BR112022006749A2 - Método para identificar uma composição de anfólito de teste com atividade adequada - Google Patents

Método para identificar uma composição de anfólito de teste com atividade adequada

Info

Publication number
BR112022006749A2
BR112022006749A2 BR112022006749A BR112022006749A BR112022006749A2 BR 112022006749 A2 BR112022006749 A2 BR 112022006749A2 BR 112022006749 A BR112022006749 A BR 112022006749A BR 112022006749 A BR112022006749 A BR 112022006749A BR 112022006749 A2 BR112022006749 A2 BR 112022006749A2
Authority
BR
Brazil
Prior art keywords
ampholyte
test
composition
identify
adequate activity
Prior art date
Application number
BR112022006749A
Other languages
English (en)
Inventor
Mullen Rachel
Ryan Clare
O'connor Seamus
Helming Stacey
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of BR112022006749A2 publication Critical patent/BR112022006749A2/pt

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44756—Apparatus specially adapted therefor
    • G01N27/44795—Isoelectric focusing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44704—Details; Accessories
    • G01N27/44747—Composition of gel or of carrier mixture
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/62—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
    • G01N27/622—Ion mobility spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/86—Signal analysis
    • G01N30/8624—Detection of slopes or peaks; baseline correction
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
    • G16C20/00—Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
    • G16C20/20—Identification of molecular entities, parts thereof or of chemical compositions
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N2030/022—Column chromatography characterised by the kind of separation mechanism
    • G01N2030/027—Liquid chromatography

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Electrochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Computing Systems (AREA)
  • Theoretical Computer Science (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)

Abstract

MÉTODO PARA IDENTIFICAR UMA COMPOSIÇÃO DE ANFÓLITO DE TESTE COM ATIVIDADE ADEQUADA. A divulgação refere-se a métodos de caracterização de composições de anfólitos adequadas para aplicações a jusante, como focagem isoelétrica capilar usando cromatografia líquida-espectrometria de massa.
BR112022006749A 2019-10-10 2020-10-09 Método para identificar uma composição de anfólito de teste com atividade adequada BR112022006749A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962913450P 2019-10-10 2019-10-10
PCT/US2020/055031 WO2021072230A1 (en) 2019-10-10 2020-10-09 Liquid chromatography-mass spectrometry (lc-ms) methods for analyzing ampholyte lot variation

Publications (1)

Publication Number Publication Date
BR112022006749A2 true BR112022006749A2 (pt) 2022-06-28

Family

ID=73172803

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112022006749A BR112022006749A2 (pt) 2019-10-10 2020-10-09 Método para identificar uma composição de anfólito de teste com atividade adequada

Country Status (11)

Country Link
US (1) US20210109063A1 (pt)
EP (1) EP4042151A1 (pt)
JP (1) JP2022552266A (pt)
KR (1) KR20220078610A (pt)
CN (2) CN118032980A (pt)
AU (1) AU2020364006A1 (pt)
BR (1) BR112022006749A2 (pt)
CA (1) CA3153535A1 (pt)
IL (1) IL291806A (pt)
MX (1) MX2022004356A (pt)
WO (1) WO2021072230A1 (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023059595A1 (en) * 2021-10-08 2023-04-13 Intabio, Llc Software for microfluidic systems interfacing with mass spectrometry

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5605798A (en) 1993-01-07 1997-02-25 Sequenom, Inc. DNA diagnostic based on mass spectrometry
DE69432791T2 (de) 1993-05-28 2004-06-03 Baylor College Of Medicine, Houston Verfahren und massenspektrometer zur desorption und ionisierung von analyten
US5879670A (en) * 1997-03-31 1999-03-09 Calgon Corporation Ampholyte polymers for use in personal care products
GB9717926D0 (en) 1997-08-22 1997-10-29 Micromass Ltd Methods and apparatus for tandem mass spectrometry
WO1999038194A1 (en) 1998-01-23 1999-07-29 Analytica Of Branford, Inc. Mass spectrometry from surfaces
WO2007139956A2 (en) * 2006-05-26 2007-12-06 Laboratory Corporation Of America Holdings Methods and systems for the quantitative analysis of biomarkers
CN104067116B (zh) * 2011-11-02 2017-03-08 莱克公司 离子迁移率谱仪
CA2948823C (en) 2014-05-12 2020-09-22 Quest Diagnostics Investments Incorporated Quantitation of tamoxifen and metabolites thereof by mass spectrometry
WO2016115561A1 (en) * 2015-01-18 2016-07-21 Biogen Ma Inc. Formulations and screening of biological therapeutic agents
CN106932459A (zh) * 2015-12-31 2017-07-07 深圳翰宇药业股份有限公司 一种多肽聚合物毛细管等电聚焦分析方法
EP3668546A4 (en) * 2017-08-18 2021-05-12 Regeneron Pharmaceuticals, Inc. IMAGE CAPILLARY ISOELECTRIC FOCUSING FOR ANALYSIS OF PROTEIN VARIANTS IN A SAMPLING MATRIX

Also Published As

Publication number Publication date
AU2020364006A2 (en) 2022-07-21
IL291806A (en) 2022-06-01
AU2020364006A1 (en) 2022-05-05
CN114585915A (zh) 2022-06-03
JP2022552266A (ja) 2022-12-15
CN118032980A (zh) 2024-05-14
US20210109063A1 (en) 2021-04-15
CA3153535A1 (en) 2021-04-15
WO2021072230A1 (en) 2021-04-15
CN114585915B (zh) 2024-02-23
MX2022004356A (es) 2022-04-27
EP4042151A1 (en) 2022-08-17
KR20220078610A (ko) 2022-06-10

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