BRPI0011407B8 - molécula de ácido nucléico quimérica, polipeptídeo de fusão, vetor de expressão, sistema de vetor hospedeiro, e, métodos de produzir um polipeptídeo de fusão - Google Patents
molécula de ácido nucléico quimérica, polipeptídeo de fusão, vetor de expressão, sistema de vetor hospedeiro, e, métodos de produzir um polipeptídeo de fusãoInfo
- Publication number
- BRPI0011407B8 BRPI0011407B8 BRPI0011407A BRPI0011407A BRPI0011407B8 BR PI0011407 B8 BRPI0011407 B8 BR PI0011407B8 BR PI0011407 A BRPI0011407 A BR PI0011407A BR PI0011407 A BRPI0011407 A BR PI0011407A BR PI0011407 B8 BRPI0011407 B8 BR PI0011407B8
- Authority
- BR
- Brazil
- Prior art keywords
- fusion polypeptide
- nucleic acid
- producing
- methods
- acid molecule
- Prior art date
Links
- 229920001184 polypeptide Polymers 0.000 title abstract 9
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 9
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 9
- 230000004927 fusion Effects 0.000 title abstract 5
- 239000013598 vector Substances 0.000 title abstract 3
- 102000039446 nucleic acids Human genes 0.000 title abstract 2
- 108020004707 nucleic acids Proteins 0.000 title abstract 2
- 150000007523 nucleic acids Chemical class 0.000 title abstract 2
- 239000013604 expression vector Substances 0.000 title 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 230000008728 vascular permeability Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Wood Science & Technology (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Ophthalmology & Optometry (AREA)
- Heart & Thoracic Surgery (AREA)
- Physics & Mathematics (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Plant Pathology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
- Communicable Diseases (AREA)
Abstract
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13813399P | 1999-06-08 | 1999-06-08 | |
PCT/US2000/014142 WO2000075319A1 (en) | 1999-06-08 | 2000-05-23 | Modified chimeric polypeptides with improved pharmacokinetic properties |
Publications (2)
Publication Number | Publication Date |
---|---|
BRPI0011407B1 BRPI0011407B1 (pt) | 2018-09-25 |
BRPI0011407B8 true BRPI0011407B8 (pt) | 2021-05-25 |
Family
ID=22480568
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0011407A BRPI0011407B8 (pt) | 1999-06-08 | 2000-05-23 | molécula de ácido nucléico quimérica, polipeptídeo de fusão, vetor de expressão, sistema de vetor hospedeiro, e, métodos de produzir um polipeptídeo de fusão |
BR0011407-3A BR0011407A (pt) | 1999-06-08 | 2000-05-23 | Molécula de ácido nucléico isolada, polipeptìdeo de fusão, composição, vetor, sistema de vetor, sistema de vetor hospedeiro, métodos de produzir um polipeptìdeo de fusão. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0011407-3A BR0011407A (pt) | 1999-06-08 | 2000-05-23 | Molécula de ácido nucléico isolada, polipeptìdeo de fusão, composição, vetor, sistema de vetor, sistema de vetor hospedeiro, métodos de produzir um polipeptìdeo de fusão. |
Country Status (33)
Country | Link |
---|---|
EP (2) | EP1183353B1 (pt) |
JP (2) | JP4723140B2 (pt) |
KR (1) | KR100659477B1 (pt) |
CN (3) | CN101433715B (pt) |
AT (2) | ATE417928T1 (pt) |
AU (2) | AU779303B2 (pt) |
BE (1) | BE2013C029I2 (pt) |
BR (2) | BRPI0011407B8 (pt) |
CA (1) | CA2376379C (pt) |
CY (2) | CY1108883T1 (pt) |
CZ (2) | CZ303656B6 (pt) |
DE (2) | DE60019415T2 (pt) |
DK (2) | DK1183353T3 (pt) |
ES (2) | ES2237429T3 (pt) |
FR (1) | FR13C0028I2 (pt) |
HK (3) | HK1043388A1 (pt) |
HR (1) | HRP20010908B1 (pt) |
HU (3) | HU230159B1 (pt) |
IL (3) | IL146890A0 (pt) |
LT (1) | LTC1183353I2 (pt) |
LU (1) | LU92195I2 (pt) |
ME (2) | MEP3208A (pt) |
MX (1) | MXPA01012630A (pt) |
NO (3) | NO330775B1 (pt) |
NZ (1) | NZ515913A (pt) |
PL (1) | PL208247B1 (pt) |
PT (2) | PT1544299E (pt) |
RS (1) | RS50073B (pt) |
RU (1) | RU2265661C2 (pt) |
SK (1) | SK287332B6 (pt) |
UA (1) | UA74146C2 (pt) |
WO (1) | WO2000075319A1 (pt) |
ZA (1) | ZA200110068B (pt) |
Families Citing this family (99)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6710174B2 (en) | 2001-09-13 | 2004-03-23 | Isis Pharmaceuticals, Inc. | Antisense inhibition of vascular endothelial growth factor receptor-1 expression |
US6100071A (en) | 1996-05-07 | 2000-08-08 | Genentech, Inc. | Receptors as novel inhibitors of vascular endothelial growth factor activity and processes for their production |
US7396664B2 (en) | 1999-06-08 | 2008-07-08 | Regeneron Pharmaceuticals, Inc. | VEGF-binding fusion proteins and nucleic acids encoding the same |
US7070959B1 (en) | 1999-06-08 | 2006-07-04 | Regeneron Pharmaceuticals, Inc. | Modified chimeric polypeptides with improved pharmacokinetic properties |
US6833349B2 (en) * | 1999-06-08 | 2004-12-21 | Regeneron Pharmaceuticals, Inc. | Methods of treating inflammatory skin diseases |
US7087411B2 (en) * | 1999-06-08 | 2006-08-08 | Regeneron Pharmaceuticals, Inc. | Fusion protein capable of binding VEGF |
CN1494552A (zh) | 2001-01-19 | 2004-05-05 | ·��ά��֢�о�Ժ | Flt4(VEGFR-3)作为靶用于肿瘤成像和抗肿瘤治疗 |
US6734017B2 (en) | 2001-09-28 | 2004-05-11 | Isis Pharmaceuticals, Inc. | Antisense modulation of vascular endothelial growth factor receptor-2 expression |
EP2301564A1 (en) | 2002-05-04 | 2011-03-30 | Acorda Therapeutics, Inc. | Compositions and methods for promoting neuronal outgrowth |
EP1608685B1 (en) * | 2003-03-28 | 2007-02-21 | Regeneron Pharmaceuticals, Inc. | Vegf antagonists for the treatment of diabetes |
AU2004247025B8 (en) * | 2003-05-16 | 2011-06-30 | Acorda Therapeutics, Inc. | Fusion proteins for the treatment of CNS |
MX348062B (es) | 2003-05-16 | 2017-05-26 | Acorda Therapeutics Inc | Mutantes que degradan proteoglicanos para tratamiento del snc. |
US7959914B2 (en) | 2003-05-16 | 2011-06-14 | Acorda Therapeutics, Inc. | Methods of reducing extravasation of inflammatory cells |
EP1626989A2 (en) * | 2003-05-28 | 2006-02-22 | Regeneron Pharmaceuticals, Inc. | Method of treating corneal transplant rejection by using vegf antagonists |
US7186699B2 (en) | 2003-06-03 | 2007-03-06 | Cell Genesys, Inc. | Method for treating cancer by vector-mediated delivery of one or more anti-angiogenic or pro-apoptotic genes |
CA2519875C (en) | 2003-06-06 | 2014-01-14 | Regeneron Pharmaceuticals, Inc. | Method of tumor regression with vegf inhibitors |
US7399612B2 (en) | 2003-06-30 | 2008-07-15 | Regeneron Pharmaceuticals, Inc. | VEGF-binding fusion proteins and nucleic acids encoding the same |
AR046510A1 (es) * | 2003-07-25 | 2005-12-14 | Regeneron Pharma | Composicion de un antagonista de vegf y un agente anti-proliferativo |
WO2005016369A1 (en) * | 2003-08-06 | 2005-02-24 | Regeneron Pharmaceuticals, Inc. | Use of a vegf antagonist in combination with radiation therapy |
ES2411504T3 (es) | 2004-05-18 | 2013-07-05 | Acorda Therapeutics, Inc. | Métodos de purificación de condroitinasa y formulaciones estables de la misma |
WO2005121176A1 (fr) * | 2004-06-08 | 2005-12-22 | Chengdu Kanghong Biotechnologies Co. Ltd | Proteine chimerique inhibitrice d'angiogenese et utilisation associee |
EP1753442A2 (en) | 2004-06-10 | 2007-02-21 | Regeneron Pharmaceuticals, Inc. | Method of administering and using vegf inhibitors for the treatment of human cancer |
AU2005265071A1 (en) * | 2004-06-18 | 2006-01-26 | Memorial Sloan-Kettering Cancer Center | VEGF inhibitors for the treatment of malignant pleural effusion |
CN1997386B (zh) | 2004-07-30 | 2012-05-30 | 瑞泽恩制药公司 | 通过阻断vegf介导的活性来治疗i型糖尿病的方法 |
JP4944032B2 (ja) | 2004-09-13 | 2012-05-30 | ジェンザイム・コーポレーション | 多量体構築物 |
FR2878749B1 (fr) * | 2004-12-03 | 2007-12-21 | Aventis Pharma Sa | Combinaisons antitumorales contenant en agent inhibiteur de vegt et du 5fu ou un de ses derives |
WO2006088650A2 (en) * | 2005-02-02 | 2006-08-24 | Regeneron Pharmaceuticals, Inc. | Method of treating eye injury with local administration of a vegf inhibitor |
US20060217311A1 (en) | 2005-03-25 | 2006-09-28 | Daniel Dix | VEGF antagonist formulations |
US7485295B2 (en) | 2005-09-26 | 2009-02-03 | Acorda Therapeutics, Inc. | Compositions and methods of using chondroitinase ABCI mutants |
AU2006326417B2 (en) † | 2005-12-16 | 2012-05-24 | Regeneron Pharmaceuticals, Inc. | Therapeutic methods for inhibiting tumor growth with Dll4 antagonists |
FR2895258B1 (fr) | 2005-12-22 | 2008-03-21 | Aventis Pharma Sa | Combinaison comprenant de la combretastatine et des agents anticancereux |
US8216575B2 (en) | 2006-03-31 | 2012-07-10 | Chengdu Kanghong Biotechnologies Co., Ltd. | Inhibition of neovascularization with a soluble chimeric protein comprising VEGF FLT-1 and KDR domains |
CN100502945C (zh) * | 2006-03-31 | 2009-06-24 | 成都康弘生物科技有限公司 | Vegf受体融合蛋白在治疗眼睛疾病中的应用 |
CA2654510C (en) | 2006-06-16 | 2015-03-17 | Regeneron Pharmaceuticals, Inc. | Vegf antagonist formulations suitable for intravitreal administration |
MX2009003229A (es) | 2006-09-29 | 2009-06-18 | Oncomed Pharm Inc | Composiciones y metodos para diagnosticar y tratar cancer. |
CA2666536C (en) | 2006-10-10 | 2018-08-07 | Acorda Therapeutics, Inc. | Compositions and methods of using chondroitinase abci mutants |
FR2918279B1 (fr) * | 2007-07-05 | 2010-10-22 | Aventis Pharma Sa | Combinaisons antitumorales contenant un agent inhibiteur de vegf et de l'irinotecan |
CN101575379B (zh) * | 2008-05-09 | 2012-05-30 | 上海抗体药物国家工程研究中心有限公司 | 可溶性vegfr双功能融合受体、其制备方法及用途 |
JP5954990B2 (ja) | 2008-11-03 | 2016-07-20 | モレキュラー・パートナーズ・アーゲーMolecular Partners Ag | Vegf−aレセプター相互作用を阻害する結合タンパク質 |
CN101838329A (zh) | 2009-03-18 | 2010-09-22 | 嘉和生物药业有限公司 | 抗血管新生融合蛋白 |
ES2895226T3 (es) | 2009-10-16 | 2022-02-18 | Mereo Biopharma 5 Inc | Combinación terapéutica y uso de anticuerpos antagonistas de DLL4 y agentes antihipertensivos |
AR081361A1 (es) | 2010-04-30 | 2012-08-29 | Molecular Partners Ag | Proteinas de union modificadas que inhiben la interaccion de receptor del factor de crecimiento endotelial vascular de glicoproteina a vegf-a |
ES2652508T3 (es) | 2010-08-06 | 2018-02-02 | Genzyme Corporation | Composiciones de antagonistas de VEGF y sus usos |
EP3539991A1 (en) * | 2011-01-07 | 2019-09-18 | Chugai Seiyaku Kabushiki Kaisha | Method for improving physical properties of antibody |
SG191334A1 (en) | 2011-01-13 | 2013-08-30 | Regeneron Pharma | Use of a vegf antagonist to treat angiogenic eye disorders |
JO3283B1 (ar) | 2011-04-26 | 2018-09-16 | Sanofi Sa | تركيب يتضمن أفليبيرسيبت, حمض فولينيك, 5- فلورويوراسيل (5- Fu) وإرينوسيتان (FOLFIRI) |
KR101397088B1 (ko) | 2011-06-10 | 2014-05-19 | 강원대학교산학협력단 | 암세포 증식 억제와 혈관신생 억제를 위한 융합 단백질 및 이를 포함한 항암 조성물 |
JO3370B1 (ar) * | 2011-11-10 | 2019-03-13 | Regeneron Pharma | طريقة لتثبيط نمو الورم عن طريق تثبيط مستقبل انترلوكين 6 |
US9988611B2 (en) | 2011-12-01 | 2018-06-05 | Ap Biosciences, Inc. | Protein inhibitors to complement and VEGF pathways and methods of use thereof |
CN103304668B (zh) * | 2012-03-12 | 2015-10-28 | 江苏健德生物药业有限公司 | Ultra-VEGF-trap免疫融合蛋白、其制备方法及其应用 |
ES2753135T3 (es) | 2012-05-07 | 2020-04-07 | Allergan Inc | Método de tratamiento de DMAE en pacientes resistentes a terapia anti-VEGF |
WO2014006113A1 (en) | 2012-07-03 | 2014-01-09 | Sanofi | Method of treating cancer by effective amounts of aflibercept |
TW201438736A (zh) | 2012-11-14 | 2014-10-16 | Regeneron Pharma | 以dll4拮抗劑治療卵巢癌之方法 |
WO2014124487A1 (en) | 2013-02-18 | 2014-08-21 | Vegenics Pty Limited | Ligand binding molecules and uses thereof |
AR095196A1 (es) | 2013-03-15 | 2015-09-30 | Regeneron Pharma | Medio de cultivo celular libre de suero |
CN104193828B (zh) * | 2013-09-12 | 2017-04-05 | 北京韩美药品有限公司 | 同时阻断her2和vegfr信号通路的重组融合蛋白 |
EP3065761B1 (en) | 2013-11-05 | 2020-01-08 | Allergan, Inc. | Method of treating conditions of the eye with an anti-vegf darpin |
EP3143044A1 (en) | 2014-05-12 | 2017-03-22 | Formycon AG | Pre-filled plastic syringe containing a vegf antagonist |
TR201909951T4 (tr) | 2014-07-18 | 2019-07-22 | Sanofi Sa | Kanser olduğundan şüphelenilen bir hastanın aflibersept ile tedavisinin sonucunun öngörülmesine yönelik yöntem. |
JP2016036322A (ja) * | 2014-08-11 | 2016-03-22 | 日本化薬株式会社 | 血管新生因子と結合するキメラタンパク質 |
HUE057653T2 (hu) | 2014-12-11 | 2022-05-28 | Bayer Healthcare Llc | Kis aktív choroidális neurovaszkularizáció lézióval jellemzett idõskori makuladegeneráció kezelése |
GB201503453D0 (en) | 2015-03-01 | 2015-04-15 | Jain Arjun | Endothelin-1"sponge" |
TW202340452A (zh) | 2015-08-04 | 2023-10-16 | 美商再生元醫藥公司 | 補充牛磺酸之細胞培養基及用法 |
WO2017046140A1 (en) | 2015-09-18 | 2017-03-23 | Bayer Pharma Aktiengesellschaft | Treatment regimens for dr and rvo in dependence of the extent of retinal ischemia |
KR101936049B1 (ko) * | 2015-10-15 | 2019-01-08 | (주)알테오젠 | IgG Fc 도메인을 가지는 융합 단백질의 생산방법 |
WO2017065559A1 (ko) | 2015-10-15 | 2017-04-20 | (주)알테오젠 | Igg fc 도메인을 가지는 융합 단백질의 생산방법 |
WO2017087798A1 (en) | 2015-11-18 | 2017-05-26 | Formycon Ag | Pre-filled pharmaceutical package comprising a liquid formulation of a vegf-antagonist |
US20180326126A1 (en) | 2015-11-18 | 2018-11-15 | Formycon Ag | Pre-filled plastic syringe containing a vegf antagonist |
MX2018006139A (es) | 2015-11-18 | 2019-03-14 | Sio2 Medical Products Inc | Envase farmaceutico para formulaciones oftalmicas. |
WO2017084616A1 (en) * | 2015-11-19 | 2017-05-26 | Zhuhai Tairuishang Biopharm Ltd. | Methods and compositions for binding vegf |
SI3384049T1 (sl) | 2015-12-03 | 2023-10-30 | Regeneron Pharmaceuticals, Inc. | Postopki povezovanja genetskih različic s kliničnim izidom pri bolnikih s starostno degeneracijo makule, zdravljenih s proti-VEGF |
AU2017213103B2 (en) | 2016-01-26 | 2022-08-11 | Formycon Ag | Liquid formulation of a VEGF antagonist |
JPWO2018070390A1 (ja) | 2016-10-12 | 2019-08-22 | 第一三共株式会社 | 抗robo4抗体と他剤を含む組成物 |
WO2018094316A1 (en) | 2016-11-21 | 2018-05-24 | Just Biotherapeutics, Inc. | Aflibercept formulations and uses thereof |
WO2018215580A1 (en) | 2017-05-24 | 2018-11-29 | Formycon Ag | Method for sterilizing prefilled plastic syringes containing a vegf antagonist |
US20200237997A1 (en) | 2017-05-24 | 2020-07-30 | Formycon Ag | Sterilizable pre-filled pharmaceutical packages comprising a liquid formulation of a vegf-antagonist |
US20200171244A1 (en) | 2017-05-24 | 2020-06-04 | Sio2 Medical Products, Inc. | Sterilizable pharmaceutical package for ophthalmic formulations |
TW201904610A (zh) | 2017-06-14 | 2019-02-01 | 德商拜耳製藥公司 | 用於治療新生血管型青光眼之非抗體vegf拮抗劑 |
WO2019020777A1 (en) | 2017-07-26 | 2019-01-31 | Formycon Ag | LIQUID FORMULATION OF A VEGF ANTAGONIST |
DK3668985T3 (da) | 2017-08-17 | 2021-09-20 | Just Evotec Biologics Inc | Fremgangsmåde til rensning af glycosyleret protein fra værtscellegalectiner og andre urenheder |
EP3713591A1 (en) | 2017-11-20 | 2020-09-30 | Just-Evotec Biologics, Inc. | Aflibercept formulations containing a lysine salt as tonicifying agent and uses thereof |
EP3717636B1 (en) | 2017-11-27 | 2023-03-08 | 4D Molecular Therapeutics Inc. | Adeno-associated virus variant capsids and use for inhibiting angiogenesis |
IL274711B1 (en) | 2017-11-30 | 2024-06-01 | Regeneron Pharma | Use of VEGF antagonist to treat angiogenic eye disorders |
CN117405806A (zh) * | 2017-12-13 | 2024-01-16 | 里珍纳龙药品有限公司 | 管理层析柱床支架的装置和系统及相关方法 |
KR20200112893A (ko) * | 2018-01-26 | 2020-10-05 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 항-vegf 제제를 사용한 혈관신생 장애의 치료 방법 및 조성물 |
JOP20200275A1 (ar) | 2018-05-10 | 2020-11-02 | Regeneron Pharma | صيغ تحتوي على بروتين اندماج لمستقبلvegf مرتفعة التركيز |
US11519020B2 (en) | 2018-05-25 | 2022-12-06 | Regeneron Pharmaceuticals, Inc. | Methods of associating genetic variants with a clinical outcome in patients suffering from age-related macular degeneration treated with anti-VEGF |
CN111378044B (zh) | 2018-12-28 | 2022-07-15 | 长春金赛药业有限责任公司 | 抗体融合蛋白、制备方法及其应用 |
EP3969564A1 (en) | 2019-05-16 | 2022-03-23 | Formycon AG | Method for reducing methionine oxidation in recombinant proteins |
TW202123988A (zh) | 2019-09-03 | 2021-07-01 | 美商安進公司 | 用於藥物遞送之注入裝置及用於注入裝置之包裝物 |
US20210077645A1 (en) | 2019-09-16 | 2021-03-18 | Amgen Inc. | Method for external sterilization of drug delivery device |
JP2022553640A (ja) | 2019-10-10 | 2022-12-26 | コディアック サイエンシーズ インコーポレイテッド | 眼障害を処置する方法 |
JP2023502501A (ja) | 2019-11-25 | 2023-01-24 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 眼内血管新生のための長時間作用型vegf阻害剤 |
PE20221770A1 (es) | 2019-12-06 | 2022-11-11 | Regeneron Pharma | Composiciones de proteina anti-vegf y metodos para producir la misma |
BR112022010686A2 (pt) | 2019-12-06 | 2022-08-23 | Regeneron Pharma | Mini-traps de vegf e métodos de uso dos mesmos |
CA3167020A1 (en) | 2020-02-24 | 2021-09-02 | Amgen Inc. | Containers and systems for use during external sterilization of drug delivery devices |
EP4145456A1 (en) | 2021-09-06 | 2023-03-08 | Bayer AG | Prediction of a change related to a macular fluid |
WO2023092324A1 (zh) | 2021-11-24 | 2023-06-01 | 苏州光度生物科技有限公司 | 多特异性配体结合分子及其应用 |
WO2024029876A1 (ko) * | 2022-08-02 | 2024-02-08 | 주식회사 파노로스바이오사이언스 | 변형된 융합 단백질 및 이의 용도 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9506466D0 (en) * | 1994-08-26 | 1995-05-17 | Prolifix Ltd | Cell cycle regulated repressor and dna element |
US6100071A (en) * | 1996-05-07 | 2000-08-08 | Genentech, Inc. | Receptors as novel inhibitors of vascular endothelial growth factor activity and processes for their production |
-
2000
- 2000-05-23 NZ NZ515913A patent/NZ515913A/xx not_active IP Right Cessation
- 2000-05-23 CA CA002376379A patent/CA2376379C/en not_active Expired - Lifetime
- 2000-05-23 SK SK1752-2001A patent/SK287332B6/sk not_active IP Right Cessation
- 2000-05-23 CN CN2008101093559A patent/CN101433715B/zh not_active Expired - Lifetime
- 2000-05-23 BR BRPI0011407A patent/BRPI0011407B8/pt unknown
- 2000-05-23 AT AT05001328T patent/ATE417928T1/de active
- 2000-05-23 ME MEP-32/08A patent/MEP3208A/xx unknown
- 2000-05-23 BR BR0011407-3A patent/BR0011407A/pt not_active IP Right Cessation
- 2000-05-23 AU AU50404/00A patent/AU779303B2/en active Active
- 2000-05-23 HU HU1300086A patent/HU230159B1/hu unknown
- 2000-05-23 PT PT05001328T patent/PT1544299E/pt unknown
- 2000-05-23 DE DE60019415T patent/DE60019415T2/de not_active Expired - Lifetime
- 2000-05-23 AT AT00932721T patent/ATE293164T1/de active
- 2000-05-23 JP JP2001502582A patent/JP4723140B2/ja not_active Expired - Lifetime
- 2000-05-23 ES ES00932721T patent/ES2237429T3/es not_active Expired - Lifetime
- 2000-05-23 CN CN201310118971.1A patent/CN103349781B/zh not_active Expired - Lifetime
- 2000-05-23 CZ CZ20100386A patent/CZ303656B6/cs not_active IP Right Cessation
- 2000-05-23 ES ES05001328T patent/ES2319305T3/es not_active Expired - Lifetime
- 2000-05-23 WO PCT/US2000/014142 patent/WO2000075319A1/en active Application Filing
- 2000-05-23 ME MEP-2008-32A patent/ME00024B/me unknown
- 2000-05-23 KR KR1020017015839A patent/KR100659477B1/ko active Protection Beyond IP Right Term
- 2000-05-23 UA UA2001128378A patent/UA74146C2/uk unknown
- 2000-05-23 DK DK00932721T patent/DK1183353T3/da active
- 2000-05-23 HU HU0201515A patent/HU229156B1/hu active Protection Beyond IP Right Term
- 2000-05-23 PL PL352246A patent/PL208247B1/pl active Protection Beyond IP Right Term
- 2000-05-23 MX MXPA01012630A patent/MXPA01012630A/es active IP Right Grant
- 2000-05-23 DE DE60041159T patent/DE60041159D1/de not_active Expired - Lifetime
- 2000-05-23 IL IL14689000A patent/IL146890A0/xx unknown
- 2000-05-23 RU RU2002100071/13A patent/RU2265661C2/ru active Protection Beyond IP Right Term
- 2000-05-23 CN CNB008115443A patent/CN100523187C/zh not_active Expired - Lifetime
- 2000-05-23 EP EP00932721A patent/EP1183353B1/en not_active Expired - Lifetime
- 2000-05-23 CZ CZ20014387A patent/CZ302689B6/cs unknown
- 2000-05-23 RS YUP-869/01A patent/RS50073B/sr unknown
- 2000-05-23 EP EP05001328A patent/EP1544299B1/en not_active Expired - Lifetime
- 2000-05-23 PT PT00932721T patent/PT1183353E/pt unknown
- 2000-05-23 DK DK05001328T patent/DK1544299T3/da active
-
2001
- 2001-12-03 IL IL146890A patent/IL146890A/en active Protection Beyond IP Right Term
- 2001-12-06 ZA ZA200110068A patent/ZA200110068B/xx unknown
- 2001-12-07 HR HR20010908A patent/HRP20010908B1/xx not_active IP Right Cessation
- 2001-12-10 NO NO20016036A patent/NO330775B1/no active Protection Beyond IP Right Term
-
2002
- 2002-07-04 HK HK02105009A patent/HK1043388A1/xx not_active IP Right Cessation
-
2005
- 2005-03-31 AU AU2005201365A patent/AU2005201365B2/en not_active Expired
-
2008
- 2008-03-17 IL IL190234A patent/IL190234A0/en not_active IP Right Cessation
-
2009
- 2009-03-16 CY CY20091100288T patent/CY1108883T1/el unknown
- 2009-11-05 HK HK09110323.8A patent/HK1132653A1/xx unknown
-
2010
- 2010-05-06 NO NO20100656A patent/NO332559B1/no not_active IP Right Cessation
- 2010-10-06 JP JP2010226970A patent/JP5273746B2/ja not_active Expired - Lifetime
-
2013
- 2013-05-13 CY CY2013019C patent/CY2013019I2/el unknown
- 2013-05-13 BE BE2013C029C patent/BE2013C029I2/fr unknown
- 2013-05-14 LU LU92195C patent/LU92195I2/fr unknown
- 2013-05-14 LT LTPA2013009C patent/LTC1183353I2/lt unknown
- 2013-05-14 FR FR13C0028C patent/FR13C0028I2/fr active Active
- 2013-05-15 NO NO2013010C patent/NO2013010I1/no unknown
- 2013-09-17 HU HUS1300052C patent/HUS1300052I1/hu unknown
- 2013-11-26 HK HK13113191.5A patent/HK1185798A1/xx unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BRPI0011407B8 (pt) | molécula de ácido nucléico quimérica, polipeptídeo de fusão, vetor de expressão, sistema de vetor hospedeiro, e, métodos de produzir um polipeptídeo de fusão | |
BR0007414A (pt) | Expressão e exportação de proteìnas antiobesidade como proteìnas de fusão fc | |
DE69533923D1 (de) | Cytokinin-designiertes lerk-5 | |
BR9814404A (pt) | " clonagem de expressão em fungos filamentosos " | |
BR0113921A (pt) | ácidos nucléicos e polipeptìdeos receptores | |
AU9174398A (en) | Peptides | |
BR0009393A (pt) | Polipeptìdeo, sequência de ácido nucleico isolada, construção de ácido nucleico, vetor de expressão recombinante, célula hospedeira recombinante, método para a produção do polipeptìdeo, uso de um polipeptìdeo, e, composição detergente | |
BR0214350A (pt) | Sequências de ácido nucleico e aminoácido de adenovìrus de sìmio, vetores contendo as mesmas e métodos de uso | |
DE69634640D1 (de) | Mutierte alpha-amylase enzyme mit erhöhter stabilität | |
AU3246300A (en) | Polypeptides having galactose oxidase activity and nucleic acids encoding same | |
DE69836092D1 (de) | Rekombinatorisches klonieren unter verwendung von nukleinsaüren mit rekombinationsstellen | |
BR0209896A (pt) | Composição de insulina para administração pulmonar, e, métodos para suprir insulina a um indivìduo mamìfero, para prover uma composição de insulina não-imunogênica e uma composição de insulina de efeito prolongado para administração ao pulmão de um indivìduo | |
ATE368682T1 (de) | Als 2f1 bezeichnetes rezeptorprotein | |
BR9612359A (pt) | Derivado covalente de uma proteína ob composição polipeptídeo quimérico sequência de ácido nucleico vetor de express o replicável célula hospedeira e métodos associados aos mesmos | |
DE60024659D1 (de) | Vektoren und verfahren für rekombinante proteinexpression | |
DE69826452D1 (de) | Stellenspezifische proteinmodifizierung | |
ATE270337T1 (de) | Materialen und methoden im zusammenhang mit bindung und präsentation von substanzen auf zelloberflächen | |
DE69511399D1 (de) | Isolierte, von mage-3 abgeleitete peptide, welche mit hla-a2 molekülen komplexieren | |
WO2002062999A8 (en) | Proteins and nucleic acids encoding same | |
WO2002059315A3 (en) | Human nucleic acids and polypeptides and methods of use thereof | |
PT1025245E (pt) | Criacao rapida de linhas celulares estaveis de mamifero produzindo elevados iiveis de proteinas recombinantes | |
WO2002046409A3 (en) | Proteins and nucleic acids encoding same | |
WO1994003601A3 (en) | Cloning, expression and uses for neurocan as a chondroitin sulfate proteoglycan | |
WO1994028132A3 (en) | Opioid receptors: compositions and methods | |
DK1144666T3 (da) | Replikationsdeficient baculovirusekspressionssystem |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B19A | Notification of judicial decision: notification of judicial decision |
Free format text: PROCESSO INPI NO 52402.007729/2023-82 NUP: 00424.114254/2023-28 (REF. 1029948-81.2023.4.01.3400) POLO ATIVO: REGENERON PHARMACEUTICALS, INC POLO PASSIVO:INSTITUTO NACIONAL DA PROPRIEDADE INDUSTRIAL ? INPI SENTENCA: DEVERA O INPI PUBLICAR A INFORMACAO DE QUE O PRAZO DE VIGENCIA DA PATENTE OBJETO DESTA ACAO ESTA SUB JUDICE, TANTO NA REVISTA DE PROPRIEDADE INDUSTRIAL, QUANTO NO STATUS DA RESPECTIVA PATENTE NO SITIO DO INPI NA INTERNET (ART. 59, INCISO II, 60 E 226 DA LPI). |
|
B22O | Other matters related to patents and certificates of addition of invention: legal action concerning patent |
Free format text: INPI NO 52402.007729/2023-82 ORIGEM: 7A VARA FEDERAL CIVEL DA SJDF (TRF1) PROCESSO NO: 1029948-81.2023.4.01.3400 ACAO PELO PROCEDIMENTO COMUM AUTOR: REGENERON PHARMACEUTICALS, INC. REU(S): INSTITUTO NACIONAL DA PROPRIEDADE INDUSTRIAL |