MX2017011312A - Metodos para la cuantificacion de los niveles de insulina por espectrometria de masas. - Google Patents
Metodos para la cuantificacion de los niveles de insulina por espectrometria de masas.Info
- Publication number
- MX2017011312A MX2017011312A MX2017011312A MX2017011312A MX2017011312A MX 2017011312 A MX2017011312 A MX 2017011312A MX 2017011312 A MX2017011312 A MX 2017011312A MX 2017011312 A MX2017011312 A MX 2017011312A MX 2017011312 A MX2017011312 A MX 2017011312A
- Authority
- MX
- Mexico
- Prior art keywords
- methods
- mass spectrometric
- quantitation
- mass spectrometry
- insulin levels
- Prior art date
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 8
- 238000000034 method Methods 0.000 title abstract 6
- 102000004877 Insulin Human genes 0.000 title abstract 4
- 108090001061 Insulin Proteins 0.000 title abstract 4
- 229940125396 insulin Drugs 0.000 title abstract 4
- 238000004949 mass spectrometry Methods 0.000 title abstract 3
- 239000012472 biological sample Substances 0.000 abstract 2
- 238000000746 purification Methods 0.000 abstract 2
- VOUAQYXWVJDEQY-QENPJCQMSA-N 33017-11-7 Chemical compound OC(=O)CC[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)NCC(=O)NCC(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(O)=O)CCC1 VOUAQYXWVJDEQY-QENPJCQMSA-N 0.000 abstract 1
- 108010075254 C-Peptide Proteins 0.000 abstract 1
- 239000000523 sample Substances 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/62—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
- G01N27/64—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode using wave or particle radiation to ionise a gas, e.g. in an ionisation chamber
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6848—Methods of protein analysis involving mass spectrometry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
- G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
- G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/575—Hormones
- G01N2333/62—Insulins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2560/00—Chemical aspects of mass spectrometric analysis of biological material
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/04—Endocrine or metabolic disorders
- G01N2800/042—Disorders of carbohydrate metabolism, e.g. diabetes, glucose metabolism
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/62—Detectors specially adapted therefor
- G01N30/72—Mass spectrometers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Bioinformatics & Computational Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Ecology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Electrochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Toxicology (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
Abstract
Se describen métodos para determinar la cantidad de insulina en una muestra. En el presente documento se proporcionan métodos espectrométricos de masas para detectar y cuantificar insulina y péptido C en una muestra biológica al utilizar métodos de enriquecimiento y/o purificación acoplados con técnicas espectrométricas de masas en tándem o técnicas espectrométricas de masas de alta resolución/alta exactitud. También en el presente documento se proporcionan métodos espectrométricos de masas para detectar y cuantificar insulina y cadena B en una muestra biológica al utilizar métodos de enriquecimiento y/o purificación acoplados con técnicas espectrométricas de masas en tándem o técnicas espectrométricas de masas de alta resolución/alta exactitud.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562127770P | 2015-03-03 | 2015-03-03 | |
US201562128236P | 2015-03-04 | 2015-03-04 | |
PCT/US2016/020723 WO2016141204A1 (en) | 2015-03-03 | 2016-03-03 | Methods for quantitation of insulin levels by mass spectrometry |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2017011312A true MX2017011312A (es) | 2018-04-30 |
Family
ID=56848765
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2017011312A MX2017011312A (es) | 2015-03-03 | 2016-03-03 | Metodos para la cuantificacion de los niveles de insulina por espectrometria de masas. |
Country Status (8)
Country | Link |
---|---|
US (3) | US10324082B2 (es) |
EP (2) | EP3796004B1 (es) |
JP (1) | JP2018511812A (es) |
CN (2) | CN116298029A (es) |
BR (1) | BR112017018821B1 (es) |
CA (1) | CA2978570C (es) |
MX (1) | MX2017011312A (es) |
WO (1) | WO2016141204A1 (es) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3091562B1 (en) | 2010-12-28 | 2019-01-30 | Quest Diagnostics Investments LLC | Quantitation of insulin by mass spectrometry |
US10704021B2 (en) | 2012-03-15 | 2020-07-07 | Flodesign Sonics, Inc. | Acoustic perfusion devices |
WO2014105858A1 (en) * | 2012-12-26 | 2014-07-03 | Quest Diagnostics Investments Incorporated | C peptide detection by mass spectrometry |
WO2015105955A1 (en) | 2014-01-08 | 2015-07-16 | Flodesign Sonics, Inc. | Acoustophoresis device with dual acoustophoretic chamber |
US10324082B2 (en) * | 2015-03-03 | 2019-06-18 | Quest Diagnostics Investments Llc | Methods for quantitation of insulin levels by mass spectrometry |
US11377651B2 (en) | 2016-10-19 | 2022-07-05 | Flodesign Sonics, Inc. | Cell therapy processes utilizing acoustophoresis |
US11708572B2 (en) | 2015-04-29 | 2023-07-25 | Flodesign Sonics, Inc. | Acoustic cell separation techniques and processes |
KR20180103961A (ko) * | 2016-01-23 | 2018-09-19 | 바이오콘 리미티드 | 인슐린 유사체에 대한 생물학적 분석 방법 |
US11214789B2 (en) | 2016-05-03 | 2022-01-04 | Flodesign Sonics, Inc. | Concentration and washing of particles with acoustics |
BR112019020473A2 (pt) * | 2017-03-31 | 2020-04-28 | Quest Diagnostics Invest Llc | métodos para quantificação de insulina e c-peptídeo |
DK3422005T3 (da) * | 2017-06-27 | 2020-07-27 | Univ Graz Medizinische | Bestemmelse af berigelser af glukosesporstoffer ved massespektrometri |
CA3085784A1 (en) | 2017-12-14 | 2019-06-20 | Flodesign Sonics, Inc. | Acoustic transducer driver and controller |
MX2020009618A (es) | 2018-03-16 | 2020-12-07 | Quest Diagnostics Invest Llc | Métodos para detectar cromogranina a por espectrometría de masas. |
CN108693280A (zh) * | 2018-08-23 | 2018-10-23 | 重庆美莱德生物医药有限公司 | 通过uplc-ms/ms定量测定生物样品中德谷胰岛素含量的方法 |
CN109061196A (zh) * | 2018-09-25 | 2018-12-21 | 王毅超 | 一种基于硅纳米颗粒-质谱联合检测胰岛素的方法 |
CN109991351A (zh) * | 2019-03-27 | 2019-07-09 | 苏州旭辉检测有限公司 | 一种血液样本中胰岛素类似物的检测方法 |
CN113906293A (zh) * | 2019-05-31 | 2022-01-07 | 株式会社新日本科学 | 使用色谱质谱分析装置的质谱分析方法 |
CN113075342B (zh) * | 2020-01-04 | 2024-02-27 | 东莞市东阳光仿制药研发有限公司 | 一种分离检测德谷胰岛素侧链有关物质的方法 |
CN111366646B (zh) * | 2020-02-27 | 2022-09-23 | 苏州新波生物技术有限公司 | 一种基于免疫纯化结合质谱检测的25-羟维生素d分析方法 |
WO2023205281A1 (en) * | 2022-04-20 | 2023-10-26 | Siemens Healthcare Diagnostics Inc. | Quantitation of alkylphenol ethoxylate compounds in aqueous samples |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5605798A (en) | 1993-01-07 | 1997-02-25 | Sequenom, Inc. | DNA diagnostic based on mass spectrometry |
ES2201077T3 (es) | 1993-05-28 | 2004-03-16 | Baylor College Of Medicine | Metodo y espectrometro de masas para la desorcion e ionizacion de analitos. |
US5772874A (en) | 1995-11-02 | 1998-06-30 | Cohesive Technologies, Inc. | High performance liquid chromatography method and apparatus |
ATE184702T1 (de) | 1996-01-19 | 1999-10-15 | Cohesive Tech Inc | Hochleistungsflüssigchromatographieverfahren und vorrichtung |
GB9717926D0 (en) | 1997-08-22 | 1997-10-29 | Micromass Ltd | Methods and apparatus for tandem mass spectrometry |
WO1999038194A1 (en) | 1998-01-23 | 1999-07-29 | Analytica Of Branford, Inc. | Mass spectrometry from surfaces |
US6680203B2 (en) | 2000-07-10 | 2004-01-20 | Esperion Therapeutics, Inc. | Fourier transform mass spectrometry of complex biological samples |
GB2404784B (en) | 2001-03-23 | 2005-06-22 | Thermo Finnigan Llc | Mass spectrometry method and apparatus |
US7196323B2 (en) | 2002-02-28 | 2007-03-27 | Metanomics Gmbh & Co. Kgaa | Mass spectrometry method for analyzing mixtures of substances |
AU2006235320A1 (en) | 2005-04-05 | 2006-10-19 | Protein Discovery, Inc. | Improved methods and devices for concentration and fractionation of analytes for chemical analysis including Matrix-Assisted Laser Desorption/Ionization (MALDI) Mass Spectrometry (MS) |
WO2006124713A2 (en) | 2005-05-13 | 2006-11-23 | Microbia, Inc. | 4-biarylyl-1-phenylazetidin-2-ones |
JP2009540856A (ja) | 2006-06-27 | 2009-11-26 | バイオリポックス エービー | エオキシン形成の修飾物質の同定方法 |
KR101409436B1 (ko) | 2006-11-09 | 2014-06-24 | 알콘 리서치, 리미티드 | 수불용성 폴리머 매트릭스를 포함하는 누점마개 |
WO2008150488A1 (en) | 2007-06-01 | 2008-12-11 | Laboratory Corporation Of America Holdings | Methods and systems for quantification of peptides and other analytes |
US20090035807A1 (en) * | 2007-07-31 | 2009-02-05 | Wyeth | Analysis of polypeptide production |
EP2231602A1 (en) | 2007-12-13 | 2010-09-29 | Amgen, Inc | Gamma secretase modulators |
US8871527B2 (en) | 2008-04-29 | 2014-10-28 | Becton, Dickinson And Company | Method and system for measuring a sample to determine the presence of and optionally treat a pathologic condition |
CA2763749A1 (en) | 2009-06-05 | 2010-12-09 | Mcmaster University | Synthesis and use of radiolabelled insulin analogues |
EP3091562B1 (en) | 2010-12-28 | 2019-01-30 | Quest Diagnostics Investments LLC | Quantitation of insulin by mass spectrometry |
US8669519B2 (en) | 2011-12-05 | 2014-03-11 | Quest Diagnostics Investments, Inc. | Methods for detecting reverse triiodothyronine by mass spectrometry |
CN103454433B (zh) * | 2012-06-05 | 2016-08-03 | 许洋 | 一种新型检测内外源性胰岛素的免疫质谱试剂盒 |
WO2014105858A1 (en) | 2012-12-26 | 2014-07-03 | Quest Diagnostics Investments Incorporated | C peptide detection by mass spectrometry |
US10324082B2 (en) * | 2015-03-03 | 2019-06-18 | Quest Diagnostics Investments Llc | Methods for quantitation of insulin levels by mass spectrometry |
-
2016
- 2016-03-02 US US15/059,247 patent/US10324082B2/en active Active
- 2016-03-03 JP JP2017564761A patent/JP2018511812A/ja active Pending
- 2016-03-03 EP EP20206370.7A patent/EP3796004B1/en active Active
- 2016-03-03 MX MX2017011312A patent/MX2017011312A/es unknown
- 2016-03-03 CA CA2978570A patent/CA2978570C/en active Active
- 2016-03-03 BR BR112017018821-0A patent/BR112017018821B1/pt active IP Right Grant
- 2016-03-03 EP EP16759509.9A patent/EP3265805B1/en active Active
- 2016-03-03 WO PCT/US2016/020723 patent/WO2016141204A1/en active Application Filing
- 2016-03-03 CN CN202211298738.1A patent/CN116298029A/zh active Pending
- 2016-03-03 CN CN201680025350.0A patent/CN107548460A/zh active Pending
-
2019
- 2019-06-17 US US16/442,894 patent/US11486874B2/en active Active
-
2022
- 2022-10-31 US US17/977,976 patent/US20230184740A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
CA2978570C (en) | 2023-09-19 |
CA2978570A1 (en) | 2016-09-09 |
BR112017018821A2 (pt) | 2018-04-24 |
EP3265805A4 (en) | 2018-08-15 |
EP3265805B1 (en) | 2020-11-11 |
EP3265805A1 (en) | 2018-01-10 |
CN116298029A (zh) | 2023-06-23 |
BR112017018821B1 (pt) | 2022-07-26 |
JP2018511812A (ja) | 2018-04-26 |
US20160282328A1 (en) | 2016-09-29 |
US20230184740A1 (en) | 2023-06-15 |
CN107548460A (zh) | 2018-01-05 |
US10324082B2 (en) | 2019-06-18 |
US20190302095A1 (en) | 2019-10-03 |
WO2016141204A1 (en) | 2016-09-09 |
EP3796004A1 (en) | 2021-03-24 |
EP3796004B1 (en) | 2023-07-12 |
US11486874B2 (en) | 2022-11-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX2017011312A (es) | Metodos para la cuantificacion de los niveles de insulina por espectrometria de masas. | |
MX2019011775A (es) | Metodos para la cuantificacion de insulina y peptido c. | |
WO2012092281A3 (en) | Quantitation of insulin by mass spectrometry | |
EP3862439A3 (en) | Liver cancer detection kit or device, and detection method | |
EP3757225A3 (en) | Pancreatic cancer detection kit or device, and detection method | |
GB2521579A (en) | Mass spectrometer, system comprising the same, and methods for determining isotopic anatomy of compounds | |
SI3138489T1 (sl) | Komplet za določanje koncentracije analita | |
EP4250336A3 (en) | Methods for detecting estradiol by mass spectrometry | |
EP3654036A3 (en) | Stomach cancer biomarker and detection method | |
WO2018072862A8 (de) | Verfahren zum auswerten von daten einer massenspektrometrie und massenspektrometrisches verfahren sowie ein maldi tof massenspektrometer | |
BR112013015504A2 (pt) | dispositivo de amostragem para um espectrômetro de migração de íon, método para introduzir uma amostra de gás a ser detectada pelo uso do dispositivo, e, espectrômetro de migração de íon | |
MX2018014867A (es) | Metodo de espectrometria de masa para deteccion y cuantificacion de metabolitos. | |
MX2018013686A (es) | Abundancia fraccional de secuencias de polinucleotidos en una muestra. | |
WO2013026026A3 (en) | Shift correction for spectral analysis | |
EP3612094A4 (en) | DETECTION AND CORRECTION OF CHANGES TO AN ANALYT INDICATOR | |
MX2011003653A (es) | Metodos para detectar dihidrotestosterona mediante espectrometria de masa. | |
BR112014012366A2 (pt) | processos para a detecção de triiodotironina inversa por espectrometria de massa | |
EP3438277A4 (en) | PROCESS FOR DETERMINING WHETHER A TEST PROCEDURE CONTAINS PHYTOPATHOGENIC MUSHROOMS OR NOT | |
MX2016011807A (es) | Membrana sensible al magnesio para un electrodo potenciometrico de ion selectivo para medicion de magnesio ionizado y metodos de produccion y uso de la misma. | |
MX2015013310A (es) | Metodo y reactivo para determinar metabolitos de la vitamina d. | |
EP3252462A4 (en) | Method for measuring liquid samples, and liquid sample sensor | |
BR112017024043A2 (pt) | sistema aparelho e método para medir concentração de íons com uma correção de desvio padrão. | |
BR112016000231A8 (pt) | métodos para identificações de condições de separação com cromatografia de troca de íons e para análises de composições de polipeptídeos | |
EP3208333A4 (en) | Method for detecting and quantifying target nucleic acid in test sample using novel positive control nucleic acid | |
MX2020001830A (es) | Deteccion y cuantificacion de guanidinoacetato, creatina, y creatinina mediante espectrometria de masas. |