NO20070074L - Propan-1,3-dionderivat eller dets salt - Google Patents

Propan-1,3-dionderivat eller dets salt

Info

Publication number
NO20070074L
NO20070074L NO20070074A NO20070074A NO20070074L NO 20070074 L NO20070074 L NO 20070074L NO 20070074 A NO20070074 A NO 20070074A NO 20070074 A NO20070074 A NO 20070074A NO 20070074 L NO20070074 L NO 20070074L
Authority
NO
Norway
Prior art keywords
propane
compounds
gnrh receptor
useful
compound
Prior art date
Application number
NO20070074A
Other languages
English (en)
Inventor
Masaaki Hirano
Eiji Kawaminami
Isao Kinoyama
Shunichiro Matsumoto
Kei Ohnuki
Kazuyoshi Obitsu
Toshiyuki Kusayama
Original Assignee
Astellas Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astellas Pharma Inc filed Critical Astellas Pharma Inc
Publication of NO20070074L publication Critical patent/NO20070074L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A61P5/08—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH for decreasing, blocking or antagonising the activity of the anterior pituitary hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Det er tilveiebrakt en forbindelse som er anvendbar som en GnRH-reseptor-antagonist. Som resultater av studier på propan-1,3-dionderivater er det bekreftet at blant propan-1,3-dion-forbindelser som har 2-(1,3-dihydro-2H-benzimidazol-2-yliden), har en forbindelse med en benzen- eller tiofenring substituert med en gruppe avledet fra 1-hydroksyalkyl glimrende blodover-føringsegenskaper i tillegg til en glimrende GnRH-reseptorantagonisme. Fordi de har glimrende blodoverførings-egenskaper i tillegg til en kraftig GnRH-reseptorantagonisme, er de ovenfor angitte forbindelser forventet å utvise glimrende legemiddeletfekt in vivo og å være anvendbare til behandling av kjønnshormonavhengige sykdommer, slik som prostatakreft, brystkreft, endo-metriose, uterint myom og prostata-hypertrofi. Enn videre er forbindelsene glimrende når det gjelder metabolsk stabilitet hos mennesker og viser liten interaksjon blant legemidler. De har foretrukne egenskaper som legemidler til anvendelse for de ovenfor angitte sykdommer.
NO20070074A 2004-06-04 2007-01-04 Propan-1,3-dionderivat eller dets salt NO20070074L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2004166486 2004-06-04
JP2005099815 2005-03-30
PCT/JP2005/010184 WO2005118556A1 (ja) 2004-06-04 2005-06-02 プロパン－１，３－ジオン誘導体又はその塩

Publications (1)

Publication Number Publication Date
NO20070074L true NO20070074L (no) 2007-03-02

Family

ID=35462868

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20070074A NO20070074L (no) 2004-06-04 2007-01-04 Propan-1,3-dionderivat eller dets salt

Country Status (16)

Country Link
US (2) US7709519B2 (no)
EP (1) EP1752452A4 (no)
JP (1) JP4595938B2 (no)
CN (1) CN1964950A (no)
AR (1) AR049436A1 (no)
AU (1) AU2005250273B2 (no)
BR (1) BRPI0511796A (no)
CA (1) CA2568590C (no)
IL (1) IL179437A (no)
MX (1) MXPA06014131A (no)
NO (1) NO20070074L (no)
NZ (1) NZ552372A (no)
RU (1) RU2347781C2 (no)
TW (1) TWI342307B (no)
UA (1) UA83928C2 (no)
WO (1) WO2005118556A1 (no)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO341019B1 (no) * 2005-03-31 2017-08-07 Astellas Pharma Inc Propan-1,3-dion-derivat og salt derav, farmasøytisk preparat, anvendelse til fremstilling av et medikament, samt anvendelse i en fremgangsmåte for behandling

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EP1752452A4 (en) 2004-06-04 2010-07-14 Astellas Pharma Inc DERIVATIVE OF PROPANE-1, 3-DIONE OR ITS SALT
EP2095818A1 (en) * 2008-02-29 2009-09-02 AEterna Zentaris GmbH Use of LHRH antagonists at non-castrating doses
US8609717B2 (en) 2010-08-18 2013-12-17 Samumed, Llc β- and γ-diketones and γ-hydroxyketones as WNT/β-catenin signaling pathway activators
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BR112015020391B1 (pt) 2013-02-22 2022-07-26 Samumed, Llc Gama-dicetonas como ativadoras da via de sinalização de wnt/beta-catenina
US9618507B2 (en) 2014-02-24 2017-04-11 Betanien Hospital Methods of treating rheumatoid arthritis
DK3206686T3 (da) 2014-08-20 2019-12-16 Samumed Llc Gamma-diketoner til behandling og forebyggelse af ældning af huden og rynker
EP3185881B1 (en) * 2014-08-26 2022-03-09 Betanien Hospital Methods, agents and compositions for treatment of inflammatory conditions
CA3019281A1 (en) * 2016-03-31 2017-10-05 Toyama Chemical Co., Ltd. Novel method for producing hydroxamic acid derivative and intermediate therefor

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO341019B1 (no) * 2005-03-31 2017-08-07 Astellas Pharma Inc Propan-1,3-dion-derivat og salt derav, farmasøytisk preparat, anvendelse til fremstilling av et medikament, samt anvendelse i en fremgangsmåte for behandling

Also Published As

Publication number Publication date
AU2005250273B2 (en) 2010-10-14
EP1752452A4 (en) 2010-07-14
US20090018177A1 (en) 2009-01-15
BRPI0511796A (pt) 2008-01-15
US7709519B2 (en) 2010-05-04
RU2006142689A (ru) 2008-06-10
EP1752452A1 (en) 2007-02-14
IL179437A (en) 2011-11-30
JPWO2005118556A1 (ja) 2008-04-03
JP4595938B2 (ja) 2010-12-08
CA2568590C (en) 2011-01-18
CA2568590A1 (en) 2005-12-15
WO2005118556A1 (ja) 2005-12-15
US20100173946A1 (en) 2010-07-08
US8076367B2 (en) 2011-12-13
TW200613281A (en) 2006-05-01
EP1752452A9 (en) 2007-12-12
CN1964950A (zh) 2007-05-16
TWI342307B (en) 2011-05-21
AR049436A1 (es) 2006-08-02
UA83928C2 (ru) 2008-08-26
IL179437A0 (en) 2007-05-15
AU2005250273A1 (en) 2005-12-15
NZ552372A (en) 2009-11-27
RU2347781C2 (ru) 2009-02-27
MXPA06014131A (es) 2007-03-07

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