PT686161E - Novas sub-unidades humanas de alfa integrina 2 - Google Patents

Novas sub-unidades humanas de alfa integrina 2

Info

Publication number
PT686161E
PT686161E PT95905459T PT95905459T PT686161E PT 686161 E PT686161 E PT 686161E PT 95905459 T PT95905459 T PT 95905459T PT 95905459 T PT95905459 T PT 95905459T PT 686161 E PT686161 E PT 686161E
Authority
PT
Portugal
Prior art keywords
alpha
disclosed
integrina
units
new human
Prior art date
Application number
PT95905459T
Other languages
English (en)
Inventor
W Michael Gallatin
Monica Van Der Vieren
Original Assignee
Icos Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/173,497 external-priority patent/US5437958A/en
Application filed by Icos Corp filed Critical Icos Corp
Publication of PT686161E publication Critical patent/PT686161E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70546—Integrin superfamily
    • C07K14/70553—Integrin beta2-subunit-containing molecules, e.g. CD11, CD18
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • C07K16/2845—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta2-subunit-containing molecules, e.g. CD11, CD18
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6818—Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/04—Endocrine or metabolic disorders
    • G01N2800/042—Disorders of carbohydrate metabolism, e.g. diabetes, glucose metabolism

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Percussion Or Vibration Massage (AREA)
  • Physical Deposition Of Substances That Are Components Of Semiconductor Devices (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Sorption Type Refrigeration Machines (AREA)
  • Eye Examination Apparatus (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
PT95905459T 1993-12-23 1994-12-21 Novas sub-unidades humanas de alfa integrina 2 PT686161E (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/173,497 US5437958A (en) 1993-12-23 1993-12-23 Human β2 integrin α subunit
US08/286,889 US5470953A (en) 1993-12-23 1994-08-05 Human β2 integrin α subunit

Publications (1)

Publication Number Publication Date
PT686161E true PT686161E (pt) 2004-11-30

Family

ID=26869214

Family Applications (1)

Application Number Title Priority Date Filing Date
PT95905459T PT686161E (pt) 1993-12-23 1994-12-21 Novas sub-unidades humanas de alfa integrina 2

Country Status (11)

Country Link
US (2) US5470953A (pt)
EP (1) EP0686161B1 (pt)
JP (1) JP3261383B2 (pt)
AT (1) ATE270330T1 (pt)
AU (1) AU1860395A (pt)
CA (1) CA2156622A1 (pt)
DE (1) DE69433869T2 (pt)
DK (1) DK0686161T3 (pt)
ES (1) ES2229234T3 (pt)
PT (1) PT686161E (pt)
WO (1) WO1995017412A1 (pt)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5817515A (en) * 1993-12-23 1998-10-06 Icos Corporation Human B2 integrin alpha subunit antibodies
US6620915B2 (en) * 1993-12-23 2003-09-16 Icos Corporation Monoclonal antibodies specific for integrin α-d subunit
US5837478A (en) * 1993-12-23 1998-11-17 Icos Corporation Method of identifying modulators of binding between and VCAM-1
PL323998A1 (en) * 1996-04-15 1998-04-27 Icos Corp Cytoplasmatic modulator for regulating/signalling integrins
US6075004A (en) * 1996-04-26 2000-06-13 The University Of Kansas Peptide compositions which induce immune tolerance and methods of use
CA2250291A1 (en) * 1997-01-29 1998-07-30 Toray Industries Inc. Chimeric proteins, their heterodimer complexes, and platelet substitutes
US6080910A (en) * 1997-02-20 2000-06-27 Case Western Reserve University Transgenic knockout animals lacking IgG3
CA2317816C (en) 1998-01-09 2009-02-17 Tvw Telethon Institute For Child Health Research Peptide detection method
EP2182008A3 (en) * 1998-11-16 2010-07-14 ICOS Corporation Monoclonal anti alpha-D (ITGAD) antibodies for use in the treatment of inflammation
US7270969B2 (en) 1999-05-05 2007-09-18 Phylogica Limited Methods of constructing and screening diverse expression libraries
US7803765B2 (en) 1999-05-05 2010-09-28 Phylogica Limited Methods of constructing biodiverse gene fragment libraries and biological modulators isolated therefrom
AU771534B2 (en) 1999-05-05 2004-03-25 Phylogica Limited Isolating biological modulators from biodiverse gene fragment libraries
AU7099900A (en) * 1999-09-03 2001-04-10 Brigham And Women's Hospital Peptides that bind to urokinase receptor
US6951927B2 (en) 2000-07-07 2005-10-04 California Institute Of Technology Proteins with integrin-like activity
DE60140457D1 (de) * 2000-09-01 2009-12-24 Blood Res Center Veränderte, in gewünschter konformation stabilisierte polypeptide und verfahren zu deren herstellung
CA2429353A1 (en) * 2000-11-28 2002-08-01 Genentech, Inc. Lfa-1 antagonist compounds
EP1682537B1 (en) 2003-11-05 2012-03-28 SARcode Bioscience Inc. Modulators of cellular adhesion
DK1881823T3 (en) * 2005-05-17 2015-03-02 Sarcode Bioscience Inc COMPOSITION AND PROCEDURES FOR TREATMENT OF EYE DISORDERS
WO2007097923A2 (en) 2006-02-20 2007-08-30 Phylogica Limited Method of constructing and screening libraries of peptide structures
EP2074138A4 (en) 2006-09-19 2009-12-30 Phylogica Ltd NEUROPROTECTIVE PEPTIDE AP-1 SIGNALING INHIBITORS AND USES THEREOF
EP2170932A4 (en) 2007-06-20 2012-10-10 Phylogica Ltd COMPOSITIONS AND APPLICATIONS THEREOF IN THE TREATMENT OF ACUTE ATOMIC SYNDROME (ARDS) AND ASSOCIATED CLINICAL ILLNESSES
AU2008317473B2 (en) 2007-10-19 2014-07-17 Bausch + Lomb Ireland Limited Compositions and methods for treatment of diabetic retinopathy
JP2011518155A (ja) * 2008-04-15 2011-06-23 サーコード コーポレイション 免疫関連障害の局所治療に使用するためのエアゾール化ｌｆａ−１アンタゴニスト
CN102065893A (zh) * 2008-04-15 2011-05-18 萨可德公司 Lfa-1拮抗剂向胃肠系统的递送
CN102056485A (zh) * 2008-04-15 2011-05-11 萨可德公司 用于局部治疗免疫相关疾病的局部lfa-1拮抗剂
WO2009139817A2 (en) 2008-04-15 2009-11-19 Sarcode Corporation Crystalline pharmaceutical and methods of preparation and use thereof
WO2011050175A1 (en) 2009-10-21 2011-04-28 Sarcode Corporation Crystalline pharmaceutical and methods of preparation and use thereof
WO2014018748A1 (en) 2012-07-25 2014-01-30 Sarcode Bioscience Inc. Lfa-1 inhibitor and polymorph thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4271139A (en) * 1978-03-27 1981-06-02 Hiram Hart Scintillation proximity assay
US4568649A (en) * 1983-02-22 1986-02-04 Immunex Corporation Immediate ligand detection assay
CA2132637A1 (en) * 1993-01-22 1994-08-04 Michael W. Gallatin Icam-related protein

Also Published As

Publication number Publication date
EP0686161B1 (en) 2004-06-30
DE69433869T2 (de) 2005-08-25
EP0686161A4 (en) 1997-07-16
JP3261383B2 (ja) 2002-02-25
AU1860395A (en) 1995-07-10
DK0686161T3 (da) 2004-11-15
JPH08507933A (ja) 1996-08-27
ATE270330T1 (de) 2004-07-15
WO1995017412A1 (en) 1995-06-29
ES2229234T3 (es) 2005-04-16
US5766850A (en) 1998-06-16
EP0686161A1 (en) 1995-12-13
DE69433869D1 (de) 2004-08-05
US5470953A (en) 1995-11-28
CA2156622A1 (en) 1995-06-29
HK1011999A1 (en) 1999-07-23

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