ATE516348T1 - Glykoprotein vi und dessen anwendungen - Google Patents
Glykoprotein vi und dessen anwendungenInfo
- Publication number
- ATE516348T1 ATE516348T1 AT00946953T AT00946953T ATE516348T1 AT E516348 T1 ATE516348 T1 AT E516348T1 AT 00946953 T AT00946953 T AT 00946953T AT 00946953 T AT00946953 T AT 00946953T AT E516348 T1 ATE516348 T1 AT E516348T1
- Authority
- AT
- Austria
- Prior art keywords
- nucleic acid
- acid molecules
- glycoprotein
- expression vectors
- provides isolated
- Prior art date
Links
- 102000003886 Glycoproteins Human genes 0.000 title abstract 2
- 108090000288 Glycoproteins Proteins 0.000 title abstract 2
- 102000039446 nucleic acids Human genes 0.000 abstract 4
- 108020004707 nucleic acids Proteins 0.000 abstract 4
- 150000007523 nucleic acids Chemical class 0.000 abstract 4
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 4
- 229920001184 polypeptide Polymers 0.000 abstract 3
- 239000013604 expression vector Substances 0.000 abstract 2
- 241001465754 Metazoa Species 0.000 abstract 1
- 102000015795 Platelet Membrane Glycoproteins Human genes 0.000 abstract 1
- 108010010336 Platelet Membrane Glycoproteins Proteins 0.000 abstract 1
- 230000000692 anti-sense effect Effects 0.000 abstract 1
- 230000000890 antigenic effect Effects 0.000 abstract 1
- 229920001436 collagen Polymers 0.000 abstract 1
- 230000004927 fusion Effects 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- 230000009261 transgenic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/81—Packaged device or kit
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Cell Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/345,468 US6245527B1 (en) | 1999-06-30 | 1999-06-30 | Nucleic acid molecules encoding glycoprotein VI and recombinant uses thereof |
| US45482499A | 1999-12-06 | 1999-12-06 | |
| US09/503,387 US7291714B1 (en) | 1999-06-30 | 2000-02-14 | Glycoprotein VI and uses thereof |
| PCT/US2000/018152 WO2001000810A1 (en) | 1999-06-30 | 2000-06-30 | Glycoprotein vi and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE516348T1 true ATE516348T1 (de) | 2011-07-15 |
Family
ID=27407686
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00946953T ATE516348T1 (de) | 1999-06-30 | 2000-06-30 | Glykoprotein vi und dessen anwendungen |
Country Status (5)
| Country | Link |
|---|---|
| US (5) | US7291714B1 (de) |
| EP (3) | EP1190043B1 (de) |
| AT (1) | ATE516348T1 (de) |
| AU (1) | AU6063500A (de) |
| WO (1) | WO2001000810A1 (de) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60038675T2 (de) * | 1999-05-07 | 2009-07-02 | Sanofi-Aventis Deutschland Gmbh | Rekombinantes plättchenkollagenrezeptorglykoprotein und dessen pharmazeutische verwendung |
| US7291714B1 (en) * | 1999-06-30 | 2007-11-06 | Millennium Pharmaceuticals, Inc. | Glycoprotein VI and uses thereof |
| US20090311267A1 (en) * | 1999-08-10 | 2009-12-17 | University Of Wurzburg | Inhibition of VWF - GPIb/V/IX interaction and platelet-collagen interaction for prevention and treatment of cerebral attacks |
| WO2001016321A1 (en) * | 1999-09-01 | 2001-03-08 | Otsuka Pharmaceutical Co., Ltd. | Platelet membrane glycoprotein vi (gpvi) dna and protein sequences, and uses thereof |
| EP1224942A1 (de) * | 2001-01-23 | 2002-07-24 | Bernhard Dr. Nieswandt | Use of JAQ1 (monoclonal antibody anti GPVI) as a medicament for the protection against thrombotic diseases |
| WO2003066661A2 (en) * | 2001-07-03 | 2003-08-14 | Genentech, Inc. | Human dr4 antibodies and uses thereof |
| CA2453986A1 (en) | 2001-07-18 | 2003-01-30 | Merck Patent Gesellschaft Mit Beschraenkter Haftung | Glycoprotein vi fusion proteins |
| GB0130543D0 (en) * | 2001-12-20 | 2002-02-06 | Univ Cambridge Tech | Human antibodies and their use |
| US20070071744A1 (en) | 2002-06-07 | 2007-03-29 | Gotz Munch | Agents which bind to epitopes of glycoprotein VI |
| GB0511590D0 (en) * | 2005-06-07 | 2005-07-13 | Procorde Gmbh | Anti-thrombotic agents |
| EP1369128A1 (de) * | 2002-06-07 | 2003-12-10 | Procorde GmbH | Glycoprotein VI Inhibitoren und deren therapeutische Verwendung |
| US7531178B2 (en) | 2002-06-07 | 2009-05-12 | Trigen Gmbh | Immunoadhesin comprising a glycoprotein VI domain |
| EP1538165A1 (de) * | 2003-12-03 | 2005-06-08 | Procorde GmbH | Glycoprotein VI Inhibitoren auf der Basis des monoklonalen Antikörpers hgp 5c4 |
| CA2565063A1 (en) * | 2004-04-29 | 2005-11-24 | Otsuka Pharmaceutical Co., Ltd. | Glycoprotein vi antibodies and method thereof |
| US7645592B2 (en) * | 2004-04-29 | 2010-01-12 | Otsuka Pharmaceutical Co., Ltd. | Glycoprotein VI antibodies and methods of use thereof |
| US20090041783A1 (en) | 2005-04-28 | 2009-02-12 | Mochida Pharmaceutical Co., Ltd. | Anti-platelet membrane glycoprotein vi monoclonal antibody |
| WO2007030930A1 (en) | 2005-09-13 | 2007-03-22 | National Research Council Of Canada | Methods and compositions for modulating tumor cell activity |
| EP1916259A1 (de) | 2006-10-26 | 2008-04-30 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Anti-Glycoprotein VI SCFV Fragment zur Thrombosebehandlung |
| US8278271B2 (en) * | 2006-12-13 | 2012-10-02 | University Of Massachusetts | Inhibiting collagen-induced platelet aggregation and activation with peptide variants |
| US9410744B2 (en) | 2010-05-12 | 2016-08-09 | Molten Metal Equipment Innovations, Llc | Vessel transfer insert and system |
| US20110044993A1 (en) * | 2008-04-22 | 2011-02-24 | Ulrich Kronthaler | Method for the prevention and treatment of cancer by inhibition of gpvi |
| WO2010111240A2 (en) * | 2009-03-23 | 2010-09-30 | The Brigham And Women's Hospital, Inc. | Methods for treating inflammatory arthritis |
| SG176644A1 (en) * | 2009-06-03 | 2012-01-30 | Regado Biosciences Inc | Nucleic acid modulators of glycoprotein vi |
| US8889646B2 (en) | 2009-06-03 | 2014-11-18 | Regado Biosciences, Inc. | Nucleic acid modulators of glycoprotein VI |
| US8889645B2 (en) | 2009-06-03 | 2014-11-18 | Regado Biosciences, Inc. | Nucleic acid modulators of glycoprotein VI |
| US9108244B2 (en) | 2009-09-09 | 2015-08-18 | Paul V. Cooper | Immersion heater for molten metal |
| US8802826B2 (en) | 2009-11-24 | 2014-08-12 | Alethia Biotherapeutics Inc. | Anti-clusterin antibodies and antigen binding fragments and their use to reduce tumor volume |
| EP2336188A1 (de) * | 2009-12-18 | 2011-06-22 | Sanofi-Aventis | Neuartige Antagonistenantikörper und ihre FAB-Fragmente gegen GPVI und Verwendungen davon |
| SG10201405259PA (en) | 2009-12-18 | 2014-10-30 | Sanofi Sa | Novel antagonist antibodies and their fab fragments against gpvi and uses thereof |
| EP2397495A1 (de) * | 2010-06-21 | 2011-12-21 | Sanofi | Neuartige Antagonistenantikörper und ihre FAB-Fragmente gegen GPVI und Verwendungen davon |
| EP2402371A1 (de) * | 2010-07-01 | 2012-01-04 | Sanofi | Neuartige Antagonistenantikörper und ihre FAB-Fragmente gegen GPVI und Verwendungen davon |
| CA2810479A1 (en) | 2010-09-07 | 2012-03-15 | Mochida Pharmaceutical Co., Ltd. | Method for diagnosing alzheimer's disease using soluble gpvi in blood |
| US9029095B2 (en) | 2010-12-01 | 2015-05-12 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Method and kits for determining platelet susceptibility to activation in a patient |
| EP2817028A4 (de) | 2012-02-22 | 2015-11-04 | Alethia Biotherapeutics Inc | Gemeinsame verwendung eines clusterin-inhibitors und eines egfr-inhibitors zur behandlung von krebs |
| EP4091628A1 (de) | 2015-08-05 | 2022-11-23 | Acticor Biotech | Neuartige anti-human-gpvi-antikörper und verwendungen davon |
| TWI810173B (zh) | 2017-02-03 | 2023-08-01 | 法商艾提寇生物技術公司 | 使用抗人類gpvi抗體抑制血小板凝集 |
| AU2019270342A1 (en) | 2018-05-16 | 2020-10-29 | Morphosys Ag | Antibodies targeting glycoprotein VI |
| US20240182582A1 (en) * | 2021-03-31 | 2024-06-06 | Janssen Biothech, Inc. | Materials and methods for immune effector cells redirection |
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| AU728657B2 (en) | 1996-03-18 | 2001-01-18 | Board Of Regents, The University Of Texas System | Immunoglobulin-like domains with increased half-lives |
| JP2001509030A (ja) * | 1997-01-21 | 2001-07-10 | ヒューマン ジノーム サイエンシーズ,インコーポレイテッド | Fcレセプターおよびポリペプチド |
| GB9701425D0 (en) | 1997-01-24 | 1997-03-12 | Bioinvent Int Ab | A method for in vitro molecular evolution of protein function |
| US6448035B1 (en) * | 1997-04-24 | 2002-09-10 | Immunex Corporation | Family of immunoregulators designated leukocyte immunoglobulin-like receptor (LIR) |
| WO1999011662A1 (en) | 1997-09-05 | 1999-03-11 | Millennium Biotherapeutics, Inc. | Novel molecules of the tnfr-ligand-related protein family and uses thereof |
| US6194151B1 (en) | 1997-09-26 | 2001-02-27 | Millenium Pharmaceuticals, Inc. | Molecules of the TNF receptor superfamily and uses therefor |
| DE60038675T2 (de) | 1999-05-07 | 2009-07-02 | Sanofi-Aventis Deutschland Gmbh | Rekombinantes plättchenkollagenrezeptorglykoprotein und dessen pharmazeutische verwendung |
| US20040001826A1 (en) * | 1999-06-30 | 2004-01-01 | Millennium Pharmaceuticals, Inc. | Glycoprotein VI and uses thereof |
| US7291714B1 (en) | 1999-06-30 | 2007-11-06 | Millennium Pharmaceuticals, Inc. | Glycoprotein VI and uses thereof |
| US6245527B1 (en) * | 1999-06-30 | 2001-06-12 | Millennium Pharmaceuticals, Inc. | Nucleic acid molecules encoding glycoprotein VI and recombinant uses thereof |
| CA2565063A1 (en) | 2004-04-29 | 2005-11-24 | Otsuka Pharmaceutical Co., Ltd. | Glycoprotein vi antibodies and method thereof |
-
2000
- 2000-02-14 US US09/503,387 patent/US7291714B1/en not_active Expired - Lifetime
- 2000-06-30 WO PCT/US2000/018152 patent/WO2001000810A1/en not_active Ceased
- 2000-06-30 AT AT00946953T patent/ATE516348T1/de not_active IP Right Cessation
- 2000-06-30 EP EP00946953A patent/EP1190043B1/de not_active Revoked
- 2000-06-30 US US09/610,118 patent/US6989144B1/en not_active Expired - Lifetime
- 2000-06-30 EP EP10184690.5A patent/EP2322558B1/de not_active Expired - Lifetime
- 2000-06-30 AU AU60635/00A patent/AU6063500A/en not_active Abandoned
- 2000-06-30 EP EP14190169.4A patent/EP2902414A1/de not_active Withdrawn
-
2006
- 2006-06-06 US US11/447,460 patent/US20060216291A1/en not_active Abandoned
- 2006-06-29 US US11/478,074 patent/US7597888B2/en not_active Expired - Fee Related
-
2010
- 2010-01-20 US US12/690,710 patent/US8137923B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP2322558B1 (de) | 2015-01-07 |
| US20100261200A1 (en) | 2010-10-14 |
| US20080050380A1 (en) | 2008-02-28 |
| EP1190043A4 (de) | 2004-12-29 |
| US7291714B1 (en) | 2007-11-06 |
| AU6063500A (en) | 2001-01-31 |
| EP2902414A1 (de) | 2015-08-05 |
| EP1190043A1 (de) | 2002-03-27 |
| US6989144B1 (en) | 2006-01-24 |
| EP1190043B1 (de) | 2011-07-13 |
| EP2322558A1 (de) | 2011-05-18 |
| WO2001000810A1 (en) | 2001-01-04 |
| US7597888B2 (en) | 2009-10-06 |
| US20060216291A1 (en) | 2006-09-28 |
| US8137923B2 (en) | 2012-03-20 |
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