BR112021024111A2 - Determinação de antidepressivos por espetrometria de massa - Google Patents

Determinação de antidepressivos por espetrometria de massa

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Publication number
BR112021024111A2
BR112021024111A2 BR112021024111A BR112021024111A BR112021024111A2 BR 112021024111 A2 BR112021024111 A2 BR 112021024111A2 BR 112021024111 A BR112021024111 A BR 112021024111A BR 112021024111 A BR112021024111 A BR 112021024111A BR 112021024111 A2 BR112021024111 A2 BR 112021024111A2
Authority
BR
Brazil
Prior art keywords
antidepressants
mass spectrometry
determination
antidepressant
metabolites
Prior art date
Application number
BR112021024111A
Other languages
English (en)
Inventor
Anita Dermartirosian
Asad Shah
Edith Shahbol
Karin Thomassian
Shaun Rezaei
Original Assignee
Quest Diagnostics Invest Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Quest Diagnostics Invest Llc filed Critical Quest Diagnostics Invest Llc
Publication of BR112021024111A2 publication Critical patent/BR112021024111A2/pt

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/493—Physical analysis of biological material of liquid biological material urine
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N2030/042—Standards
    • G01N2030/045—Standards internal
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/06—Preparation
    • G01N30/08—Preparation using an enricher
    • G01N2030/085—Preparation using an enricher using absorbing precolumn
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N2030/626—Detectors specially adapted therefor calibration, baseline
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8804—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 automated systems
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/78—Detectors specially adapted therefor using more than one detector
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G01N33/492—Determining multiple analytes

Abstract

determinação de antidepressivos por espetrometria de massa. a presente invenção refere-se a métodos que são descritos para detectar ou determinar a quantidade de antidepressivos e/ou metabólitos antidepressivos em uma amostra. mais especificamente, métodos de espectrometria de massa são descritos para detectar e quantificar antidepressivos e/ou metabólitos antidepressivos em uma amostra.
BR112021024111A 2019-05-31 2020-05-29 Determinação de antidepressivos por espetrometria de massa BR112021024111A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962855863P 2019-05-31 2019-05-31
PCT/US2020/035233 WO2020243503A1 (en) 2019-05-31 2020-05-29 Determination of antidepressants by mass spectrometry

Publications (1)

Publication Number Publication Date
BR112021024111A2 true BR112021024111A2 (pt) 2022-03-22

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
BR112021024111A BR112021024111A2 (pt) 2019-05-31 2020-05-29 Determinação de antidepressivos por espetrometria de massa

Country Status (8)

Country Link
US (2) US11887828B2 (pt)
EP (1) EP3977138A4 (pt)
JP (1) JP2022534288A (pt)
CN (1) CN114127554A (pt)
BR (1) BR112021024111A2 (pt)
CA (1) CA3141326A1 (pt)
MX (1) MX2021014426A (pt)
WO (1) WO2020243503A1 (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110806449B (zh) * 2019-11-29 2023-03-28 济南和合医学检验有限公司 同时检测血液中氯米帕明和n-去甲氯米帕明含量的方法
CN112578059A (zh) * 2020-12-14 2021-03-30 北京和合医学诊断技术股份有限公司 氟西汀和去甲氟西汀的检测方法
CN112697919B (zh) * 2020-12-22 2023-02-28 北京和合医学诊断技术股份有限公司 度洛西汀的检测方法
CN114965720B (zh) * 2021-02-20 2024-02-23 成都康弘药业集团股份有限公司 一种测定氢溴酸伏硫西汀有关物质的方法
CN113075340A (zh) * 2021-05-14 2021-07-06 华农（肇庆）生物产业技术研究院有限公司 一种高效液相色谱法测定宠物血浆中米氮平浓度的方法
CN114994198B (zh) * 2022-05-20 2023-02-28 上海市精神卫生中心（上海市心理咨询培训中心） 一种液相色谱质谱联用法同时定量检测78种神经精神类药物的方法
CN114778747B (zh) * 2022-06-23 2022-09-02 北京和合医学诊断技术股份有限公司 Uplc-ms/ms法同时检测血液中16种药物及其代谢物的方法
CN115078610A (zh) * 2022-07-22 2022-09-20 郑州大学第一附属医院 一种检测体液中疏水性药物含量的方法
CN116148401B (zh) * 2023-04-20 2023-07-07 广东省科学院微生物研究所(广东省微生物分析检测中心) 一种同步高效检测污泥中36种抗抑郁药物残留量的方法

Family Cites Families (6)

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Publication number Priority date Publication date Assignee Title
EP3570036A1 (en) 2010-10-29 2019-11-20 Cohesive Technologies Inc. Lc-ms configuration for purification and detection of analytes having a broad range of hydrophobicities
US20180017580A1 (en) 2014-12-05 2018-01-18 Myriad Genetics, Inc. Biomarkers for distinguishing mood disorders
WO2016112467A1 (en) 2015-01-15 2016-07-21 Centre For Addiction And Mental Health Peripheral measure of central brain inflammation, markers therefor and uses thereof
US9817006B2 (en) 2015-06-19 2017-11-14 Amy J. Reisinger Rapid and sensitive method of forensic toxicology in post-mortem subjects using oral fluid testing
WO2018078018A2 (en) 2016-10-27 2018-05-03 Glostrup Hospital Detection of hypocretin-1 and -2
CN109890293B (zh) 2016-10-28 2023-06-13 苏尔吉维索公司 用于确定x射线成像系统的轨迹的方法和系统

Also Published As

Publication number Publication date
CA3141326A1 (en) 2020-12-03
EP3977138A1 (en) 2022-04-06
WO2020243503A1 (en) 2020-12-03
EP3977138A4 (en) 2023-08-30
WO2020243503A9 (en) 2021-01-07
US20200381228A1 (en) 2020-12-03
US11887828B2 (en) 2024-01-30
US20240120188A1 (en) 2024-04-11
MX2021014426A (es) 2022-01-18
JP2022534288A (ja) 2022-07-28
CN114127554A (zh) 2022-03-01

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