * | 2004-09-13 | 2018-12-18 | Genzyme Corp | proteína de fusão de acordo com fórmula x-y-z, composição, molécula de ácido nucleico, seus usos e método de multimerização de um polipeptídeo x |
FR2878749B1 (fr) * | 2004-12-03 | 2007-12-21 | Aventis Pharma Sa | Combinaisons antitumorales contenant en agent inhibiteur de vegt et du 5fu ou un de ses derives |
AU2006214658A1 (en) | 2005-02-02 | 2006-08-24 | Regeneron Pharmaceuticals, Inc. | Method of treating eye injury with local administration of a VEGF inhibitor |
PT2586459T (pt) | 2005-03-25 | 2017-07-25 | Regeneron Pharma | Formulações antagonistas de fcev |
WO2007038548A2 (fr) | 2005-09-26 | 2007-04-05 | Acorda Therapeutics, Inc. | Compositions et procedes d'utilisation de mutants des chondroitinases abci |
ES2400666T5 (es) † | 2005-12-16 | 2016-03-10 | Regeneron Pharmaceuticals, Inc. | Uso terapéutico de un antagonista de DII4 y un inhibidor de VEGF para inhibir el crecimiento tumoral |
FR2895258B1 (fr) | 2005-12-22 | 2008-03-21 | Aventis Pharma Sa | Combinaison comprenant de la combretastatine et des agents anticancereux |
CN100502945C (zh) * | 2006-03-31 | 2009-06-24 | 成都康弘生物科技有限公司 | Vegf受体融合蛋白在治疗眼睛疾病中的应用 |
US8216575B2 (en) | 2006-03-31 | 2012-07-10 | Chengdu Kanghong Biotechnologies Co., Ltd. | Inhibition of neovascularization with a soluble chimeric protein comprising VEGF FLT-1 and KDR domains |
EP3753548A1 (fr) | 2006-06-16 | 2020-12-23 | Regeneron Pharmaceuticals, Inc. | Formulations antagonistes vegf appropriées pour l'administration intravitréenne |
EP2066694B1 (fr) | 2006-09-29 | 2015-11-04 | Oncomed Pharmaceuticals, Inc. | Compositions et procédés permettant de diagnostiquer et de traiter le cancer |
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LT2601214T (lt) | 2010-08-06 | 2018-02-26 | Genzyme Corporation | Vegf antagonistų kompozicijos ir jų panaudojimas |
US20140080153A1 (en) * | 2011-01-07 | 2014-03-20 | Chugai Seiyaku Kabushiki Kaisha | Method for improving physical properties of antibody |
CA2824422A1 (fr) | 2011-01-13 | 2012-07-19 | Regeneron Pharmaceuticals, Inc. | Utilisation d'antagoniste de vegf pour traiter des troubles oculaires angiogeniques |
JO3283B1 (ar) | 2011-04-26 | 2018-09-16 | Sanofi Sa | تركيب يتضمن أفليبيرسيبت, حمض فولينيك, 5- فلورويوراسيل (5- Fu) وإرينوسيتان (FOLFIRI) |
KR101397088B1 (ko) | 2011-06-10 | 2014-05-19 | 강원대학교산학협력단 | 암세포 증식 억제와 혈관신생 억제를 위한 융합 단백질 및 이를 포함한 항암 조성물 |
JO3370B1 (ar) * | 2011-11-10 | 2019-03-13 | Regeneron Pharma | طريقة لتثبيط نمو الورم عن طريق تثبيط مستقبل انترلوكين 6 |
BR112014013205A2 (pt) | 2011-12-01 | 2020-10-27 | Protevobio, Inc. | proteína de fusão, seu uso e seu método de produção, composição farmacêutica, ácido nucleico, e kit |
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KR20170003973A (ko) | 2014-05-12 | 2017-01-10 | 포르미콘 아게 | Vegf 안타고니스트를 포함하는 사전충전형 플라스틱제 주사기 |
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TW202330904A (zh) | 2015-08-04 | 2023-08-01 | 美商再生元醫藥公司 | 補充牛磺酸之細胞培養基及用法 |
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CA3011638C (fr) | 2016-01-26 | 2023-01-10 | Formycon Ag | Formulation liquide d'un antagoniste du vegf |
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WO2018215580A1 (fr) | 2017-05-24 | 2018-11-29 | Formycon Ag | Procédé de stérilisation de seringues en plastique pré-remplies contenant un antagoniste du vegf |
WO2018217995A1 (fr) | 2017-05-24 | 2018-11-29 | Formycon Ag | Conditionnements pharmaceutiques pré-remplis stérilisables comprenant une formulation liquide d'un antagoniste du vegf |
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WO2019020777A1 (fr) | 2017-07-26 | 2019-01-31 | Formycon Ag | Formulation liquide d'un antagoniste du vegf |
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CN111356471A (zh) | 2017-11-20 | 2020-06-30 | 济世发展生物药业有限公司 | 包含赖氨酸盐作为张力调节剂的阿柏西普制剂及其用途 |
CR20200282A (es) | 2017-11-27 | 2021-02-18 | 4D Molecular Therapeutics Inc | Cápsides variantes de virus adenoasociados y su uso para inhibir la angiogénesis |
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EA039731B1 (ru) * | 2017-12-13 | 2022-03-04 | Ридженерон Фармасьютикалз, Инк. | Устройства и системы для управления опорой слоя сорбента хроматографической колонки и связанные с ними способы |
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EP4069264A1 (fr) | 2019-12-06 | 2022-10-12 | Regeneron Pharmaceuticals, Inc. | Mini-pièges de vegf et leurs procédés d'utilisation |
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EP4145456A1 (fr) | 2021-09-06 | 2023-03-08 | Bayer AG | Prédiction d'un changement relatif à un fluide maculaire |
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2000
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