LT2314589T - Oksikodono hidrochlorido kompozicijų, turinčių mažiau nei 25 ppm 14-hidroksikodeinono, paruošimo procesas - Google Patents

Oksikodono hidrochlorido kompozicijų, turinčių mažiau nei 25 ppm 14-hidroksikodeinono, paruošimo procesas

Info

Publication number
LT2314589T
LT2314589T LTEP10011793.6T LT10011793T LT2314589T LT 2314589 T LT2314589 T LT 2314589T LT 10011793 T LT10011793 T LT 10011793T LT 2314589 T LT2314589 T LT 2314589T
Authority
LT
Lithuania
Prior art keywords
hydroxycodeinone
25ppm
less
oxycodone hydrochloride
hydrochloride compositions
Prior art date
Application number
LTEP10011793.6T
Other languages
English (en)
Inventor
Robert Chapman
Lonn S. Rider
Qi Hong
Donald Kyle
Robert Kupper
Original Assignee
Euro-Celtique S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35124996&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LT2314589(T) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Euro-Celtique S.A. filed Critical Euro-Celtique S.A.
Publication of LT2314589T publication Critical patent/LT2314589T/lt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/485Morphinan derivatives, e.g. morphine, codeine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2095Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4833Encapsulating processes; Filling of capsules
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D489/00Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D489/00Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • C07D489/04Salts; Organic complexes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D489/00Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08Oxygen atom
LTEP10011793.6T 2004-03-30 2005-03-30 Oksikodono hidrochlorido kompozicijų, turinčių mažiau nei 25 ppm 14-hidroksikodeinono, paruošimo procesas LT2314589T (lt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US55749204P 2004-03-30 2004-03-30
US60153404P 2004-08-13 2004-08-13
US62007204P 2004-10-18 2004-10-18
US64862505P 2005-01-31 2005-01-31
US65177805P 2005-02-10 2005-02-10

Publications (1)

Publication Number Publication Date
LT2314589T true LT2314589T (lt) 2023-06-12

Family

ID=35124996

Family Applications (2)

Application Number Title Priority Date Filing Date
LTEP10011788.6T LT2316837T (lt) 2004-03-30 2005-03-30 Oksikodono hidrochlorido, turinčio mažiau nei 25ppm 14-hidroksikodeinono, gamybos būdas
LTEP10011793.6T LT2314589T (lt) 2004-03-30 2005-03-30 Oksikodono hidrochlorido kompozicijų, turinčių mažiau nei 25 ppm 14-hidroksikodeinono, paruošimo procesas

Family Applications Before (1)

Application Number Title Priority Date Filing Date
LTEP10011788.6T LT2316837T (lt) 2004-03-30 2005-03-30 Oksikodono hidrochlorido, turinčio mažiau nei 25ppm 14-hidroksikodeinono, gamybos būdas

Country Status (39)

Country Link
US (35) US7129248B2 (lt)
EP (7) EP2316837B1 (lt)
JP (8) JP4912294B2 (lt)
KR (12) KR20120106784A (lt)
CN (5) CN101812065B (lt)
AP (1) AP2232A (lt)
AR (1) AR049012A1 (lt)
AT (2) ATE501150T1 (lt)
AU (2) AU2005230826C1 (lt)
BR (1) BRPI0508758B8 (lt)
CA (3) CA2774121C (lt)
CR (2) CR8593A (lt)
CY (5) CY1111487T1 (lt)
DE (2) DE202005021371U1 (lt)
DK (6) DK2319846T3 (lt)
EA (1) EA013208B1 (lt)
EC (1) ECSP066953A (lt)
ES (6) ES2665287T3 (lt)
FI (1) FI7843U1 (lt)
HK (3) HK1098745A1 (lt)
HR (5) HRP20110425T4 (lt)
HU (3) HUE028233T2 (lt)
IL (8) IL178038A (lt)
LT (2) LT2316837T (lt)
MA (1) MA28492B1 (lt)
ME (4) ME02482B (lt)
MX (2) MX363228B (lt)
MY (3) MY143205A (lt)
NO (1) NO337669B1 (lt)
NZ (3) NZ601326A (lt)
PE (1) PE20050880A1 (lt)
PL (5) PL2319846T3 (lt)
PT (5) PT2426132E (lt)
RS (5) RS53891B1 (lt)
SG (3) SG10201406658VA (lt)
SI (5) SI2305683T1 (lt)
TW (3) TW201509943A (lt)
WO (1) WO2005097801A1 (lt)
ZA (1) ZA200607181B (lt)

Families Citing this family (109)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7776314B2 (en) 2002-06-17 2010-08-17 Grunenthal Gmbh Abuse-proofed dosage system
DE10336400A1 (de) 2003-08-06 2005-03-24 Grünenthal GmbH Gegen Missbrauch gesicherte Darreichungsform
DE102005005446A1 (de) * 2005-02-04 2006-08-10 Grünenthal GmbH Bruchfeste Darreichungsformen mit retardierter Freisetzung
DE10361596A1 (de) * 2003-12-24 2005-09-29 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
US20070048228A1 (en) 2003-08-06 2007-03-01 Elisabeth Arkenau-Maric Abuse-proofed dosage form
NZ545202A (en) * 2003-08-06 2010-03-26 Gruenenthal Chemie Abuse-proofed dosage form comprising opiods and a high molecular weight polyethylene oxide
DE102004020220A1 (de) * 2004-04-22 2005-11-10 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten, festen Darreichungsform
US8075872B2 (en) 2003-08-06 2011-12-13 Gruenenthal Gmbh Abuse-proofed dosage form
US7201920B2 (en) 2003-11-26 2007-04-10 Acura Pharmaceuticals, Inc. Methods and compositions for deterring abuse of opioid containing dosage forms
TW201509943A (zh) * 2004-03-30 2015-03-16 Euro Celtique Sa 含有小於25ppm14-羥可待因酮之羥可酮鹽酸鹽之組成物、醫藥劑型、延遲釋出口服劑型及醫藥上可以接受的包裝
DE102004032103A1 (de) * 2004-07-01 2006-01-19 Grünenthal GmbH Gegen Missbrauch gesicherte, orale Darreichungsform
DE102004032049A1 (de) * 2004-07-01 2006-01-19 Grünenthal GmbH Gegen Missbrauch gesicherte, orale Darreichungsform
GB0421149D0 (en) * 2004-09-23 2004-10-27 Johnson Matthey Plc Preparation of oxycodone
US20080152595A1 (en) * 2004-11-24 2008-06-26 Acura Pharmaceuticals, Inc. Methods and compositions for deterring abuse of orally administered pharmaceutical products
DE102005005449A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
JP5314894B2 (ja) 2005-03-04 2013-10-16 ユーロ−セルティーク エス.エイ. オピオイド組成物中のアルファ,ベータ不飽和ケトンの減少方法
WO2007011819A2 (en) * 2005-07-15 2007-01-25 The Penn State Research Foundation Ferritin as a therapeutic target in abnormal cells
WO2007062184A2 (en) * 2005-11-22 2007-05-31 Controlled Chemicals, Inc. Processes for reducing contaminating michael acceptor levels in oxycodone and other compositions
US20070117826A1 (en) * 2005-11-23 2007-05-24 Forest Laboratories, Inc. Pharmaceutical formulations comprising ibuprofen, oxycodone, and 14-hydroxycodeinone
WO2007103105A2 (en) 2006-03-02 2007-09-13 Mallinckrodt Inc. Processes for preparing morphinan-6-one products with low levels of alpha, beta-unsaturated ketone compounds
SA07280459B1 (ar) 2006-08-25 2011-07-20 بيورديو فارما إل. بي. أشكال جرعة صيدلانية للتناول عن طريق الفم مقاومة للعبث تشتمل على مسكن شبه أفيوني
DK2073636T3 (da) * 2006-10-17 2012-11-19 Penick Corp Fremgangsmåde til fremstilling af oxymorphon
CA2674915C (en) * 2006-10-17 2015-06-30 Penick Corporation Process for preparing oxymorphone
US20080125592A1 (en) * 2006-10-17 2008-05-29 Penick Corporation Process for preparing oxymorphone, naltrexone, and buprenorphine
CA2671518C (en) 2006-12-04 2016-06-07 Noramco, Inc. Process for preparing oxycodone having reduced levels of 14-hydroxycodeinone
JP2010511725A (ja) * 2006-12-04 2010-04-15 ノランコ・インコーポレーテツド オキシコドン塩基中の不純物を減少させる方法
GB0624880D0 (en) * 2006-12-14 2007-01-24 Johnson Matthey Plc Improved method for making analgesics
DE102007011485A1 (de) 2007-03-07 2008-09-11 Grünenthal GmbH Darreichungsform mit erschwertem Missbrauch
AU2008231127B2 (en) * 2007-03-23 2013-05-02 SpecGx LLC Improved preparation of oxymorphone from oripavine
AU2008241528B2 (en) * 2007-04-16 2013-07-04 Mallinckrodt Llc Novel opiate reduction utilizing catalytic hydrogen transfer reaction
TWI454288B (zh) 2008-01-25 2014-10-01 Gruenenthal Chemie 藥物劑型
EP2262484B1 (en) * 2008-03-11 2013-01-23 Depomed, Inc. Gastric retentive extended-release dosage forms comprising combinations of a non-opioid analgesic and an opioid analgesic
US8372432B2 (en) * 2008-03-11 2013-02-12 Depomed, Inc. Gastric retentive extended-release dosage forms comprising combinations of a non-opioid analgesic and an opioid analgesic
PT2273983T (pt) 2008-05-09 2016-10-28 Gruenenthal Gmbh Processo para a preparação de uma formulação em pó intermediária e uma forma de dosagem sólida final sob utilização de uma etapa de congelamento por atomização
US20110165248A1 (en) * 2008-09-18 2011-07-07 Meridith Lee Machonis Pharmaceutical dosage forms comprising poly(e-caprolactone)
KR101747156B1 (ko) 2009-07-22 2017-06-27 그뤼넨탈 게엠베하 산화-안정화된 탬퍼-내성 용량형
RU2547555C2 (ru) * 2009-07-22 2015-04-10 Грюненталь Гмбх Экструдированная из горячего расплава фармацевтическая лекарственная форма
RU2012112552A (ru) * 2009-08-31 2013-10-10 Дипомед, Инк. Удерживаемые в желудке фармацевтические композиции для немедленного и продленного высвобождения ацетаминофена
EP3064064A1 (en) 2009-09-30 2016-09-07 Acura Pharmaceuticals, Inc. Methods and compositions for deterring abuse
US9198861B2 (en) 2009-12-22 2015-12-01 Mallinckrodt Llc Methods of producing stabilized solid dosage pharmaceutical compositions containing morphinans
US8597681B2 (en) 2009-12-22 2013-12-03 Mallinckrodt Llc Methods of producing stabilized solid dosage pharmaceutical compositions containing morphinans
ES2606227T3 (es) * 2010-02-03 2017-03-23 Grünenthal GmbH Preparación de una composición farmacéutica en polvo mediante una extrusora
EP2377866B1 (en) 2010-03-23 2014-02-26 Siegfried AG Preparation of low impurity opiates in a continuous flow reactor
WO2011141490A1 (en) 2010-05-10 2011-11-17 Euro-Celtique S.A. Combination of active loaded granules with additional actives
CH705273B1 (de) 2010-05-10 2016-06-15 Euro Celtique Sa Pharmazeutische Zusammensetzung – umfassend Hydromorphon und Naloxon.
CN103002882B (zh) 2010-05-10 2016-03-02 欧洲凯尔特公司 不含活性剂之颗粒及包含其之片剂的制备
EP2580218B1 (en) 2010-06-11 2015-02-25 Rhodes Technologies Process for n-dealkylation of tertiary amines
EP2580201B1 (en) 2010-06-11 2017-08-02 Rhodes Technologies Transition metal-catalyzed processes for the preparation of n-allyl compounds and use thereof
US8703950B2 (en) 2010-07-02 2014-04-22 Johnson Matthey Public Limited Co. Low ABUK oxycodone, its salts and methods of making same
US8912781B2 (en) * 2010-07-30 2014-12-16 Cirrus Logic, Inc. Integrated circuit switching power supply controller with selectable buck mode operation
EP2611425B1 (en) 2010-09-02 2014-07-02 Grünenthal GmbH Tamper resistant dosage form comprising an anionic polymer
EP2611426B1 (en) 2010-09-02 2014-06-25 Grünenthal GmbH Tamper resistant dosage form comprising inorganic salt
US8741885B1 (en) 2011-05-17 2014-06-03 Mallinckrodt Llc Gastric retentive extended release pharmaceutical compositions
US9050335B1 (en) 2011-05-17 2015-06-09 Mallinckrodt Llc Pharmaceutical compositions for extended release of oxycodone and acetaminophen resulting in a quick onset and prolonged period of analgesia
US8858963B1 (en) 2011-05-17 2014-10-14 Mallinckrodt Llc Tamper resistant composition comprising hydrocodone and acetaminophen for rapid onset and extended duration of analgesia
US20130028972A1 (en) 2011-07-29 2013-01-31 Grunenthal Gmbh Tamper-resistant tablet providing immediate drug release
DK2736495T3 (da) 2011-07-29 2017-11-13 Gruenenthal Gmbh Misbrugsbestandig tablet som tilvejebringer øjeblikkelig frigivelse af lægemiddel
WO2013034273A1 (en) * 2011-09-05 2013-03-14 Siegfried Ltd. Kit comprising a packaging material and a solid pharmaceutical or nutraceutical product contained in the packaging material
EP2755640B1 (en) 2011-09-16 2017-07-26 Purdue Pharma LP Tamper resistant pharmaceutical formulations
US20140294947A1 (en) 2011-09-16 2014-10-02 Purdue Pharma L.P. Tamper resistant immediate release formulations
CA2858868C (en) 2011-12-09 2017-08-22 Purdue Pharma L.P. Pharmaceutical dosage forms comprising poly (epsilon-caprolactone) and polyethylene oxide
CA2864949A1 (en) 2012-02-28 2013-09-06 Grunenthal Gmbh Tamper-resistant dosage form comprising pharmacologically active compound and anionic polymer
EA028224B1 (ru) 2012-03-02 2017-10-31 Роудс Фармасьютикалз Л.П. Лекарственные формы немедленного высвобождения с защитой от несанкционированного применения
DE112013002074T5 (de) 2012-04-17 2015-01-29 Purdue Pharma L.P. Systeme und Methoden zur Behandlung einer Opioid-induzierten unerwünschten pharmakodynamischen Reaktion
EA201401139A1 (ru) 2012-04-18 2015-03-31 Грюненталь Гмбх Устойчивая к разрушению и к сбросу дозы фармацевтическая лекарственная форма
US10064945B2 (en) 2012-05-11 2018-09-04 Gruenenthal Gmbh Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc
CA2877774C (en) 2012-07-12 2017-07-18 Mallinckrodt Llc Extended release, abuse deterrent pharmaceutical compositions
US20150259355A1 (en) 2012-07-16 2015-09-17 Rhodes Technologies Process for improved opioid synthesis
EA028092B1 (ru) * 2012-07-16 2017-10-31 Родс Текнолоджис Способ усовершенствованного синтеза опиоидов
SI2880037T1 (sl) 2012-08-03 2019-04-30 Johnson Matthey Public Limited Company Postopek za pripravo oksikodona
ES2691982T3 (es) 2012-11-30 2018-11-29 Acura Pharmaceuticals, Inc. Liberación autorregulada de un principio activo farmacéutico
SG11201506064UA (en) 2013-02-05 2015-08-28 Purdue Pharma Lp Tamper resistant pharmaceutical formulations
WO2014130714A1 (en) * 2013-02-20 2014-08-28 University Of Washington Through Its Center For Commercialization Hydrogenation and disproportionation catalysis
US10751287B2 (en) 2013-03-15 2020-08-25 Purdue Pharma L.P. Tamper resistant pharmaceutical formulations
MX371432B (es) 2013-05-29 2020-01-30 Gruenenthal Gmbh Forma de dosificacion resistente al uso indebido que contiene una o mas particulas.
JP6466417B2 (ja) 2013-05-29 2019-02-06 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 二峰性放出プロファイルを有する改変防止(tamper−resistant)剤形
KR20160031526A (ko) 2013-07-12 2016-03-22 그뤼넨탈 게엠베하 에틸렌-비닐 아세테이트 중합체를 함유하는 템퍼 내성 투여형
GB201313211D0 (en) 2013-07-24 2013-09-04 Cambrex Karlskoga Ab New process
GB2517000B (en) 2013-08-02 2018-05-09 Johnson Matthey Plc Process for the synthesis of oxymorphone alkaloid and oxymorphone salts
GB201313915D0 (en) * 2013-08-02 2013-09-18 Johnson Matthey Plc Process
US9193737B2 (en) 2013-11-07 2015-11-24 Mallinckrodt Llc Production of 6-hydroxy morphinans without the isolation of intermediates
CN105916505A (zh) 2013-11-13 2016-08-31 欧洲凯尔特公司 用于治疗疼痛和阿片样物质肠功能障碍综合征的氢吗啡酮和纳洛酮
CN105934241B (zh) 2013-11-26 2020-06-05 格吕伦塔尔有限公司 通过低温研磨制备粉末状药物组合物
US8846923B1 (en) 2013-12-18 2014-09-30 Cody Laboratories, Inc. Preparation of 14-hydroxycodeinone sulfate
US10227354B2 (en) 2013-12-18 2019-03-12 Cody Laboratories, Inc. Conversion of oxycodone base to oxycodone hydrochloride
US9062062B1 (en) 2013-12-18 2015-06-23 Cody Laboratories, Inc. Synthesis of oxycodone hydrochloride
ES2672795T3 (es) 2014-01-15 2018-06-18 Rhodes Technologies Proceso para la síntesis mejorada de oximorfona
AU2015207733A1 (en) 2014-01-15 2016-07-14 Rhodes Technologies Process for improved oxycodone synthesis
WO2015120201A1 (en) 2014-02-05 2015-08-13 Kashiv Pharma, Llc Abuse-resistant drug formulations with built-in overdose protection
WO2015145461A1 (en) 2014-03-26 2015-10-01 Sun Pharma Advanced Research Company Ltd. Abuse deterrent immediate release biphasic matrix solid dosage form
EP3142646A1 (en) 2014-05-12 2017-03-22 Grünenthal GmbH Tamper resistant immediate release capsule formulation comprising tapentadol
MX2016015417A (es) 2014-05-26 2017-02-22 Gruenenthal Gmbh Multiparticulas protegidas contra vertido de dosis etanolico.
CA2954600A1 (en) 2014-07-09 2016-01-14 Rhodes Technologies Reduction of alpha, beta-unsaturated ketone levels in morphinan derivative compositions
CA2910865C (en) 2014-07-15 2016-11-29 Isa Odidi Compositions and methods for reducing overdose
US20160052932A1 (en) 2014-08-25 2016-02-25 Johnson Matthey Public Limited Company Processes for Making Opioids Including 14-Hydroxycodeinone and 14-hydroxymorphinone
US9849124B2 (en) 2014-10-17 2017-12-26 Purdue Pharma L.P. Systems and methods for treating an opioid-induced adverse pharmacodynamic response
CN105777766B (zh) * 2014-12-15 2017-11-24 北大方正集团有限公司 Delta‑7溴甲纳曲酮的制备方法
US9918979B2 (en) * 2015-01-29 2018-03-20 Johnson Matthey Public Limited Company Process of preparing low ABUK oxymorphone hydrochloride
EP3285745A1 (en) 2015-04-24 2018-02-28 Grünenthal GmbH Tamper-resistant dosage form with immediate release and resistance against solvent extraction
GB201513203D0 (en) 2015-07-27 2015-09-09 Cambrex Charles City Inc New process
WO2017040607A1 (en) 2015-08-31 2017-03-09 Acura Pharmaceuticals, Inc. Methods and compositions for self-regulated release of active pharmaceutical ingredient
JP2018526414A (ja) 2015-09-10 2018-09-13 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 乱用抑止性の即放性製剤を用いた経口過剰摂取に対する保護
US9943513B1 (en) 2015-10-07 2018-04-17 Banner Life Sciences Llc Opioid abuse deterrent dosage forms
US10335405B1 (en) 2016-05-04 2019-07-02 Patheon Softgels, Inc. Non-burst releasing pharmaceutical composition
WO2018055199A1 (en) 2016-09-26 2018-03-29 Euro-Celtique S.A. Methods of treatment comprising administering a high daily dose of oxycodone and naloxone in a 2:1 weight ratio
US10335375B2 (en) 2017-05-30 2019-07-02 Patheon Softgels, Inc. Anti-overingestion abuse deterrent compositions
EP3642207B1 (en) 2017-06-20 2022-08-31 Johnson Matthey Public Limited Company Hydrogenation process for preparing oxycodone hydrochloride from 14-hydroxycodeinone
CN110330500B (zh) * 2019-07-12 2021-11-23 宜昌人福药业有限责任公司 一种6β-羟基-7,8-二氢-吗啡衍生物的立体选择性合成方法
CN113009060B (zh) * 2021-02-24 2022-10-21 西南药业股份有限公司 高效液相色谱法测定盐酸羟考酮含量的方法

Family Cites Families (94)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1485673A (en) 1924-03-04 Ministrator
DE296916C (lt)
US100000A (en) * 1870-02-22 Improved sun-bonnet for horses
DE286431C (lt)
US1468805A (en) 1923-09-25 Htabtin ereund
US420098A (en) * 1890-01-28 Mowing-machine
US105553A (en) 1870-07-19 Improvement in kettle for melting, mixing, and casting metals
US710223A (en) * 1901-06-10 1902-09-30 Thew Automatic Shovel Company Power-shovel.
SU64699A1 (ru) 1944-01-26 1944-11-30 А.И. Лютенберг Способ получени сол нокислого дигидрооксикодеинона
ES212554A1 (es) 1953-12-01 1954-08-16 Casanovas Albajes Cesar Un procedimiento para la obtención de un vidrio orgánico
US2772270A (en) 1954-10-21 1956-11-27 M J Lewenstein 14-hydroxymorphinone and 8, 14-dihydroxydihydromorphinone
US2806033A (en) 1955-08-03 1957-09-10 Lewenstein Morphine derivative
US3173878A (en) * 1960-02-26 1965-03-16 Ibm Process of making microcapsules
US3173876A (en) 1960-05-27 1965-03-16 John C Zobrist Cleaning methods and compositions
NL271831A (lt) 1960-11-29
US3276586A (en) 1963-08-30 1966-10-04 Rosaen Filter Co Indicating means for fluid filters
US3916898A (en) 1964-05-20 1975-11-04 Searle & Co Administration of medicaments and the like
NL6714885A (lt) 1967-11-02 1969-05-06
US3541006A (en) 1968-07-03 1970-11-17 Amicon Corp Ultrafiltration process
US3541005A (en) 1969-02-05 1970-11-17 Amicon Corp Continuous ultrafiltration of macromolecular solutions
US3845770A (en) 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
US3916899A (en) 1973-04-25 1975-11-04 Alza Corp Osmotic dispensing device with maximum and minimum sizes for the passageway
US3905981A (en) 1973-10-12 1975-09-16 Research Corp N-dealkylation of tertiary amines
US3894026A (en) 1973-10-16 1975-07-08 Merck & Co Inc Production of thebaine
GB1478759A (en) 1974-11-18 1977-07-06 Alza Corp Process for forming outlet passageways in pills using a laser
US4077407A (en) 1975-11-24 1978-03-07 Alza Corporation Osmotic devices having composite walls
US4063064A (en) 1976-02-23 1977-12-13 Coherent Radiation Apparatus for tracking moving workpiece by a laser beam
US3984026A (en) * 1976-03-26 1976-10-05 Shoup Russel W Combined can opening and sealing device
US4045440A (en) 1976-09-16 1977-08-30 The United States Of America As Represented By The Department Of Health, Education And Welfare Method of producing thebaine from codeine and oripavine from morphine
US4200098A (en) 1978-10-23 1980-04-29 Alza Corporation Osmotic system with distribution zone for dispensing beneficial agent
US4285987A (en) 1978-10-23 1981-08-25 Alza Corporation Process for manufacturing device with dispersion zone
US4272540A (en) 1979-04-24 1981-06-09 Sisa, Incorporated 14-Methoxymorphinan-6-one compounds and therapeutic methods of treating pain and drug dependence with them
US4370333A (en) * 1981-06-29 1983-01-25 Sisa, Incorporated 17-Cyclopropylmethyl-3-hydroxy-14-methoxy 7α-methyl-morphinan-6-one and therapeutic method of treating pain with it
US4795813A (en) 1981-08-17 1989-01-03 The Florida Board Of Regents On Behalf Of The Florida State University Synthesis of derivatives of codeine and other 3-O-alkylmorphines
US4639520A (en) 1984-03-27 1987-01-27 Mallinckrodt, Inc. Preparation of 14-hydroxy-N-ethoxy-carbonyl-norcodeinone
US5112975A (en) 1984-03-27 1992-05-12 Mallinckrodt Specialty Chemicals Company Preparation of noroxymorphone from morphine
US4861598A (en) 1986-07-18 1989-08-29 Euroceltique, S.A. Controlled release bases for pharmaceuticals
US4810699A (en) 1987-02-20 1989-03-07 American Home Products Corporation Substituted 1,3,4,9-tetrahydropyrano[3,4,-b]indole-1-acetic acids, pharmaceutical compositions containing them, and methods for treating inflammatory conditions and for analgesic purposes using them
US4810669A (en) * 1987-07-07 1989-03-07 Oki Electric Industry Co., Ltd. Method of fabricating a semiconductor device
DE3812567A1 (de) 1988-04-15 1989-10-26 Basf Ag Verfahren zur herstellung pharmazeutischer mischungen
HU208633B (en) 1991-02-04 1993-12-28 Alkaloida Vegyeszeti Gyar Process for production of analgetic compositions as applicable for blocking of opioid-binding spaces /2-receptors/ causing respiration depression
US5215758A (en) 1991-09-11 1993-06-01 Euroceltique, S.A. Controlled release matrix suppository for pharmaceuticals
US5266331A (en) 1991-11-27 1993-11-30 Euroceltique, S.A. Controlled release oxycodone compositions
US5656295A (en) 1991-11-27 1997-08-12 Euro-Celtique, S.A. Controlled release oxycodone compositions
US5286493A (en) 1992-01-27 1994-02-15 Euroceltique, S.A. Stabilized controlled release formulations having acrylic polymer coating
US5273760A (en) 1991-12-24 1993-12-28 Euroceltigue, S.A. Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer
US5472712A (en) 1991-12-24 1995-12-05 Euroceltique, S.A. Controlled-release formulations coated with aqueous dispersions of ethylcellulose
US5324351A (en) 1992-08-13 1994-06-28 Euroceltique Aqueous dispersions of zein and preparation thereof
JP3433871B2 (ja) * 1996-01-26 2003-08-04 株式会社デンソー 集積化半導体歪みセンサ及びその製造方法
US5869669A (en) 1996-07-26 1999-02-09 Penick Corporation Preparation of 14-hydroxynormorphinones from normorphinone dienol acylates
ES2121554B1 (es) * 1996-12-23 1999-06-16 Univ Santiago Compostela Procedimiento de obtencion de 14-hidroximofinonas mediante fotooxidac ion de alcaloides morfinicos con sistema alcoxidienico en el anillo c.
GB9713703D0 (en) 1997-06-30 1997-09-03 Johnson Matthey Plc Preparation of opiates
GB9717629D0 (en) 1997-08-21 1997-10-22 Johnson Matthey Plc Removal of residual organic solvents
US6710223B1 (en) 1997-09-10 2004-03-23 The Procter & Gamble Company Method for improving skin condition
GB9805516D0 (en) 1998-03-17 1998-05-13 Johnson Matthey Plc Preparation of opiates
DE69911802T2 (de) * 1998-10-14 2004-07-29 Gyros Ab Form und verfahren zu deren herstellung
US6177567B1 (en) 1999-10-15 2001-01-23 Boehringer Ingelheim Chemicals, Inc. Method for preparing oxycodone
US6284769B1 (en) * 1999-12-03 2001-09-04 The Board Of Trustees Of The University Of Illinois Nonpeptide kappa opioid receptor antagonists
US6133132A (en) * 2000-01-20 2000-10-17 Advanced Micro Devices, Inc. Method for controlling transistor spacer width
ES2326730T3 (es) * 2000-02-08 2009-10-19 Euro-Celtique S.A. Formulaciones orales de agonistas opioides resistentes a manipulaciones indebidas.
AU2001258825A1 (en) 2000-05-29 2001-12-11 Shionogi And Co., Ltd. Method for labeling with tritium
US7200357B2 (en) * 2000-10-20 2007-04-03 Universal Electronics Inc. Automotive storage and playback device and method for using the same
UA81224C2 (uk) 2001-05-02 2007-12-25 Euro Celtic S A Дозована форма оксикодону та її застосування
AU2002305816B2 (en) * 2001-06-05 2008-04-10 Psivida Us Inc. Sustained-release analgesic compounds
JP2004534056A (ja) 2001-06-08 2004-11-11 エンドー ファーマシューティカルズ, インコーポレイティド アクリルポリマーを使用する制御放出投薬形態、およびそれを作製するためのプロセス
ES2319620T3 (es) 2001-07-18 2009-05-11 Euro-Celtique S.A. Conbinaciones farmaceuticas de oxicodona y naloxona.
EP1474198B1 (en) * 2002-01-15 2015-12-30 Novartis AG System for clearing aerosols from the effective anatomic dead space
WO2003082204A2 (en) * 2002-03-26 2003-10-09 Euro-Celtique S.A. Sustained-release gel coated compositions
AU2003234216A1 (en) 2002-04-29 2003-11-17 Alza Corporation Methods and dosage forms for controlled delivery of oxycodone
CN1290352C (zh) * 2002-05-27 2006-12-13 株式会社Ntt都科摩 移动通信系统、发送站、接收站、中继站、通信路径决定方法
JP2005528423A (ja) 2002-05-31 2005-09-22 アルザ・コーポレーシヨン オキシコドンの変動性投薬用量の浸透圧的送達のための剤形および組成物
US20040058946A1 (en) * 2002-07-05 2004-03-25 Buchwald Stephen L. Abuse-resistant prodrugs of oxycodone and other pharmaceuticals
JP4694207B2 (ja) * 2002-07-05 2011-06-08 コルジウム ファーマシューティカル, インコーポレイテッド オピオイドおよび他の薬物に関する乱用抑止性の薬学的組成物
CN100439373C (zh) * 2002-08-15 2008-12-03 诺拉姆科有限公司 羟考酮盐酸盐多晶型物
AU2003291103A1 (en) 2002-11-15 2004-06-15 Branded Products For The Future Pharmaceutical composition
AU2003293180A1 (en) * 2002-11-29 2004-06-23 Forest Laboratories Inc Combination of ibuprofen and oxycodone for acute pain relief
FR2850576B1 (fr) * 2003-02-05 2007-03-23 Ethypharm Sa Composition comprenant un melange de principes actifs, et procede de preparation
JP2006520392A (ja) 2003-03-13 2006-09-07 コントロールド・ケミカルズ・インコーポレーテッド 薬物の乱用可能性を低下させ且つ作用持続時間を延長する化合物および方法
US6864370B1 (en) 2003-06-05 2005-03-08 Zhaiwei Lin Process for manufacturing oxycodone
TW201509943A (zh) 2004-03-30 2015-03-16 Euro Celtique Sa 含有小於25ppm14-羥可待因酮之羥可酮鹽酸鹽之組成物、醫藥劑型、延遲釋出口服劑型及醫藥上可以接受的包裝
US20070172958A1 (en) * 2004-03-30 2007-07-26 Euro-Celtique S.A. Methods for detecting 14-hydroxy codeinone and codeinone
US20050226929A1 (en) 2004-04-12 2005-10-13 Jianbo Xie Controlled release opioid analgesic formulation
WO2006004672A1 (en) 2004-06-25 2006-01-12 Tessera, Inc. Components with posts and pads
GB0421149D0 (en) 2004-09-23 2004-10-27 Johnson Matthey Plc Preparation of oxycodone
JP5314894B2 (ja) 2005-03-04 2013-10-16 ユーロ−セルティーク エス.エイ. オピオイド組成物中のアルファ,ベータ不飽和ケトンの減少方法
ES2357216T3 (es) 2005-06-16 2011-04-20 Mallinckrodt, Inc. Una ruta de síntesis de 14-hidroxil-opiáceos a través de 1-halo-tebaína o análogos.
WO2007062184A2 (en) 2005-11-22 2007-05-31 Controlled Chemicals, Inc. Processes for reducing contaminating michael acceptor levels in oxycodone and other compositions
US20070117826A1 (en) 2005-11-23 2007-05-24 Forest Laboratories, Inc. Pharmaceutical formulations comprising ibuprofen, oxycodone, and 14-hydroxycodeinone
WO2007103105A2 (en) 2006-03-02 2007-09-13 Mallinckrodt Inc. Processes for preparing morphinan-6-one products with low levels of alpha, beta-unsaturated ketone compounds
CA2671518C (en) 2006-12-04 2016-06-07 Noramco, Inc. Process for preparing oxycodone having reduced levels of 14-hydroxycodeinone
JP2010511725A (ja) 2006-12-04 2010-04-15 ノランコ・インコーポレーテツド オキシコドン塩基中の不純物を減少させる方法
GB2450691A (en) 2007-07-02 2009-01-07 Alpharma Aps One-pot preparation of oxycodone from thebaine
US8703950B2 (en) * 2010-07-02 2014-04-22 Johnson Matthey Public Limited Co. Low ABUK oxycodone, its salts and methods of making same
US9062062B1 (en) * 2013-12-18 2015-06-23 Cody Laboratories, Inc. Synthesis of oxycodone hydrochloride

Also Published As

Publication number Publication date
DK1730151T4 (da) 2020-10-19
ES2938727T3 (es) 2023-04-14
CY1120171T1 (el) 2018-12-12
JP2011157370A (ja) 2011-08-18
CN102127086A (zh) 2011-07-20
JP5543991B2 (ja) 2014-07-09
US20090227615A1 (en) 2009-09-10
US7674800B2 (en) 2010-03-09
ES2362282T3 (es) 2011-06-30
BRPI0508758A (pt) 2007-08-28
NZ601326A (en) 2013-10-25
PL1730151T3 (pl) 2011-08-31
RS51693B (en) 2011-10-31
CY1117228T1 (el) 2017-04-05
DK1730151T3 (da) 2011-06-20
US20160175299A1 (en) 2016-06-23
KR20130020962A (ko) 2013-03-04
IL214050A0 (en) 2011-08-31
AU2009200335B2 (en) 2011-07-28
SI2319846T1 (sl) 2016-08-31
US20230365578A1 (en) 2023-11-16
EP2305683A1 (en) 2011-04-06
JP5118223B2 (ja) 2013-01-16
EA013208B1 (ru) 2010-04-30
EP2426132A1 (en) 2012-03-07
AU2005230826C1 (en) 2014-10-16
US20070117831A1 (en) 2007-05-24
IL235298A (en) 2016-11-30
SI1730151T1 (sl) 2011-06-30
DK2426132T3 (en) 2016-04-04
MA28492B1 (fr) 2007-03-01
US20150265598A1 (en) 2015-09-24
ES2585576T3 (es) 2016-10-06
CA2913355C (en) 2021-04-20
CR20110376A (es) 2011-09-19
KR20140133615A (ko) 2014-11-19
ME02482B (me) 2017-02-20
ME01299B (me) 2011-10-31
NZ549430A (en) 2010-05-28
HK1155729A1 (zh) 2012-05-25
KR20120046309A (ko) 2012-05-09
IL178038A0 (en) 2006-12-31
DK200700214U1 (da) 2007-11-23
US20060173029A1 (en) 2006-08-03
PT2319846T (pt) 2016-08-12
JP2015187134A (ja) 2015-10-29
IL241117A0 (en) 2015-11-30
HK1155728A1 (en) 2012-05-25
JP2014139205A (ja) 2014-07-31
TWI365880B (en) 2012-06-11
KR20140021716A (ko) 2014-02-20
AU2005230826B2 (en) 2008-11-06
PT1730151E (pt) 2011-06-01
US20070117829A1 (en) 2007-05-24
IL241117B (en) 2020-06-30
US20190161492A1 (en) 2019-05-30
US20160175298A1 (en) 2016-06-23
CA2774121C (en) 2016-02-16
MX363228B (es) 2019-03-15
BRPI0508758B8 (pt) 2021-05-25
FI7843U1 (fi) 2008-04-28
US20210094963A1 (en) 2021-04-01
US20070179169A1 (en) 2007-08-02
IL178038A (en) 2015-10-29
TW200540177A (en) 2005-12-16
US20160250205A1 (en) 2016-09-01
PL1730151T5 (pl) 2023-09-18
EP2314589A1 (en) 2011-04-27
US20160185789A1 (en) 2016-06-30
US20200062772A1 (en) 2020-02-27
SI2426132T1 (sl) 2016-04-29
AP2006003738A0 (en) 2006-10-31
BRPI0508758B1 (pt) 2018-10-09
NO20064935L (no) 2006-12-18
US20210198268A1 (en) 2021-07-01
RS54598B1 (en) 2016-08-31
CN102887903A (zh) 2013-01-23
SI2316837T1 (en) 2018-05-31
AT9952U1 (de) 2008-06-15
US20160251363A1 (en) 2016-09-01
IL213889A0 (en) 2011-07-31
CR8593A (es) 2007-07-19
CY1117841T1 (el) 2017-05-17
IL213888A0 (en) 2011-07-31
KR100993911B1 (ko) 2010-11-11
US20110207762A1 (en) 2011-08-25
PL2426132T3 (pl) 2016-06-30
US20230159548A1 (en) 2023-05-25
US20150265597A1 (en) 2015-09-24
CA2557845C (en) 2013-10-01
EP2305683B8 (en) 2015-03-04
JP2012188439A (ja) 2012-10-04
PT2305683E (pt) 2015-05-18
EP2316837A1 (en) 2011-05-04
MY143205A (en) 2011-03-31
KR101410141B1 (ko) 2014-06-25
EP2316837B1 (en) 2018-01-10
PL2305683T3 (pl) 2015-07-31
US7683072B2 (en) 2010-03-23
HUE028233T2 (en) 2016-12-28
JP2012072162A (ja) 2012-04-12
US20160264588A1 (en) 2016-09-15
TW201231469A (en) 2012-08-01
HRP20160223T1 (hr) 2016-03-25
HK1098745A1 (en) 2007-07-27
EP2311839A1 (en) 2011-04-20
US20130005977A1 (en) 2013-01-03
PL2316837T3 (pl) 2018-07-31
US20160176888A1 (en) 2016-06-23
AR049012A1 (es) 2006-06-21
CN1960994A (zh) 2007-05-09
US20180022754A1 (en) 2018-01-25
SG170735A1 (en) 2011-05-30
JP6503392B2 (ja) 2019-04-17
LT2316837T (lt) 2018-04-10
US10407434B2 (en) 2019-09-10
EP2319846A1 (en) 2011-05-11
DK200700214U3 (da) 2008-02-08
EP1730151A4 (en) 2007-05-23
AU2009200335A1 (en) 2009-02-26
DE202005021371U1 (de) 2007-10-25
SG170736A1 (en) 2011-05-30
US20160176889A1 (en) 2016-06-23
US10696684B2 (en) 2020-06-30
CY1111487T1 (el) 2015-08-05
KR100930730B1 (ko) 2009-12-09
US20160250204A1 (en) 2016-09-01
ES2665287T3 (es) 2018-04-25
EP2426132B1 (en) 2016-01-13
NZ602862A (en) 2014-01-31
US11236098B2 (en) 2022-02-01
HRP20110425T4 (hr) 2020-11-27
ATE501150T1 (de) 2011-03-15
EA200601520A1 (ru) 2007-02-27
KR20150046393A (ko) 2015-04-29
US20070117830A1 (en) 2007-05-24
ZA200607181B (en) 2007-11-28
US9777011B2 (en) 2017-10-03
US10259819B2 (en) 2019-04-16
HRP20110425T1 (en) 2011-07-31
HUE029913T2 (en) 2017-04-28
IL214050A (en) 2013-09-30
CN1960994B (zh) 2012-09-05
US20150258086A1 (en) 2015-09-17
HUE036451T2 (hu) 2018-07-30
DE602005026786D1 (de) 2011-04-21
US7129248B2 (en) 2006-10-31
EP2305683B1 (en) 2015-01-28
TW201509943A (zh) 2015-03-16
AU2005230826A1 (en) 2005-10-20
US20050222188A1 (en) 2005-10-06
US20160251365A1 (en) 2016-09-01
PL2319846T3 (pl) 2016-12-30
CA2557845A1 (en) 2005-10-20
KR20200000499A (ko) 2020-01-02
KR20090104145A (ko) 2009-10-05
JP2007531756A (ja) 2007-11-08
ES2362282T5 (es) 2021-06-24
MY154985A (en) 2015-08-28
ECSP066953A (es) 2006-12-20
CN101812065B (zh) 2012-03-28
CN101812065A (zh) 2010-08-25
WO2005097801A1 (en) 2005-10-20
PT2316837T (pt) 2018-04-02
JP2018184462A (ja) 2018-11-22
RS51693B2 (sr) 2021-02-26
ME03068B (me) 2019-01-20
NO337669B1 (no) 2016-05-30
EP1730151A1 (en) 2006-12-13
US20160185788A1 (en) 2016-06-30
US20160175300A1 (en) 2016-06-23
CN102887903B (zh) 2016-01-27
HRP20160885T1 (hr) 2016-09-23
CA2774121A1 (en) 2005-10-20
RS54941B1 (sr) 2016-11-30
US7674798B2 (en) 2010-03-09
CN102838607B (zh) 2016-08-03
US20160251364A1 (en) 2016-09-01
TWI483944B (zh) 2015-05-11
US10689389B2 (en) 2020-06-23
KR20120106784A (ko) 2012-09-26
IL213891A0 (en) 2011-07-31
US20160185790A1 (en) 2016-06-30
CY1116327T1 (el) 2017-02-08
JP2017125052A (ja) 2017-07-20
IL213890A0 (en) 2011-07-31
KR20180088505A (ko) 2018-08-03
HRP20180407T1 (hr) 2018-04-20
SG10201406658VA (en) 2014-12-30
RS57000B1 (sr) 2018-05-31
US20100152449A1 (en) 2010-06-17
KR101200700B1 (ko) 2012-11-13
US11384091B2 (en) 2022-07-12
FIU20070284U0 (fi) 2007-07-04
KR20070022033A (ko) 2007-02-23
EP2314589B1 (en) 2022-12-28
US9073933B2 (en) 2015-07-07
SI2305683T1 (sl) 2015-04-30
DK2319846T3 (en) 2016-08-15
DK2316837T3 (en) 2018-04-16
PE20050880A1 (es) 2005-11-16
KR20110110377A (ko) 2011-10-06
EP1730151B2 (en) 2020-09-16
SI1730151T2 (sl) 2021-03-31
US8822687B2 (en) 2014-09-02
DK2305683T3 (en) 2015-04-07
JP4912294B2 (ja) 2012-04-11
US7674799B2 (en) 2010-03-09
AP2232A (en) 2011-05-04
CN102127086B (zh) 2013-11-27
EP1730151B1 (en) 2011-03-09
ES2535618T3 (es) 2015-05-13
KR20100069719A (ko) 2010-06-24
ME02411B (me) 2016-09-20
MX2020008878A (es) 2020-11-09
RS53891B1 (en) 2015-08-31
PT2426132E (pt) 2016-03-31
IL213889A (en) 2012-06-28
JP5378486B2 (ja) 2013-12-25
US9522919B2 (en) 2016-12-20
ES2566363T3 (es) 2016-04-12
HRP20150358T1 (hr) 2015-05-08
IL213890A (en) 2015-10-29
CN102838607A (zh) 2012-12-26
US20200087316A1 (en) 2020-03-19
CA2913355A1 (en) 2005-10-20
EP2319846B1 (en) 2016-05-04
MY172063A (en) 2019-11-13

Similar Documents

Publication Publication Date Title
SI2426132T1 (sl) Postopek za pripravo oksikodon hidrokloridnih sestavkov z manj kot 25 ppm 14-hidroksikodeinona
HK1135389A1 (en) Process for preparing n-alkyl naltrexone halides
EP2073636A4 (en) PROCESS FOR PREPARING OXYMORPHONE
EP1751123A4 (en) PROCESS FOR PREPARING IRBESARTAN
HK1099298A1 (en) Improved process for preparing rebamipide
GB0416694D0 (en) Process for preparing microcrystals
IL179994A0 (en) Improved process for preparing imiquimod
IL183804A0 (en) Process for preparing substituted 2-alkoxycarbonyl-3-aminothiophenes
GEP20094655B (en) Process for preparing oxycodone hydrochloride having less than 25 pm 14-hydroxycodeinone
GB0409133D0 (en) Methods for preparing pharmaceutical compositions
GB0407724D0 (en) Process for preparing bicyclic compounds
GB0408249D0 (en) Improved process for tea manufacture