KR102637699B1 - 변형된 fgf-21 폴리펩티드 및 그의 용도 - Google Patents
변형된 fgf-21 폴리펩티드 및 그의 용도 Download PDFInfo
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- KR102637699B1 KR102637699B1 KR1020177013555A KR20177013555A KR102637699B1 KR 102637699 B1 KR102637699 B1 KR 102637699B1 KR 1020177013555 A KR1020177013555 A KR 1020177013555A KR 20177013555 A KR20177013555 A KR 20177013555A KR 102637699 B1 KR102637699 B1 KR 102637699B1
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factor [FGF]
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1825—Fibroblast growth factor [FGF]
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Molecular Biology (AREA)
- Ophthalmology & Optometry (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Dermatology (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Pulmonology (AREA)
- Emergency Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020247005003A KR102854572B1 (ko) | 2014-10-24 | 2015-10-23 | 변형된 fgf-21 폴리펩티드 및 그의 용도 |
Applications Claiming Priority (15)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462068296P | 2014-10-24 | 2014-10-24 | |
| US201462068514P | 2014-10-24 | 2014-10-24 | |
| US201462068534P | 2014-10-24 | 2014-10-24 | |
| US201462068526P | 2014-10-24 | 2014-10-24 | |
| US201462068523P | 2014-10-24 | 2014-10-24 | |
| US62/068,526 | 2014-10-24 | ||
| US62/068,296 | 2014-10-24 | ||
| US62/068,514 | 2014-10-24 | ||
| US62/068,534 | 2014-10-24 | ||
| US62/068,523 | 2014-10-24 | ||
| US201562141383P | 2015-04-01 | 2015-04-01 | |
| US201562141337P | 2015-04-01 | 2015-04-01 | |
| US62/141,337 | 2015-04-01 | ||
| US62/141,383 | 2015-04-01 | ||
| PCT/US2015/057228 WO2016065326A2 (en) | 2014-10-24 | 2015-10-23 | Modified fgf-21 polypeptides and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020247005003A Division KR102854572B1 (ko) | 2014-10-24 | 2015-10-23 | 변형된 fgf-21 폴리펩티드 및 그의 용도 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20170070227A KR20170070227A (ko) | 2017-06-21 |
| KR102637699B1 true KR102637699B1 (ko) | 2024-02-19 |
Family
ID=54397031
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020247005003A Active KR102854572B1 (ko) | 2014-10-24 | 2015-10-23 | 변형된 fgf-21 폴리펩티드 및 그의 용도 |
| KR1020177013555A Active KR102637699B1 (ko) | 2014-10-24 | 2015-10-23 | 변형된 fgf-21 폴리펩티드 및 그의 용도 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020247005003A Active KR102854572B1 (ko) | 2014-10-24 | 2015-10-23 | 변형된 fgf-21 폴리펩티드 및 그의 용도 |
Country Status (28)
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|---|---|
| US (6) | US9434778B2 (enExample) |
| EP (3) | EP3909596A1 (enExample) |
| JP (2) | JP6702962B2 (enExample) |
| KR (2) | KR102854572B1 (enExample) |
| CN (6) | CN114805532A (enExample) |
| AU (3) | AU2015335603B2 (enExample) |
| BR (1) | BR112017008157A2 (enExample) |
| CA (1) | CA2965502A1 (enExample) |
| CL (1) | CL2017000999A1 (enExample) |
| CO (1) | CO2017004489A2 (enExample) |
| CY (1) | CY1124309T1 (enExample) |
| DK (1) | DK3412302T3 (enExample) |
| EA (1) | EA036697B1 (enExample) |
| ES (1) | ES2874331T3 (enExample) |
| HR (1) | HRP20211053T1 (enExample) |
| HU (1) | HUE055311T2 (enExample) |
| IL (2) | IL251795B (enExample) |
| LT (1) | LT3412302T (enExample) |
| MX (1) | MX2017004947A (enExample) |
| PE (1) | PE20170950A1 (enExample) |
| PL (1) | PL3412302T3 (enExample) |
| PT (1) | PT3412302T (enExample) |
| SG (2) | SG11201702824UA (enExample) |
| SI (1) | SI3412302T1 (enExample) |
| SM (1) | SMT202100388T1 (enExample) |
| TW (2) | TW202124419A (enExample) |
| UY (1) | UY36370A (enExample) |
| WO (1) | WO2016065326A2 (enExample) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2068909B1 (en) | 2007-03-30 | 2012-04-25 | Ambrx, Inc. | Modified fgf-21 polypeptides and their uses |
| US20170065678A1 (en) | 2014-03-11 | 2017-03-09 | Novartis Ag | Methods of treating metabolic disorders associated with lipodystrophies and defects in insulin production or signaling |
| KR102854572B1 (ko) | 2014-10-24 | 2025-09-02 | 브리스톨-마이어스 스큅 컴퍼니 | 변형된 fgf-21 폴리펩티드 및 그의 용도 |
| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| KR102668200B1 (ko) | 2015-10-28 | 2024-05-23 | 주식회사유한양행 | 지속형 fgf21 융합 단백질 및 이를 포함하는 약학적 조성물 |
| KR102670157B1 (ko) | 2015-10-28 | 2024-05-29 | 주식회사유한양행 | 이중 작용 단백질 및 이를 포함하는 약학적 조성물 |
| ES2827776T3 (es) | 2015-11-23 | 2021-05-24 | Bristol Myers Squibb Co | Sistemas de aditivos para uso en la PEGilación de proteínas |
| TW201731867A (zh) * | 2015-12-02 | 2017-09-16 | 賽諾菲公司 | Fgf21變異體 |
| AU2017268469C1 (en) * | 2016-05-20 | 2025-01-02 | President And Fellows Of Harvard College | Gene therapy methods for age-related diseases and conditions |
| US11318186B2 (en) | 2016-05-25 | 2022-05-03 | Board Of Regents, The University Of Texas System | Use of FGF21 in methods of increasing exocrine pancreatic secretion |
| CN106083817B (zh) * | 2016-06-14 | 2019-01-18 | 四川大学 | 吡非尼酮衍生物及其制备方法 |
| CA3034275A1 (en) * | 2016-08-22 | 2018-03-01 | Elanco Us Inc. | Bovine fibroblast growth factor 21 and ketosis in dairy cattle |
| AU2017358289C1 (en) * | 2016-11-10 | 2025-05-08 | Yuhan Corporation | Pharmaceutical composition for preventing or treating hepatitis, hepatic fibrosis, and hepatic cirrhosis comprising fusion proteins |
| US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| EP4470551A3 (en) * | 2017-03-14 | 2025-02-26 | Sunshine Lake Pharma Co., Ltd. | Dual-target fusion proteins comprising the fc portion of an immunoglobulin |
| CN108619490A (zh) * | 2017-03-22 | 2018-10-09 | 天士力医药集团股份有限公司 | 一种长效化突变的人源成纤维生长因子的新用途 |
| US11560416B2 (en) | 2017-04-21 | 2023-01-24 | Yuhan Corporation | Method for producing dual function proteins and its derivatives |
| KR102798461B1 (ko) * | 2017-08-18 | 2025-04-18 | 리제너론 파마슈티칼스 인코포레이티드 | 샘플 매트릭스에서 단백질 변이체를 분석하기 위한 이미지 모세관 등전 집속 |
| DK3678687T3 (da) * | 2017-09-04 | 2022-11-14 | 89Bio Ltd | Mutant fgf-21 peptidkonjugater og anvendelser deraf |
| EP3678686A1 (en) * | 2017-09-08 | 2020-07-15 | Bristol-Myers Squibb Company | Modified fibroblast growth factor 21 (fgf-21) for use in methods for treating nonalcoholic steatohepatitis (nash) |
| CN109806386A (zh) * | 2017-11-20 | 2019-05-28 | 江苏恒瑞医药股份有限公司 | Fxr激动剂与glp-1类似物的药物组合物和用途 |
| CN111518770B (zh) | 2017-12-19 | 2023-01-06 | 北京吉源生物科技有限公司 | 一种表达glp1和fgf21的干细胞及其用途 |
| SMT202400277T1 (it) * | 2017-12-22 | 2024-09-16 | Novartis Ag | Trattamento di disturbi metabolici con varianti di fgf21 |
| CN108434441A (zh) * | 2018-04-17 | 2018-08-24 | 哈尔滨博翱生物医药技术开发有限公司 | 新型成纤维细胞生长因子-21类似物在治疗弥漫性间质性肺脏疾病中的应用 |
| US20210275643A1 (en) * | 2018-06-21 | 2021-09-09 | Sanofi | Fgf21 compound / glp-1r agonist combinations with optimized activity ratio |
| US12226451B2 (en) * | 2018-07-03 | 2025-02-18 | Bristol-Myers Squibb Company | FGF-21 formulations |
| US12049505B2 (en) * | 2018-12-06 | 2024-07-30 | Cytomx Therapeutics, Inc. | Matrix metalloprotease-cleavable and serine or cysteine protease-cleavable substrates and methods of use thereof |
| CN109536519B (zh) * | 2018-12-21 | 2021-11-02 | 广西壮族自治区水牛研究所 | 一种在分子水平调控水牛乳腺细胞甘油酸三酯含量的方法 |
| CN111909256A (zh) * | 2019-05-10 | 2020-11-10 | 宁波鲲鹏生物科技有限公司 | 多肽衍生物及其制备方法 |
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