MX2012012414A - Inhibidores de pirazoll quinazolina cinasa. - Google Patents

Inhibidores de pirazoll quinazolina cinasa.

Info

Publication number
MX2012012414A
MX2012012414A MX2012012414A MX2012012414A MX2012012414A MX 2012012414 A MX2012012414 A MX 2012012414A MX 2012012414 A MX2012012414 A MX 2012012414A MX 2012012414 A MX2012012414 A MX 2012012414A MX 2012012414 A MX2012012414 A MX 2012012414A
Authority
MX
Mexico
Prior art keywords
alkyl
substituted
formula
alkoxy
haloalkyl
Prior art date
Application number
MX2012012414A
Other languages
English (en)
Spanish (es)
Inventor
Lieven Meerpoel
Eddy Jean Edgard Freyne
Jean Fernand Armand Lacrampe
Werner Constant Johan Embrechts
Patrick Rene Angibaud
Valerio Berdini
Christopher Norbert Johnson
Christopher Charles Frederick Hamlett
Christopher William Murray
Gordon Saxty
Steven John Woodhead
Tom Cornelis Hortense Govaerts
Gilbert Ebai Besong
Michael Reader
David Charles Rees
Laurence Anne Mevellec
Johan Erwin Edmond Weerts
Timothy Pietro Suren Perera
Ronaldus Arnodus Hendrika Joseph Gilissen
Berthold Wroblowski
Alexandra Papanikos
Oliver Alexis Georges Querolle
Elisabeth Therese Jeanne Pasquier
Isabelle Noelle Constance Pilatte
Pascal Ghislain Andre Bonnet
Rhalid Akkari
Original Assignee
Astex Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astex Therapeutics Ltd filed Critical Astex Therapeutics Ltd
Publication of MX2012012414A publication Critical patent/MX2012012414A/es

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C—CHEMISTRY; METALLURGY
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    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/113—Spiro-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6524—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having four or more nitrogen atoms as the only ring hetero atoms

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Otolaryngology (AREA)
  • Hospice & Palliative Care (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Psychology (AREA)
  • Gastroenterology & Hepatology (AREA)
MX2012012414A 2010-04-30 2011-04-28 Inhibidores de pirazoll quinazolina cinasa. MX2012012414A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US32988410P 2010-04-30 2010-04-30
GB201007286A GB201007286D0 (en) 2010-04-30 2010-04-30 New compounds
PCT/GB2011/050851 WO2011135376A1 (en) 2010-04-30 2011-04-28 Pyrazolyl quinazoline kinase inhibitors

Publications (1)

Publication Number Publication Date
MX2012012414A true MX2012012414A (es) 2013-02-26

Family

ID=42289929

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2012012414A MX2012012414A (es) 2010-04-30 2011-04-28 Inhibidores de pirazoll quinazolina cinasa.
MX2015012476A MX365702B (es) 2010-04-30 2011-04-28 Inhibidores de pirazolil quinoxalina cinasa.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2015012476A MX365702B (es) 2010-04-30 2011-04-28 Inhibidores de pirazolil quinoxalina cinasa.

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EP (3) EP3178818B1 (enExample)
JP (1) JP5639261B2 (enExample)
KR (2) KR101889565B1 (enExample)
CN (2) CN104725362B (enExample)
AP (1) AP3210A (enExample)
AR (1) AR080982A1 (enExample)
AU (2) AU2011247047B2 (enExample)
BR (1) BR112012027509B1 (enExample)
CA (1) CA2796204C (enExample)
CL (1) CL2012003048A1 (enExample)
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EA (2) EA023222B8 (enExample)
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ES (3) ES2899937T3 (enExample)
FI (1) FIC20250009I1 (enExample)
FR (1) FR25C1006I1 (enExample)
GB (1) GB201007286D0 (enExample)
HR (1) HRP20211675T1 (enExample)
HU (4) HUE045893T2 (enExample)
IL (1) IL222600A (enExample)
IN (1) IN2012MN02591A (enExample)
JO (1) JO3366B1 (enExample)
LT (4) LT3178818T (enExample)
ME (1) ME01825B (enExample)
MX (2) MX2012012414A (enExample)
MY (2) MY189427A (enExample)
NL (1) NL301318I2 (enExample)
NO (1) NO2025011I1 (enExample)
NZ (1) NZ602726A (enExample)
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PL (3) PL3590934T3 (enExample)
PT (3) PT2563775T (enExample)
RS (3) RS55863B1 (enExample)
SG (2) SG10201708578QA (enExample)
SI (3) SI2563775T1 (enExample)
SM (3) SMT201900469T1 (enExample)
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GB201118654D0 (en) 2011-10-28 2011-12-07 Astex Therapeutics Ltd New compounds
GB201118656D0 (en) 2011-10-28 2011-12-07 Astex Therapeutics Ltd New compounds
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TWI647220B (zh) 2013-03-15 2019-01-11 美商西建卡爾有限責任公司 雜芳基化合物及其用途
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