KR102919209B1 - 트리-펩타이드 그리고 대사, 심장혈관 및 염증성 장애의 치료 - Google Patents

트리-펩타이드 그리고 대사, 심장혈관 및 염증성 장애의 치료

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Publication number
KR102919209B1
KR102919209B1 KR1020217005207A KR20217005207A KR102919209B1 KR 102919209 B1 KR102919209 B1 KR 102919209B1 KR 1020217005207 A KR1020217005207 A KR 1020217005207A KR 20217005207 A KR20217005207 A KR 20217005207A KR 102919209 B1 KR102919209 B1 KR 102919209B1
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South Korea
Prior art keywords
glycine
gly
delete delete
nash
liver
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KR1020217005207A
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English (en)
Korean (ko)
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KR20210043588A (ko
Inventor
오렌 롬
지펑 장
잉 자오
유칭 유진 천
Original Assignee
다이아핀 테라퓨틱스, 엘엘씨
더 리젠츠 오브 더 유니버시티 오브 미시간
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Application filed by 다이아핀 테라퓨틱스, 엘엘씨, 더 리젠츠 오브 더 유니버시티 오브 미시간 filed Critical 다이아핀 테라퓨틱스, 엘엘씨
Priority to KR1020267002371A priority Critical patent/KR20260016620A/ko
Publication of KR20210043588A publication Critical patent/KR20210043588A/ko
Application granted granted Critical
Publication of KR102919209B1 publication Critical patent/KR102919209B1/ko
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020217005207A 2018-08-10 2019-08-09 트리-펩타이드 그리고 대사, 심장혈관 및 염증성 장애의 치료 Active KR102919209B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020267002371A KR20260016620A (ko) 2018-08-10 2019-08-09 트리-펩타이드 그리고 대사, 심장혈관 및 염증성 장애의 치료

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862717546P 2018-08-10 2018-08-10
US62/717,546 2018-08-10
PCT/US2019/046052 WO2020033919A1 (en) 2018-08-10 2019-08-09 Tri-peptides and treatment of metabolic, cardiovascular and inflammatory disorders

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020267002371A Division KR20260016620A (ko) 2018-08-10 2019-08-09 트리-펩타이드 그리고 대사, 심장혈관 및 염증성 장애의 치료

Publications (2)

Publication Number Publication Date
KR20210043588A KR20210043588A (ko) 2021-04-21
KR102919209B1 true KR102919209B1 (ko) 2026-01-28

Family

ID=69413710

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020217005207A Active KR102919209B1 (ko) 2018-08-10 2019-08-09 트리-펩타이드 그리고 대사, 심장혈관 및 염증성 장애의 치료
KR1020267002371A Pending KR20260016620A (ko) 2018-08-10 2019-08-09 트리-펩타이드 그리고 대사, 심장혈관 및 염증성 장애의 치료

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020267002371A Pending KR20260016620A (ko) 2018-08-10 2019-08-09 트리-펩타이드 그리고 대사, 심장혈관 및 염증성 장애의 치료

Country Status (13)

Country Link
US (2) US20210315963A1 (enExample)
EP (1) EP3833373B1 (enExample)
JP (2) JP7560061B2 (enExample)
KR (2) KR102919209B1 (enExample)
CN (1) CN112739365B (enExample)
AU (2) AU2019318209B2 (enExample)
BR (1) BR112021002207A2 (enExample)
CA (1) CA3108700A1 (enExample)
EA (1) EA202190481A1 (enExample)
IL (1) IL280698A (enExample)
MX (1) MX2021001435A (enExample)
SG (1) SG11202100993RA (enExample)
WO (1) WO2020033919A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4199895A4 (en) * 2020-08-18 2024-11-20 The Regents of The University of Michigan N-ACYL AMINO ACID PRODUCTS AND THEIR USES
CN112410355B (zh) * 2020-11-23 2022-03-25 昆明理工大学 一种酰基辅酶a氧化酶2基因rkacox2及其应用
CA3215775A1 (en) * 2021-04-20 2022-10-27 Noriyuki Inoue Combination medicine for preventing/treating dyslipidemia or cardiovascular disease
US20240148833A1 (en) * 2022-11-03 2024-05-09 EFIL BioScience Inc. Composition comprising glp-1 receptor agonist and acat inhibitor
WO2024167964A1 (en) * 2023-02-08 2024-08-15 Kowa Company, Ltd. Methods of treating and preventing peripheral artery disease
AU2023438775A1 (en) * 2023-03-17 2025-10-02 Peking University Products and methods for treating metabolic, cardiovascular, inflammatory and oncological diseases
US20260091010A1 (en) * 2024-09-30 2026-04-02 EFIL BioScience Inc. Compositions and methods for managing rebound of body weight and metabolic parameters

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003212775A (ja) * 2002-01-16 2003-07-30 Tadashi Goino 生理活性組成物
JP2014506579A (ja) * 2011-02-11 2014-03-17 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン トリペプチド組成物および糖尿病を治療する方法

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