EA201401139A1 - Устойчивая к разрушению и к сбросу дозы фармацевтическая лекарственная форма - Google Patents

Устойчивая к разрушению и к сбросу дозы фармацевтическая лекарственная форма

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Publication number
EA201401139A1
EA201401139A1 EA201401139A EA201401139A EA201401139A1 EA 201401139 A1 EA201401139 A1 EA 201401139A1 EA 201401139 A EA201401139 A EA 201401139A EA 201401139 A EA201401139 A EA 201401139A EA 201401139 A1 EA201401139 A1 EA 201401139A1
Authority
EA
Eurasian Patent Office
Prior art keywords
destruction
sustainable
release pharmaceutical
drug form
pharmaceutical drug
Prior art date
Application number
EA201401139A
Other languages
English (en)
Inventor
Клаус Венинг
Лутц Барншайд
Зебастиан Швир
Original Assignee
Грюненталь Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Грюненталь Гмбх filed Critical Грюненталь Гмбх
Publication of EA201401139A1 publication Critical patent/EA201401139A1/ru

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/2027Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0002Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2013Organic compounds, e.g. phospholipids, fats
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/2031Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2095Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36Opioid-abuse

Abstract

Изобретение относится к устойчивой к разрушению фармацевтической лекарственной форме, содержащей фармакологически действующее вещество, заключенное в матрицу пролонгированного высвобождения, которая содержит матричный материал пролонгированного высвобождения, выбранный из группы, состоящей из неионогенных акриловых полимеров и воскообразных веществ, и которая обеспечивает пролонгированное высвобождение фармакологически действующего вещества, устойчивость к экстракции растворителем, устойчивость к измельчению и устойчивость к сбросу дозы в водный этанол.
EA201401139A 2012-04-18 2013-04-16 Устойчивая к разрушению и к сбросу дозы фармацевтическая лекарственная форма EA201401139A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12002708 2012-04-18
PCT/EP2013/057851 WO2013156453A1 (en) 2012-04-18 2013-04-16 Tamper resistant and dose-dumping resistant pharmaceutical dosage form

Publications (1)

Publication Number Publication Date
EA201401139A1 true EA201401139A1 (ru) 2015-03-31

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
EA201401139A EA201401139A1 (ru) 2012-04-18 2013-04-16 Устойчивая к разрушению и к сбросу дозы фармацевтическая лекарственная форма

Country Status (21)

Country Link
US (1) US10335373B2 (ru)
EP (1) EP2838512B1 (ru)
JP (1) JP6282261B2 (ru)
CN (1) CN104394851B (ru)
AR (1) AR090695A1 (ru)
AU (1) AU2013248351B2 (ru)
CA (1) CA2868142A1 (ru)
CY (1) CY1120783T1 (ru)
DK (1) DK2838512T3 (ru)
EA (1) EA201401139A1 (ru)
ES (1) ES2692944T3 (ru)
HK (1) HK1206647A1 (ru)
HR (1) HRP20181716T1 (ru)
LT (1) LT2838512T (ru)
MX (1) MX362357B (ru)
PL (1) PL2838512T3 (ru)
PT (1) PT2838512T (ru)
RS (1) RS57913B1 (ru)
SI (1) SI2838512T1 (ru)
TR (1) TR201815502T4 (ru)
WO (1) WO2013156453A1 (ru)

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