DK0686161T3 - Alfa-underenhed af humane beta2-integriner - Google Patents
Alfa-underenhed af humane beta2-integrinerInfo
- Publication number
- DK0686161T3 DK0686161T3 DK95905459T DK95905459T DK0686161T3 DK 0686161 T3 DK0686161 T3 DK 0686161T3 DK 95905459 T DK95905459 T DK 95905459T DK 95905459 T DK95905459 T DK 95905459T DK 0686161 T3 DK0686161 T3 DK 0686161T3
- Authority
- DK
- Denmark
- Prior art keywords
- alpha
- disclosed
- human
- alpha subunit
- dna
- Prior art date
Links
- 108010044426 integrins Proteins 0.000 title abstract 2
- 102000006495 integrins Human genes 0.000 title abstract 2
- 239000012634 fragment Substances 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 101001033280 Homo sapiens Cytokine receptor common subunit beta Proteins 0.000 abstract 1
- 102000009786 Immunoglobulin Constant Regions Human genes 0.000 abstract 1
- 108010009817 Immunoglobulin Constant Regions Proteins 0.000 abstract 1
- 230000004071 biological effect Effects 0.000 abstract 1
- 102000037865 fusion proteins Human genes 0.000 abstract 1
- 108020001507 fusion proteins Proteins 0.000 abstract 1
- 102000055647 human CSF2RB Human genes 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 241000894007 species Species 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70546—Integrin superfamily
- C07K14/70553—Integrin beta2-subunit-containing molecules, e.g. CD11, CD18
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
- C07K16/2845—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta2-subunit-containing molecules, e.g. CD11, CD18
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/6818—Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/04—Endocrine or metabolic disorders
- G01N2800/042—Disorders of carbohydrate metabolism, e.g. diabetes, glucose metabolism
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Biotechnology (AREA)
- Toxicology (AREA)
- Cell Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Compounds Of Unknown Constitution (AREA)
- Percussion Or Vibration Massage (AREA)
- Diaphragms For Electromechanical Transducers (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Eye Examination Apparatus (AREA)
- Sorption Type Refrigeration Machines (AREA)
- Physical Deposition Of Substances That Are Components Of Semiconductor Devices (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/173,497 US5437958A (en) | 1993-12-23 | 1993-12-23 | Human β2 integrin α subunit |
| US08/286,889 US5470953A (en) | 1993-12-23 | 1994-08-05 | Human β2 integrin α subunit |
| PCT/US1994/014832 WO1995017412A1 (en) | 1993-12-23 | 1994-12-21 | NOVEL HUMAN β2 INTEGRIN ALPHA SUBUNIT |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0686161T3 true DK0686161T3 (da) | 2004-11-15 |
Family
ID=26869214
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK95905459T DK0686161T3 (da) | 1993-12-23 | 1994-12-21 | Alfa-underenhed af humane beta2-integriner |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US5470953A (da) |
| EP (1) | EP0686161B1 (da) |
| JP (1) | JP3261383B2 (da) |
| AT (1) | ATE270330T1 (da) |
| AU (1) | AU1860395A (da) |
| CA (1) | CA2156622A1 (da) |
| DE (1) | DE69433869T2 (da) |
| DK (1) | DK0686161T3 (da) |
| ES (1) | ES2229234T3 (da) |
| PT (1) | PT686161E (da) |
| WO (1) | WO1995017412A1 (da) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5837478A (en) * | 1993-12-23 | 1998-11-17 | Icos Corporation | Method of identifying modulators of binding between and VCAM-1 |
| US5817515A (en) * | 1993-12-23 | 1998-10-06 | Icos Corporation | Human B2 integrin alpha subunit antibodies |
| US6620915B2 (en) * | 1993-12-23 | 2003-09-16 | Icos Corporation | Monoclonal antibodies specific for integrin α-d subunit |
| SK170497A3 (en) * | 1996-04-15 | 1998-09-09 | Icos Corp | Cytoplasmic modulators of integrin regulation/signaling |
| US6075004A (en) | 1996-04-26 | 2000-06-13 | The University Of Kansas | Peptide compositions which induce immune tolerance and methods of use |
| EP0896002A4 (en) * | 1997-01-29 | 2005-02-02 | Toray Industries | CHIMERIC PROTEINS, THEIR HETERODIMER COMPLEXES AND BLOOD PLATE REPLACEMENT |
| US6080910A (en) * | 1997-02-20 | 2000-06-27 | Case Western Reserve University | Transgenic knockout animals lacking IgG3 |
| US6610495B1 (en) | 1998-01-09 | 2003-08-26 | Tvw Telethon Intstitute For Child Health Research | Method for detecting proteinaceous inhibitors of protein-protein or DNA-protein interactions |
| EP2182008A3 (en) * | 1998-11-16 | 2010-07-14 | ICOS Corporation | Monoclonal anti alpha-D (ITGAD) antibodies for use in the treatment of inflammation |
| US7270969B2 (en) | 1999-05-05 | 2007-09-18 | Phylogica Limited | Methods of constructing and screening diverse expression libraries |
| DK2230303T3 (da) * | 1999-05-05 | 2013-04-15 | Phylogica Ltd | Isolering af biologiske modulatorer fra biodiverse genfragment-biblioteker |
| US7803765B2 (en) | 1999-05-05 | 2010-09-28 | Phylogica Limited | Methods of constructing biodiverse gene fragment libraries and biological modulators isolated therefrom |
| WO2001017544A1 (en) * | 1999-09-03 | 2001-03-15 | The Brigham And Women's Hospital, Inc. | Peptides that bind to urokinase receptor |
| AU2001282880A1 (en) * | 2000-07-07 | 2002-01-21 | California Institute Of Technology | Proteins with integrin-like activity |
| JP5113314B2 (ja) | 2000-09-01 | 2013-01-09 | ザ センター フォー ブラッド リサーチ インク | 所望のコンホメーションで安定させた改変ポリペプチド及び該ポリペプチドの作製方法 |
| CA2429353A1 (en) * | 2000-11-28 | 2002-08-01 | Genentech, Inc. | Lfa-1 antagonist compounds |
| DK1682537T3 (da) | 2003-11-05 | 2012-07-09 | Sarcode Bioscience Inc | Modulatorer af celleadhæsion |
| EP2444079B1 (en) | 2005-05-17 | 2016-11-30 | SARcode Bioscience Inc. | Compositions and Methods for Treatment of Eye Disorders |
| JP5576610B2 (ja) | 2006-02-20 | 2014-08-20 | フィロジカ リミテッド | ペプチド構造のライブラリーの構築およびスクリーニング方法 |
| EP2074138A4 (en) | 2006-09-19 | 2009-12-30 | Phylogica Ltd | NEUROPROTECTIVE PEPTIDE AP-1 SIGNALING INHIBITORS AND USES THEREOF |
| WO2008154700A1 (en) | 2007-06-20 | 2008-12-24 | Phylogica Limited | Compositions and uses thereof for the treatment of acute respiratory distress syndrome (ards) and clinical disorders associated with therewith |
| CA2702984C (en) | 2007-10-19 | 2017-04-11 | Sarcode Corporation | Compositions and methods for treatment of diabetic retinopathy |
| US20090257957A1 (en) * | 2008-04-15 | 2009-10-15 | John Burnier | Aerosolized LFA-1 antagonists for use in localized treatment of immune related disorders |
| CN102056485A (zh) * | 2008-04-15 | 2011-05-11 | 萨可德公司 | 用于局部治疗免疫相关疾病的局部lfa-1拮抗剂 |
| CN102065893A (zh) * | 2008-04-15 | 2011-05-18 | 萨可德公司 | Lfa-1拮抗剂向胃肠系统的递送 |
| US8080562B2 (en) * | 2008-04-15 | 2011-12-20 | Sarcode Bioscience Inc. | Crystalline pharmaceutical and methods of preparation and use thereof |
| WO2011050175A1 (en) | 2009-10-21 | 2011-04-28 | Sarcode Corporation | Crystalline pharmaceutical and methods of preparation and use thereof |
| WO2014018748A1 (en) | 2012-07-25 | 2014-01-30 | Sarcode Bioscience Inc. | Lfa-1 inhibitor and polymorph thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4271139A (en) * | 1978-03-27 | 1981-06-02 | Hiram Hart | Scintillation proximity assay |
| US4568649A (en) * | 1983-02-22 | 1986-02-04 | Immunex Corporation | Immediate ligand detection assay |
| CA2132637A1 (en) * | 1993-01-22 | 1994-08-04 | Michael W. Gallatin | Icam-related protein |
-
1994
- 1994-08-05 US US08/286,889 patent/US5470953A/en not_active Expired - Lifetime
- 1994-12-21 CA CA002156622A patent/CA2156622A1/en not_active Abandoned
- 1994-12-21 DK DK95905459T patent/DK0686161T3/da active
- 1994-12-21 AT AT95905459T patent/ATE270330T1/de not_active IP Right Cessation
- 1994-12-21 DE DE69433869T patent/DE69433869T2/de not_active Expired - Fee Related
- 1994-12-21 AU AU18603/95A patent/AU1860395A/en not_active Abandoned
- 1994-12-21 WO PCT/US1994/014832 patent/WO1995017412A1/en not_active Ceased
- 1994-12-21 ES ES95905459T patent/ES2229234T3/es not_active Expired - Lifetime
- 1994-12-21 US US08/362,652 patent/US5766850A/en not_active Expired - Fee Related
- 1994-12-21 PT PT95905459T patent/PT686161E/pt unknown
- 1994-12-21 JP JP51761995A patent/JP3261383B2/ja not_active Expired - Fee Related
- 1994-12-21 EP EP95905459A patent/EP0686161B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| HK1011999A1 (en) | 1999-07-23 |
| ES2229234T3 (es) | 2005-04-16 |
| US5470953A (en) | 1995-11-28 |
| PT686161E (pt) | 2004-11-30 |
| US5766850A (en) | 1998-06-16 |
| EP0686161A1 (en) | 1995-12-13 |
| CA2156622A1 (en) | 1995-06-29 |
| DE69433869D1 (de) | 2004-08-05 |
| ATE270330T1 (de) | 2004-07-15 |
| JP3261383B2 (ja) | 2002-02-25 |
| JPH08507933A (ja) | 1996-08-27 |
| WO1995017412A1 (en) | 1995-06-29 |
| DE69433869T2 (de) | 2005-08-25 |
| EP0686161B1 (en) | 2004-06-30 |
| AU1860395A (en) | 1995-07-10 |
| EP0686161A4 (en) | 1997-07-16 |
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