EA202090003A1 - Связывающие молекулы, модулирующие биологическую активность, которую проявляет клетка - Google Patents

Связывающие молекулы, модулирующие биологическую активность, которую проявляет клетка

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Publication number
EA202090003A1
EA202090003A1 EA202090003A EA202090003A EA202090003A1 EA 202090003 A1 EA202090003 A1 EA 202090003A1 EA 202090003 A EA202090003 A EA 202090003A EA 202090003 A EA202090003 A EA 202090003A EA 202090003 A1 EA202090003 A1 EA 202090003A1
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EA
Eurasian Patent Office
Prior art keywords
biological activity
cell
binding
manifestates
binding molecules
Prior art date
Application number
EA202090003A
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English (en)
Inventor
Сесилия Анна Вильгельмина Гёин
Ринсе Клостер
Корнелис Адриан Де Крёйф
Паулус Йоханнес Таккен
Марк Тросби
Тон Логтенберг
Original Assignee
Мерус Н.В.
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Publication date
Application filed by Мерус Н.В. filed Critical Мерус Н.В.
Publication of EA202090003A1 publication Critical patent/EA202090003A1/ru

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46Hybrid immunoglobulins
    • C07K16/468Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52Constant or Fc region; Isotype
    • C07K2317/526CH3 domain
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55Fab or Fab'
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/74Inducing cell proliferation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

В соответствии с изобретением предложены средства и способы ингибирования биологической активности клеток. В одном варианте реализации настоящего изобретения предложен способ ингибирования биологической активности в первой или второй клетке, опосредуемой связыванием двух мембранных белков, которые являются партнерами по связыванию друг для друга. Упомянутая биологическая активность ингибируется при контакте клеток с антителом или подобной антителу молекулой, способным связываться с каждым из упомянутых партнеров по связыванию, и данное связывание блокирует связывание двух партнеров по связыванию, тем самым ингибируя упомянутую биологическую активность.
EA202090003A 2017-07-06 2018-07-06 Связывающие молекулы, модулирующие биологическую активность, которую проявляет клетка EA202090003A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17180064 2017-07-06
PCT/NL2018/050449 WO2019009726A1 (en) 2017-07-06 2018-07-06 BINDING MOLECULES FOR MODULATING THE BIOLOGICAL ACTIVITY EXPRESSED BY A CELL

Publications (1)

Publication Number Publication Date
EA202090003A1 true EA202090003A1 (ru) 2020-06-18

Family

ID=59295094

Family Applications (1)

Application Number Title Priority Date Filing Date
EA202090003A EA202090003A1 (ru) 2017-07-06 2018-07-06 Связывающие молекулы, модулирующие биологическую активность, которую проявляет клетка

Country Status (14)

Country Link
US (2) US11667714B2 (ru)
EP (1) EP3649154A1 (ru)
JP (2) JP7438098B2 (ru)
KR (1) KR20200037791A (ru)
CN (1) CN111094347A (ru)
AU (1) AU2018296067B2 (ru)
BR (1) BR112020000209A8 (ru)
CA (1) CA3068929A1 (ru)
EA (1) EA202090003A1 (ru)
IL (1) IL271817A (ru)
PH (1) PH12020550011A1 (ru)
SG (1) SG11202000014UA (ru)
TW (1) TW201920264A (ru)
WO (1) WO2019009726A1 (ru)

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CN118027197A (zh) * 2017-07-06 2024-05-14 美勒斯公司 调节由细胞表达的生物活性的抗体
SG11202009036YA (en) * 2018-03-30 2020-10-29 Merus Nv Multivalent antibody
CA3119161A1 (en) * 2018-11-13 2020-05-22 Compass Therapeutics Llc Multispecific binding constructs against checkpoint molecules and uses thereof
TW202102544A (zh) * 2019-04-04 2021-01-16 日商小野藥品工業股份有限公司 雙特異性抗體
MX2021004897A (es) * 2019-04-26 2021-06-18 I Mab Biopharma Us Ltd Anticuerpos pd-l1 humano.
SG11202112399PA (en) 2019-05-09 2021-12-30 Merus Nv Variant domains for multimerizing proteins and separation thereof
KR102607909B1 (ko) 2020-08-19 2023-12-01 젠코어 인코포레이티드 항-cd28 조성물
CN112225813B (zh) * 2020-10-21 2021-12-21 北京智仁美博生物科技有限公司 针对破伤风毒素的抗体及其用途
AU2022214939A1 (en) * 2021-01-28 2023-07-20 Nextpoint Therapeutics, Inc. Hhla2 binding agents with novel activity
CA3211727A1 (en) * 2021-03-31 2022-10-06 Merus N.V. Novel pd-1 binding domains
AU2022251985A1 (en) 2021-03-31 2023-10-19 Merus N.V. Novel multispecific antibodies
CN114702569B (zh) * 2022-05-25 2023-01-10 深圳吉诺因生物科技有限公司 Pd-l1相关疫苗及其应用

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DE69830901T2 (de) 1997-05-02 2006-05-24 Genentech Inc., San Francisco ein verfahren zur herstellung multispezifischer antikörper die heteromultimere und gemeinsame komponenten besitzen
PT2314629E (pt) 2002-07-18 2014-01-22 Merus B V Produção recombinante de misturas de anticorpos
CN101213297B (zh) * 2005-05-09 2013-02-13 小野药品工业株式会社 程序性死亡-1(pd-1)的人单克隆抗体及单独使用或与其它免疫治疗剂联合使用抗pd-1抗体来治疗癌症的方法
CA2721093A1 (en) 2008-04-11 2009-10-15 Merrimack Pharmaceuticals, Inc. Human serum albumin linkers and conjugates thereof
SI3456190T1 (sl) 2008-06-27 2022-06-30 Merus N.V. Transgena mišja živali, ki proizvaja protitelesa
PE20120341A1 (es) 2008-12-09 2012-04-24 Genentech Inc Anticuerpos anti-pd-l1 y su uso para mejorar la funcion de celulas t
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JP6471095B2 (ja) 2012-09-27 2019-02-20 メルス ナムローゼ フェンノートシャップ T細胞エンゲージャーとしての二重特異性IgG抗体
TWI680138B (zh) * 2014-01-23 2019-12-21 美商再生元醫藥公司 抗pd-l1之人類抗體
JOP20200094A1 (ar) 2014-01-24 2017-06-16 Dana Farber Cancer Inst Inc جزيئات جسم مضاد لـ pd-1 واستخداماتها

Also Published As

Publication number Publication date
AU2018296067B2 (en) 2021-06-10
US20200325227A1 (en) 2020-10-15
TW201920264A (zh) 2019-06-01
JP2023171782A (ja) 2023-12-05
JP7438098B2 (ja) 2024-02-26
WO2019009726A1 (en) 2019-01-10
CA3068929A1 (en) 2019-01-10
CN111094347A (zh) 2020-05-01
IL271817A (en) 2020-02-27
US11667714B2 (en) 2023-06-06
KR20200037791A (ko) 2020-04-09
JP2020532280A (ja) 2020-11-12
US20240034794A1 (en) 2024-02-01
BR112020000209A2 (pt) 2020-07-21
EP3649154A1 (en) 2020-05-13
AU2018296067A1 (en) 2020-01-30
BR112020000209A8 (pt) 2020-08-11
SG11202000014UA (en) 2020-01-30
PH12020550011A1 (en) 2020-10-12

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