NO20080750L - (Indol-3-YL)-heterocykelderivater som agonister av cannabinoid CB1 reseptor - Google Patents

(Indol-3-YL)-heterocykelderivater som agonister av cannabinoid CB1 reseptor

Info

Publication number
NO20080750L
NO20080750L NO20080750A NO20080750A NO20080750L NO 20080750 L NO20080750 L NO 20080750L NO 20080750 A NO20080750 A NO 20080750A NO 20080750 A NO20080750 A NO 20080750A NO 20080750 L NO20080750 L NO 20080750L
Authority
NO
Norway
Prior art keywords
cannabinoid
indol
agonists
receptor
heterocycle derivatives
Prior art date
Application number
NO20080750A
Other languages
English (en)
Inventor
Julia Adam-Worrall
Angus John Morrison
Paul David Ratcliffe
Stuart John Francis
Tako Kiyoi
Original Assignee
Organon Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Organon Nv filed Critical Organon Nv
Publication of NO20080750L publication Critical patent/NO20080750L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

Oppfinnelsen angår indolderivat som har den generelle formel I Formel I hvor A, X1, X2 ,X3 ,Y, R1 ,R2 ,R3 og R4 er som definert i kravene, eller et farmasøytisk akseptabelt salt derav, farmasøytiske preparater omfattende disse og anvendelse av nevnte indolderivater ved behandling av smerte.
NO20080750A 2005-08-23 2008-02-12 (Indol-3-YL)-heterocykelderivater som agonister av cannabinoid CB1 reseptor NO20080750L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05107725 2005-08-23
PCT/EP2006/065496 WO2007023143A1 (en) 2005-08-23 2006-08-21 (indol-3-yl)-heterocycle derivatives as agonists of the cannabinoid cb1 receptor

Publications (1)

Publication Number Publication Date
NO20080750L true NO20080750L (no) 2008-05-14

Family

ID=35539284

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20080750A NO20080750L (no) 2005-08-23 2008-02-12 (Indol-3-YL)-heterocykelderivater som agonister av cannabinoid CB1 reseptor

Country Status (18)

Country Link
EP (1) EP1919471B1 (no)
JP (1) JP5283505B2 (no)
KR (1) KR20080038239A (no)
CN (1) CN101272783B (no)
AR (1) AR055384A1 (no)
AU (1) AU2006283884B2 (no)
BR (1) BRPI0615201A2 (no)
CA (1) CA2619038A1 (no)
EC (1) ECSP088270A (no)
IL (1) IL189390A0 (no)
MX (1) MX2008002539A (no)
NO (1) NO20080750L (no)
NZ (1) NZ566007A (no)
PE (1) PE20070236A1 (no)
RU (1) RU2008110961A (no)
TW (1) TW200745096A (no)
WO (1) WO2007023143A1 (no)
ZA (1) ZA200801519B (no)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI330635B (en) 2004-03-05 2010-09-21 Organon Nv (indol-3-yl)-heterocycle derivatives
US7763732B2 (en) 2005-08-24 2010-07-27 N.V. Organon Indole derivatives
TW200848417A (en) 2007-02-22 2008-12-16 Organon Nv Indole derivatives
CN101679355B (zh) * 2007-03-30 2014-01-29 詹森药业有限公司 苯并咪唑大麻素类激动剂
WO2010082627A1 (ja) 2009-01-16 2010-07-22 ダイソー株式会社 ２－ヒドロキシメチルモルホリン塩の製造方法
US9310374B2 (en) 2012-11-16 2016-04-12 Redwood Bioscience, Inc. Hydrazinyl-indole compounds and methods for producing a conjugate
KR102114323B1 (ko) * 2013-12-09 2020-05-22 이니스트에스티 주식회사 광학활성 1-(인돌린-5-일)프로판-2-올 유도체의 제조방법
ES2787855T3 (es) * 2015-12-09 2020-10-19 Hoffmann La Roche Derivados de fenilo como agonistas del receptor canabinoide 2
CN115667212A (zh) 2020-05-29 2023-01-31 富士胶片富山化学株式会社 高纯度的n-(5-甲氧基-2-苯氧基苯基)甲磺酰胺及其制造方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPR118000A0 (en) * 2000-11-02 2000-11-23 Amrad Operations Pty. Limited Therapeutic molecules and methods
TW200402417A (en) * 2002-06-21 2004-02-16 Akzo Nobel Nv 1-[(Indol-3-yl)carbonyl]piperazine derivatives
EP1556373A1 (en) * 2002-10-18 2005-07-27 Pfizer Products Inc. Cannabinoid receptor ligands and uses thereof
US7247628B2 (en) * 2002-12-12 2007-07-24 Pfizer, Inc. Cannabinoid receptor ligands and uses thereof
TWI330635B (en) * 2004-03-05 2010-09-21 Organon Nv (indol-3-yl)-heterocycle derivatives

Also Published As

Publication number Publication date
IL189390A0 (en) 2008-06-05
ECSP088270A (es) 2008-04-28
TW200745096A (en) 2007-12-16
CN101272783A (zh) 2008-09-24
NZ566007A (en) 2009-12-24
ZA200801519B (en) 2008-12-31
BRPI0615201A2 (pt) 2011-05-10
KR20080038239A (ko) 2008-05-02
AR055384A1 (es) 2007-08-22
RU2008110961A (ru) 2009-09-27
AU2006283884A1 (en) 2007-03-01
CA2619038A1 (en) 2007-03-01
EP1919471B1 (en) 2014-01-08
AU2006283884B2 (en) 2011-06-02
EP1919471A1 (en) 2008-05-14
WO2007023143A1 (en) 2007-03-01
CN101272783B (zh) 2011-05-25
JP2009506010A (ja) 2009-02-12
JP5283505B2 (ja) 2013-09-04
MX2008002539A (es) 2008-03-14
PE20070236A1 (es) 2007-04-16

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