EP4250336A3 - Methods for detecting estradiol by mass spectrometry - Google Patents

Methods for detecting estradiol by mass spectrometry Download PDF

Info

Publication number
EP4250336A3
EP4250336A3 EP23186684.9A EP23186684A EP4250336A3 EP 4250336 A3 EP4250336 A3 EP 4250336A3 EP 23186684 A EP23186684 A EP 23186684A EP 4250336 A3 EP4250336 A3 EP 4250336A3
Authority
EP
European Patent Office
Prior art keywords
methods
mass spectrometry
estradiol
detecting estradiol
detecting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP23186684.9A
Other languages
German (de)
French (fr)
Other versions
EP4250336A2 (en
Inventor
Mildred M. Goldman
Nigel J. Clarke
Richard E. Reitz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Quest Diagnostics Investments LLC
Original Assignee
Quest Diagnostics Investments LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40668902&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EP4250336(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Quest Diagnostics Investments LLC filed Critical Quest Diagnostics Investments LLC
Publication of EP4250336A2 publication Critical patent/EP4250336A2/en
Publication of EP4250336A3 publication Critical patent/EP4250336A3/en
Pending legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G01N33/743—Steroid hormones
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G01N33/6851—Methods of protein analysis involving laser desorption ionisation mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/0027—Methods for using particle spectrometers
    • H01J49/0031—Step by step routines describing the use of the apparatus
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0431—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for liquid samples

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Endocrinology (AREA)
  • Optics & Photonics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)

Abstract

Provided are methods for determining the amount of estradiol in a sample using mass spectrometry. The methods generally involve ionizing estradiol in a sample and detecting and quantifying the amount of the ion to determine the amount of estradiol in the sample.
EP23186684.9A 2007-11-27 2008-11-24 Methods for detecting estradiol by mass spectrometry Pending EP4250336A3 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US11/946,017 US20090134325A1 (en) 2007-11-27 2007-11-27 Methods for detecting estradiol by mass spectrometry
EP14169040.4A EP2777792B1 (en) 2007-11-27 2008-11-24 Methods for detecting estradiol by mass spectrometry
PCT/US2008/084561 WO2009070539A1 (en) 2007-11-27 2008-11-24 Methods for detecting estradiol by mass spectrometry
EP08855326.8A EP2231297B2 (en) 2007-11-27 2008-11-24 Methods for detecting estradiol by mass spectrometry
EP18176001.8A EP3388127B1 (en) 2007-11-27 2008-11-24 Methods for detecting estradiol by mass spectrometry

Related Parent Applications (4)

Application Number Title Priority Date Filing Date
EP08855326.8A Division EP2231297B2 (en) 2007-11-27 2008-11-24 Methods for detecting estradiol by mass spectrometry
EP14169040.4A Division EP2777792B1 (en) 2007-11-27 2008-11-24 Methods for detecting estradiol by mass spectrometry
EP18176001.8A Division-Into EP3388127B1 (en) 2007-11-27 2008-11-24 Methods for detecting estradiol by mass spectrometry
EP18176001.8A Division EP3388127B1 (en) 2007-11-27 2008-11-24 Methods for detecting estradiol by mass spectrometry

Publications (2)

Publication Number Publication Date
EP4250336A2 EP4250336A2 (en) 2023-09-27
EP4250336A3 true EP4250336A3 (en) 2023-11-01

Family

ID=40668902

Family Applications (4)

Application Number Title Priority Date Filing Date
EP18176001.8A Active EP3388127B1 (en) 2007-11-27 2008-11-24 Methods for detecting estradiol by mass spectrometry
EP14169040.4A Active EP2777792B1 (en) 2007-11-27 2008-11-24 Methods for detecting estradiol by mass spectrometry
EP23186684.9A Pending EP4250336A3 (en) 2007-11-27 2008-11-24 Methods for detecting estradiol by mass spectrometry
EP08855326.8A Active EP2231297B2 (en) 2007-11-27 2008-11-24 Methods for detecting estradiol by mass spectrometry

Family Applications Before (2)

Application Number Title Priority Date Filing Date
EP18176001.8A Active EP3388127B1 (en) 2007-11-27 2008-11-24 Methods for detecting estradiol by mass spectrometry
EP14169040.4A Active EP2777792B1 (en) 2007-11-27 2008-11-24 Methods for detecting estradiol by mass spectrometry

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP08855326.8A Active EP2231297B2 (en) 2007-11-27 2008-11-24 Methods for detecting estradiol by mass spectrometry

Country Status (7)

Country Link
US (3) US20090134325A1 (en)
EP (4) EP3388127B1 (en)
JP (4) JP5602636B2 (en)
CN (2) CN103323561B (en)
BR (1) BRPI0819611A2 (en)
CA (1) CA2706847C (en)
WO (1) WO2009070539A1 (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090134325A1 (en) * 2007-11-27 2009-05-28 Goldman Mildred M Methods for detecting estradiol by mass spectrometry
US8399829B2 (en) * 2008-12-18 2013-03-19 Quest Diagnostics Investments Incorporated Vitamin B2 detection by mass spectrometry
US20100155594A1 (en) * 2008-12-23 2010-06-24 Goldman Mildred M Mass spectrometry assay for estrogenic compounds
CN102175792B (en) * 2010-12-24 2012-04-25 北京师范大学 Method for detecting estrogen, nonyl phenol, octylphenol and bisphenol A together in water environment
WO2012095948A1 (en) * 2011-01-11 2012-07-19 株式会社島津製作所 Mass spectrometry data analysis method, mass spectrometry data analysis device, and mass spectrometry data analysis program
US9029162B2 (en) * 2011-02-07 2015-05-12 Laboratory Corporation Of America Holdings Methods and systems for determining the presence or amount of testosterone in a sample
CN102183606B (en) * 2011-03-02 2012-04-25 北京师范大学 Method for detecting estrogen, nonyl phenol, octyl phenol and bisphenol A in water body sediment together
US8669519B2 (en) * 2011-12-05 2014-03-11 Quest Diagnostics Investments, Inc. Methods for detecting reverse triiodothyronine by mass spectrometry
US9404900B2 (en) * 2012-12-21 2016-08-02 Thermo Finnigan Llc System for analysis of phase-I and phase-II metabolites and parent compounds without hydrolysis
WO2015162426A1 (en) * 2014-04-23 2015-10-29 Micromass Uk Limited Self-calibration of spectra using precursor mass to charge ratio and fragment mass to charge ratio known differences
US9459267B2 (en) * 2014-05-12 2016-10-04 Quest Diagnostics Investments Incorporated Quantitation of tamoxifen and metabolites thereof by mass spectrometry
CN105572238B (en) * 2014-10-16 2017-11-10 无锡市寰创环境科技发展有限公司 A kind of method of estrogen in detection livestock waste
CN104678022A (en) * 2015-03-09 2015-06-03 黑龙江省乳品工业技术开发中心 Method for predicting content reduction of beta-estradiol in secreted milk of postpartum cow as well as application
US11360098B2 (en) * 2015-09-28 2022-06-14 Quest Diagnostics Investments Llc Amyloid beta detection by mass spectrometry
CN108459104A (en) * 2017-12-26 2018-08-28 华南师范大学 A kind of method of personal care articles in detection Fish Bile
CN110243917A (en) * 2018-03-09 2019-09-17 中国科学院天津工业生物技术研究所 A kind of method of quick detection small molecule compound
US11536733B2 (en) * 2019-04-16 2022-12-27 Laboratory Corporation Of America Holdings Methods and systems for the detection of 11-oxo androgens by LC-MS/MS
CN111103380A (en) * 2019-12-25 2020-05-05 南京希麦迪医药科技有限公司 Method for determining concentration of endogenous estradiol in human plasma by liquid chromatography-mass spectrometry

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040235193A1 (en) * 2003-04-14 2004-11-25 Soldin Steven J. Steroid hormone analysis by mass spectrometry
US20060040256A1 (en) * 2003-09-08 2006-02-23 Quest Diagnostics Inc Determination of testosterone by mass spectrometry
US20060105408A1 (en) * 2001-01-02 2006-05-18 Stanley Hazen Myeloperoxidase, a risk indicator for cardiovascular disease
US20070043441A1 (en) * 2005-08-02 2007-02-22 Perumala Corporation Total artificial disc

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5605798A (en) * 1993-01-07 1997-02-25 Sequenom, Inc. DNA diagnostic based on mass spectrometry
CA2163426C (en) * 1993-05-28 2005-11-01 T. William Hutchens Method and apparatus for desorption and ionization of analytes
US5772874A (en) * 1995-11-02 1998-06-30 Cohesive Technologies, Inc. High performance liquid chromatography method and apparatus
PL327920A1 (en) * 1996-01-19 1999-01-04 Cohesive Technologies Highly efficient liquid chromatography process and chromatographic apparatus therefor
GB9717926D0 (en) * 1997-08-22 1997-10-29 Micromass Ltd Methods and apparatus for tandem mass spectrometry
US6040575A (en) * 1998-01-23 2000-03-21 Analytica Of Branford, Inc. Mass spectrometry from surfaces
JP2000088834A (en) * 1998-09-16 2000-03-31 Sumika Chemical Analysis Service Ltd Analyzing method
JP2001116736A (en) * 1999-10-21 2001-04-27 Sumika Chemical Analysis Service Ltd Method for analyzing estrogen
DE10028974A1 (en) * 2000-06-16 2002-01-03 Henkel Kgaa Thixotropic oral and dental care products
US6680203B2 (en) * 2000-07-10 2004-01-20 Esperion Therapeutics, Inc. Fourier transform mass spectrometry of complex biological samples
JP2002056040A (en) * 2000-08-14 2002-02-20 Nec Corp Method for designing cable clamp and cable shapes by three-dimensional cad and computer-readable recording medium
US6635173B2 (en) * 2000-12-28 2003-10-21 Cohesive Technologies, Inc. Multi column chromatography system
JP2003090839A (en) * 2001-09-18 2003-03-28 Toru Ueda Endocrine disrupting substance group and method for evaluating biotic waste processed product using its activity as indicator
JP2003098169A (en) * 2001-09-25 2003-04-03 Toru Ueda Method for evaluating grains, fruit, and vegetable with endocrine disrupting action as index and its application method
DE60306750T2 (en) * 2002-01-31 2007-09-20 Centre National De La Recherche Scientifique (C.N.R.S.) PEPTIDE FRAGMENT OF THE LIGAND BINDING POCKET OF THE ESTROGEN RECEPTOR 3 (ERR3), CRYSTAL STRUCTURES THEREOF AND THEIR USE
JP2003342291A (en) * 2002-05-27 2003-12-03 Sumika Chemical Analysis Service Ltd Estradiol conjugate
JP3844741B2 (en) * 2003-03-03 2006-11-15 株式会社荏原製作所 Female hormone-degrading bacteria and their uses
JP2005283380A (en) * 2004-03-30 2005-10-13 Teikoku Hormone Mfg Co Ltd Method for measuring bioavailable steroid hormone
JP4667832B2 (en) * 2004-11-15 2011-04-13 あすか製薬株式会社 A new method for measuring trace amounts of estradiol in vivo
WO2006107339A2 (en) * 2005-03-31 2006-10-12 Georgetown University Free thyroxine and free triiodothyronine analysis by mass spectrometry
WO2007029668A1 (en) * 2005-09-08 2007-03-15 National University Corporation Kanazawa University Derivatization reagent for soft ionization process
JP4634913B2 (en) * 2005-11-09 2011-02-16 あすか製薬株式会社 Steroid measurement method
CN1834641A (en) * 2006-04-14 2006-09-20 清华大学 Sampling and monitoring method and device for polarity endocrine interferent in water environment
CA2820957A1 (en) * 2006-05-26 2007-12-06 Laboratory Corporation Of America Holdings Liquid chromatography with tandem mass spectrometry of estrone, estradiol and free thyroxine
US20090134325A1 (en) 2007-11-27 2009-05-28 Goldman Mildred M Methods for detecting estradiol by mass spectrometry
US8202736B2 (en) * 2009-02-26 2012-06-19 The Governing Council Of The University Of Toronto Method of hormone extraction using digital microfluidics

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060105408A1 (en) * 2001-01-02 2006-05-18 Stanley Hazen Myeloperoxidase, a risk indicator for cardiovascular disease
US20040235193A1 (en) * 2003-04-14 2004-11-25 Soldin Steven J. Steroid hormone analysis by mass spectrometry
US20060040256A1 (en) * 2003-09-08 2006-02-23 Quest Diagnostics Inc Determination of testosterone by mass spectrometry
US20070043441A1 (en) * 2005-08-02 2007-02-22 Perumala Corporation Total artificial disc

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
LOPEZ DE ALDA M J ET AL: "Liquid chromatography-(tandem) mass spectrometry of selected emerging pollutants (steroid sex hormones, drugs and alkylphenolic surfactants) in the aquatic environment", JOURNAL OF CHROMATOGRAPHY A (ELSEVIER SCIENCE PUBLISHERS B.V, NL), vol. 1000, no. 1-2, 6 June 2003 (2003-06-06), Amsterdam, NL, pages 503 - 526, XP004427310, ISSN: 0021-9673, DOI: 10.1016/S0021-9673(03)00509-0 *
R. DRAISCI ET AL: "Quantification of 17β-estradiol residues in bovine serum by liquid chromatography-tandem mass spectrometry with atmospheric pressure chemical ionization†", THE ANALYST, vol. 123, no. 12, 1 January 1998 (1998-01-01), pages 2605 - 2609, XP055153998, ISSN: 0003-2654, DOI: 10.1039/a805224g *
vol. 50, part 2 1 February 2004, CLINICAL CHEMISTRY, AMERICAN ASSOCIATION FOR CLINICAL CHEMISTRY, CHAPEL HILL NC USA, ISSN: 0009-9147, article NELSON ROBERT E ET AL: "Liquid chromatography-tandem mass spectrometry assay for simultaneous measurement of estradiol and estrone in human plasma", pages: 373 - 384, XP002622663 *

Also Published As

Publication number Publication date
WO2009070539A1 (en) 2009-06-04
BRPI0819611A2 (en) 2015-05-05
JP2011505013A (en) 2011-02-17
JP2014238419A (en) 2014-12-18
EP3388127B1 (en) 2023-08-23
EP3388127A1 (en) 2018-10-17
EP2231297A1 (en) 2010-09-29
EP2231297A4 (en) 2011-04-20
EP4250336A2 (en) 2023-09-27
JP7199392B2 (en) 2023-01-05
CN103323561B (en) 2019-05-07
CN101918098A (en) 2010-12-15
CA2706847A1 (en) 2009-06-04
JP6176735B2 (en) 2017-08-09
CN103323561A (en) 2013-09-25
US20090134325A1 (en) 2009-05-28
CA2706847C (en) 2020-10-13
EP2231297B2 (en) 2017-03-29
CN101918098B (en) 2013-06-19
EP2777792A2 (en) 2014-09-17
EP2777792B1 (en) 2018-07-25
US20150309055A1 (en) 2015-10-29
EP2777792A3 (en) 2015-01-14
US20220326260A1 (en) 2022-10-13
JP2017198703A (en) 2017-11-02
JP5602636B2 (en) 2014-10-08
JP2020112562A (en) 2020-07-27
EP2231297B1 (en) 2014-05-21
JP6673875B2 (en) 2020-03-25

Similar Documents

Publication Publication Date Title
EP4250336A3 (en) Methods for detecting estradiol by mass spectrometry
MX2011003653A (en) Methods for detecting dihydrotestosterone by mass spectrometry.
WO2009076139A3 (en) Thyroglobulin quantitation by mass spectrometry
MX2017011312A (en) Methods for quantitation of insulin levels by mass spectrometry.
EP2138841B8 (en) System and method for measuring an analyte in a sample
GB2521579A (en) Mass spectrometer, system comprising the same, and methods for determining isotopic anatomy of compounds
BRPI0820876B8 (en) method for determining the amount of estrone in a body fluid sample
WO2009134944A3 (en) Methods of determining the health status of an individual
EP2565905A3 (en) Mass spectrometry assay for plasma-renin
GB2455831B (en) Concentrating mass spectrometer ion guide, spectrometer and method
MY161825A (en) Methods for counting cells
IN2014DN02241A (en)
GB0811574D0 (en) Characterising planar samples by mass spectrometry
WO2009129505A3 (en) Compositions, methods, and kits using synthetic probes for determining the presence of a target nucleic acid
WO2008011158A3 (en) Method of detecting and/ or measuring hepcidin in a sample
EP2264465A4 (en) Sample preparation apparatus and sample preparation method, and cell analysis apparatus and cell analysis method
GB2448562B (en) Top-down protein analysis in mass spectrometers with ion traps
GB0507457D0 (en) Improvements in or relating to methods and apparatus for analyzing biological samples by mass spectrometry
IL199798A0 (en) A high sensitivity multiparameter method for rare event analysis in a biological sample
WO2009113044A3 (en) Method for a highly sensitive detection and quantification of biomolecules using secondary ion mass spectrometry (sims)
EP2419198A4 (en) Acquisition and analysis of mixed ion populations in a mass spectrometer
BR112014012366A2 (en) Processes for the detection of inverse triiodothyronine by mass spectrometry
EP1930937A4 (en) Ion trap, multiple-electrode-pole system and electrode pole for mass spectrometic analysis
GB2417124B (en) Measuring cell for Ion cyclotron resonance mass spectrometer
WO2009105212A3 (en) Detection of polyomavirus

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION HAS BEEN PUBLISHED

AC Divisional application: reference to earlier application

Ref document number: 2231297

Country of ref document: EP

Kind code of ref document: P

Ref document number: 2777792

Country of ref document: EP

Kind code of ref document: P

Ref document number: 3388127

Country of ref document: EP

Kind code of ref document: P

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR

REG Reference to a national code

Ref country code: DE

Ref legal event code: R079

Free format text: PREVIOUS MAIN CLASS: H01J0049260000

Ipc: B01D0015080000

PUAL Search report despatched

Free format text: ORIGINAL CODE: 0009013

AK Designated contracting states

Kind code of ref document: A3

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR

RIC1 Information provided on ipc code assigned before grant

Ipc: H01J 49/00 20060101ALI20230927BHEP

Ipc: G01N 33/74 20060101ALI20230927BHEP

Ipc: G01N 33/68 20060101ALI20230927BHEP

Ipc: H01J 49/26 20060101ALI20230927BHEP

Ipc: G01N 30/60 20060101ALI20230927BHEP

Ipc: G01N 30/00 20060101ALI20230927BHEP

Ipc: B01D 15/08 20060101AFI20230927BHEP

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE

17P Request for examination filed

Effective date: 20240502

RBV Designated contracting states (corrected)

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR

REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 40102323

Country of ref document: HK