WO2002103015A3 - Abca10 transporter - Google Patents

Abca10 transporter Download PDF

Info

Publication number
WO2002103015A3
WO2002103015A3 PCT/CA2002/000873 CA0200873W WO02103015A3 WO 2002103015 A3 WO2002103015 A3 WO 2002103015A3 CA 0200873 W CA0200873 W CA 0200873W WO 02103015 A3 WO02103015 A3 WO 02103015A3
Authority
WO
WIPO (PCT)
Prior art keywords
transporter
abca10
nucleic acid
acid molecules
expression vectors
Prior art date
Application number
PCT/CA2002/000873
Other languages
French (fr)
Other versions
WO2002103015A2 (en
Inventor
Bihan Stephane Le
Hongyun Chen
Ligia Kilinski
Original Assignee
Active Pass Pharmaceuticals In
Bihan Stephane Le
Hongyun Chen
Ligia Kilinski
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Active Pass Pharmaceuticals In, Bihan Stephane Le, Hongyun Chen, Ligia Kilinski filed Critical Active Pass Pharmaceuticals In
Priority to AU2002344853A priority Critical patent/AU2002344853A1/en
Publication of WO2002103015A2 publication Critical patent/WO2002103015A2/en
Publication of WO2002103015A3 publication Critical patent/WO2002103015A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Abstract

The invention provides isolated nucleic acid molecules, designated ABCA10 transporter nucleic acid molecules, which encode novel ABC transporter family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing ABCA10 transporter nucleic acid molecules, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which an ABCA10 transporter gene has been introduced or disrupted. The invention further provides isolated ABCA10 transporter proteins, fusion proteins, antigenic peptides, anti-ABCA10 transporter antibodies, and screening assays for ABCA10 transporter modulators. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.
PCT/CA2002/000873 2001-06-14 2002-06-13 Abca10 transporter WO2002103015A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002344853A AU2002344853A1 (en) 2001-06-14 2002-06-13 Abca10 transporter

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29860401P 2001-06-14 2001-06-14
US60/298,604 2001-06-14

Publications (2)

Publication Number Publication Date
WO2002103015A2 WO2002103015A2 (en) 2002-12-27
WO2002103015A3 true WO2002103015A3 (en) 2003-09-18

Family

ID=23151230

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA2002/000873 WO2002103015A2 (en) 2001-06-14 2002-06-13 Abca10 transporter

Country Status (2)

Country Link
AU (1) AU2002344853A1 (en)
WO (1) WO2002103015A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9328346B2 (en) 2010-11-12 2016-05-03 The General Hospital Corporation Polycomb-associated non-coding RNAs

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9920317B2 (en) 2010-11-12 2018-03-20 The General Hospital Corporation Polycomb-associated non-coding RNAs
DK2850186T3 (en) 2012-05-16 2019-04-08 Translate Bio Ma Inc COMPOSITIONS AND PROCEDURES FOR MODULATING SMN GENFAMILY EXPRESSION
JP2015518710A (en) 2012-05-16 2015-07-06 ラナ セラピューティクス インコーポレイテッド Compositions and methods for regulating hemoglobin gene family expression
US10837014B2 (en) 2012-05-16 2020-11-17 Translate Bio Ma, Inc. Compositions and methods for modulating SMN gene family expression
EP2849801A4 (en) * 2012-05-16 2016-05-25 Rana Therapeutics Inc Compositions and methods for modulating apoa1 and abca1 expression
KR20160074368A (en) 2012-05-16 2016-06-28 라나 테라퓨틱스, 인크. Compositions and methods for modulating utrn expression
WO2013173608A1 (en) 2012-05-16 2013-11-21 Rana Therapeutics, Inc. Compositions and methods for modulating mecp2 expression
WO2013173598A1 (en) 2012-05-16 2013-11-21 Rana Therapeutics, Inc. Compositions and methods for modulating atp2a2 expression
WO2016070060A1 (en) 2014-10-30 2016-05-06 The General Hospital Corporation Methods for modulating atrx-dependent gene repression
EP3271460A4 (en) 2015-03-17 2019-03-13 The General Hospital Corporation The rna interactome of polycomb repressive complex 1 (prc1)
WO2021096929A1 (en) * 2019-11-11 2021-05-20 Anand Rene Neural-derived human exosomes for alzheimer's disease and co-morbidities thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000078953A2 (en) * 1999-06-17 2000-12-28 Incyte Genomics, Inc. Human transport proteins
WO2001007658A1 (en) * 1999-07-23 2001-02-01 Human Genome Sciences, Inc. Abc transport polynucleotides, polypeptides, and antibodies

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000078953A2 (en) * 1999-06-17 2000-12-28 Incyte Genomics, Inc. Human transport proteins
WO2001007658A1 (en) * 1999-07-23 2001-02-01 Human Genome Sciences, Inc. Abc transport polynucleotides, polypeptides, and antibodies

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ALLIKMETS R ET AL: "CHARACTERIZATION OF THE HUMAN ABC SUPERFAMILY: ISOLATION AND MAPPING OF 21 NEW GENES USING THE EXPRESSED SEQUENCE TAGS DATABASE", HUMAN MOLECULAR GENETICS, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 5, no. 10, 1996, pages 1649 - 1655, XP002074412, ISSN: 0964-6906 *
DATABASE EMBL [online] 17 August 1998 (1998-08-17), BIRREN B. ET AL.: "Homo sapiens chromosome 17, clone RP11-293K20", XP002246290, Database accession no. AC005495 *
DATABASE EMBL [online] 26 April 2001 (2001-04-26), HARRINGTON J.J. ET AL: "Creation of genome-wide protein expression libraries using random activation of gene expression", XP002246289, Database accession no. BG186997 *
DATABASE EMBL [online] 5 December 2001 (2001-12-05), SCHRINL L.M. ET AL.: "Identification and characterization of a cluster of five new ATP-binding cassette trasnporter genes on human chromosome 17q24: a novel subgroup within the ABCA sub-family", XP002246291, Database accession no. AY028900 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9328346B2 (en) 2010-11-12 2016-05-03 The General Hospital Corporation Polycomb-associated non-coding RNAs

Also Published As

Publication number Publication date
AU2002344853A1 (en) 2003-01-02
WO2002103015A2 (en) 2002-12-27

Similar Documents

Publication Publication Date Title
MXPA02001878A (en) Novel b74 molecules and uses therefor.
WO2001021796A3 (en) Gl50 molecules and uses therefor
WO2002070652A3 (en) Novel molecules of the card-related protein family and uses thereof
WO2003042362A3 (en) PGC-1β, A NOVEL PGC-1 HOMOLOGUE AND USES THEREFOR
WO2001000826A3 (en) Novel molecules of the card-related protein family and uses thereof
WO2002103015A3 (en) Abca10 transporter
WO2001087978A3 (en) Human abc transporter and its use
WO2003004613A3 (en) Novel pgc-1 isoforms and uses therefor
WO2001061005A3 (en) Molecules of the pyrin domain protein family and uses thereof
WO2000008045A3 (en) Novel molecules of the tango-93-related protein family and uses thereof
WO2003029434A3 (en) Novel molecules of the hkid-1-related protein family and uses thereof
WO2002070691A3 (en) Abcg4 transporter and uses thereof
WO2001077151A3 (en) Fdrg proteins and nucleic acid molecules and uses therefor
WO2002038767A3 (en) G protein-coupled receptor protein and nucleic acid molecules and uses therefor
WO2002085939A8 (en) Novel molecules of the card-related protein family and uses thereof
WO2001014414A3 (en) Human abc2 transporter and uses thereof
WO2002070690A3 (en) Abca5 transporter and uses thereof
WO2000018923A3 (en) Slgp protein and nucleic acid molecule and uses therefor
WO2001083523A3 (en) Stmst protein and nucleic acid molecules and uses therefor
WO1999062943A3 (en) Novel molecules of the aip-related protein family and uses thereof
WO2002070692A3 (en) Abca9 transporter and uses thereof
WO2001059065A3 (en) Novel molecules of the card-related protein family and uses thereof
WO2002070693A3 (en) Novel abca6 transporter and uses thereof
WO2001064905A3 (en) 2504, 15977, and 14760, novel protein kinase family members and uses therefor
WO2001083753A3 (en) Molecules of the nbs/lrr protein family and uses thereof

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SL TJ TM TN TR TT TZ UA UG US UZ VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Country of ref document: JP