BRPI0917497B8 - métodos para medir a quantidade de angiotensina 1 e a atividade da renina em uma amostra - Google Patents

métodos para medir a quantidade de angiotensina 1 e a atividade da renina em uma amostra

Info

Publication number
BRPI0917497B8
BRPI0917497B8 BRPI0917497A BRPI0917497A BRPI0917497B8 BR PI0917497 B8 BRPI0917497 B8 BR PI0917497B8 BR PI0917497 A BRPI0917497 A BR PI0917497A BR PI0917497 A BRPI0917497 A BR PI0917497A BR PI0917497 B8 BRPI0917497 B8 BR PI0917497B8
Authority
BR
Brazil
Prior art keywords
angiotensin
sample
amount
measuring
methods
Prior art date
Application number
BRPI0917497A
Other languages
English (en)
Inventor
E Bystrom Cory
J Clarke Nigel
E Reitz Richard
Original Assignee
Quest Diagnostics Invest Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41652003&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0917497(B8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Quest Diagnostics Invest Inc filed Critical Quest Diagnostics Invest Inc
Publication of BRPI0917497A2 publication Critical patent/BRPI0917497A2/pt
Publication of BRPI0917497B1 publication Critical patent/BRPI0917497B1/pt
Publication of BRPI0917497B8 publication Critical patent/BRPI0917497B8/pt

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96402—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from non-mammals
    • G01N2333/96405—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from non-mammals in general
    • G01N2333/96408—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from non-mammals in general with EC number
    • G01N2333/96416—Aspartic endopeptidases (3.4.23)

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

método para medir a quantidade de angiotensina 1 e a atividade da renina em uma amostra. a presente invenção refere-se a métodos para medir a atividade da renina em uma amostra de plasma usando a espectrometria de massa. os métodos em geral envolvem ionizar a angiotensina 1 purificada a partir da amostra e detectar a quantidade de íons de angiotensina 1 gerados. a quantidade de íons de angiotensina 1 detectados é então relacionada à quantidade de angiotensina 1 gerada na amostra, a qual, por sua vez, é relacionada à atividade da renina na amostra.
BRPI0917497A 2008-08-08 2009-08-07 métodos para medir a quantidade de angiotensina 1 e a atividade da renina em uma amostra BRPI0917497B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12/189,092 US7834313B2 (en) 2008-08-08 2008-08-08 Mass spectrometry assay for plasma-renin
PCT/US2009/053189 WO2010017499A1 (en) 2008-08-08 2009-08-07 Mass spectrometry assay for plasma-renin

Publications (3)

Publication Number Publication Date
BRPI0917497A2 BRPI0917497A2 (pt) 2015-12-01
BRPI0917497B1 BRPI0917497B1 (pt) 2020-01-28
BRPI0917497B8 true BRPI0917497B8 (pt) 2021-07-27

Family

ID=41652003

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0917497A BRPI0917497B8 (pt) 2008-08-08 2009-08-07 métodos para medir a quantidade de angiotensina 1 e a atividade da renina em uma amostra

Country Status (7)

Country Link
US (1) US7834313B2 (pt)
EP (2) EP2565905B1 (pt)
JP (5) JP5373902B2 (pt)
CN (2) CN103743848B (pt)
BR (1) BRPI0917497B8 (pt)
CA (1) CA2732109C (pt)
WO (1) WO2010017499A1 (pt)

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US7834313B2 (en) * 2008-08-08 2010-11-16 Quest Diagnostics Investments Incorporated Mass spectrometry assay for plasma-renin
US8106351B2 (en) * 2008-08-08 2012-01-31 Quest Diagnostics Investments Incorporated Mass spectrometry assay for plasma-renin
JP5675442B2 (ja) * 2011-03-04 2015-02-25 株式会社日立ハイテクノロジーズ 質量分析方法及び質量分析装置
RU2014118941A (ru) * 2011-10-13 2015-11-20 Конинклейке Филипс Н.В. Автоматическая генерация рейтинговых запросов от рекомендательной системы
EP3647790A1 (en) * 2012-06-06 2020-05-06 Attoquant Diagnostics GmbH Method for measurement of peptidic degradation products of a proteolytic cascade in blood samples
WO2015175561A1 (en) 2014-05-12 2015-11-19 Quest Diagnostics Investments Incorporated Quantitation of tamoxifen and metabolites thereof by mass spectrometry
JP6198693B2 (ja) * 2014-08-06 2017-09-20 三菱電機株式会社 リモコン装置
CN109964131A (zh) * 2016-11-17 2019-07-02 美国控股实验室公司 用于测量血浆肾素活性的方法和系统
JP7067758B2 (ja) * 2017-06-30 2022-05-16 国立大学法人 新潟大学 試料中のアンジオテンシンペプチドの量を測定するための方法及びアンジオテンシンペプチドの定量キット
CN110243917A (zh) * 2018-03-09 2019-09-17 中国科学院天津工业生物技术研究所 一种快速检测小分子化合物的方法
JP7326356B2 (ja) * 2018-03-16 2023-08-15 クエスト ダイアグノスティックス インヴェストメンツ エルエルシー 多重化した患者サンプル中のテストステロンのマススペクトロメトリーによる決定
CN112014509A (zh) * 2020-09-03 2020-12-01 复旦大学附属中山医院 同步测定样品中血管紧张素i和醛固酮的方法
CN117647606A (zh) * 2024-01-30 2024-03-05 西湖欧米(杭州)生物科技有限公司 适于lc-ms/ms能同时检测多种蛋白的试剂盒

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Also Published As

Publication number Publication date
BRPI0917497B1 (pt) 2020-01-28
EP2565905A3 (en) 2013-04-17
JP6396525B2 (ja) 2018-09-26
JP6110469B2 (ja) 2017-04-05
CN103743848B (zh) 2015-11-18
JP5855062B2 (ja) 2016-02-09
US7834313B2 (en) 2010-11-16
JP5373902B2 (ja) 2013-12-18
CN102112857B (zh) 2013-11-06
JP2014013258A (ja) 2014-01-23
WO2010017499A1 (en) 2010-02-11
CA2732109C (en) 2016-01-19
JP7154887B2 (ja) 2022-10-18
EP2565905B1 (en) 2015-12-30
EP2310824A1 (en) 2011-04-20
JP2019039923A (ja) 2019-03-14
CN103743848A (zh) 2014-04-23
JP2011530701A (ja) 2011-12-22
US20100032558A1 (en) 2010-02-11
JP2017151111A (ja) 2017-08-31
CA2732109A1 (en) 2010-02-11
EP2310824B1 (en) 2013-06-26
JP2016075698A (ja) 2016-05-12
EP2565905A2 (en) 2013-03-06
BRPI0917497A2 (pt) 2015-12-01
EP2310824A4 (en) 2011-10-05
CN102112857A (zh) 2011-06-29

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Ipc: G01N 33/68 (1980.01)

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
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