MX2020001818A - Isoelectroenfoque capilar con imagenes para analizar variantes de proteina en una matriz de muestra. - Google Patents

Isoelectroenfoque capilar con imagenes para analizar variantes de proteina en una matriz de muestra.

Info

Publication number
MX2020001818A
MX2020001818A MX2020001818A MX2020001818A MX2020001818A MX 2020001818 A MX2020001818 A MX 2020001818A MX 2020001818 A MX2020001818 A MX 2020001818A MX 2020001818 A MX2020001818 A MX 2020001818A MX 2020001818 A MX2020001818 A MX 2020001818A
Authority
MX
Mexico
Prior art keywords
isoelectric focusing
sample matrix
protein variants
capillary isoelectric
analyze protein
Prior art date
Application number
MX2020001818A
Other languages
English (en)
Inventor
Anu Rambhadran
Peng Cui
Clare Ryan
Paul Bigwarfe
Michele Lastro
Junyu Ma
Kun Lu
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of MX2020001818A publication Critical patent/MX2020001818A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/24—Extraction; Separation; Purification by electrochemical means
    • C07K1/26—Electrophoresis
    • C07K1/28—Isoelectric focusing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44756—Apparatus specially adapted therefor
    • G01N27/44795—Isoelectric focusing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/60—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrostatic variables, e.g. electrographic flaw testing

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • General Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Las modalidades de la presente descripción se refieren a métodos, sistemas, dispositivos y kits que corresponden a un método para analizar variantes de carga de una proteína tal como una trampa de factor de crecimiento endoteliar vascular VEGF.
MX2020001818A 2017-08-18 2018-08-17 Isoelectroenfoque capilar con imagenes para analizar variantes de proteina en una matriz de muestra. MX2020001818A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762547602P 2017-08-18 2017-08-18
PCT/US2018/046893 WO2019036604A1 (en) 2017-08-18 2018-08-17 IMAGE CAPILLARY ISOELECTRIC FOCUSING FOR ANALYSIS OF PROTEIN VARIANTS IN A SAMPLING MATRIX

Publications (1)

Publication Number Publication Date
MX2020001818A true MX2020001818A (es) 2020-07-13

Family

ID=65361327

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020001818A MX2020001818A (es) 2017-08-18 2018-08-17 Isoelectroenfoque capilar con imagenes para analizar variantes de proteina en una matriz de muestra.

Country Status (14)

Country Link
US (2) US20190056350A1 (es)
EP (1) EP3668546A4 (es)
JP (2) JP7399845B2 (es)
KR (2) KR102584848B1 (es)
CN (1) CN111132695A (es)
AR (1) AR112783A1 (es)
AU (1) AU2018317438A1 (es)
CA (1) CA3065562A1 (es)
EA (1) EA202090515A1 (es)
IL (1) IL271237A (es)
MX (1) MX2020001818A (es)
SG (1) SG11201911919PA (es)
TW (1) TWI774827B (es)
WO (1) WO2019036604A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112022006749A2 (pt) * 2019-10-10 2022-06-28 Regeneron Pharma Método para identificar uma composição de anfólito de teste com atividade adequada
TW202346856A (zh) * 2022-03-18 2023-12-01 美商里珍納龍藥品有限公司 分析多肽變體的方法及系統

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100958165B1 (ko) * 2008-05-26 2010-05-14 연세대학교 산학협력단 비젤방식의 2차원 단백질분리용 다중채널장치
FR2947632B1 (fr) * 2009-07-01 2011-11-11 Sebia Sa Analyse et dosage d'hemoglobines glyquees par electrophorese capillaire, compositions tampon et kits pour electrophorese capillaire
PL3485903T3 (pl) 2011-09-23 2023-06-12 Mereo Biopharma 5, Inc. Środki wiążące VEGF/DLL4 i ich zastosowania
WO2013166297A2 (en) 2012-05-03 2013-11-07 Medimmune, Llc Method for analyzing sample components
JP6702962B2 (ja) * 2014-10-24 2020-06-03 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ 改変ｆｇｆ−２１ポリペプチドおよびその使用
CN107148283A (zh) * 2014-10-31 2017-09-08 豪夫迈·罗氏有限公司 抗il‑17a和il‑17f交叉反应性抗体变体、包含其的组合物及其制备和使用方法
US20160144025A1 (en) * 2014-11-25 2016-05-26 Regeneron Pharmaceuticals, Inc. Methods and formulations for treating vascular eye diseases
TN2017000440A1 (en) 2015-04-17 2019-04-12 Bristol Myers Squibb Co Compositions comprising a combination of an anti-pd-1 antibody and another antibody
RU2734958C2 (ru) * 2015-11-18 2020-10-26 Формикон Аг Предварительно заполненная фармацевтическая упаковка, содержащая жидкий состав на основе антагониста vegf
EP4059492B1 (en) * 2015-12-16 2024-04-17 Regeneron Pharmaceuticals, Inc. Compositions and methods of manufacturing protein microparticles

Also Published As

Publication number Publication date
US20220317088A1 (en) 2022-10-06
IL271237A (en) 2020-01-30
JP2023145494A (ja) 2023-10-11
AU2018317438A1 (en) 2020-01-16
KR102584848B1 (ko) 2023-10-04
TW202242403A (zh) 2022-11-01
JP2020531802A (ja) 2020-11-05
US20190056350A1 (en) 2019-02-21
EA202090515A1 (ru) 2020-05-26
TWI774827B (zh) 2022-08-21
EP3668546A1 (en) 2020-06-24
WO2019036604A1 (en) 2019-02-21
CA3065562A1 (en) 2019-02-21
CN111132695A (zh) 2020-05-08
EP3668546A4 (en) 2021-05-12
KR20200078466A (ko) 2020-07-01
SG11201911919PA (en) 2020-02-27
TW201920927A (zh) 2019-06-01
AR112783A1 (es) 2019-12-11
KR20230141948A (ko) 2023-10-10
WO2019036604A9 (en) 2019-04-04
JP7399845B2 (ja) 2023-12-18

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