ATE270330T1 - Alpha untereinheit des humanen beta-2 integrins - Google Patents
Alpha untereinheit des humanen beta-2 integrinsInfo
- Publication number
- ATE270330T1 ATE270330T1 AT95905459T AT95905459T ATE270330T1 AT E270330 T1 ATE270330 T1 AT E270330T1 AT 95905459 T AT95905459 T AT 95905459T AT 95905459 T AT95905459 T AT 95905459T AT E270330 T1 ATE270330 T1 AT E270330T1
- Authority
- AT
- Austria
- Prior art keywords
- alpha
- disclosed
- integrin
- human beta
- human
- Prior art date
Links
- 108010059108 CD18 Antigens Proteins 0.000 title 1
- 239000012634 fragment Substances 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 101001033280 Homo sapiens Cytokine receptor common subunit beta Proteins 0.000 abstract 1
- 102000009786 Immunoglobulin Constant Regions Human genes 0.000 abstract 1
- 108010009817 Immunoglobulin Constant Regions Proteins 0.000 abstract 1
- 230000004071 biological effect Effects 0.000 abstract 1
- 102000037865 fusion proteins Human genes 0.000 abstract 1
- 108020001507 fusion proteins Proteins 0.000 abstract 1
- 102000055647 human CSF2RB Human genes 0.000 abstract 1
- 108010044426 integrins Proteins 0.000 abstract 1
- 102000006495 integrins Human genes 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 241000894007 species Species 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70546—Integrin superfamily
- C07K14/70553—Integrin beta2-subunit-containing molecules, e.g. CD11, CD18
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
- C07K16/2845—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta2-subunit-containing molecules, e.g. CD11, CD18
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/6818—Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/04—Endocrine or metabolic disorders
- G01N2800/042—Disorders of carbohydrate metabolism, e.g. diabetes, glucose metabolism
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Compounds Of Unknown Constitution (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Eye Examination Apparatus (AREA)
- Diaphragms For Electromechanical Transducers (AREA)
- Percussion Or Vibration Massage (AREA)
- Physical Deposition Of Substances That Are Components Of Semiconductor Devices (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Sorption Type Refrigeration Machines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/173,497 US5437958A (en) | 1993-12-23 | 1993-12-23 | Human β2 integrin α subunit |
| US08/286,889 US5470953A (en) | 1993-12-23 | 1994-08-05 | Human β2 integrin α subunit |
| PCT/US1994/014832 WO1995017412A1 (en) | 1993-12-23 | 1994-12-21 | NOVEL HUMAN β2 INTEGRIN ALPHA SUBUNIT |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE270330T1 true ATE270330T1 (de) | 2004-07-15 |
Family
ID=26869214
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95905459T ATE270330T1 (de) | 1993-12-23 | 1994-12-21 | Alpha untereinheit des humanen beta-2 integrins |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US5470953A (de) |
| EP (1) | EP0686161B1 (de) |
| JP (1) | JP3261383B2 (de) |
| AT (1) | ATE270330T1 (de) |
| AU (1) | AU1860395A (de) |
| CA (1) | CA2156622A1 (de) |
| DE (1) | DE69433869T2 (de) |
| DK (1) | DK0686161T3 (de) |
| ES (1) | ES2229234T3 (de) |
| HK (1) | HK1011999A1 (de) |
| PT (1) | PT686161E (de) |
| WO (1) | WO1995017412A1 (de) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5837478A (en) * | 1993-12-23 | 1998-11-17 | Icos Corporation | Method of identifying modulators of binding between and VCAM-1 |
| US5817515A (en) * | 1993-12-23 | 1998-10-06 | Icos Corporation | Human B2 integrin alpha subunit antibodies |
| US6620915B2 (en) * | 1993-12-23 | 2003-09-16 | Icos Corporation | Monoclonal antibodies specific for integrin α-d subunit |
| IL122557A0 (en) * | 1996-04-15 | 1998-06-15 | Icos Corp | Cytoplasmic modulators of integrin regulation/signaling |
| US6075004A (en) | 1996-04-26 | 2000-06-13 | The University Of Kansas | Peptide compositions which induce immune tolerance and methods of use |
| WO1998032771A1 (fr) * | 1997-01-29 | 1998-07-30 | Toray Industries, Inc. | Proteines chimeres, complexes heterodimeres de ces proteines et substituant de plaquette |
| US6080910A (en) * | 1997-02-20 | 2000-06-27 | Case Western Reserve University | Transgenic knockout animals lacking IgG3 |
| DE69935313T2 (de) | 1998-01-09 | 2007-11-15 | Phylogica Ltd., Northbridge | Nachweisverfahren für peptide |
| EP2182008A3 (de) * | 1998-11-16 | 2010-07-14 | ICOS Corporation | Monoklonaler anti alpha-D (ITGAD) Antikörper zur Behandlung von Inflammation |
| DE60044514D1 (de) * | 1999-05-05 | 2010-07-15 | Phylogica Ltd | Isolierung von biologischen Modulatoren aus Bibliotheken mit biologisch vielvältigen Genfragmenten |
| US7270969B2 (en) | 1999-05-05 | 2007-09-18 | Phylogica Limited | Methods of constructing and screening diverse expression libraries |
| US7803765B2 (en) | 1999-05-05 | 2010-09-28 | Phylogica Limited | Methods of constructing biodiverse gene fragment libraries and biological modulators isolated therefrom |
| WO2001017544A1 (en) * | 1999-09-03 | 2001-03-15 | The Brigham And Women's Hospital, Inc. | Peptides that bind to urokinase receptor |
| AU2001282880A1 (en) | 2000-07-07 | 2002-01-21 | California Institute Of Technology | Proteins with integrin-like activity |
| JP5113314B2 (ja) | 2000-09-01 | 2013-01-09 | ザ センター フォー ブラッド リサーチ インク | 所望のコンホメーションで安定させた改変ポリペプチド及び該ポリペプチドの作製方法 |
| AU2002248142B2 (en) * | 2000-11-28 | 2007-11-01 | Genentech, Inc. | LFA-1 antagonist compounds |
| CA2544678C (en) * | 2003-11-05 | 2013-12-31 | Sunesis Pharmaceuticals, Inc. | Modulators of cellular adhesion |
| SI2444079T1 (sl) | 2005-05-17 | 2017-05-31 | Sarcode Bioscience Inc. | Sestavki in postopki za zdravljenje očesnih motenj |
| AU2007218045B2 (en) | 2006-02-20 | 2011-11-10 | Phylogica Limited | Method of constructing and screening libraries of peptide structures |
| EP2074138A4 (de) | 2006-09-19 | 2009-12-30 | Phylogica Ltd | Neuroprotektive peptidinhibitoren der ap-1-signalvermittlung und anwendungen davon |
| WO2008154700A1 (en) | 2007-06-20 | 2008-12-24 | Phylogica Limited | Compositions and uses thereof for the treatment of acute respiratory distress syndrome (ards) and clinical disorders associated with therewith |
| EP2209371B1 (de) | 2007-10-19 | 2017-01-04 | SARcode Bioscience Inc. | Zusammensetzungen und verfahren zur behandlung von diabetischer retinopathie |
| ES2763703T3 (es) * | 2008-04-15 | 2020-05-29 | Sarcode Bioscience Inc | Antagonistas de LFA-1 tópicos utilizados en el tratamiento localizado de trastornos inmunes |
| US8080562B2 (en) | 2008-04-15 | 2011-12-20 | Sarcode Bioscience Inc. | Crystalline pharmaceutical and methods of preparation and use thereof |
| WO2009128932A1 (en) * | 2008-04-15 | 2009-10-22 | Sarcode Corporation | Delivery of lfa-1 antagonists to the gastrointestinal system |
| EP2265124A4 (de) * | 2008-04-15 | 2011-12-28 | Sarcode Bioscience Inc | Aerosolisierte lfa-1-antagonisten zur verwendung bei der lokalen behandlung von immunerkrankungen |
| WO2011050175A1 (en) | 2009-10-21 | 2011-04-28 | Sarcode Corporation | Crystalline pharmaceutical and methods of preparation and use thereof |
| US9085553B2 (en) | 2012-07-25 | 2015-07-21 | SARcode Bioscience, Inc. | LFA-1 inhibitor and methods of preparation and polymorph thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4271139A (en) * | 1978-03-27 | 1981-06-02 | Hiram Hart | Scintillation proximity assay |
| US4568649A (en) * | 1983-02-22 | 1986-02-04 | Immunex Corporation | Immediate ligand detection assay |
| WO1994017100A1 (en) * | 1993-01-22 | 1994-08-04 | Icos Corporation | Icam-related protein |
-
1994
- 1994-08-05 US US08/286,889 patent/US5470953A/en not_active Expired - Lifetime
- 1994-12-21 CA CA002156622A patent/CA2156622A1/en not_active Abandoned
- 1994-12-21 ES ES95905459T patent/ES2229234T3/es not_active Expired - Lifetime
- 1994-12-21 WO PCT/US1994/014832 patent/WO1995017412A1/en active IP Right Grant
- 1994-12-21 JP JP51761995A patent/JP3261383B2/ja not_active Expired - Fee Related
- 1994-12-21 EP EP95905459A patent/EP0686161B1/de not_active Expired - Lifetime
- 1994-12-21 US US08/362,652 patent/US5766850A/en not_active Expired - Fee Related
- 1994-12-21 DK DK95905459T patent/DK0686161T3/da active
- 1994-12-21 PT PT95905459T patent/PT686161E/pt unknown
- 1994-12-21 AU AU18603/95A patent/AU1860395A/en not_active Abandoned
- 1994-12-21 AT AT95905459T patent/ATE270330T1/de not_active IP Right Cessation
- 1994-12-21 DE DE69433869T patent/DE69433869T2/de not_active Expired - Fee Related
-
1998
- 1998-12-09 HK HK98113003A patent/HK1011999A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU1860395A (en) | 1995-07-10 |
| DK0686161T3 (da) | 2004-11-15 |
| ES2229234T3 (es) | 2005-04-16 |
| DE69433869D1 (de) | 2004-08-05 |
| US5766850A (en) | 1998-06-16 |
| WO1995017412A1 (en) | 1995-06-29 |
| JPH08507933A (ja) | 1996-08-27 |
| PT686161E (pt) | 2004-11-30 |
| CA2156622A1 (en) | 1995-06-29 |
| DE69433869T2 (de) | 2005-08-25 |
| EP0686161A1 (de) | 1995-12-13 |
| JP3261383B2 (ja) | 2002-02-25 |
| EP0686161A4 (de) | 1997-07-16 |
| US5470953A (en) | 1995-11-28 |
| EP0686161B1 (de) | 2004-06-30 |
| HK1011999A1 (en) | 1999-07-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 0686161 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |